{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:04:17Z","timestamp":1785420257274,"version":"3.56.0"},"reference-count":51,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Paraplegic Research and Swiss Paraplegic Foundation"},{"id":[{"id":"https:\/\/ror.org\/03a5vha87","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>This pilot study examined longitudinal changes in psychological distress and biomarkers related to stress, inflammation, and biological aging during the first inpatient rehabilitation after Spinal Cord Injury (SCI). We analyzed data from 120 participants in the SwiSCI inception cohort at two timepoints: the beginning of the first post-injury rehabilitation and discharge. A subset of 50 participants representing four distress patterns (high chronic, low, transient, increasing distress) underwent biomarker analyses, including measurements of immune and inflammatory proteins and whole-blood transcriptomic profiling. The results showed that psychological distress, depression, and protein carbonyl content decreased significantly by discharge. In contrast, cortisol levels and telomere length showed no significant changes. Proteomic analyses revealed a broad downregulation of inflammatory proteins (e.g., IFN-\u03b3, IL-10, LIF) at discharge, whereas transcriptomic profiles did not differ between timepoints. The high chronic distress group showed lower expression of six genes involved in adaptive immunity, neural development and apoptosis. Psychological distress was not linearly associated with global biomarker profiles. However, CXCL1 and IL-7 showed low-to-moderate correlations with depression and anxiety, respectively. This pilot study demonstrates the feasibility of integrating psychological and molecular data to investigate biological response following SCI. The findings are exploratory and need validation in larger studies with longer follow-up periods.<\/jats:p>","DOI":"10.3390\/ijms27156574","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:13:17Z","timestamp":1784826797000},"page":"6574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological Distress and Biological Stress Markers After Spinal Cord Injury: A Longitudinal Multi-Omics Pilot Study"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2643-5543","authenticated-orcid":false,"given":"Simona","family":"Capossela","sequence":"first","affiliation":[{"name":"SCI Population Biobanking and Translational Research, Swiss Paraplegic Research, 6207 Nottwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-5071","authenticated-orcid":false,"given":"Alessandro","family":"Bertolo","sequence":"additional","affiliation":[{"name":"SCI Population Biobanking and Translational Research, Swiss Paraplegic Research, 6207 Nottwil, Switzerland"},{"name":"Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8653-2317","authenticated-orcid":false,"given":"Alexander","family":"Stacul","sequence":"additional","affiliation":[{"name":"SCI Population Biobanking and Translational Research, Swiss Paraplegic Research, 6207 Nottwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-1595","authenticated-orcid":false,"given":"Franziska","family":"Singer","sequence":"additional","affiliation":[{"name":"NEXUS Personalized Health, ETH Zurich, 8092 Zurich, Switzerland"},{"name":"SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Health, ZHAW Zurich University of Applied Sciences, 8400 Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-0057","authenticated-orcid":false,"given":"Xavier","family":"Jordan","sequence":"additional","affiliation":[{"name":"Clinique Romande de R\u00e9adaptation, 1951 Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-2888","authenticated-orcid":false,"given":"Margret","family":"Hund-Georgiadis","sequence":"additional","affiliation":[{"name":"REHAB Basel, 4055 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Z\u00f6rner","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Center, 6207 Nottwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-6284","authenticated-orcid":false,"given":"Jivko","family":"Stoyanov","sequence":"additional","affiliation":[{"name":"SCI Population Biobanking and Translational Research, Swiss Paraplegic Research, 6207 Nottwil, Switzerland"},{"name":"Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/bjhp.12143","article-title":"Adjustment following chronic spinal cord injury: Determining factors that contribute to social participation","volume":"20","author":"Craig","year":"2015","journal-title":"Br. 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