{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:46:41Z","timestamp":1785422801430,"version":"3.56.0"},"reference-count":128,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Central public welfare research institutes","award":["ZZ17-YQ-037"],"award-info":[{"award-number":["ZZ17-YQ-037"]}]},{"name":"Fundamental Research Funds for the Central public welfare research institutes","award":["ZZ16-XRZ-092"],"award-info":[{"award-number":["ZZ16-XRZ-092"]}]},{"name":"Fundamental Research Funds for the Central public welfare research institutes","award":["XTCX2023003"],"award-info":[{"award-number":["XTCX2023003"]}]},{"name":"Fundamental Research Funds for the Central public welfare research institutes","award":["CZSYSPY2025001"],"award-info":[{"award-number":["CZSYSPY2025001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["T2341017"],"award-info":[{"award-number":["T2341017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["T2341017"],"award-info":[{"award-number":["T2341017"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences","award":["NLTS2025001"],"award-info":[{"award-number":["NLTS2025001"]}]},{"award":["NLTS2025001"],"award-info":[{"award-number":["NLTS2025001"]}],"id":[{"id":"https:\/\/ror.org\/042pgcv68","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes mellitus comprises a group of heterogeneous metabolic disorders characterized by persistent hyperglycemia, progressive \u03b2-cell dysfunction, and multi-organ complications. Although type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) have distinct pathogenic origins, both involve immune dysregulation, tissue stress, release of danger signals, and chronic inflammation. Dendritic cells (DCs), as antigen-presenting cells, integrate innate immune sensing, antigen presentation, cytokine production, T-cell regulation, and peripheral immune tolerance, placing them at a critical interface between autoimmunity and metabolic inflammation. In T1DM, DCs contribute to \u03b2-cell autoantigen presentation, tolerance breakdown, autoreactive T-cell activation, and insulitis amplification. In T2DM, DCs may contribute to adipose tissue inflammation, hepatic immunometabolic crosstalk, \u03b2-cell stress, vascular inflammation, and immune remodeling associated with diabetes-related complications. Here, we review the disease-specific roles of DC subsets in T1DM and T2DM and discuss shared molecular mechanisms, including pattern-recognition receptor signaling, metabolic reprogramming, inflammasome activation, cytokine networks, and the shift from immune tolerance to inflammation. We also evaluate therapeutic DC reprogramming strategies and their potential implications for targeted immunometabolic intervention in diabetes.<\/jats:p>","DOI":"10.3390\/ijms27136057","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"6057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dendritic Cells as Immunometabolic Regulatory Nodes in Diabetes: Molecular Mechanisms and Therapeutic Reprogramming"],"prefix":"10.3390","volume":"27","author":[{"given":"Fangfang","family":"Jin","sequence":"first","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0580-6227","authenticated-orcid":false,"given":"Xuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Fan","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC202203150","article-title":"Type 1 Diabetes Mellitus","volume":"175","author":"Syed","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-024-01951-9","article-title":"Type 2 diabetes mellitus in adults: Pathogenesis, prevention and therapy","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0140-6736(13)62154-6","article-title":"Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future","volume":"383","author":"Kahn","year":"2014","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41577-019-0213-9","article-title":"Targeting innate immune mediators in type 1 and type 2 diabetes","volume":"19","author":"Donath","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115734","DOI":"10.1016\/j.biopha.2023.115734","article-title":"Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments","volume":"168","author":"Antar","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"a007724","DOI":"10.1101\/cshperspect.a007724","article-title":"Connecting type 1 and type 2 diabetes through innate immunity","volume":"2","author":"Odegaard","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.immuni.2023.07.001","article-title":"Dendritic cell type 3 arises from Ly6C(+) monocyte-dendritic cell progenitors","volume":"56","author":"Liu","year":"2023","journal-title":"Immunity"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13045-020-00939-6","article-title":"Dendritic cell biology and its role in tumor immunotherapy","volume":"13","author":"Wang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-101819-025146","article-title":"Dendritic Cell Regulation of T Helper Cells","volume":"39","author":"Yin","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Khan, F.U., Khongorzul, P., Raki, A.A., Rajasekaran, A., Gris, D., and Amrani, A. (2022). Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094885"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nri2787","article-title":"Immune cell crosstalk in type 1 diabetes","volume":"10","author":"Lehuen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108528","DOI":"10.1016\/j.diabres.2020.108528","article-title":"Insulin resistance and obesity affect monocyte-derived dendritic cell phenotype and function","volume":"170","author":"Paccosi","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Soedono, S., and Cho, K.W. (2021). Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168666"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zatterale, F., Longo, M., Naderi, J., Raciti, G.A., Desiderio, A., Miele, C., and Beguinot, F. (2019). Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01607"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e2219790120","DOI":"10.1073\/pnas.2219790120","article-title":"Dynamic interactome of the MHC I peptide loading complex in human dendritic cells","volume":"120","author":"Barends","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41577-024-01079-5","article-title":"Striking a balance: New perspectives on homeostatic dendritic cell maturation","volume":"25","author":"Bosteels","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s43556-025-00300-8","article-title":"Dendritic cells: Understanding ontogeny, subsets, functions, and their clinical applications","volume":"6","author":"Li","year":"2025","journal-title":"Mol. Biomed."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41423-020-0465-0","article-title":"Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses","volume":"17","author":"Hilligan","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41574-023-00853-0","article-title":"Heterogeneity and endotypes in type 1 diabetes mellitus","volume":"19","author":"Redondo","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41574-025-01128-6","article-title":"Type 1 diabetes mellitus prevention: Present and future","volume":"21","author":"Henriques","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev-med-042320-015952","article-title":"Enteroviruses and Type 1 Diabetes: Multiple Mechanisms and Factors?","volume":"73","author":"Lloyd","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41577-023-00985-4","article-title":"The immunology of type 1 diabetes","volume":"24","author":"Herold","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/db16-0671","article-title":"Primary Human and Rat \u03b2-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity","volume":"66","author":"Cianciaruso","year":"2017","journal-title":"Diabetes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/imr.12430","article-title":"The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse","volume":"272","author":"Unanue","year":"2016","journal-title":"Immunol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41467-023-35844-2","article-title":"TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction","volume":"14","author":"Sakaniwa","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Morse, Z.J., and Horwitz, M.S. (2017). Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00249"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2007.06.010","article-title":"Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes","volume":"27","author":"Kim","year":"2007","journal-title":"Immunity"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/nm.2028","article-title":"Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors","volume":"15","author":"Ghiringhelli","year":"2009","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1074-7613(02)00388-6","article-title":"Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation","volume":"17","author":"Delneste","year":"2002","journal-title":"Immunity"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4049\/jimmunol.173.1.307","article-title":"High mobility group box protein 1: An endogenous signal for dendritic cell maturation and Th1 polarization","volume":"173","author":"Messmer","year":"2004","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/eji.200526066","article-title":"Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells","volume":"35","author":"Dumitriu","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-Associated Molecular Patterns in Inflammatory Diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Welzen-Coppens, J.M., van Helden-Meeuwsen, C.G., Leenen, P.J., Drexhage, H.A., and Versnel, M.A. (2013). The kinetics of plasmacytoid dendritic cell accumulation in the pancreas of the NOD mouse during the early phases of insulitis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055071"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1189\/jlb.3MR1115-500R","article-title":"Type 1 diabetes genetic susceptibility and dendritic cell function: Potential targets for treatment","volume":"100","author":"Tarbell","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nm.3042","article-title":"Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes","volume":"19","author":"Diana","year":"2013","journal-title":"Nat. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1038\/s41598-020-65851-y","article-title":"Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes","volume":"10","author":"Badal","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70455","DOI":"10.1002\/mco2.70455","article-title":"Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential","volume":"6","author":"Jin","year":"2025","journal-title":"MedComm"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e2517132122","DOI":"10.1073\/pnas.2517132122","article-title":"A time-gated PKA-CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4(+) T cells","volume":"122","author":"Zhao","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41423-021-00753-1","article-title":"Metabolic programming in dendritic cells tailors immune responses and homeostasis","volume":"19","author":"Wang","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhang, S., Audiger, C., Chopin, M., and Nutt, S.L. (2023). Transcriptional regulation of dendritic cell development and function. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1182553"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bachem, A., Hartung, E., G\u00fcttler, S., Mora, A., Zhou, X., Hegemann, A., Plantinga, M., Mazzini, E., Stoitzner, P., and Gurka, S. (2012). Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front. Immunol., 3.","DOI":"10.3389\/fimmu.2012.00214"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Price, J.D., and Tarbell, K.V. (2015). The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00288"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e2219956120","DOI":"10.1073\/pnas.2219956120","article-title":"WDFY4 deficiency in NOD mice ameliorates autoimmune diabetes and insulitis","volume":"120","author":"Ferris","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3858\/emm.2012.44.4.021","article-title":"Toll-like receptor 4 on islet \u03b2 cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes","volume":"44","author":"Li","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Parackova, Z., Zentsova, I., Vrabcova, P., Klocperk, A., Sumnik, Z., Pruhova, S., Petruzelkova, L., Hasler, R., and Sediva, A. (2020). Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00661"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"39","author":"Cardoso","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhao, L., and Yang, X. (2022). Cross Talk Between Natural Killer T and Dendritic Cells and Its Impact on T Cell Responses in Infections. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.837767"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41574-025-01114-y","article-title":"Insulin resistance in type 2 diabetes mellitus","volume":"21","author":"Accili","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/mnfr.201200058","article-title":"Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance","volume":"56","author":"Reynolds","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.2337\/db11-1274","article-title":"Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients","volume":"61","author":"Bertola","year":"2012","journal-title":"Diabetes"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1038\/s41467-023-43283-2","article-title":"SEPTIN2 suppresses an IFN-\u03b3-independent, proinflammatory macrophage activation pathway","volume":"14","author":"Fu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopha.2018.02.103","article-title":"The potential pathogenic role of IL-17\/Th17 cells in both type 1 and type 2 diabetes mellitus","volume":"101","author":"Bakery","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/mi.2012.113","article-title":"A mechanistic role for leptin in human dendritic cell migration: Differences between ileum and colon in health and Crohn\u2019s disease","volume":"6","author":"Bernardo","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2119\/molmed.2010.00105","article-title":"Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin\u2014In chronic hepatitis","volume":"17","author":"Kukla","year":"2011","journal-title":"Mol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1053\/gast.2001.29594","article-title":"Kupffer cell-mediated recruitment of rat dendritic cells to the liver: Roles of N-acetylgalactosamine-specific sugar receptors","volume":"121","author":"Uwatoku","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Briceno Noriega, D., Zenker, H.E., Croes, C.A., Ewaz, A., Ruinemans-Koerts, J., Savelkoul, H.F.J., van Neerven, R.J.J., and Teodorowicz, M. (2022). Receptor Mediated Effects of Advanced Glycation End Products (AGEs) on Innate and Adaptative Immunity: Relevance for Food Allergy. Nutrients, 14.","DOI":"10.3390\/nu14020371"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.atherosclerosis.2009.01.002","article-title":"oxLDL uptake by dendritic cells induces upregulation of scavenger-receptors, maturation and differentiation","volume":"205","author":"Nickel","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1182\/blood-2009-07-234468","article-title":"LOX-1 as a natural IFN-alpha-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells","volume":"115","author":"Parlato","year":"2010","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s10020-022-00431-6","article-title":"Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKC\u03b2(1) signaling pathway in diabetic atherosclerosis","volume":"28","author":"Zhao","year":"2022","journal-title":"Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.immuni.2021.02.019","article-title":"Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery","volume":"54","author":"Clement","year":"2021","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.immuni.2025.09.011","article-title":"Obesity, diabetes, and inflammation: Pathophysiology and clinical implications","volume":"58","author":"Donath","year":"2025","journal-title":"Immunity"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4239\/wjd.v14.i3.130","article-title":"Pancreatic \u03b2-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress","volume":"14","author":"Dludla","year":"2023","journal-title":"World J. Diabetes"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.immuni.2021.02.002","article-title":"Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut","volume":"54","author":"Yan","year":"2021","journal-title":"Immunity"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41423-021-00812-7","article-title":"Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity","volume":"19","author":"Cueto","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1038\/s41467-024-49820-x","article-title":"Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells","volume":"15","author":"Marcelin","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s00125-017-4341-0","article-title":"Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice","volume":"60","author":"Hannibal","year":"2017","journal-title":"Diabetologia"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Alluri, K., Srinivas, B., Belmadani, S., and Matrougui, K. (2023). Plasmacytoid dendritic cells contribute to vascular endothelial dysfunction in type 2 diabetes. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1222243"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1475-2840-12-80","article-title":"High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells","volume":"12","author":"Lu","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2337\/db13-1444","article-title":"Pronounced reduction of cutaneous Langerhans cell density in recently diagnosed type 2 diabetes","volume":"63","author":"Strom","year":"2014","journal-title":"Diabetes"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1742-2094-10-64","article-title":"Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia","volume":"10","author":"Dauch","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.molmed.2024.06.011","article-title":"Virus as the cause of type 1 diabetes","volume":"30","year":"2024","journal-title":"Trends Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00125-023-05970-z","article-title":"Islet autoimmunity in human type 1 diabetes: Initiation and progression from the perspective of the beta cell","volume":"66","author":"Thompson","year":"2023","journal-title":"Diabetologia"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Khalid, M., Petroianu, G., and Adem, A. (2022). Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives. Biomolecules, 12.","DOI":"10.3390\/biom12040542"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jmb.2019.09.016","article-title":"Recent Insights Into Mechanisms of \u03b2-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes","volume":"432","author":"Lytrivi","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2147\/DDDT.S468147","article-title":"Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies","volume":"18","author":"Elkanawati","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Steer, S.A., Scarim, A.L., Chambers, K.T., and Corbett, J.A. (2006). Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med., 3.","DOI":"10.1371\/journal.pmed.0030017"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2024.03.002","article-title":"DAMPs and DAMP-sensing receptors in inflammation and diseases","volume":"57","author":"Ma","year":"2024","journal-title":"Immunity"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"Liu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Zirpel, H., and Roep, B.O. (2021). Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot\u2019s Print. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.666795"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wu, L., Yan, Z., Jiang, Y., Chen, Y., Du, J., Guo, L., Xu, J., Luo, Z., and Liu, Y. (2023). Metabolic regulation of dendritic cell activation and immune function during inflammation. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1140749"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2013.03.004","article-title":"Influence of metabolism on epigenetics and disease","volume":"153","author":"Kaelin","year":"2013","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Bencze, D., Fekete, T., Pfliegler, W., Sz\u00f6\u0151r, \u00c1., Csoma, E., Sz\u00e1nt\u00f3, A., Tarr, T., B\u00e1csi, A., Kem\u00e9ny, L., and Ver\u00e9b, Z. (2022). Interactions between the NLRP3-Dependent IL-1\u03b2 and the Type I Interferon Pathways in Human Plasmacytoid Dendritic Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012154"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"a016287","DOI":"10.1101\/cshperspect.a016287","article-title":"Inflammasomes","volume":"6","author":"Palm","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41419-025-08059-0","article-title":"IL-1\u03b2 priming triggers an adaptive stress response that enhances pancreatic \u03b2-cell resilience to subsequent cytotoxic inflammatory insult","volume":"16","author":"Orellano","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1016\/j.celrep.2018.02.044","article-title":"IL-23 and IL-1\u03b2 Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation","volume":"22","author":"Revu","year":"2018","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10641","DOI":"10.1038\/s41598-025-93647-5","article-title":"Metformin prevents diabetes development in type 1 diabetes models via suppression of mTOR and STAT3 signaling in immune cells","volume":"15","author":"Suzuki","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00018-023-04932-3","article-title":"Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming","volume":"80","author":"Liu","year":"2023","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1182\/blood-2007-06-096222","article-title":"PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolism","volume":"110","author":"Szatmari","year":"2007","journal-title":"Blood"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1182\/blood-2004-12-4709","article-title":"PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways","volume":"106","author":"Appel","year":"2005","journal-title":"Blood"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2016.09.028","article-title":"PPAR-\u03b3 agonist pioglitazone regulates dendritic cells immunogenicity mediated by DC-SIGN via the MAPK and NF-\u03baB pathways","volume":"41","author":"Zhu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"155832","DOI":"10.1016\/j.cyto.2022.155832","article-title":"Aqueous extract of Passiflora alata leaves modulates in vitro the indoleamine 2,3-dioxygenase (IDO) and CD86 expression in bone marrow-derived professional antigen-presenting cells polarizing NOD mice T cells to a Treg profile","volume":"152","author":"Schumacher","year":"2022","journal-title":"Cytokine"},{"key":"ref_101","first-page":"304","article-title":"Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.2337\/db11-0275","article-title":"Targeting curcusomes to inflammatory dendritic cells inhibits NF-\u03baB and improves insulin resistance in obese mice","volume":"60","author":"Yekollu","year":"2011","journal-title":"Diabetes"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"9963","DOI":"10.2147\/IJN.S522994","article-title":"Dendritic Cell Repression by TNF-\u03b1-Primed Exosomes Accelerate T2DM Wound Healing Through miR-146a-5p\/TXNIP\/NLRP3 Axis","volume":"20","author":"Li","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10875-010-9430-5","article-title":"IL-10\/TGF-beta-treated dendritic cells, pulsed with insulin, specifically reduce the response to insulin of CD4+ effector\/memory T cells from type 1 diabetic individuals","volume":"30","author":"Jara","year":"2010","journal-title":"J. Clin. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jcyt.2020.12.003","article-title":"1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications","volume":"23","author":"Chen","year":"2021","journal-title":"Cytotherapy"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.4049\/jimmunol.1302350","article-title":"1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice","volume":"192","author":"Ferreira","year":"2014","journal-title":"J. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1080\/21645515.2019.1616504","article-title":"Tolerogenic vaccine composited with islet-derived multipeptides and cyclosporin A induces pTreg and prevents Type 1 diabetes in murine model","volume":"16","author":"Zhou","year":"2020","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/imm.13476","article-title":"Activation of T cell checkpoint pathways during \u03b2-cell antigen presentation by engineered dendritic cells promotes protection from type 1 diabetes","volume":"166","author":"Gudi","year":"2022","journal-title":"Immunology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"103051","DOI":"10.1016\/j.jaut.2023.103051","article-title":"Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases","volume":"138","author":"Passeri","year":"2023","journal-title":"J. Autoimmun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.intimp.2017.05.023","article-title":"Transplantation of Aire-overexpressing bone marrow-derived dendritic cells delays the onset of type 1 diabetes","volume":"49","author":"Li","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Pogu, J., Tzima, S., Kollias, G., Anegon, I., Blancou, P., and Simon, T. (2019). Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071676"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s00125-018-4593-3","article-title":"Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice","volume":"61","author":"Chen","year":"2018","journal-title":"Diabetologia"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1021\/acsbiomaterials.9b00332","article-title":"Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model","volume":"5","author":"Lewis","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.clim.2015.03.023","article-title":"A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice","volume":"160","author":"Lewis","year":"2015","journal-title":"Clin. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1021\/acsbiomaterials.0c01075","article-title":"Combination Treatment with Antigen-Specific Dual-Sized Microparticle System Plus Anti-CD3 Immunotherapy Fails to Synergize to Improve Late-Stage Type 1 Diabetes Prevention in Nonobese Diabetic Mice","volume":"6","author":"Stewart","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"122265","DOI":"10.1016\/j.biomaterials.2023.122265","article-title":"Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes","volume":"301","author":"Kinney","year":"2023","journal-title":"Biomaterials"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1600773","DOI":"10.1002\/adhm.201600773","article-title":"Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation","volume":"6","author":"Verbeke","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Phillips, B.E., Garciafigueroa, Y., Engman, C., Liu, W., Wang, Y., Lakomy, R.J., Meng, W.S., Trucco, M., and Giannoukakis, N. (2021). Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.586220"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1021\/acs.molpharmaceut.1c00054","article-title":"In Vivo Insulin Peptide Autoantigen Delivery by Mannosylated Sodium Alginate Nanoparticles Delayed but Could Not Prevent the Onset of Type 1 Diabetes in Nonobese Diabetic Mice","volume":"18","author":"Qu","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41419-018-1135-3","article-title":"PPAR\u03b1 and PPAR\u03b3 activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression","volume":"10","author":"Ye","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4239\/wjd.v12.i5.603","article-title":"Current advances in using tolerogenic dendritic cells as a therapeutic alternative in the treatment of type 1 diabetes","volume":"12","year":"2021","journal-title":"World J. Diabetes"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S2213-8587(20)30104-2","article-title":"Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes","volume":"8","author":"Nikolic","year":"2020","journal-title":"Lancet. Diabetes Endocrinol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Nikolic, T., Suwandi, J.S., Wesselius, J., Laban, S., Joosten, A.M., Sonneveld, P., Mul, D., Aanstoot, H.J., Kaddis, J.S., and Zwaginga, J.J. (2022). Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1054968"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dc11-0472","article-title":"Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients","volume":"34","author":"Giannoukakis","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"EVIDoa2300238","DOI":"10.1056\/EVIDoa2300238","article-title":"Novel Autologous Dendritic Cell Therapy AVT001 for Type 1 Diabetes","volume":"3","author":"Gaglia","year":"2024","journal-title":"NEJM Evid."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"E1418","DOI":"10.1210\/jc.2013-3864","article-title":"\u03b11-Antitrypsin therapy downregulates toll-like receptor-induced IL-1\u03b2 responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes","volume":"99","author":"Gottlieb","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14366","DOI":"10.3390\/cimb46120861","article-title":"Clinical Trial: Effect of Autologous Dendritic Cell Administration on Improving Neuropathy Symptoms and Inflammatory Biomarkers in Diabetic Neuropathy","volume":"46","author":"Setiawan","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"13662","DOI":"10.3390\/cimb46120816","article-title":"Open-Label Clinical Trial on the Impact of Autologous Dendritic Cell Therapy on Albuminuria and Inflammatory Biomarkers (Interleukin-6, Interleukin-10, Tumor Necrosis Factor \u03b1) in Diabetic Kidney Disease (DKD)","volume":"46","author":"Jonny","year":"2024","journal-title":"Curr. Issues Mol. Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/6057\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:00:57Z","timestamp":1783486857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/6057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":128,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27136057"],"URL":"https:\/\/doi.org\/10.3390\/ijms27136057","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}