{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:14:24Z","timestamp":1783743264935,"version":"3.55.0"},"reference-count":180,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIA-designated Florida Alzheimer\u2019s Disease Research Center","award":["AG025711, 1R43NS090653-01A, and 9R44AG073096-02A1"],"award-info":[{"award-number":["AG025711, 1R43NS090653-01A, and 9R44AG073096-02A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A unifying theory of both human consciousness and memory is presented that is based on neuronal microtubules (MTs) being central to both, and different populations of pyramidal cells in neocortex and hippocampus being responsible for consciousness or memory. First, two quantum theories of consciousness are presented\u2014the Orchestrated Objective Reduction (Orch OR) theory of Penrose\/Hameroff and the Environmental-Induced Decoherence Theory (EID) theory of Neven. A Hybrid (MT\/EID) theory is proposed in the context of \u201cconsciousness\u201d-dedicated pyramidal cells in Layer V of the cerebral cortex. This MT\/EID theory involves the MT vibrations of the Orch OR Theory, along with the continual superposition qubit (SPQ) formation and SPQ entanglement of the EID Theory to collectively induce SPQ formation\/entanglement in Layer V of the cerebral cortex. Orch OR\u2019s objective reduction (collapse of the waveform) is not included in this Hybrid theory because the system of SPQs themselves continuously collapses due to EID. For memory, it is proposed that Orch OR forms its basis with three specific modifications: (1) presenting \u201cendogenous\u201d radiofrequency (RF) vibrations generated by neuronal microtubules as forming a microtubule\/RF wave \u201cvibrational fabric\u201d involving microtubular crystalline water cores, (2) refining Orch OR for memory by proposing SPQ formation for short-term memory and objective reduction of those qubits primarily in \u201cmemory-dedicated\u201d pyramidal cells within cortical Layers II\/III for long-term memory storage through \u201cQuantum Darwinism\u201d (SPQ\/OR), and (3) integrating SPQ\/OR with the ability of \u201cexternally\u201d applied RF waves at 1 GHz to beneficially influence human memory through microtubule-enhancing mechanisms. It is proposed that a vibrational fabric consisting of MTs, RF waves, and generated photons provides the Photonic\/RF-wave quantum coherence necessary for brain memory processing. Strong evidence for beneficial effects of exogenous RF wave treatment on memory is provided by a new bioengineered technology\u2014Transcranial Radiofrequency Wave Treatment (TRFT; also known as TEMT). This evidence is presented in both pre-clinical and clinical studies involving normal and Alzheimer\u2019s Disease (AD) transgenic mice, and AD patients bearing memory loss. In support of MT involvement in memory, TRFT would appear to be an ideal non-pharmacologic technology to beneficially modulate the microtubule\/RF wave vibrational fabric\u2014an intraneuronal fabric that may be at the deep core of human memory, and thus the key to Alzheimer\u2019s Disease memory rescue.<\/jats:p>","DOI":"10.3390\/ijms27136090","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:27:31Z","timestamp":1783531651000},"page":"6090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuronal Microtubules and Radiofrequency Waves: The Quantum Core of Human Consciousness, Memory, and Pathway to Memory Enhancement\/Recovery"],"prefix":"10.3390","volume":"27","author":[{"given":"Gary W.","family":"Arendash","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, University of South Florida, Tampa, FL 33620, USA"},{"name":"RF Longevity SE, 428 E. Thunderbird Rd., Phoenix, AZ 85022, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuron.2020.01.026","article-title":"Conscious Processing and the Global Neuronal Workspace Hypothesis","volume":"105","author":"Mashour","year":"2020","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41583-022-00587-4","article-title":"Theories of consciousness","volume":"23","author":"Seth","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-025-08888-1","article-title":"Adversarial testing of global neuronal workspace and integrated information theories of consciousness","volume":"642","author":"Ferrante","year":"2025","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hunt, T., Jones, M., McFadden, J., Delorme, A., Hales, C.G., Ericson, M., and Schooler, J. (2024). Editorial: Electromagnetic field theories of consciousness: Opportunities and obstacles. Front. Hum. Neurosci. Sec. Cogn. Neurosci., 17.","DOI":"10.3389\/fnhum.2023.1342634"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Keppler, J. (2018). The role of the brain in conscious processes: A new way of looking at the neural correlates of consciousness. Front. Psychol., 9.","DOI":"10.3389\/fpsyg.2018.01346"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Keppler, J. (2025). Macroscopic quantum effects in the brain: New insights into the fundamental principle underlying conscious processes. Front. Hum. Neurosci., 19.","DOI":"10.3389\/fnhum.2025.1676585"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106351","DOI":"10.1016\/j.bandc.2025.106351","article-title":"The neural basis of cognitive processing: A review and a speculative architecture","volume":"189","author":"Verwey","year":"2025","journal-title":"Brain Cogn."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sridhar, S., Khamaj, A., and Astana, M. (2023). Cognitive neuroscience perspective on memory: Overview and summary. Front. Hum. Neurosci., 17.","DOI":"10.3389\/fnhum.2023.1217093"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Brown, R., Bligh, T., and Garden, J. (2021). The Hebb Synapse Before Hebb: Theories of Synaptic Function in Learning and Memory Before Hebb (1949), With a Discussion of the Long-Lost Synaptic Theory of William McDougall. Front. Behav. Neurosci., 15.","DOI":"10.3389\/fnbeh.2021.732195"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104811","DOI":"10.1016\/j.neubiorev.2022.104811","article-title":"Epigenetic mechanisms regulate cue memory underlying discriminative behavior","volume":"141","author":"Shang","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.conb.2018.09.001","article-title":"Plasticity of intrinsic neuronal excitability","volume":"54","author":"Debanne","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zeleznikow-Johnston, A., Kendziorra, E., and McKenzie, A. (2025). What are memories made of? A survey of neuroscientists on the structural basis of long-term memory. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0326920"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.plrev.2013.08.002","article-title":"Consciousness in the universe: A review of the \u2018Orch OR\u2019 theory","volume":"11","author":"Hameroff","year":"2014","journal-title":"Phys. Life Rev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hameroff, S. (2022). Consciousness, Cognition and the Neuronal Cytoskeleton\u2014A New Paradigm Needed in Neuroscience. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.869935"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Craddock, T., Tuszynski, J., and Hameroff, S. (2012). Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation?. PLoS Comput. Biol., 8.","DOI":"10.1371\/journal.pcbi.1002421"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11910-023-01276-0","article-title":"The Current of Consciousness: Neural Correlates and Clinical Aspects","volume":"23","author":"Friedman","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1749-6632.2001.tb05710.x","article-title":"Consciousness, the brain, and spacetime geometry: An addendum. Some new developments on the Orch OR model for consciousness","volume":"929","author":"Penrose","year":"2001","journal-title":"Rev. Ann. N. Y Acad. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gao, S. (2022). New physics for the Orch OR consciousness proposal. Consciousness and Quantum Mechanics, Oxford Press.","DOI":"10.1093\/oso\/9780197501665.001.0001"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.neuron.2023.04.015","article-title":"Hippocampo-cortical circuits for selective memory encoding, routing, and replay","volume":"111","author":"Harvey","year":"2023","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hipo.23495","article-title":"CA2 orchestrates hippocampal network dynamics","volume":"33","author":"Oliva","year":"2023","journal-title":"Hippocampus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.tics.2020.07.006","article-title":"Cellular Mechanisms of Conscious Processing","volume":"24","author":"Aru","year":"2020","journal-title":"Trends Cogn. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3233\/JAD-190367","article-title":"A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer\u2019s Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain Imaging","volume":"71","author":"Arendash","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Arendash, G., Abulaban, H., Steen, S., Andel, R., Wang, Y., Bai, Y., Baranowski, R., McGarity, J., Scritsmier, L., and Lin, X. (2022). Transcranial electromagnetic treatment stops Alzheimer\u2019s cognitive decline over a 2\u00bd year period: A pilot study. Medicines, 9.","DOI":"10.3390\/medicines9080042"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1016\/j.cub.2022.07.034","article-title":"A unicellular walker controlled by a microtubule-based finite-state machine","volume":"12","author":"Larson","year":"2022","journal-title":"Curr. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1749-6632.1986.tb38388.x","article-title":"Biochemical and chemical properties of tubulin subspecies","volume":"466","author":"Lee","year":"1986","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s10571-022-01304-6","article-title":"Tubulin cytoskeleton in neurodegenerative diseases\u2014Not only primary tubulinopathies","volume":"43","author":"Cyske","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/312237a0","article-title":"Dynamic instability of microtubule growth","volume":"312","author":"Mitchison","year":"1984","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.drudis.2020.11.033","article-title":"Microtubule-targeting agents and neurodegeneration","volume":"26","author":"Boiarska","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.201407095","article-title":"The contribution of \u0251\u03b2-tubulin curvature to microtubule dynamics","volume":"207","author":"Brouhard","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nlm.2015.07.011","article-title":"Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules","volume":"124","author":"Uchida","year":"2015","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1091\/mbc.e15-11-0769","article-title":"Of microtubules and memory: Implications for microtubule dynamics in dendrites and spines","volume":"28","author":"Dent","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hameroff, S. (2012). How quantum brain biology can rescue conscious free will. Front. Integr. Neurosci., 6.","DOI":"10.3389\/fnint.2012.00093"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8215","DOI":"10.3390\/ijms22158215","article-title":"Generation of Electromagnetic Field by Microtubules","volume":"22","author":"Pokorny","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1152\/jn.00478.2020","article-title":"Electrophysiology using coaxial atom probe array: Live imaging reveals hidden circuits of a hippocampal neural network","volume":"125","author":"Singh","year":"2021","journal-title":"J. Neurophysiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.56280\/1600841751","article-title":"Dodecanogram (DDG): Advancing EEG technology with a high-frequency brain activity measurement device","volume":"3","author":"Singh","year":"2024","journal-title":"J. Multiscale Neurosci."},{"key":"ref_36","first-page":"171","article-title":"Vibrations in microtubules","volume":"23","author":"Pokorny","year":"1997","journal-title":"Astrophys. Space Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bioelechem.2003.09.028","article-title":"Excitation of vibrations in microtubules in living cells","volume":"63","author":"Pokorny","year":"2004","journal-title":"Bioelectrochemistry"},{"key":"ref_38","unstructured":"Flores, J.A. (2011). Evidence of New Biophysical Properties of Microtubules. Focus on Artificial Neural Networks, Nova Science Publisher Inc.. Chapter 9."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0302-4598(99)00016-1","article-title":"Conditions for coherent vibrations in the cytoskeleton","volume":"48","author":"Pokorny","year":"1999","journal-title":"Bioelectrochem. Bioenerg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bios.2013.02.050","article-title":"Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly","volume":"47","author":"Sahu","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12370","DOI":"10.1063\/1.4793995","article-title":"Multi-level memory-switching properties of a single brain microtubule","volume":"102","author":"Sahu","year":"2013","journal-title":"Appl. Phys. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.53765\/20512201.33.1.211","article-title":"Microtubules are \u2018Fractal Time Crystals\u2019 Implications for Life and Consciousness","volume":"33","author":"Hameroff","year":"2026","journal-title":"J. Conscious. Stud."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Penrose, R., and Mermin, N.D. (1989). The Emperor\u2019s New Mind: Concerning Computers, Minds, and the Laws of Physics, Oxford University Press.","DOI":"10.1093\/oso\/9780198519737.001.0001"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0378-4754(96)80476-9","article-title":"Orchestrated Reduction of Quantum Coherence in Brain Microtubules: A Model for Consciousness","volume":"40","author":"Hameroff","year":"1996","journal-title":"Math. Comput. Simul."},{"key":"ref_45","unstructured":"Poznanski, R.R., Tuszynski, J.A., and Feinberg, T.E. (2016). The \u2018Quantum Underground\u2019: Where Life and Consciousness Originate in Biophysics of Consciousness: A Foundational Approach, World Scientific."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0022-5193(82)90137-0","article-title":"Information processing in microtubules","volume":"98","author":"Hameroff","year":"1982","journal-title":"J. Theor. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9877","DOI":"10.1038\/s41598-017-09992-7","article-title":"Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction","volume":"7","author":"Craddock","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Neven, H., Zalcman, A., Read, P., Kosik, K.S., van der Molen, T., Bouwmeester, D., Bodnia, E., Turin, L., and Koch, C. (2024). Testing the Conjecture That Quantum Processes Create Conscious Experience. Entropy, 26.","DOI":"10.20944\/preprints202402.1751.v1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1523\/JNEUROSCI.0150-18.2018","article-title":"Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences","volume":"38","author":"Baker","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_50","first-page":"495","article-title":"Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making","volume":"26","author":"Musall","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e70393","DOI":"10.1002\/brb3.70393","article-title":"Context-Sensitive Conscious Interpretation and Layer-5 Pyramidal Neurons in Multistable Perception","volume":"15","author":"Bachmann","year":"2025","journal-title":"Brain Behav."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"niab036","DOI":"10.1093\/nc\/niab036","article-title":"Apical amplification\u2014A cellular mechanism of conscious perception?","volume":"2021","author":"Marvan","year":"2021","journal-title":"Neurosci. Conscious."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"eadr3675","DOI":"10.1126\/science.adr3675","article-title":"Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop","volume":"388","author":"Fang","year":"2025","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1038\/s41598-021-83680-5","article-title":"Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: Analysis of basal dendrites","volume":"11","author":"Takata","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0166-2236(00)01922-6","article-title":"The thalamic matrix and thalamocortical synchrony","volume":"24","author":"Jones","year":"2001","journal-title":"Trends Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bachmann, T., and Hudetz, A. (2014). It is time to combine the two main traditions in the research on the neural correlates of consciousness: C = L \u00d7 D. Front. Psychol., 5.","DOI":"10.3389\/fpsyg.2014.00940"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0140525X07000891","article-title":"Consciousness without a cerebral cortex: A challenge for neuroscience and medicine","volume":"30","author":"Merker","year":"2007","journal-title":"Behav. Brain Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nrn.2016.44","article-title":"Integrated information theory: From consciousness to its physical substrate","volume":"17","author":"Tononi","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Baars, B., Geld, N., and Kozma, R. (2021). Global Workspace Theory (GWT) and Prefrontal Cortex: Recent Developments. Front. Psychol., 12.","DOI":"10.3389\/fpsyg.2021.749868"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/sleep\/32.9.1191","article-title":"Lucid dreaming: A state of consciousness with features of both waking and non-lucid dreaming","volume":"32","author":"Voss","year":"2009","journal-title":"Sleep"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Horton, C. (2020). Key Concepts in Dream Research: Cognition and Consciousness Are Inherently Linked, but Do Not Control \u201cControl\u201d!. Front. Hum. Neurosci., 14.","DOI":"10.3389\/fnhum.2020.00259"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.concog.2005.09.007","article-title":"Apical dendrite activity in cognition and consciousness","volume":"15","author":"LaBerge","year":"2006","journal-title":"Conscious. Cogn."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.neuron.2018.10.029","article-title":"Dendritic inhibition in Layer 1 cortex gates associate memory","volume":"100","author":"Hu","year":"2018","journal-title":"Neuron"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fncir.2016.00061","article-title":"How Does the Sparse Memory \u201cEngram\u201d Neurons Encode the Memory of a Spatial\u2013Temporal Event?","volume":"10","author":"Guan","year":"2016","journal-title":"Front. Neural Circuits"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrn2286","article-title":"Pyramidal neurons: Dendritic structure and synaptic integration","volume":"9","author":"Spruston","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41593-019-0493-1","article-title":"The neurobiological foundation of memory retrieval","volume":"22","author":"Frankland","year":"2019","journal-title":"Nat. NeuroSci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1083\/jcb.142.1.167","article-title":"STOP Proteins are Responsible for the High Degree of Microtubule Stabilization Observed in Neuronal Cells","volume":"142","author":"Guillaud","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/cr.2016.76","article-title":"Cortical neurons gradually attain a post-mitotic state","volume":"26","author":"Anda","year":"2016","journal-title":"Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e70670","DOI":"10.1002\/alz.70670","article-title":"Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases","volume":"21","author":"Damuka","year":"2025","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"243702","DOI":"10.1063\/1.4884118","article-title":"Multi-mode electro-mechanical vibrations of a microtubule: In silico demonstration of electric pulse moving along a microtubule","volume":"104","author":"Havelka","year":"2014","journal-title":"Appl. Phys. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"58","DOI":"10.14311\/1125","article-title":"Calculation of the electromagnetic field around a microtubule","volume":"49","author":"Havelka","year":"2009","journal-title":"Acta Polytech."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.clinph.2009.11.002","article-title":"Mobile phone emission modulates inter-hemispheric functional coupling of EEG alpha rhythms in elderly compared to young subjects","volume":"121","author":"Vecchio","year":"2010","journal-title":"Clin. Neurophysiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/bem.20583","article-title":"Effects of 2G and 3G mobile phones on human alpha rhythms: Resting EEG in adolescents, young adults, and the elderly","volume":"31","author":"Croft","year":"2010","journal-title":"Bioelectromagnetics"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.11648\/j.ajop.20150305.11","article-title":"Possible Existence of Superluminal Photons Inside Microtubules and the Resulting Explanation for Brain Mechanism","volume":"3","author":"Musha","year":"2015","journal-title":"Am. J. Opt. Photonics"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.tiv.2008.04.014","article-title":"In vitro testing of cellular response to ultra high frequency electromagnetic field radiation","volume":"22","author":"Pavicic","year":"2008","journal-title":"Toxicol. Vitr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/18722148113079990007","article-title":"Effect of radio frequency waves of electromagnetic field on the tubulin","volume":"7","author":"Taghi","year":"2013","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"DePaolis, L., Francini, R., Davoli, I., De Matteis, F., Scordo, A., Clozza, A., Grandi, M., Pace, E., Curceanu, C., and Grigolini, P. (2024). Biophotons: A hard problem. Appl. Sci., 14.","DOI":"10.3390\/app14135496"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.radmp.2024.06.004","article-title":"Biophoton signaling in mediation of cell-to-cell communication and radiation-induced bystander effects","volume":"5","author":"Tong","year":"2024","journal-title":"Radiat. Med. Prot."},{"key":"ref_79","first-page":"722","article-title":"Quantum mechanics and the explanation of life: The inclusion of human consciousness in quantum physics recognizes mind as the primary reality: Will a new science arise that can harmonize quantum physics and biology?","volume":"61","author":"Mehra","year":"2021","journal-title":"Am. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Nevoit, G., Poderiene, K., Potyazhenko, M., Mintser, O., Jarusevicius, G., and Vainoras, A. (2025). The concept of bioophotonic signaling in the human body and brain: Rationale, problems, and directions. Front. Syst. Neurosci., 19.","DOI":"10.3389\/fnsys.2025.1597329"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1103\/RevModPhys.75.715","article-title":"Decoherence, einselection, and the quantum origins of the classical","volume":"75","author":"Zurek","year":"2003","journal-title":"Rev. Mod. Phys."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"112019","DOI":"10.1016\/j.isci.2025.112019","article-title":"Exploring ultraweak photon emissions as optical markers of brain activity","volume":"28","author":"Casey","year":"2015","journal-title":"iScience"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jphotobiol.2013.12.008","article-title":"Biophoton signal transmission and processing in the brain","volume":"139","author":"Tang","year":"2014","journal-title":"J. Photochem. Photobiol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Tang, R., and Dai, J. (2014). Spatiotemporal imaging of glutamate-induced biophotonic activities and transmission in neural circuits. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085643"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0168-0102(99)00040-1","article-title":"In vivo imaging of spontaneous ultraweak photon emission from a rat\u2019s brain correlated with cerebral energy metabolism and oxidative stress","volume":"34","author":"Kobayashi","year":"1999","journal-title":"Neurosci. Res."},{"key":"ref_86","first-page":"452","article-title":"Correlation between fluctuations in human ultra-weak photon emission and EEG alpha rhythm","volume":"6","author":"Bosman","year":"2008","journal-title":"NeuroQuantology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10484-018-9418-0","article-title":"Neurofeedback improves memory and peak alpha frequency in individuals with Mild Cognitive Impairment","volume":"44","author":"Lavy","year":"2019","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpsycho.2020.04.019","article-title":"Frontal alpha asymmetry during prayerful and resting states: An EEG study in Catholic sisters","volume":"155","author":"Barcelona","year":"2020","journal-title":"Int. J. Psychophysiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1089\/acm.2013.0426","article-title":"Effect of Muslim prayer (Salat) on \u03b1 electroencephalography and its relationship with autonomic nervous system activity","volume":"20","author":"Doufesh","year":"2014","journal-title":"J. Altern. Complement. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"190601","DOI":"10.1103\/fdvq-9m8m","article-title":"Quantum advantage in storage and retrieval of isometry channels","volume":"136","author":"Yoshida","year":"2026","journal-title":"Phys. Rev. Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/BF00292170","article-title":"Brain and physics of many-body problems","volume":"4","author":"Ricciardi","year":"1967","journal-title":"Kybernetik"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.conb.2014.07.017","article-title":"The use of many-body physics and thermodynamics to describe the dynamics of rhythmic generators in sensory cortices engaged in memory and learning","volume":"31","author":"Vitiello","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"701","DOI":"10.31083\/j.jin.2020.04.310","article-title":"Matter, mind and consciousness: From information to meaning","volume":"19","author":"Vitiello","year":"2020","journal-title":"J. Integr. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.biosystems.2010.02.007","article-title":"Electric field generated by axial longitudinal vibration modes of microtubule","volume":"100","author":"Cifra","year":"2010","journal-title":"BioSystems"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1521-186X(200004)21:3<151::AID-BEM1>3.0.CO;2-Q","article-title":"Low-level exposure to pulsed 900 MHz microwave radiation does not cause deficits in the performance of a spatial learning task in mice","volume":"21","author":"Sienkiewicz","year":"2000","journal-title":"Bioelectromagnetics"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(01)00344-8","article-title":"Does head-only exposure to GSM-900 electromagnetic fields affect the performance of rats in spatial learning tasks?","volume":"129","author":"Dubreil","year":"2002","journal-title":"Behav. Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-4328(03)00100-1","article-title":"Head-only exposure to GSM 900-MHz electromagnetic fields does not alter rat\u2019s memory in spatial and non-spatial tasks","volume":"145","author":"Dubreuil","year":"2003","journal-title":"Behav. Brain Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/02699050802530599","article-title":"Effect of head-only sub-chronic and chronic exposure to 900-MHz GSM electromagnetic fields on spatial memory in rats","volume":"22","author":"Ammari","year":"2008","journal-title":"Brain Inj."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3233\/JAD-2010-1228","article-title":"Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer\u2019s disease mice","volume":"19","author":"Arendash","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Arendash, G., Mori, T., Dorsey, M., Gonzalez, R., Tajiri, N., and Borlongan, C. (2012). Electromagnetic treatment to old Alzheimer\u2019s mice reverses-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035751"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/JAD-2012-120943","article-title":"Transcranial electromagnetic treatment against Alzheimer\u2019s disease: Why it has the potential to trump Alzheimer\u2019s disease drug development","volume":"32","author":"Arendash","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3233\/JAD-160165","article-title":"Review of the evidence that Transcranial Electromagnetic Treatment will be a safe and effective therapeutic against Alzheimer\u2019s Disease","volume":"53","author":"Arendash","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"035106","DOI":"10.1063\/1.3184794","article-title":"Non equilibrium molecular dynamics study of electric and low-frequency microwave fields on hen egg white lysozyme","volume":"131","author":"English","year":"2009","journal-title":"J. Chem. Phys."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00420-010-0513-7","article-title":"Increased protein synthesis by cells exposed to a 1800 MHz RF mobile phone electromagnetic field, detected by proteome profiling","volume":"83","author":"Gerner","year":"2010","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"085101","DOI":"10.1063\/1.4941108","article-title":"Electromagnetic-field effects on structure and dynamics of amyloidogenic peptides","volume":"144","author":"Todorova","year":"2016","journal-title":"J. Chem. Phys."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1521-186X(200001)21:1<52::AID-BEM8>3.0.CO;2-6","article-title":"Acute exposure to pulsed 2450-MHz microwaves affects water-maze performance of rats","volume":"21","author":"Wang","year":"2000","journal-title":"Bioelectromagnetics"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbr.2005.02.026","article-title":"Whole-body exposure to 2.45 GHz electromagnetic fields does not alter 12-arm radial-maze with reduced access to spatial cues in rats","volume":"161","author":"Cosquer","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref_108","first-page":"182","article-title":"Relationship between cognition function and hippocampus structure after long-term microwave exposure","volume":"25","author":"Zhao","year":"2012","journal-title":"Biomed. Environ. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.nlm.2007.07.010","article-title":"Acute exposure to a 50 Hz magnetic field impairs consolidation of spatial memory in rats","volume":"88","author":"Jadidi","year":"2007","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1440-1681.2008.04922.x","article-title":"Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice","volume":"35","author":"Fu","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_111","first-page":"2","article-title":"Electromagnetic field treatment enhances neuronal activity: Linkage to cognitive benefit and therapeutic implications for Alzheimer\u2019s Disease","volume":"1","author":"Mori","year":"2011","journal-title":"J. Alzheimer\u2019s Dis. Park."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2011.04.012","article-title":"Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer\u2019s transgenic mice and normal mice: A mechanism for electromagnetic field-induced cognitive benefit?","volume":"185","author":"Dragicevic","year":"2011","journal-title":"Neuroscience"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"12120","DOI":"10.1523\/JNEUROSCI.2509-08.2008","article-title":"Microtubules in dendritic spine development","volume":"28","author":"Gu","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1523\/JNEUROSCI.3074-08.2008","article-title":"Activity-dependent dynamic microtubule invasion of dendritic spines","volume":"28","author":"Hu","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuron.2008.11.013","article-title":"Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity","volume":"61","author":"Jaworski","year":"2009","journal-title":"Neuron"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Merriam, E.B., Lumbard, D.C., Viesselmann, C., Ballweg, J., Stevenson, M., Pietila, L., Hu, X., and Dent, E.W. (2011). Dynamic microtubules promote synaptic NMDA receptor-dependent spine enlargement. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027688"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"15597","DOI":"10.1523\/JNEUROSCI.2445-11.2011","article-title":"BDNF-induced increase of PSD-95 in dendritic spines requires dynamic microtubule invasions","volume":"31","author":"Hu","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Sfeera, A., Nicita, F., and Bertini, E. (2020). Microtubule dysfunction: A common feature of neurodegenerative diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197354"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Cao, C., Abulaban, H., Baranowski, R., Wang, Y., Bai, Y., Lin, X., Shen, N., Zhang, X., and Arendash, G.W. (2022). Transcranial Electromagnetic Treatment \u201crebalances\u201d blood and brain cytokines levels in Alzheimer\u2019s patients: A new mechanism for reversal of their cognitive impairment. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.829049"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroscience.2009.05.071","article-title":"Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer\u2019s mice","volume":"163","author":"Song","year":"2009","journal-title":"Neuroscience"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/bem.20635","article-title":"Effects of mobile phone electromagnetic fields: Critical evaluation of behavioral and neurophysiological studies","volume":"32","author":"Kwon","year":"2011","journal-title":"Bioelectromagnetics"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1080\/00207450600936882","article-title":"Electroencephalographic, personality, and executive function measures associated with frequent mobile phone use","volume":"117","author":"Arns","year":"2007","journal-title":"Int. J. Neurosci."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Schuz, J., Waldemar, G., Olsen, J., and Johansen, C. (2009). Risks for central nervous system diseases among mobile phone subscribers: A Danish retrospective cohort study. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004389"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/ana.20906","article-title":"Mobile phone emissions and human brain excitability","volume":"60","author":"Ferreri","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/jama.2011.186","article-title":"Effects of cell phone radiofrequency signal exposure on brain glucose metabolism","volume":"305","author":"Volkow","year":"2020","journal-title":"JAMA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1289\/ehp.9633","article-title":"Workgroup report: Base stations and wireless networks radiofrequency (RF) exposures and health consequences","volume":"115","author":"Valberg","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/15287390600974973","article-title":"Recent advances in research on radiofrequency fields and health: 2001\u20132003","volume":"10","author":"Krewski","year":"2007","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"ref_128","first-page":"1097","article-title":"Meta-analysis of long-term mobile phone use and the association with brain tumours","volume":"32","author":"Hardell","year":"2008","journal-title":"Int. J. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pathophys.2009.01.003","article-title":"Epidemiological evidence for an association between use of wireless phones and tumor diseases","volume":"16","author":"Hardell","year":"2009","journal-title":"Pathophysiology"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"INTERPHONEStudy Group (48 collaborators) (2010). Brain tumour risk in relation to mobile telephone use: Results of the INTERPHONEinternational case-control study. Int. J. Epidemiol., 39, 675\u2013694.","DOI":"10.1093\/ije\/dyq079"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1289\/ehp.1103693","article-title":"Mobile phones, brain tumors, and the inter- phone study: Where are we now?","volume":"119","author":"Swerdlow","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"d6387","DOI":"10.1136\/bmj.d6387","article-title":"Use of mobile phones and risk of brain tumours: Update of Danish cohort study","volume":"343","author":"Frei","year":"2011","journal-title":"BMJ"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/ije\/dyt072","article-title":"Million Women Study Collaborators Mobile phone use risk of brain neoplasms other cancers: Prospective study","volume":"42","author":"Benson","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11060-018-03019-5","article-title":"Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden","volume":"141","author":"Olsson","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_135","unstructured":"(2025, December 05). Alzheimer\u2019s Association (USA). Available online: https:\/\/www.alz.org\/alzheimers-dementia\/facts-figures."},{"key":"ref_136","unstructured":"Licholai, G. (2025). Two Alzheimer\u2019s Trial Failures Reveal Clinical Challenges. Forbes, Available online: https:\/\/www.forbes.com\/sites\/greglicholai\/2025\/11\/25\/two-alzheimers-trial-failures-reveal-clinical-challenges\/."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Gerson, J., and Kayed, R. (2013). Formation and propagation of tau oligomeric seeds. Front. Neurol., 4.","DOI":"10.3389\/fneur.2013.00093"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/ac400023c","article-title":"Analysis of protein aggregation in neurodegenerative disease","volume":"85","author":"Pedersen","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/alzrt272","article-title":"Targeting the proper amyloid-beta neuronal toxins: A path forward for Alzheimer\u2019s disease immunotherapeutics","volume":"6","author":"Goure","year":"2014","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Guerrero-Mu\u00f1oz, M., Gerson, J., and Castillo-Carranza, D. (2015). Tau oligomers: The toxic player at synapses in Alzheimer\u2019s Disease. Front. Cell. Neurosci., 9.","DOI":"10.3389\/fncel.2015.00464"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"19393","DOI":"10.1038\/srep19393","article-title":"Extracellular tau oligomers produce an immediate impairment of LTP and memory","volume":"6","author":"Puzzo","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S567","DOI":"10.3233\/JAD-179941","article-title":"The Amyloid-\u03b2 Oligomer Hypothesis: Beginning of the Third Decade","volume":"64","author":"Cline","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"11938","DOI":"10.1523\/JNEUROSCI.2357-10.2010","article-title":"Abeta oligomers cause localized calcium elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines","volume":"30","author":"Zempel","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000332816","article-title":"Linking amyloid-beta and tau: Amyloid-beta induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton","volume":"10","author":"Zempel","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1073\/pnas.1017033108","article-title":"Soluble amyloid-beta protein dimers isolated from Alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration","volume":"108","author":"Jin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","article-title":"Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation","volume":"5","author":"Norat","year":"2020","journal-title":"npj Regen. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/cimb46030130","article-title":"Mitochondrial dysfunction: A key player in brain aging and diseases","volume":"46","author":"Bartman","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1326-6-39","article-title":"Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice","volume":"6","author":"Sengupta","year":"2011","journal-title":"Mol. Neurodegen."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40478-015-0230-2","article-title":"Intracellular amyloid-beta oligomers impair organelle transport and induce dendritic spine loss in primary neurons","volume":"3","author":"Umeda","year":"2015","journal-title":"Acta Neuropathol. Comm."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000353687","article-title":"Prefibrillar tau oligomers in mild cognitive impairment and Alzheimer\u2019s disease","volume":"13","author":"Mufson","year":"2014","journal-title":"Neurodegener. Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"S535","DOI":"10.3233\/JAD-2010-100342","article-title":"Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer\u2019s transgenic mice","volume":"20","author":"Dragicevic","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","article-title":"Mitochondria are a direct site of A- beta accumulation in Alzheimer\u2019s disease neurons: Implications for free radical generation and oxidative damage in disease progression","volume":"15","author":"Manczak","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Knott","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2012.11.021","article-title":"Whole body exposure to 2.4 GHz WIFI signals: Effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer\u2019s disease (3xTg-AD)","volume":"240","author":"Banaceu","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/156720501205150526114448","article-title":"1950 MHz electromagnetic fields ameliorate A-beta pathology in Alzheimer\u2019s disease mice","volume":"12","author":"Jeong","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neulet.2017.12.042","article-title":"Long-term RF exposure on behavior and cerebral glucose metabolism in 5xFAD mice","volume":"666","author":"Son","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2023.03.083","article-title":"900 MHz electromagnetic field exposure relieved AD-like symptoms on APP\/PS1 mice: A potential non-invasive strategy for AD treatment","volume":"658","author":"Zhi","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s13246-024-01508-8","article-title":"Memory enhancement by transcranial radiofrequency wave treatment occurs without appreciably increasing brain temperature","volume":"48","author":"Baranowski","year":"2025","journal-title":"Phys. Eng. Sci. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/WAD.0b013e31827bdc6f","article-title":"Differential longitudinal decline on the mini-mental state examination in Frontotemporal Lobar Degeneration and Alzheimer\u2019s Disease","volume":"27","author":"Tan","year":"2013","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_160","unstructured":"Jeffrey, G. (1997). An Introduction to Hydrogen Bonding, Oxford University Press."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1006\/jmbi.1997.1348","article-title":"Common core structure of amyloid fibrils by synchrotron X-ray diffraction","volume":"273","author":"Sunde","year":"1997","journal-title":"J. Mol. Biol."},{"key":"ref_162","first-page":"325","article-title":"Microwave absorption in oligomers of ethylene glycol","volume":"36","author":"Segwa","year":"1999","journal-title":"Indian J. Biochem. Biophys."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jcp.20004","article-title":"Initial interactions in electromagnetic field-induced biosynthesis","volume":"199","author":"Blank","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Ciepak, A. (2017). Protein folding, misfolding, and aggregation: The importance of two-electron stabilizing interactions. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180905"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.3233\/JAD-240600","article-title":"Enhanced brain clearance of Tau and A\u03b2 in Alzheimer\u2019s patients by Transcranial Radiofrequency Wave Treatment: A central role of VEGF","volume":"100","author":"Arendash","year":"2024","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Arendash, G. (2025). The Brain Toxin Cleansing of Sleep Achieved During Wakefulness. J. Clin. Med., 14.","DOI":"10.3390\/jcm14030926"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.neurobiolaging.2009.07.002","article-title":"Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI","volume":"32","author":"Landau","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Younes, L., Albert, M., Moghekar, A., Soldan, A., Pettigrew, C., and Miller, M. (2019). Identifying Changepoints in Biomarkers during the preclinical phase of Alzheimer\u2019s Disease. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00074"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","article-title":"Preclinical evidence of Alzheimer\u2019s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E","volume":"334","author":"Reiman","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer\u2019s dementia","volume":"101","author":"Reiman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuroimage.2010.02.064","article-title":"Twelve-month metabolic declines in probable Alzheimer\u2019s disease and amnestic mild cognitive impairment assessed using an empirically pre-defined statistical region-of-interest: Findings from the Alzheimer\u2019s Disease Neuroimaging Initiative","volume":"51","author":"Chen","year":"2010","journal-title":"Neuroimage"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0197-4580(80)90005-6","article-title":"Positron emission tomography in the study of aging and senile dementia","volume":"1","author":"Ferris","year":"1980","journal-title":"Neurobiol. Aging"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2018.05.008","article-title":"The cingulum bundle: Anatomy, function, and dysfunction","volume":"92","author":"Bubb","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/gps.4053","article-title":"The efficacy of plasma biomarkers in early diagnosis of Alzheimer\u2019s disease","volume":"29","author":"Wang","year":"2014","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jalz.2012.05.2186","article-title":"Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer\u2019s disease","volume":"9","author":"Nowrangi","year":"2013","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1242\/jeb.02208","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"209","author":"Magistretti","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"141","DOI":"10.56280\/1564010613","article-title":"Is Alzheimer\u2019s disease a manifestation of brain quantum decoherence resulting from mitochondrial and microtubular deterioration?","volume":"2","author":"Nichols","year":"2023","journal-title":"J. Multiscale Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Chan, D., Suk, H.-J., Jackson, B.L., Milman, N.P., Stark, D., Klerman, E.B., Kitchener, E., Avalos, V.S.F., de Weck, G., and Banerjee, A. (2022). Gamma frequency sensory stimulation in mild probable Alzheimer\u2019s dementia patients: Results of feasibility and pilot studies. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0278412"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"E70792","DOI":"10.1002\/alz.70792","article-title":"Gamma sensory stimulation in mild Alzheimer\u2019s dementia: An open-label extension study","volume":"21","author":"Chan","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.plrev.2013.11.014","article-title":"Reply to criticism of the \u2018Orch OR qubit\u2019 Orchestrated objective reduction\u2019 is scientifically justified","volume":"11","author":"Hameroff","year":"2014","journal-title":"Phys. Life Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/6090\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:10:53Z","timestamp":1783743053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/13\/6090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":180,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27136090"],"URL":"https:\/\/doi.org\/10.3390\/ijms27136090","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}