{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:05:24Z","timestamp":1785409524889,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vedeck\u00e1 grantov\u00e1 agent\u00fara M\u0160VVaM SR a SAV VEGA","award":["2\/0008\/23"],"award-info":[{"award-number":["2\/0008\/23"]}]},{"award":["2\/0008\/23"],"award-info":[{"award-number":["2\/0008\/23"]}],"id":[{"id":"https:\/\/ror.org\/02z80ct15","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oxidative stress significantly impairs wound healing by prolonging inflammation and damaging surrounding tissue. l-(+)-Ergothioneine (EGT), a naturally occurring thione\u2013thiol antioxidant transported by OCTN1, exhibits potent cytoprotective and anti-inflammatory properties. The aim of the study was to investigate whether EGT applied topically to the periwound region can accelerate healing via transdermal antioxidant action. Full-thickness excisional wounds were created on the dorsum of Wistar rats. Animals were divided into three groups: the untreated rats (control), the rats treated with EGT at concentrations of 130 or 650 \u03bcg\/cm2 applied on gauze positioned in the periwound region. Wound areas were measured over 15 days. Healing kinetics were analyzed using Logistic and Weibull models. The results showed that in the EGT-treated groups wound closures accelerated compared with controls. The Logistic model predicted ~ 70% healing in controls vs. &gt; 90% in EGT-treated animals by day 15. The 130 \u03bcg\/cm2 dose of EGT achieved near-maximal efficacy, while its higher loading had no substantial additional benefit. Topically applied EGT in the periwound region significantly enhances healing, supporting its role as a transdermally active antioxidant and a promising strategy for advanced wound care.<\/jats:p>","DOI":"10.3390\/ijms27146102","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:27:31Z","timestamp":1783531651000},"page":"6102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling and Benefits of Topically Applied l-(+)-Ergothioneine in Periwound Region"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1514-2258","authenticated-orcid":false,"given":"Ladislav","family":"\u0160olt\u00e9s","sequence":"first","affiliation":[{"name":"Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-2736","authenticated-orcid":false,"given":"Anwar M.","family":"Jardine","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry, University of Cape Town, Cape Town 7701, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Bir\u00f3","sequence":"additional","affiliation":[{"name":"St. Elizabeth Cancer Institute Hospital, 81250 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2642-7737","authenticated-orcid":false,"given":"Karol","family":"\u0160v\u00edk","sequence":"additional","affiliation":[{"name":"Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-1024","authenticated-orcid":false,"given":"Mojm\u00edr","family":"Mach","sequence":"additional","affiliation":[{"name":"Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-893X","authenticated-orcid":false,"given":"Katar\u00edna","family":"Valachov\u00e1","sequence":"additional","affiliation":[{"name":"Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kuo, S.-H., Shen, C.-J., Shen, C.-F., and Chen, C.-M. 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