{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:19:11Z","timestamp":1785421151220,"version":"3.56.0"},"reference-count":55,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Education and Research (CNCS-UEFISCDI","award":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"]}]},{"name":"grant of the Ministry of Education and Research, CCDI-UEFISCDI","award":["project number PN-IV-PCB-RO-MD-2024-0246, within PNCDI IV."],"award-info":[{"award-number":["project number PN-IV-PCB-RO-MD-2024-0246, within PNCDI IV."]}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education","doi-asserted-by":"publisher","award":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"],"award-info":[{"award-number":["PN-III-P4-ID-PCE-2020-2687 (grant no. 244\/2021))"]}],"id":[{"id":"https:\/\/ror.org\/00dh5gw98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes mellitus (DM) is a highly prevalent metabolic disorder and a major public health concern. Pioglitazone, a widely used antidiabetic agent, exhibits limited therapeutic efficiency due to poor water solubility and suboptimal pharmacokinetic properties. Similarly, curcumin (Cur), a natural polyphenol with pleiotropic biological activities, is hindered by low oral bioavailability. In this study, chitosan-based nanocarriers were developed for the delivery of pioglitazone (CS-Pio NPs), curcumin (CS-Cur NPs), and their co-encapsulation (CS-Pio-Cur NPs), aiming to enhance their biological performance and therapeutic efficacy. The co-loaded nanosystem (CS-Pio-Cur NPs) demonstrated significantly enhanced antioxidant activity, as evidenced by DPPH (71.29 \u00b1 0.09%), ABTS (86.08 \u00b1 0.04%), and hydroxyl radical scavenging (87.08 \u00b1 0.06%) assays, along with a strong reducing capacity (IC50 = 25.39 \u00b1 0.23 \u03bcg\/mL). In a diabetic rat model, CS-Pio-Cur NPs significantly reduced blood glucose level and HbA1c (6.60 \u00b1 0.83%), while also improving liver and kidney function parameters and lipid profile. These findings suggest that co-delivery of Pio and Cur via CS-based nanocarriers provides a combined therapeutic effect by simultaneously targeting hyperglycemia, oxidative stress, and associated metabolic dysfunctions. This nanosystem represents a promising approach for improving the management of DM and its complications.<\/jats:p>","DOI":"10.3390\/ijms27136002","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:15:53Z","timestamp":1783095353000},"page":"6002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chitosan-Based Nanocarriers Co-Delivering Pioglitazone and Curcumin: Biological Activity and Therapeutic Potential in Diabetes"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-1863","authenticated-orcid":false,"given":"Florentina-Geanina","family":"Lupascu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-9628","authenticated-orcid":false,"given":"Gabriela-Dumitri\u021ba","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Advanced Center for Research and Development in Experimental Medicine \u201cProf. Ostin C. Mungiu\u201d, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-7139","authenticated-orcid":false,"given":"Bianca-\u0218tefania","family":"Profire","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-4208","authenticated-orcid":false,"given":"Roxana-Georgiana","family":"Tau\u0219er","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-7311","authenticated-orcid":false,"given":"Dan","family":"Lupa\u0219cu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-3801","authenticated-orcid":false,"given":"Andreea-Teodora","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-2789","authenticated-orcid":false,"given":"Ioana-Mirela","family":"Vasincu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Apotrosoaei","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-4860","authenticated-orcid":false,"given":"Alexandru","family":"Sava","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-1999","authenticated-orcid":false,"given":"Bogdan-Ionel","family":"Tamba","sequence":"additional","affiliation":[{"name":"Advanced Center for Research and Development in Experimental Medicine \u201cProf. Ostin C. Mungiu\u201d, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-3023","authenticated-orcid":false,"given":"Lenu\u021ba","family":"Profire","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Therapeutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ababei-Bobu, A., Sava, A., Lupascu, F.G., Chirliu, O.M., Profire, B.S., Turin-Moleavin, I.A., Varganici, C.D., Dascalu, I.A., Pinteala, T., and Profire, L. (2026). Chitosan-Coated Niosomal Nanocarriers for the Co-Delivery of Glibenclamide and Curcumin in Diabetes Mellitus. Polymers, 12.","DOI":"10.3390\/polym18040466"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yu, X., Liu, X., and Li, H. (2025). Nutrient Metabolism and Complications of Type 2 Diabetes Mellitus: Implications for Rehabilitation and Precision Care. Front. 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