{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:07:39Z","timestamp":1784185659428,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The micellization behavior of binary mixtures of the nonionic surfactants Triton X-100 and Brij S20 was investigated in aqueous solution in the absence and presence of \u03b2-cyclodextrin (\u03b2CD) over the temperature range 283.15\u2013318.15 K. Critical micelle concentrations (CMC) were determined and analyzed using regular solution theory to evaluate mixed micelle composition, interaction parameters, activity coefficients, and excess Gibbs free energies. The Triton X-100\/Brij S20 system exhibited pronounced synergistic interactions, reflected by negative interaction parameters, reduced CMC values, and negative excess Gibbs free energies over the entire composition range. The addition of \u03b2CD systematically increased CMC values and reduced the magnitude of the interaction parameters, indicating that inclusion complex formation competes with micellization and weakens surfactant\u2013surfactant interactions. Corrected micellar compositions revealed significant redistribution of surfactants between the aqueous phase and mixed micelles due to host\u2013guest complexation. Thermodynamic analysis demonstrated spontaneous formation of \u03b2CD inclusion complexes with both surfactants, characterized by negative Gibbs free energy, enthalpy, and entropy changes. Triton X-100 exhibited a higher affinity toward \u03b2CD than Brij S20. The results demonstrate that coupled equilibria between micellization and inclusion complex formation govern the behavior of the system and suggest that conformational contributions should be considered when interpreting interaction parameters in cyclodextrin\u2013surfactant systems.<\/jats:p>","DOI":"10.3390\/ijms27146284","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:49:36Z","timestamp":1784184576000},"page":"6284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of \u03b2-Cyclodextrin on the Mixed Micellization of Triton X-100 and Brij S20: A Thermodynamic Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-9009","authenticated-orcid":false,"given":"Kosta","family":"Popovi\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Farka\u0161 Agati\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-2877","authenticated-orcid":false,"given":"Ana","family":"Pilipovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-2655","authenticated-orcid":false,"given":"Mihalj","family":"Po\u0161a","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0141-0229(01)00498-7","article-title":"Catalytic mechanism and product specificity of cyclodextrin glycosyltransferase, a prototypical transglycosylase from the \u03b1-amylase family","volume":"30","author":"Uitdehaag","year":"2002","journal-title":"Enzym. 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