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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>To overcome the bioavailability limitations of turmeric, this study developed a spray-dried turmeric extract microparticle (TEM) formulation for improved oral delivery. We investigated its transport, anti-cancer properties, anti-inflammatory effects, and impact on gut microbiota. The TEM formulation successfully improved curcuminoid dissolution by approximately 40-fold and 5-fold compared with unencapsulated extract and curcumin, respectively, and demonstrated effective transepithelial transport. Notably, the TEM formulation showed twofold superior inhibition of gastric cancer cell growth compared to curcumin and significantly suppressed nitric oxide production compared to unencapsulated extract. Furthermore, fecal fermentation studies confirmed that TEMs modulate gut microbiota, with acetate as the predominant metabolite. These findings suggest that TEMs represent a promising standardized approach for managing gastrointestinal diseases.<\/jats:p>","DOI":"10.3390\/ijms27156700","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:54:26Z","timestamp":1785153266000},"page":"6700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Oral Delivery of Turmeric Extract via Spray-Dried Microparticles: Biopharmaceutical Performance and In Vitro Microbiota Modulation"],"prefix":"10.3390","volume":"27","author":[{"given":"Suwipa","family":"Ungphaiboon","sequence":"first","affiliation":[{"name":"Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8352-7921","authenticated-orcid":false,"given":"Santad","family":"Wichienchot","sequence":"additional","affiliation":[{"name":"Functional Food and Nutrition Program, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand"},{"name":"Center of Excellence in Functional Foods and Gastronomy, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattha","family":"Tampanna","sequence":"additional","affiliation":[{"name":"Food and Nutrition Program, Faculty of Liberal Arts, Rajamangala University of Technology Srivijaya, Songkhla 90000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutha","family":"Takahashi Yupanqui","sequence":"additional","affiliation":[{"name":"Functional Food and Nutrition Program, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand"},{"name":"Center of Excellence in Functional Foods and Gastronomy, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-5229","authenticated-orcid":false,"given":"Pimonsri","family":"Mittraparp-arthorn","sequence":"additional","affiliation":[{"name":"Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-5977","authenticated-orcid":false,"given":"Apichat","family":"Kaewdech","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-2276","authenticated-orcid":false,"given":"Teerapol","family":"Srichana","sequence":"additional","affiliation":[{"name":"Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13020-025-01115-z","article-title":"Curcuma Longa (turmeric): From traditional applications to modern plant medicine research hotspots","volume":"20","author":"Tian","year":"2025","journal-title":"Chin. 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