{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:00:39Z","timestamp":1784772039276,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Terminal glial cells (TGCs) of cutaneous end-organ complexes have traditionally been regarded as structural and trophic elements, although they may also participate in mechanosensory processing. We performed an exploratory immunohistochemical and immunofluorescence study of mechanosensitivity-associated ion channel proteins in human Meissner and Pacinian corpuscles using archival formalin-fixed, paraffin-embedded glabrous skin from 64 donors and several anatomical sites. Immunoreactivity was assessed separately in mechanoreceptor axons and TGCs. In Meissner corpuscles, TGC-associated immunoreactivity for ASIC2 and TRPV4 was observed in subsets of evaluable corpuscles, whereas TRPA1 immunoreactivity was observed in selected specimens. PIEZO1- and PIEZO2-associated immunoreactivity was observed in subsets of corpuscles from the single available labia minora specimen. Among evaluable Pacinian corpuscles, inner-core TGC-associated immunoreactivity was observed for ASIC2, PIEZO2, TRPA1, and TRPV4. Because Pacinian corpuscles were unevenly distributed and scarce outside hand and foot skin, these findings were interpreted exclusively descriptively. To our knowledge, TRPA1 immunoreactivity has not previously been described in TGCs of human sensory corpuscles. These findings are hypothesis-generating and do not demonstrate protein function or mechanotransduction. Because this study used archival tissue and independent target validation was not performed, the results require confirmation using orthogonal antibody- or transcript-based approaches.<\/jats:p>","DOI":"10.3390\/ijms27146525","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:01:28Z","timestamp":1784768488000},"page":"6525","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Immunohistochemical Mapping of Mechanosensitivity-Associated Ion Channel Proteins in Terminal Glial Cells of Human Meissner and Pacinian Corpuscles"],"prefix":"10.3390","volume":"27","author":[{"given":"Irene","family":"Amigo","sequence":"first","affiliation":[{"name":"Servicio de Traumatolog\u00eda y Cirug\u00eda Ortop\u00e9dica, Hospital Universitari Son Espases, 07120 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-1095","authenticated-orcid":false,"given":"Yolanda","family":"Garc\u00eda-Mesa","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Sistema Nervioso Perif\u00e9rico y \u00d3rganos de los Sentidos, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"ISPA Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-8200","authenticated-orcid":false,"given":"Patricia","family":"Cuendias","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Sistema Nervioso Perif\u00e9rico y \u00d3rganos de los Sentidos, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"ISPA Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Feito","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Sistema Nervioso Perif\u00e9rico y \u00d3rganos de los Sentidos, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Departamento de Biolog\u00eda Celular y Patolog\u00eda, Universidad de Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Sistema Nervioso Perif\u00e9rico y \u00d3rganos de los Sentidos, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"ISPA Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-4133","authenticated-orcid":false,"given":"Ana M.","family":"Abreu-Velez","sequence":"additional","affiliation":[{"name":"Georgia Dermatopathology Associates, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-1632","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Suazo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Santiago 7500912, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS Sistema Nervioso Perif\u00e9rico y \u00d3rganos de los Sentidos, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Santiago 7500912, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/joa.13484","article-title":"Peripheral glia diversity","volume":"241","author":"Reed","year":"2022","journal-title":"J. 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