{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:20:09Z","timestamp":1783225209978,"version":"3.54.6"},"reference-count":52,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["00193-00002187\/2023-24"],"award-info":[{"award-number":["00193-00002187\/2023-24"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spontaneous Demand FAPDF and the National Council for Scientific and Technological Development (CNPq) with the Ministry of Health\/Department of Science and Technology","award":["UnB-DPG-DPI\u20140022022"],"award-info":[{"award-number":["UnB-DPG-DPI\u20140022022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Major Depressive Disorder (MDD) has a multifactorial etiology and pathogenesis that significantly impacts an individual\u2019s quality of life. One of the possible correlations for its onset is the activation of inflammatory responses resulting in neurodegeneration and, consequently, the emergence of depressive symptoms. Interleukin-1\u03b2 is a regulatory cytokine of the immune and nervous systems that acts on several processes, including mood regulation. This systematic review analyzed the IL1B (C-511T) (rs16944) variant\u2019s CC and CT genotype frequencies and their associations with MDD in different populations while also verifying the TT genotype\u2019s influence on response to antidepressant therapy. This review involved searching five databases, and articles were selected according to the PECOS inclusion criteria, resulting in eight articles. The findings highlight distinct clinical outcomes: the CC genotype was more frequently associated with greater MDD symptom severity, whereas the TT genotype was predominantly associated with antidepressant treatment response; thus, these associations should not be considered equivalent in terms of susceptibility to disease onset. However, despite these findings, other studies have found no significant association between this genetic variant and MDD. Therefore, further studies across different populations are needed to better understand the role of this polymorphism in the etiology of this disorder.<\/jats:p>","DOI":"10.3390\/ijms27135974","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:59:47Z","timestamp":1783065587000},"page":"5974","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-1\u03b2 (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-7138","authenticated-orcid":false,"given":"Bruna","family":"Rodrigues Gontijo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9452","authenticated-orcid":false,"given":"Caroline","family":"Ferreira Fratelli","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-8026","authenticated-orcid":false,"given":"Larissa","family":"Sousa Silva Bonasser","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-0735","authenticated-orcid":false,"given":"Calliandra Maria","family":"de Souza Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 72220-900, Brazil"},{"name":"Academic Unit of Biotechnology Engineering (UAEB), Center for Sustainable Development of the Semi-Arid Region (CDSA), Sum\u00e9 Campus, Federal University of Campina Grande, Sum\u00e9 58540-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-3583","authenticated-orcid":false,"given":"Izabel Cristina","family":"Rodrigues da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences and Technologies, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 72220-900, Brazil"},{"name":"Postgraduate Program in Health Sciences, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 70910-900, Brazil"},{"name":"Clinical Analysis Laboratory, Molecular Pathology Sector, Pharmacy Department, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia (UnB), Bras\u00edlia-Federal District (DF), Bras\u00edlia 72220-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41572-023-00454-1","article-title":"Major Depressive Disorder","volume":"9","author":"Marx","year":"2023","journal-title":"Nat. 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