{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:46:17Z","timestamp":1785415577388,"version":"3.56.0"},"reference-count":55,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-33\/2026-03\/200015"],"award-info":[{"award-number":["451-03-33\/2026-03\/200015"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-34\/2026-03\/200110"],"award-info":[{"award-number":["451-03-34\/2026-03\/200110"]}]},{"award":["451-03-33\/2026-03\/200015"],"award-info":[{"award-number":["451-03-33\/2026-03\/200015"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]},{"award":["451-03-34\/2026-03\/200110"],"award-info":[{"award-number":["451-03-34\/2026-03\/200110"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ischemia\u2013reperfusion injury (IRI) of the kidney represents a serious medical issue with complex pathological mechanisms that remain poorly elucidated. The development of ischemic acute kidney injury (AKI) may be mediated by NADPH oxidase and angiotensin II type 2 receptors. The aim of our study was to explore the effects of novokinin (NOV), angiotensin II type 2 receptor (AT2R) agonist and apocynin (APO), an NADPH oxidase inhibitor, on kidney structure and function, as well as the level of oxidative stress in spontaneously hypertensive rats (SHR) with induced IRI. Animals were randomly assigned into five experimental groups: the Sham-operated animals (SHAM) group, the AKI group, and AKI groups receiving APO, NOV, or their combination. Slight improvements in renal function were noted across all treated groups; however, only the combined action of APO + NOV led to a significant decrease in kidney injury molecule-1 (KIM-1) levels and markedly reduced oxidative stress compared with the control AKI group. Our results demonstrate that additively targeting NADPH oxidase and AT2R provides new insights in comparison to individual treatments. These findings suggest a potentially promising new therapeutic strategy for managing IRI and improving outcomes in critically ill patients with AKI.<\/jats:p>","DOI":"10.3390\/ijms27146345","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:00:52Z","timestamp":1784278852000},"page":"6345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Apocynin and Novokinin Treatment Attenuates Renal Damage and Reduces KIM-1 Expression in a Model of Ischemic AKI"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-5751","authenticated-orcid":false,"given":"Milan","family":"Ivanov","sequence":"first","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-8706","authenticated-orcid":false,"given":"Nevena","family":"Mihailovi\u0107-Stanojevi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-4762","authenticated-orcid":false,"given":"Una-Jovana","family":"Vuja\u010di\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-746X","authenticated-orcid":false,"given":"Danijela","family":"Karanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2741-4567","authenticated-orcid":false,"given":"Djurdjica","family":"Jovovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-6661","authenticated-orcid":false,"given":"Maja","family":"\u017divoti\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Belgrade, Dr Suboti\u0107a 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-7173","authenticated-orcid":false,"given":"Sanjin","family":"Kovacevic","sequence":"additional","affiliation":[{"name":"Institute of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Suboti\u0107a 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-5789","authenticated-orcid":false,"given":"Jelena","family":"Ne\u0161ovi\u0107-Ostoji\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Suboti\u0107a 1, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-668X","authenticated-orcid":false,"given":"Zoran","family":"Miloradovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1053-0770(98)90106-9","article-title":"Perioperative Renal Dysfunction and Cardiovascular Anesthesia: Concerns and Controversies","volume":"12","author":"Aronson","year":"1998","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrneph.2011.16","article-title":"Pathophysiology of Ischemic Acute Kidney Injury","volume":"7","author":"Sharfuddin","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_3","first-page":"20","article-title":"Renal Ischemia\/Reperfusion Injury; From Pathophysiology to Treatment","volume":"4","author":"Malek","year":"2015","journal-title":"J. Ren. Inj. Prev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.medin.2016.12.004","article-title":"Prevention of Acute Kidney Injury in Intensive Care Units","volume":"41","year":"2017","journal-title":"Med. Intensiv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ckj\/sfx087","article-title":"Angiotensinogen as a Biomarker of Acute Kidney Injury","volume":"10","author":"Sanchez","year":"2017","journal-title":"Clin. Kidney J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ivanov, M., Mihailovi\u0107-Stanojevi\u0107, N., Milanovi\u0107, J.G., Jovovi\u0107, D., Markovi\u0107-Lipkovski, J., \u0106irovi\u0107, S., and Miloradovi\u0107, Z. (2014). Losartan Improved Antioxidant Defense, Renal Function and Structure of Postischemic Hypertensive Kidney. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096353"},{"key":"ref_7","first-page":"79","article-title":"Role of AT 1 Angiotensin II Receptors in Renal Ischemic Injury","volume":"274","author":"Kontogiannis","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fang, F., Liu, G.C., Zhou, X., Yang, S., Reich, H.N., Williams, V., Hu, A., Pan, J., Konvalinka, A., and Oudit, G.Y. (2013). Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071433"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1172\/JCI118623","article-title":"Angiotensin II-Mediated Hypertension in the Rat Increases Vascular Superoxide Production via Membrane NADH\/NADPH Oxidase Activation","volume":"97","author":"Rajagopalan","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00424-012-1146-3","article-title":"AT2 Receptors: Beneficial Counter-Regulatory Role in Cardiovascular and Renal Function","volume":"465","author":"Padia","year":"2013","journal-title":"Pfl\u00fcg. Arch."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.toxrep.2015.07.019","article-title":"Effect of NADPH Oxidase Inhibitor-Apocynin on the Expression of Src Homology-2 Domain-Containing Phosphatase-1 (SHP-1) Exposed Renal Ischemia\/Reperfusion Injury in Rats","volume":"2","author":"Li","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"106507","DOI":"10.1155\/2008\/106507","article-title":"Apocynin: Molecular Aptitudes","volume":"2008","author":"Stefanska","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.peptides.2007.11.017","article-title":"Hypotensive Activity of Novokinin, a Potent Analogue of Ovokinin(2\u20137), Is Mediated by Angiotensin AT2 Receptor and Prostaglandin IP Receptor","volume":"29","author":"Yamada","year":"2008","journal-title":"Peptides"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/APhysiol.98.2011.1.1","article-title":"Prevention of Systemic and Regional Haemodynamic Alterations, Hypercreatininemia, Hyperuremia and Hyperphosphatemia by Losartan in Hypertension with Acute Renal Failure","volume":"98","author":"Ivanov","year":"2011","journal-title":"Acta Physiol. Hung."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1097\/01.ASN.0000096784.86791.21","article-title":"Angiotensin II and Oxidative Stress: An Unholy Alliance","volume":"14","author":"Ritz","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/ggi.13735","article-title":"Low Blood Pressure Is Associated with Acute Kidney Injury Development and Mortality in Octogenarians Admitted to the Emergency Room","volume":"19","author":"Slotki","year":"2019","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1476-5381.1983.tb11020.x","article-title":"Cardiovascular Responses in Rats with Glycerol-Induced Acute Renal Failure","volume":"79","author":"Bowmer","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"ref_18","first-page":"153","article-title":"Impact of AT2-Receptor Stimulation on Vascular Biology, Kidney Function, and Blood Pressure","volume":"6","author":"Danyel","year":"2013","journal-title":"Integr. Blood Press. Control"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/joim.12333","article-title":"Resting Heart Rate Is Associated with Renal Disease Outcomes in Patients with Vascular Disease: Results of the ONTARGET and TRANSCEND Studies","volume":"278","author":"Schumacher","year":"2015","journal-title":"J. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283137","DOI":"10.4061\/2011\/283137","article-title":"The Cardiorenal Syndrome: Making the Connection","volume":"2011","author":"Viswanathan","year":"2011","journal-title":"Int. J. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/ndt\/gfm213","article-title":"Bosentan and Losartan Ameliorate Acute Renal Failure Associated with Mild but Not Strong NO Blockade","volume":"22","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1054\/cupe.1999.0036","article-title":"Management of Acute Renal Failure","volume":"9","author":"Smith","year":"1999","journal-title":"Curr. Pediatr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1002\/jcb.25140","article-title":"The Protective Effect of Apocynin on Cyclosporine A- Induced Hypertension and Nephrotoxicity in Rats","volume":"116","author":"Ciarcia","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/FJC.0000000000000208","article-title":"AT2 Receptor Activities and Pathophysiological Implications","volume":"65","author":"Matavelli","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/HYPERTENSIONAHA.111.184986","article-title":"Sex-Specific Influence of Angiotensin Type 2 Receptor Stimulation on Renal Function: A Novel Therapeutic Target for HypertensionHypertension","volume":"59","author":"Hilliard","year":"2012","journal-title":"Hypertension"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9962624","DOI":"10.1155\/2021\/9962624","article-title":"Severe Hyperphosphatemia in a Patient with Mild Acute Kidney Injury","volume":"2021","author":"Pham","year":"2021","journal-title":"Case Rep. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Moon, H., Chin, H.J., Na, K.Y., Joo, K.W., Kim, Y.S., Kim, S., and Han, S.S. (2019). Hyperphosphatemia and Risks of Acute Kidney Injury, End-Stage Renal Disease, and Mortality in Hospitalized Patients. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1556-y"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"p1","DOI":"10.1159\/000084463","article-title":"Regulation of the Renal Sodium-Dependent Phosphate Cotransporter NaPi2 (Npt2) in Acute Renal Failure Due to Ischemia and Reperfusion","volume":"100","author":"Rubinger","year":"2005","journal-title":"Nephron Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Dennis, J.M., and Witting, P.K. (2017). Protective Role for Antioxidants in Acute Kidney Disease. Nutrients, 9.","DOI":"10.3390\/nu9070718"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0962-8924(00)01900-0","article-title":"Nitric Oxide and the Regulation of Gene Expression","volume":"11","author":"Bogdan","year":"2001","journal-title":"Trends Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.84.5.1404","article-title":"Direct Measurement of Free Radical Generation Following Reperfusion of Ischemic Myocardium","volume":"84","author":"Zweier","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2015.12.009","article-title":"A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant Mechanisms in Renal Injury and Disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jeong, B.Y., Lee, H.Y., Park, C.G., Kang, J., Yu, S.-L., Choi, D., Han, S.-Y., Park, M.H., Cho, S., and Lee, S.Y. (2018). Oxidative Stress Caused by Activation of NADPH Oxidase 4 Promotes Contrast-Induced Acute Kidney Injury. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191034"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.transproceed.2015.06.007","article-title":"Effects of Allopurinol and Apocynin on Renal Ischemia-Reperfusion Injury in Rats","volume":"47","author":"Choi","year":"2015","journal-title":"Transplant. Proc."},{"key":"ref_36","first-page":"512619","article-title":"Acute Superoxide Radical Scavenging Reduces Blood Pressure but Does Not Influence Kidney Function in Hypertensive Rats with Postischemic Kidney Injury","volume":"2014","author":"Ivanov","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Nesovic Ostojic, J., Kovacevic, S., De Luka, S.R., Ivanov, M., Nenadovic, A., and Vukovic, A. (2025). Therapeutic Potential of Apocynin: A Promising Antioxidant Strategy for Acute Kidney Injury. Antioxidants, 14.","DOI":"10.3390\/antiox14081025"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/j.transproceed.2006.10.184","article-title":"Hyperbaric Oxygenation Attenuates Renal Ischemia-Reperfusion Injury in Rats","volume":"38","author":"Gurer","year":"2006","journal-title":"Transplant. Proc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11906-012-0321-4","article-title":"Update on the Angiotensin AT2 Receptor","volume":"15","author":"McCarthy","year":"2013","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/147323000603400209","article-title":"Antioxidant Enzyme Activities and Lipid Peroxidation Levels in Erythrocytes of Patients with Oesophageal and Gastric Cancer","volume":"34","author":"Dursun","year":"2006","journal-title":"J. Int. Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kovacevic, S., Ivanov, M., Miloradovic, Z., Brkic, P., Vajic, U.J., Zivotic, M., Mihailovic-Stanojevic, N., Jovovic, D., Karanovic, D., and Jeremic, R. (2020). Hyperbaric Oxygen Preconditioning and the Role of NADPH Oxidase Inhibition in Postischemic Acute Kidney Injury Induced in Spontaneously Hypertensive Rats. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226974"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0735-1097(03)00846-5","article-title":"Pleiotropic Effects of Angiotensin II Receptor Blocker in Hypertensive Patients","volume":"42","author":"Koh","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1182\/blood.V73.1.334.334","article-title":"Catalase and Glutathione Peroxidase Are Equally Active in Detoxification of Hydrogen Peroxide in Human Erythrocytes","volume":"73","author":"Gaetani","year":"1989","journal-title":"Blood"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-8993(97)00233-3","article-title":"Involvement of Glutathione Peroxidase and Catalase in the Disposal of Exogenous Hydrogen Peroxide by Cultured Astroglial Cells","volume":"759","author":"Dringen","year":"1997","journal-title":"Brain Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.22462\/01.03.2020.3","article-title":"Hyperbaric oxygenation protects the kidney against ischemia-reperfusion injury","volume":"47","author":"Ivanov","year":"2020","journal-title":"Undersea Hyperb. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","article-title":"Kidney Injury Molecule-1 (KIM-1): A Novel Biomarker for Human Renal Proximal Tubule Injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1681\/ASN.2013070758","article-title":"Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes","volume":"25","author":"Sabbisetti","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"854070","DOI":"10.1155\/2015\/854070","article-title":"Kidney injury molecule-1 and cardiovascular diseases: From basic science to clinical practice","volume":"2015","author":"Medic","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00125-021-05512-5","article-title":"Effects of the SGLT2 Inhibitor Canagliflozin on Plasma Biomarkers TNFR-1, TNFR-2 and KIM-1 in the CANVAS Trial","volume":"64","author":"Sen","year":"2021","journal-title":"Diabetologia"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Tan, Y.C., Sattar, M.A., Ahmeda, A.F., Khan, N.A.K., Murugaiyah, V., Ahmad, A., Hassan, Z., Kaur, G., Abdulla, M.H., and Johns, E.J. (2020). Apocynin and Catalase Prevent Hypertension and Kidney Injury in Cyclosporine A-Induced Nephrotoxicity in Rats. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0231472"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/HYPERTENSIONAHA.110.164202","article-title":"Angiotensin AT2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension","volume":"57","author":"Matavelli","year":"2011","journal-title":"Hypertension"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"F683","DOI":"10.1152\/ajprenal.00503.2009","article-title":"Angiotensin Type 2 Receptor Actions Contribute to Angiotensin Type 1 Receptor Effects on Kidney Fibrosis","volume":"298","author":"Naito","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"R\u00e9v\u00e9sz, C., Kaucs\u00e1r, T., God\u00f3, M., Bocskai, K., Kren\u00e1cs, T., M\u00f3csai, A., Sz\u00e9n\u00e1si, G., and Hamar, P. (2024). Neutrophils and NADPH Oxidases Are Major Contributors to Mild but Not Severe Ischemic Acute Kidney Injury in Mice. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052948"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"118879","DOI":"10.1016\/j.lfs.2020.118879","article-title":"Renal Ischemia-Reperfusion Leads to Hypertension and Changes in Proximal Tubule Na+ Transport and Renin-Angiotensin-Aldosterone System: Role of NADPH Oxidase","volume":"266","author":"Lima","year":"2021","journal-title":"Life Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kovacevic, S., Ivanov, M., Zivotic, M., Brkic, P., Miloradovic, Z., Jeremic, R., Mihailovic-Stanojevic, N., Vajic, U.J., Karanovic, D., and Jovovic, D. (2021). Immunohistochemical Analysis of 4-HNE, NGAL, and HO-1 Tissue Expression after Apocynin Treatment and HBO Preconditioning in Postischemic Acute Kidney Injury Induced in Spontaneously Hypertensive Rats. Antioxidants, 10.","DOI":"10.3390\/antiox10081163"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/14\/6345\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:03:40Z","timestamp":1784279020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/14\/6345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":55,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ijms27146345"],"URL":"https:\/\/doi.org\/10.3390\/ijms27146345","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}