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P2X7R Signaling and Differential Regulation of Neuroinflammatory and Behavior Responses in Male and Female Mice During Chronic Ethanol Exposure. Int. J. Mol. Sci., 27.","DOI":"10.20944\/preprints202601.2119.v1"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sadowski, K., Zaj\u0105c, W., Milanowski, \u0141., Koziorowski, D., and Figura, M. (2024). Exploring Fecal Microbiota Transplantation for Modulating Inflammation in Parkinson\u2019s Disease: A Review of Inflammatory Markers and Potential Effects. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147741"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Seyfried, K.S., Kremer, B., Conzen-Dilger, C., Veldeman, M., Bertram, U., Blume, C., Mueller, C.A., Bi, T., J\u00fctten, K., and Clusmann, H. (2025). Mapping Inflammatory Markers in Cerebrospinal Fluid Following Aneurysmal Subarachnoid Hemorrhage: An Age- and Sex-Matched Analysis. Int. J. Mol. 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Neurosci., 19.","DOI":"10.3389\/fnmol.2026.1755292"},{"key":"ref_35","first-page":"138","article-title":"Towards Clinical Translation of Biomarkers and Therapies Targeting Autolysosomal Acidification Dysfunction in Neuroinflammation and Neurodegeneration\u2014An Interview with Prof. David Rubinsztein","volume":"6","author":"Lo","year":"2024","journal-title":"Aging Pathobiol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lo, C.H., Ren, M., Loi, G.W.Z., Saipuljumri, E.N., Indajang, J., Lim, K.L., and Zeng, J. (2026). Lysosome-Acidifying Nanoparticles Rescue A30P \u03b1-Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinsons Disease. Adv. Healthc. Mat., 15.","DOI":"10.1002\/adhm.202502906"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of Autophagy\u2013Lysosome Dysfunction in Neurodegenerative Diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e199845","DOI":"10.1172\/JCI199845","article-title":"Lysosomal Homeostasis at the Crossroads of Neurodegeneration","volume":"136","author":"Tooze","year":"2026","journal-title":"J. Clin. Investig."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eaec2042","DOI":"10.1126\/sciadv.aec2042","article-title":"IgLON5 Autoimmune Antibodies Activate Tau via Neuronal Hyperactivity","volume":"12","author":"Askin","year":"2026","journal-title":"Sci. Adv."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kim, Y.J., Cho, M.J., Yu, W.D., Kim, M.J., Kim, S.Y., and Lee, J.H. (2022). Links of Cytoskeletal Integrity with Disease and Aging. Cells, 11.","DOI":"10.3390\/cells11182896"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"103138","DOI":"10.1016\/j.arr.2026.103138","article-title":"Metabolic Reprogramming and Signalling Networks in Microglial Activation: Implications for Neurodegeneration","volume":"118","author":"Abboussi","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1016\/j.cell.2024.08.050","article-title":"Brain-Body Physiology: Local, Reflex, and Central Communication","volume":"187","author":"Sammons","year":"2024","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, F., Zhao, S., Liang, Z., Xu, Z., Bai, S., Zhou, W., Zheng, Q., Yan, W., Wang, L., and Sun, K. (2026). Brain\u2013Body Interactions in Systemic Diseases: A Survey from an Imaging Perspective. MedScience.","DOI":"10.1007\/s11684-026-1229-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ajpath.2024.12.014","article-title":"Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration","volume":"195","author":"Szczupak","year":"2025","journal-title":"Am. J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kaya, Y., and K\u0131rbo\u011fa, K.K. (2026). Shared Molecular Mechanisms in Aging and Neurodegenerative Diseases: From Mechanistic Insights to Therapeutic Strategies. Front. Hum. Neurosci., 20.","DOI":"10.3389\/fnhum.2026.1768774"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103102","DOI":"10.1016\/j.arr.2026.103102","article-title":"Hallmarks of Healthy Cognitive Aging: Inter-Individual Differences in Aging Trajectories","volume":"119","author":"Abrous","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted Protein Degradation: Mechanisms, Strategies and Application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lo, C.H., Cheong, L.Y.T., and Zeng, J. (2025). Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications. Nanomaterials, 15.","DOI":"10.3390\/nano15100704"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115411","DOI":"10.1016\/j.addr.2024.115411","article-title":"Precise Subcellular Targeting Approaches for Organelle-Related Disorders","volume":"212","author":"Shim","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wang, Y., Zhou, J., Li, H., Liu, C., Zhong, B., Liu, J., Liu, L., Zhang, L., and Sun, L. (2025). Restoring Metabolic Flexibility: Targeting Organelle Interaction Networks in the Pathogenesis and Therapy of MASLD. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1718799"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S.S., Samouda, H., La Frano, M.R., and Bohn, T. (2020). Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients, 12.","DOI":"10.3390\/nu12061562"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.csbj.2025.03.046","article-title":"Targeting the Inter-Monomeric Space of TNFR1 Pre-Ligand Dimers: A Novel Binding Pocket for Allosteric Modulators","volume":"27","author":"Lo","year":"2025","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e2308132121","DOI":"10.1073\/pnas.2308132121","article-title":"Peptide-Based Allosteric Inhibitor Targets TNFR1 Conformationally Active Region and Disables Receptor\u2013Ligand Signaling Complex","volume":"121","author":"Zeng","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jimd.12139","article-title":"The Effectiveness of Correcting Abnormal Metabolic Profiles","volume":"43","author":"Clayton","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hamooya, B.M.M., Siame, L., Muchaili, L., Masenga, S.K.K., and Kirabo, A. (2025). Metabolic Syndrome: Epidemiology, Mechanisms, and Current Therapeutic Approaches. Front. 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