{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:19:38Z","timestamp":1785410378494,"version":"3.56.0"},"reference-count":74,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014407","name":"Military Institute of Aviation Medicine","doi-asserted-by":"publisher","award":["520 04 01"],"award-info":[{"award-number":["520 04 01"]}],"id":[{"id":"10.13039\/501100014407","id-type":"DOI","asserted-by":"publisher"}]},{"award":["520 04 01"],"award-info":[{"award-number":["520 04 01"]}],"id":[{"id":"https:\/\/ror.org\/01xtcza13","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D is believed to exert an immunomodulatory effect in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and may influence the intensity of inflammatory processes. Therefore, this study aimed to assess serum vitamin D levels in relation to selected cytokines in patients with CRSwNP and without nasal polyps (CRSsNP). This prospective study included patients with clinically and radiologically confirmed diseases. In total, 39 patients were included in three phenotypic groups: CRSwNP (n = 17), CRSsNP (n = 10), and controls (n = 12). Serum concentrations of vitamin D (25(OH)D3), interleukins 4, 5, 17A, interferon-\u03b3 (IFN-\u03b3), and immunoglobulin E were assessed preoperatively. The extent of subjective and objective mucosal disease was evaluated using endoscopic and radiological staging, based on the Lund\u2013Kennedy and Lund\u2013Mackay scoring systems in accordance with the Sino-Nasal Outcome Test-22 (SNOT-22), respectively. Patients with CRSwNP demonstrated higher serum IL-4 and IL-5 concentrations, consistent with a Th2-skewed inflammatory profile, whereas patients with CRSsNP showed higher IL-17A and IFN-\u03b3 levels, suggesting a mixed Th17\/Th1 inflammatory pattern. IL-5 was positively associated with radiological disease severity. Serum vitamin D levels tended to be inversely associated with IL-5 concentration and disease severity; however, these associations did not reach statistical significance.: The findings of this study support differences in inflammatory profiles between CRSwNP and CRSsNP and confirm an association between IL-5 and radiological disease severity. Although lower vitamin D levels showed a trend toward greater inflammatory activity and disease severity, no statistically significant associations were demonstrated in this cohort. Further studies with larger populations are warranted to clarify the role of vitamin D in CRS endotypes.<\/jats:p>","DOI":"10.3390\/ijms27136061","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:43:14Z","timestamp":1783345394000},"page":"6061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Th2 and Th17\/Th1 Inflammatory Profiles in Chronic Rhinosinusitis: Associations with Vitamin D Status and Disease Severity"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-9186","authenticated-orcid":false,"given":"Agnieszka","family":"Witkowska-Janik","sequence":"first","affiliation":[{"name":"Otolaryngology Department, Military Institute of Aviation Medicine, Krasi\u0144skiego 54\/56, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Wojdas","sequence":"additional","affiliation":[{"name":"Otolaryngology Department, Military Institute of Aviation Medicine, Krasi\u0144skiego 54\/56, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-0687","authenticated-orcid":false,"given":"Maria","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Physiology and Pathophysiology, Medical University of Warsaw, Cha\u0142ubi\u0144skiego 5, 02-004 Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Pabin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Military Institute of Aviation Medicine, Krasi\u0144skiego 54\/45, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0636-2961","authenticated-orcid":false,"given":"Katarzyna","family":"Komar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Military Institute of Aviation Medicine, Krasi\u0144skiego 54\/45, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-3085","authenticated-orcid":false,"given":"Ewelina","family":"Maculewicz","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Military Institute of Aviation Medicine, Krasi\u0144skiego 54\/45, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-1046","authenticated-orcid":false,"given":"Piotr","family":"Rot","sequence":"additional","affiliation":[{"name":"Clinic of Otolaryngology and Oncological Otolaryngology with Clinical Department of Cranio-Maxillofacial Surgery, Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","first-page":"35","article-title":"Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity","volume":"32","author":"Zand","year":"2020","journal-title":"Iran. 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