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In this article, we broaden the discussion on myopathies associated with differentiation defects, examining their implications in less characterized muscle conditions that can have onset in adulthood, including facioscapulohumeral muscular dystrophy (FSHD), oculopharyngeal muscular dystrophy (OPMD), and myotonic dystrophies (DM), as well as myopathies caused by genetic variants in FHL1, GNE, DES, CAPN3, and members of the HNRNP family. Muscle damage can result from injury, exercise, or disease, necessitating a highly coordinated repair process to restore normal strength and function. Resident satellite cells are activated, differentiate, and fuse with the damaged tissue to facilitate this repair. This overview emphasizes the importance of muscle differentiation in the pathogenesis of myopathies with diverse etiologies and a broad range of underlying molecular mechanisms. These insights highlight differentiation as a potential convergent therapeutic target.<\/jats:p>","DOI":"10.3390\/ijms27146338","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:12:38Z","timestamp":1784257958000},"page":"6338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impaired Myogenic Differentiation Is a Shared Feature Across Genetic Myopathies"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-1298","authenticated-orcid":false,"given":"Tyler G. B.","family":"Soule","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-4305","authenticated-orcid":false,"given":"Mikhaela B.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-9386","authenticated-orcid":false,"given":"Carly S.","family":"Pontifex","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2677","authenticated-orcid":false,"given":"Mohamed Z.","family":"Dabaja","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Melnyk","sequence":"additional","affiliation":[{"name":"CHU Sainte-Justine Research Centre, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4188","authenticated-orcid":false,"given":"Antoine","family":"Dufour","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A.","family":"Dumont","sequence":"additional","affiliation":[{"name":"CHU Sainte-Justine Research Centre, Montreal, QC H3T 1C5, Canada"},{"name":"School of Rehabilitation, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-2943","authenticated-orcid":false,"given":"Timothy E.","family":"Shutt","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Biochemistry and Molecular Biology, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Medical Genetics, Alberta Child Health Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-7098","authenticated-orcid":false,"given":"Gerald","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Medical Genetics, Alberta Child Health Research Institute, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a008342","DOI":"10.1101\/cshperspect.a008342","article-title":"Building Muscle: Molecular Regulation of Myogenesis","volume":"4","author":"Bentzinger","year":"2012","journal-title":"Cold Spring Harb. 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