{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:08:34Z","timestamp":1792688914921,"version":"4.5.0"},"reference-count":144,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lung, breast, colorectal and prostate cancer account for over 41% of global cancer incidence and 39% of mortality, yet durable control of advanced disease remains limited. Plant secondary metabolites are promising multitarget leads, but their polypharmacological mechanisms cannot be captured by single-target approaches, and the evidence across these four cancers has not been synthesised within a unified framework. This review provides an integrated comparative analysis of network-pharmacology studies of plant-derived anticancer compounds across the four cancers, cataloguing phytochemical profiles, identifying shared and cancer-specific targets, quantifying the concordance between computational predictions and experimental validation, and appraising the translational gap. A systematic search of biomedical databases (2016\u20132026) identified 101 peer-reviewed studies (40 breast, 33 colorectal, 24 lung, and 14 prostate) combining network pharmacology with experimental validation. AKT1, EGFR, TP53, STAT3, MAPK1\/3, CASP3, and HSP90AA1 recurred as cross-cancer hub genes, with the phosphoinositide 3-kinase\/AKT and mitogen-activated protein kinase pathways most frequently implicated. Cancer-specific signatures comprised the androgen receptor in prostate, the oestrogen receptor and human epidermal growth factor receptor 2 in breast, \u03b2-catenin\/Wnt in colorectal, and the epidermal growth factor receptor\/RAS axis with epithelial-to-mesenchymal transition effectors in lung cancer. Flavonoids, terpenoids, alkaloids, and polyphenols predominated. The persistent validation gap remains the principal barrier to translation.<\/jats:p>","DOI":"10.3390\/ijms27146177","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:16:28Z","timestamp":1783689388000},"page":"6177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Network Pharmacology Review of Plant-Derived Anticancer Compounds in Lung, Breast, Colorectal and Prostate Cancer"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-4573","authenticated-orcid":false,"given":"Anna","family":"Merecz-Sadowska","sequence":"first","affiliation":[{"name":"Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5982-7887","authenticated-orcid":false,"given":"Arkadiusz","family":"Sadowski","sequence":"additional","affiliation":[{"name":"Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-9510","authenticated-orcid":false,"given":"Karolina","family":"Zajdel","sequence":"additional","affiliation":[{"name":"Department of Public Health, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"J\u0119cek","sequence":"additional","affiliation":[{"name":"Department of Public Health, Medical University of Lodz, 90-752 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-3550","authenticated-orcid":false,"given":"Przemys\u0142aw","family":"Sitarek","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Zajdel","sequence":"additional","affiliation":[{"name":"Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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