{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:59:36Z","timestamp":1785427176157,"version":"3.56.0"},"reference-count":48,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["No. RS-2023-00267453"],"award-info":[{"award-number":["No. RS-2023-00267453"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2021-KH113822"],"award-info":[{"award-number":["RS-2021-KH113822"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"award":["No. RS-2023-00267453"],"award-info":[{"award-number":["No. RS-2023-00267453"]}],"id":[{"id":"https:\/\/ror.org\/00fdzyk40","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RS-2021-KH113822"],"award-info":[{"award-number":["RS-2021-KH113822"]}],"id":[{"id":"https:\/\/ror.org\/00fdzyk40","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00223559"],"award-info":[{"award-number":["RS-2023-00223559"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2023-00223559"],"award-info":[{"award-number":["RS-2023-00223559"]}],"id":[{"id":"https:\/\/ror.org\/01wpjm123","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity is characterized by pathological adipose tissue expansion and dysregulated energy homeostasis. In this study, we examined whether KBN2201 attenuates high-fat diet (HFD)-induced obesity-associated phenotypes and whether these effects are accompanied by changes in appetite-regulatory markers. C57BL\/6J mice were fed a normal chow diet or HFD and orally administered vehicle or KBN2201 (20 mg\/kg\/day) for 12 weeks. In male mice, KBN2201 reduced HFD-induced body weight gain, adipose tissue accumulation, and adipocyte hypertrophy. KBN2201 was also associated with lower cage-level caloric intake under HFD-fed conditions. In epididymal white adipose tissue (eWAT), KBN2201 suppressed Srebf1 expression and reduced HFD-induced increases in Tnf and Tgfb1 expression. In the colon, KBN2201 further increased Pyy mRNA expression, and a positive mRNA-level association was observed between colonic Pyy and Npy2r expression in NTS-containing brainstem tissue. Behavioral analyses provided no evidence of overt locomotor suppression under the present experimental conditions. These findings suggest that KBN2201 attenuates HFD-induced obesity-associated phenotypes in male mice, accompanied by a lower cage-level food intake pattern, reduced adipose tissue expansion, and changes in the expression of colonic Pyy and NTS-containing brainstem Npy2r.<\/jats:p>","DOI":"10.3390\/ijms27146155","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:44Z","timestamp":1783613804000},"page":"6155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KBN2201 Attenuates High-Fat Diet-Induced Adipose Tissue Expansion and Body Weight Gain in Male Mice"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-1701","authenticated-orcid":false,"given":"Moonhang","family":"Kim","sequence":"first","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2483-4376","authenticated-orcid":false,"given":"Jeong-Hyeon","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hwan","family":"Chang","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeeun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"BK21 R&E Initiative for Advanced Precision Medicine, Ajou University, Suwon 16499, Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Geun","family":"Shin","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Efficacy Test Center for Mental & Behavioral Disorders, Ajou University Hospital, Suwon 16499, Republic of 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