{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:08:52Z","timestamp":1785409732013,"version":"3.56.0"},"reference-count":82,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FOCUS: Training and Guidance for UMFST Researchers in Health","award":["100455\/29.08.2025"],"award-info":[{"award-number":["100455\/29.08.2025"]}]},{"name":"FOCUS: Training and Guidance for UMFST Researchers in Health","award":["SMIS 350717"],"award-info":[{"award-number":["SMIS 350717"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Health Program of the Ministry of Investments and European Projects"},{"name":"Managing Authority for the Health Program","award":["PS\/688\/PS_P3\/OP4\/ESO4.7\/PS_P3_ESO4.7_A6"],"award-info":[{"award-number":["PS\/688\/PS_P3\/OP4\/ESO4.7\/PS_P3_ESO4.7_A6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Despite reducing hernia recurrence, synthetic meshes often trigger persistent foreign body responses (FBRs). Mesh-enriched therapies (METs), incorporating autologous cellular components (MSCs, PRP, SVF), can regeneratively reprogram the host-prosthetic interactome. Following PRISMA-ScR guidelines, this scoping review involved a systematic search of PubMed, Embase, and Scopus (2000\u20132025). We utilized the PCC (Population, Concept, Context) framework to map evidence across systemic inflammation, local FBR, and bio-augmentation strategies. A total of sixty-five studies were synthesized and categorized into three primary thematic pillars. Regarding the Systemic Response (n = 25), the data established a predictable \u201cforeign body signature\u201d characterized by prominent C-reactive protein (CRP) and interleukin-6 (IL-6) spikes within the first 48 h post-implantation. For the Local Foreign Body Reaction (FBR, n = 19), human explant data extending up to 180 months revealed a perpetual, immune-mediated state driven by matrix metalloproteinase-2 (MMP-2) matrix remodeling and the development of \u201cbridging fibrosis.\u201d Finally, concerning Mesh-Enriched Therapy (MET) Integration (n = 21), biological enrichment successfully shifted the M1\/M2 macrophage ratio toward a pro-regenerative, CD163+\/CD206+ phenotype. While MET consistently enhanced vascular endothelial growth factor (VEGF)-driven angiogenesis and optimized the Collagen I\/III ratio, a notable 22.2% discrepancy rate across the literature underscores the critical need for precise transforming growth factor-beta 1 (TGF-\u03b21) dosing and release kinetics to prevent hyper-fibrosis. MET shifts hernia repair from passive mechanical reinforcement to active \u201cbiocamouflage\u201d and integration. By modulating the Th1\/Th2 rheostat, enriched therapies mitigate chronic inflammation and long-term complications. Standardized clinical trials are essential to optimize the therapeutic window for hybrid integration.<\/jats:p>","DOI":"10.3390\/ijms27146153","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:44Z","timestamp":1783613804000},"page":"6153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Prosthetic\u2013Host Interactome: From Systemic Inflammation to Biological Integration in Mesh-Enhanced Therapies METs\u2014A Scoping Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6139-5438","authenticated-orcid":false,"given":"Florentina Cristina","family":"Finascu","sequence":"first","affiliation":[{"name":"Doctoral School of Medicine, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology, 540139 Targu-Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-4662","authenticated-orcid":false,"given":"Valentin Constantin","family":"Oprea","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"},{"name":"Department of Surgery, \u201cConstantin Papilian\u201d Emergency Clinical Military Hospital, 400132 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cConstantin Papilian\u201d Emergency Clinical Military Hospital, 400132 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-6847","authenticated-orcid":false,"given":"Carmen Elena","family":"Bucuri","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"},{"name":"Department of Surgery, \u201cConstantin Papilian\u201d Emergency Clinical Military Hospital, 400132 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin","family":"Molnar","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Emergency Clinical County Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Andrei","family":"Finascu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Liana","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Emergency Clinical County Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-4356","authenticated-orcid":false,"given":"Bogdan Andrei","family":"Suciu","sequence":"additional","affiliation":[{"name":"First Department of Surgery, Emergency Clinical County Hospital Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"HerniaSurge Group (2018). 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