{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:47:04Z","timestamp":1785836824096,"version":"3.56.0"},"reference-count":43,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["PNRR-POC-2023-12378186 CUP I73C24000330006"],"award-info":[{"award-number":["PNRR-POC-2023-12378186 CUP I73C24000330006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"award":["PNRR-POC-2023-12378186 CUP I73C24000330006"],"award-info":[{"award-number":["PNRR-POC-2023-12378186 CUP I73C24000330006"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Chronic coronary syndrome (CCS) is characterized by persistent low-grade inflammation and impaired resolution of inflammatory responses within the vascular wall. Specialized pro-resolving mediators (SPMs), including resolvins and maresins, play an essential role in terminating inflammation and restoring tissue homeostasis. This prospective observational study included 83 patients hospitalized due to stable angina or angina-equivalent symptoms. Serum concentrations of leukotriene B4 (LTB4), maresin-1 (MaR1), resolvin E1 (RvE1), resolvin D1 (RvD1), and prostaglandin E2 (PGE2) were determined using enzyme-linked immunosorbent assays. Associations between mediator concentrations and clinical characteristics\u2014including sex, age, and body mass index (BMI)\u2014were analyzed using nonparametric statistical tests with false-discovery-rate correction. Women, patients \u226565 years of age, and individuals with BMI \u2265 30 kg\/m2 demonstrated significantly higher concentrations of LTB4, MaR1, and RvD1. In contrast, higher RvE1 concentrations were observed in men, younger patients, and those with a BMI &lt; 30 kg\/m2. PGE2 levels did not differ significantly between the analyzed subgroups. Multivariable analysis identified age, LTB4, and RvD1 as independent predictors associated with coronary artery disease in the studied cohort. Circulating lipid mediator profiles differ according to sex, age, and obesity status in patients with chronic coronary syndrome. These findings demonstrate differential circulating lipid mediator profiles associated with age, sex, and obesity in patients with chronic coronary syndrome. Whether these profiles reflect adaptive inflammatory resolution or impaired resolution requires further investigation.<\/jats:p>","DOI":"10.3390\/ijms27156667","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:47:41Z","timestamp":1785145661000},"page":"6667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Regulation of Inflammatory and Pro-Resolving Lipid Mediators in Chronic Coronary Syndrome Across Cardiometabolic Phenotypes"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-1645","authenticated-orcid":false,"given":"Beata","family":"Krasi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Hypertensiology, Angiology, and Internal Medicine, Pozna\u0144 University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-2764","authenticated-orcid":false,"given":"Tomasz","family":"Urbanowicz","sequence":"additional","affiliation":[{"name":"Cardiac Surgery and Transplantology Department, Pozna\u0144 University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Hypertensiology, Angiology, and Internal Medicine, Pozna\u0144 University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-3245","authenticated-orcid":false,"given":"Maciej","family":"Kurpisz","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, 60-479 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Grywalska","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-6659","authenticated-orcid":false,"given":"Paulina","family":"Mertowska","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6993-4606","authenticated-orcid":false,"given":"Ievgen","family":"Spasenenko","sequence":"additional","affiliation":[{"name":"Department of Hypertensiology, Angiology, and Internal Medicine, Pozna\u0144 University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-2561","authenticated-orcid":false,"given":"Giuseppe Maria","family":"Raffa","sequence":"additional","affiliation":[{"name":"Department of Research, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Specialized Therapies), 90127 Palermo, Italy"},{"name":"Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-9657","authenticated-orcid":false,"given":"Paolo","family":"Manca","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiology and Heart Failure, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogera","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Research, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Specialized Therapies), 90127 Palermo, Italy"},{"name":"Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-8708","authenticated-orcid":false,"given":"Anna","family":"Olasi\u0144ska-Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Cardiac Surgery and Transplantology Department, Pozna\u0144 University of Medical Sciences, 61-848 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-0877","authenticated-orcid":false,"given":"Krzysztof J.","family":"Filipiak","sequence":"additional","affiliation":[{"name":"The Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-3245","authenticated-orcid":false,"given":"Mariusz","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7121-1396","authenticated-orcid":false,"given":"Sebastian","family":"Mertowski","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Suwalski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, 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