{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:42:03Z","timestamp":1793770923951,"version":"4.6.1"},"reference-count":118,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2024-BS-335"],"award-info":[{"award-number":["2024-BS-335"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dalian Outstanding Youth Science and Technology Talent Project","award":["2024RY007"],"award-info":[{"award-number":["2024RY007"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","award":["2024ZDJH01PT028"],"award-info":[{"award-number":["2024ZDJH01PT028"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myocardial infarction remains a major clinical challenge because ischemic injury triggers inflammation, oxidative stress, cardiomyocyte loss, impaired vascularization, and adverse ventricular remodeling. Injectable hydrogels offer a minimally invasive and versatile strategy for post-infarction cardiac repair by providing structural support, localized bioactive delivery, and dynamic modulation of the injured myocardial microenvironment. This review highlights pathology-informed design principles for injectable hydrogels, including shear-thinning injectability, in situ gelation, tissue adhesion, modulus matching, fatigue resistance, biodegradability, and controlled bioactivity. We further discuss hydrogel-based strategies for immunomodulation, angiogenesis, fibrosis attenuation, extracellular matrix remodeling, and myocardial regeneration. Finally, translational progress and key challenges involving biosafety, scalable manufacturing, standardization and long-term efficacy are examined. This review provides a concise framework for developing next-generation injectable hydrogels for myocardial infarction repair and clinical translation.<\/jats:p>","DOI":"10.3390\/ijms27146464","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:14:27Z","timestamp":1784621667000},"page":"6464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Application of Injectable Hydrogels in Myocardial Infarction Repair: Material Design, Biological Functions and Clinical Translation"],"prefix":"10.3390","volume":"27","author":[{"given":"Zhichao","family":"Zhang","sequence":"first","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"},{"name":"Faculty of Medicine, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Lang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"},{"name":"Faculty of Medicine, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-280X","authenticated-orcid":false,"given":"Xufeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"},{"name":"School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"},{"name":"Faculty of Medicine, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology, Dalian 116089, China"},{"name":"Faculty of Medicine, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1161\/CIRCULATIONAHA.123.067097","article-title":"Advanced Cardiac Patches for the Treatment of Myocardial Infarction","volume":"149","author":"Liu","year":"2024","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/jbm.a.36941","article-title":"Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility","volume":"108","author":"Spaulding","year":"2020","journal-title":"J. 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