{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:17:18Z","timestamp":1783685838639,"version":"3.55.0"},"reference-count":59,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circadian rhythms synchronize physiological processes with the light\u2013dark cycle and regulate biological functions relevant to cancer, including cell-cycle control, metabolism, DNA repair, immunity, and tissue homeostasis. Growing evidence indicates that disruption of these temporal mechanisms contributes to tumor initiation, progression, metastasis, and treatment response. In colorectal cancer (CRC), circadian clock dysregulation has emerged as an important component of tumor biology. A systematic search identified 1338 records, of which 43 studies met the eligibility criteria (20 human, 19 experimental, and 4 chronotherapy studies). Across the included studies, statistically significant associations were consistently reported between dysregulation of clock genes such as PER1, PER3, CLOCK, BMAL1, CRY1, TIMELESS, and ARNTL2 and alterations in proliferation, metabolism, epithelial plasticity, immune regulation, metastatic potential, and treatment responsiveness. Experimental evidence also supported interactions with Wnt signaling, ferroptosis, oxidative-stress adaptation, epithelial\u2013mesenchymal remodeling, and a proposed clock\u2013microbiota\u2013immune axis. Overall, the available evidence indicates that circadian dysregulation represents a systems-level disturbance that gives rise to a multidimensional biological condition, here referred to as the Tumor Temporal State, integrating the metabolic, immune, invasive, and therapeutic dimensions of colorectal cancer biology.<\/jats:p>","DOI":"10.3390\/ijms27146164","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:43:34Z","timestamp":1783683814000},"page":"6164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circadian Disruption as a Determinant of the Tumor Temporal State in Colorectal Cancer: A PRISMA-Based Systematic Review Integrating Metabolism, Immunity, and Metastasis"],"prefix":"10.3390","volume":"27","author":[{"given":"Miros\u0142aw","family":"Tarasewicz","sequence":"first","affiliation":[{"name":"Department of Hypertensiology, Gastroenterology and Internal Medicine, Medical University of Bialystok, 14 \u017burawia Street, 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-3254","authenticated-orcid":false,"given":"Edyta","family":"Zbroch","sequence":"additional","affiliation":[{"name":"Department of Hypertensiology, Gastroenterology and Internal Medicine, Medical University of Bialystok, 14 \u017burawia Street, 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-5549","authenticated-orcid":false,"given":"Adam R.","family":"Markowski","sequence":"additional","affiliation":[{"name":"Department of Hypertensiology, Gastroenterology and Internal Medicine, Medical University of Bialystok, 14 \u017burawia Street, 15-540 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100507","DOI":"10.1016\/j.coisb.2024.100507","article-title":"Coupling between the Cell Cycle and the Circadian Clock: Lessons from Computational Modelling and Consequences for Cancer Chronotherapy","volume":"37","author":"Gonze","year":"2024","journal-title":"Curr. 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