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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Existing diagnostic markers of sepsis indicate already developed inflammatory complications, whereas predictors enable preoperative identification of high-risk patients for preventive measures. This study aimed to evaluate the prognostic value of preoperative inflammatory biomarkers for postoperative complications in cardiac surgery patients. Preoperatively, we assessed age, body mass index, EuroSCORE II (European System for Cardiac Operative Risk Evaluation II), complete blood count with hematological indices including neutrophil-to-lymphocyte ratio (NLR), serum cytokines, HIF1A (hypoxia-inducible factor 1-alpha), and EPAS1 (endothelial PAS domain protein 1) expression in peripheral blood leukocytes. During surgery, cardiopulmonary bypass time, myocardial ischemia time, and blood loss were recorded. Postoperatively, complications, intensive care unit (ICU) stay, and total hospitalization were documented. No differences were found in non-modifiable risk factors or perioperative parameters between groups, except for longer ICU stay in the complications group. Preoperatively, absolute neutrophil count and NLR were higher in patients without complications, while eosinophil count, HIF1A expression, and HIF1A\/EPAS1 ratio were higher in those with it. The HIF1A\/EPAS1 ratio demonstrated the best diagnostic characteristics. Thus, preoperative predictors of postoperative inflammatory complications include low neutrophil count and NLR, as well as high HIF1A expression and HIF1A\/EPAS1 ratio. These markers may facilitate early risk stratification and preventive strategies before surgery.<\/jats:p>","DOI":"10.3390\/ijms27156616","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:47:41Z","timestamp":1785145661000},"page":"6616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Value of Preoperative HIF1A and EPAS1 Expression Levels and Inflammatory Response Molecules for Assessing the Risk of Complications in Cardiac Surgery Patients"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-5537","authenticated-orcid":false,"given":"Maria","family":"Kirillova","sequence":"first","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7160","authenticated-orcid":false,"given":"Dzhuliia","family":"Dzhalilova","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-9889","authenticated-orcid":false,"given":"Natalia","family":"Zolotova","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-8369","authenticated-orcid":false,"given":"Marina","family":"Diatroptova","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Fokichev","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"},{"name":"Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-3791","authenticated-orcid":false,"given":"Maxim","family":"Babaev","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Grin","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Eremenko","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-2560","authenticated-orcid":false,"given":"Eduard","family":"Charchyan","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-107X","authenticated-orcid":false,"given":"Olga","family":"Makarova","sequence":"additional","affiliation":[{"name":"Petrovsky National Research Centre of Surgery, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Qaddumi, J., Abo Hania, S.T.M., Alkhawaldeh, A., Albashtawy, M., Almagharbeh, W.T., Al-Rshoud, Y.H., Abdalrahim, A., Aljezawi, M., Suliman, M., and Al-Amoush, Z. 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