{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:51:28Z","timestamp":1785408688475,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["R-2023-785-020"],"award-info":[{"award-number":["R-2023-785-020"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R-2023-785-020"],"award-info":[{"award-number":["R-2023-785-020"]}],"id":[{"id":"https:\/\/ror.org\/03xddgg98","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Excessive gestational weight gain (EGWG) promotes adverse physiological and molecular changes in the placenta. In the present study, we examined the whole placental transcriptomic profile in women with EGWG to elucidate the molecular basis of EGWG pathogenesis. Whole transcriptome profile was analyzed in placentas from term patients with EGWG compared to controls using RNA-seq. Eight genes were found to be downregulated, and 318 genes were found to be upregulated in the placentas of the EGWG group in comparison with those of the women with adequate gestational weight gain (AGWG). Analysis of differentially expressed genes showed eight biological processes, nine cellular components, and ten molecular functions activated, and ten biological processes, ten cellular components, and ten molecular functions suppressed in the placentas from women with EGWG compared to AGWG. EGWG is characterized by significant alterations in placental gene expression, impacting various biological processes, cellular components, and molecular functions, including activation of chromatin organization and remodeling, nucleoplasm, and histone-modifying activity, and suppression of response to stimulus, organelle, and protein binding.<\/jats:p>","DOI":"10.3390\/ijms27136041","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"6041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental Gene Expression in Women with Excessive Gestational Weight Gain"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-8341","authenticated-orcid":false,"given":"Jorge","family":"Valencia-Ortega","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"},{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-6156","authenticated-orcid":false,"given":"Renata","family":"Saucedo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3637-4325","authenticated-orcid":false,"given":"Erika","family":"Magall\u00f3n-Gay\u00f3n","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, Escuela de Ingenier\u00eda y Ciencias, Campus Monterrey, Ave. Eugenio Garza Sada 2501 Sur, Monterrey 64700, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-9927","authenticated-orcid":false,"given":"Alejandra","family":"Contreras-Ramos","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Biolog\u00eda Molecular, Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Flor","family":"D\u00edaz-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Hospital de Gineco Obstetricia 3, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5797-6131","authenticated-orcid":false,"given":"Debbie","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Ortega-Camarillo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-9856","authenticated-orcid":false,"given":"Aldo","family":"Ferreira-Hermosillo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-7720","authenticated-orcid":false,"given":"Javier","family":"Perez-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n en Salud Reproductiva y Perinatal, Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"745.e1","DOI":"10.1016\/j.ajog.2015.12.026","article-title":"Maternal fat, but not lean, mass is increased among overweight\/obese women with excess gestational weight gain","volume":"214","author":"Berggren","year":"2016","journal-title":"Am. 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