{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:29:36Z","timestamp":1785421776004,"version":"3.56.0"},"reference-count":54,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012725","name":"Tecnol\u00f3gico Nacional de M\u00e9xico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012725","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00davry38","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Instituto Tecnol\u00f3gico de Durango","award":["8326.20-P"],"award-info":[{"award-number":["8326.20-P"]}]},{"award":["8326.20-P"],"award-info":[{"award-number":["8326.20-P"]}],"id":[{"id":"https:\/\/ror.org\/02c00pn47","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Mexican National System of Researchers","award":["209339"],"award-info":[{"award-number":["209339"]}]},{"award":["209339"],"award-info":[{"award-number":["209339"]}],"id":[{"id":"https:\/\/ror.org\/02h3fqt03","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Phytotherapy has emerged as a promising strategy for the management of obesity and related metabolic disorders. In this context, species of the Physalis genus have been widely recognized in traditional medicine for their potential therapeutic effects against these conditions. This study aimed to evaluate the effects of Physalis philadelphica husk infusion on obesity and associated metabolic disturbances such as hyperglycemia, insulin resistance, hepatic steatosis, and oxidative stress markers in diet-induced obese rats. Male Wistar rats were allocated into three groups (n = 8): (1) healthy control, (2) obese control group, and (3) intervention group (husk infusion). Obesity was induced using a high-fructose and high-saturated fat diet (~511.1 kcal\/100 g), followed by 16 weeks of husk infusion administration. After euthanasia, hyperglycemia, insulin resistance, hepatic steatosis, and oxidative stress markers were analyzed. Results showed that rats receiving the husk infusion exhibited a significant reduction in weight gain (~7.2%), serum glucose levels (22.8%), and free fatty acids (26%) compared to the obese control group, while no significant effects on insulin sensitivity, hepatic steatosis, or several lipid-related parameters were observed. Regarding oxidative stress markers, serum nitrite levels decreased by 33%, and malondialdehyde (MDA) levels in the liver (30%) and adipose tissue (38%) were significantly reduced compared to the obese control group. Moreover, treated rats showed a significant increase in catalase (~1.2-fold) and superoxide dismutase (~2.8-fold) activity in the liver. These findings suggest that Physalis philadelphica husk infusion reduces hyperglycemia and improves oxidative stress in obese rats.<\/jats:p>","DOI":"10.3390\/ijms27146500","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:48:28Z","timestamp":1784717308000},"page":"6500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Physalis philadelphica Lam. Husk Infusion on Obesity and Associated Metabolic Disturbances in an Experimental Model"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-9406","authenticated-orcid":false,"given":"Claudia I.","family":"Gamboa-G\u00f3mez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica del Instituto Mexicano del Seguro Social, Canoas 100, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-6668","authenticated-orcid":false,"given":"Jazel","family":"Barrag\u00e1n-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Centro Estatal de Cancerolog\u00eda, Secretaria de Salud Durango, Av. 5 de Febrero esq, Antonio Norman Fuentes S\/N, Zona Centro, Durango 34000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2875-5344","authenticated-orcid":false,"given":"Mar\u00eda In\u00e9s","family":"Guerra-Rosas","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional Conahcyt de Apoyo a la Evaluaci\u00f3n de Productos Bioticos (LaNAEPBi), Instituto Tecnol\u00f3gico de Durango, Tecnol\u00f3gico Nacional de M\u00e9xico (TecNM), Blvd. Felipe Pescador 1830 Ote, Colonia Nueva Vizcaya, Durango 34080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"G\u00f3nzalez","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Canoas S\/N, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Iv\u00e1n","family":"Sayago-Monreal","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional Conahcyt de Apoyo a la Evaluaci\u00f3n de Productos Bioticos (LaNAEPBi), Instituto Tecnol\u00f3gico de Durango, Tecnol\u00f3gico Nacional de M\u00e9xico (TecNM), Blvd. Felipe Pescador 1830 Ote, Colonia Nueva Vizcaya, Durango 34080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia P.","family":"Castillo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica del Instituto Mexicano del Seguro Social, Canoas 100, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla F.","family":"Valles-Araiza","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional Conahcyt de Apoyo a la Evaluaci\u00f3n de Productos Bioticos (LaNAEPBi), Instituto Tecnol\u00f3gico de Durango, Tecnol\u00f3gico Nacional de M\u00e9xico (TecNM), Blvd. Felipe Pescador 1830 Ote, Colonia Nueva Vizcaya, Durango 34080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1022-3332","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Alvarado-Aguilar","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica del Instituto Mexicano del Seguro Social, Canoas 100, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Morales-Castro","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional Conahcyt de Apoyo a la Evaluaci\u00f3n de Productos Bioticos (LaNAEPBi), Instituto Tecnol\u00f3gico de Durango, Tecnol\u00f3gico Nacional de M\u00e9xico (TecNM), Blvd. Felipe Pescador 1830 Ote, Colonia Nueva Vizcaya, Durango 34080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Rodr\u00edguez-Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica del Instituto Mexicano del Seguro Social, Canoas 100, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-9870","authenticated-orcid":false,"given":"Fernando","family":"Guerrero-Romero","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica del Instituto Mexicano del Seguro Social, Canoas 100, Durango 34067, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1001\/jama.2025.24288","article-title":"World Health Organization guideline on the use and indications of glucagon-like peptide-1 therapies for the treatment of obesity in adults","volume":"335","author":"Celletti","year":"2026","journal-title":"JAMA"},{"key":"ref_2","first-page":"58","article-title":"Oxidative stress in obesity and insulin resistance","volume":"3","author":"Stanimirovic","year":"2022","journal-title":"Explor. 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