{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:15:54Z","timestamp":1791573354825,"version":"4.3.4"},"reference-count":156,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01v1rak05","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide and are driven by the interplay between oxidative stress and chronic inflammation. Although these processes have been extensively investigated, their integration into a unified mechanistic framework and their translational relevance for biomarker-guided precision medicine remain insufficiently addressed. This narrative review integrates mechanistic, biomarker, and translational perspectives on the redox\u2013inflammation axis in atherosclerosis and acute ischemic stroke, critically evaluating oxidative and inflammatory biomarkers while highlighting current challenges and emerging therapeutic opportunities. Reactive oxygen and nitrogen species (ROS\/RNS) promote endothelial dysfunction, lipid oxidation, and activation of redox-sensitive pathways, including NF-\u03baB, Nrf2\/Keap1, JAK\/STAT, and the NLRP3 inflammasome, resulting in vascular inflammation and injury. Biomarkers such as hs-CRP, IL-6, MPO, MDA, F2-isoprostanes, oxLDL, and antioxidant enzyme activity have demonstrated associations with cardiovascular risk, disease severity, and clinical outcomes, and therefore show diagnostic and prognostic potential. However, with the exception of selected inflammatory biomarkers, most oxidative stress biomarkers have not yet been sufficiently validated for routine clinical use because of biological variability, limited specificity, and insufficient analytical standardization. Disappointing outcomes of antioxidant supplementation further reflect the complexity of redox biology and the dual physiological and pathological roles of ROS. Here, we highlight that future progress in cardiovascular medicine will require a shift from non-specific antioxidant supplementation to precision redox modulation, integrating multimarker profiling, system biology, multi-omics, and artificial intelligence and machine-learning approaches to improve cardiovascular risk stratification and personalized therapy.<\/jats:p>","DOI":"10.3390\/ijms27156705","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:08:14Z","timestamp":1785161294000},"page":"6705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Redox\u2013Inflammation Axis in Atherosclerosis and Ischemic Stroke: Mechanisms, Biomarkers, and Translational Challenges"],"prefix":"10.3390","volume":"27","author":[{"given":"Cezary","family":"Gaczy\u0144ski","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Polikowska","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Goszka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-2037","authenticated-orcid":false,"given":"Natalia","family":"Serwin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"\u0141acek","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Jerzyk","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Hery\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Surgery, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-1013","authenticated-orcid":false,"given":"Barbara","family":"Do\u0142\u0119gowska","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Cecerska-Hery\u0107","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.jacc.2020.11.021","article-title":"The global burden of cardiovascular diseases and risks: A compass for global action","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/eurjpc\/zwae281","article-title":"Global burden of cardiovascular diseases: Projections from 2025 to 2050","volume":"32","author":"Chong","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Netala, V.R., Hou, T., Wang, Y., Zhang, Z., and Teertam, S.K. (2025). Cardiovascular biomarkers: Tools for precision diagnosis and prognosis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26073218"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Netala, V.R., Teertam, S.K., Li, H., and Zhang, Z. (2024). A comprehensive review of cardiovascular disease management: Cardiac biomarkers, imaging modalities, pharmacotherapy, surgical interventions, and herbal remedies. Cells, 13.","DOI":"10.3390\/cells13171471"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102660","DOI":"10.1016\/j.eclinm.2024.102660","article-title":"Artificial intelligence for cardiovascular disease risk assessment in personalised framework: A scoping review","volume":"73","author":"Singh","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Battineni, G., Sagaro, G.G., Chintalapudi, N., Amenta, F., Tomassoni, D., and Tayebati, S.K. (2021). Impact of obesity induced inflammation on cardiovascular diseases (CVD). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094798"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108365","DOI":"10.1016\/j.mrrev.2021.108365","article-title":"Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer","volume":"787","author":"Caliri","year":"2021","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.atherosclerosis.2012.02.037","article-title":"High sodium intake adversely affects oxidative inflammatory response, cardiac remodelling and mortality after myocardial infarction","volume":"222","author":"Costa","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_9","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Perna, M., and Hewlings, S. (2023). Saturated fatty acid chain length and risk of cardiovascular disease: A systematic review. Nutrients, 15.","DOI":"10.3390\/nu15010030"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: Properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/oxygen2040030","article-title":"RONS and oxidative stress: An overview of basic concepts","volume":"2","author":"Rons","year":"2022","journal-title":"Oxygen"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tvrd\u00e1, E., and Benko, F. (2020). Free radicals: What they are and what they do. Pathology: Oxidative Stress and Dietary Antioxidants, Academic Press.","DOI":"10.1016\/B978-0-12-815972-9.00001-9"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00415-011-6006-0","article-title":"Serum levels of cytokines and C reactive protein in acute acute ischemic stroke patients and their relationship to stroke lateralization, type, and infarct volume","volume":"258","author":"Ormstad","year":"2011","journal-title":"J. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chatterjee, S. (2016). Oxidative stress, inflammation, and disease. Oxidative Stress and Biomaterials, Academic Press.","DOI":"10.1016\/B978-0-12-803269-5.00002-4"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Leone, G.M., Mangano, K., Petralia, M.C., Nicoletti, F., and Fagone, P. (2023). Past, present and foreseeable future of biological anti TNF \u03b1 therapy. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041630"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/CIRCRESAHA.116.303771","article-title":"Sodium intake and cardiovascular health","volume":"116","author":"Mente","year":"2015","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/15216540051080958","article-title":"Living with a killer: The effects of hypochlorous acid on mammalian cells","volume":"50","author":"Pullar","year":"2000","journal-title":"IUBMB Life"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/eurjpc\/zwac194","article-title":"Saturated fat: Villain and bogeyman in the development of cardiovascular disease?","volume":"29","author":"Valk","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s44200-024-00062-8","article-title":"Oxidative Stress and Its Biomarkers in Cardiovascular Diseases","volume":"30","year":"2024","journal-title":"Artery Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhang, Z., and Guo, J. (2025). Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation. Antioxidants, 14.","DOI":"10.3390\/antiox14010038"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1515\/hsz-2013-0241","article-title":"The role of oxidative stress during inflammatory processes","volume":"395","author":"Lugrin","year":"2014","journal-title":"Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: Harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13578-023-01169-2","article-title":"Ferroptosis in cardiovascular diseases: Role and mechanism","volume":"13","author":"Zhang","year":"2023","journal-title":"Cell Biosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1152\/physiol.00015.2024","article-title":"Nrf2\u2013Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse?","volume":"39","author":"Dhyani","year":"2024","journal-title":"Physiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11883-022-00992-1","article-title":"Alcohol consumption and cardiovascular disease risk: Placing new data in context","volume":"24","author":"Hoek","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pcad.2018.02.001","article-title":"Alcohol and CV health: Jekyll and Hyde J curves","volume":"61","author":"DiNicolantonio","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Dr\u0103goi, C.M., Diaconu, C.C., Nicolae, A.C., and Dumitrescu, I.B. (2024). Redox Homeostasis and Molecular Biomarkers in Precision Therapy for Cardiovascular Diseases. Antioxidants, 13.","DOI":"10.3390\/antiox13101163"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100342","DOI":"10.1016\/j.ajpc.2022.100342","article-title":"Ten things to know about ten cardiovascular disease risk factors","volume":"10","author":"Bays","year":"2022","journal-title":"Am. J. Prev. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1001\/jama.2023.23651","article-title":"Effect of dietary sodium on blood pressure: A crossover trial","volume":"330","author":"Gupta","year":"2023","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Emerging Risk Factors Collaboration (2010). Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta analysis of 102 prospective studies. Lancet, 375, 2215\u20132222. Erratum in Lancet 2010, 376, 958.","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Grillo, A., Salvi, L., Coruzzi, P., Salvi, P., and Parati, G. (2019). Sodium intake and hypertension. Nutrients, 11.","DOI":"10.3390\/nu11091970"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jaques, D.A., Wuerzner, G., and Ponte, B. (2021). Sodium intake as a cardiovascular risk factor: A narrative review. Nutrients, 13.","DOI":"10.3390\/nu13093177"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/iub.2207","article-title":"Association between passive smoking and cardiovascular disease: A systematic review and meta analysis","volume":"72","author":"Khoramdad","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1253\/circj.CJ-19-0323","article-title":"Effects of tobacco smoking on cardiovascular disease","volume":"83","author":"Kondo","year":"2019","journal-title":"Circ. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/ijerph9020391","article-title":"Physical activity and risk of cardiovascular disease\u2014A meta analysis of prospective cohort studies","volume":"9","author":"Li","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Mente, A., O\u2019Donnell, M., and Yusuf, S. (2021). Sodium intake and health: What should we recommend based on the current evidence?. Nutrients, 13.","DOI":"10.3390\/nu13093232"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11745-010-3393-4","article-title":"Saturated fat and cardiomebrak przerwolic risk factors, coronary heart disease, stroke, and diabetes: A fresh look at the evidence","volume":"45","author":"Micha","year":"2010","journal-title":"Lipids"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Prospective Studies Collaboration (2009). Body mass index and cause specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies. Lancet, 373, 1083\u20131096.","DOI":"10.1016\/S0140-6736(09)60318-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jcjd.2017.10.003","article-title":"Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome","volume":"42","author":"Punthakee","year":"2018","journal-title":"Can. J. Diabetes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/j.2040-4603.2022.tb00200.x","article-title":"Obesity, body composition, and sex hormones: Implications for cardiovascular risk","volume":"12","author":"Singh","year":"2022","journal-title":"Compr. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.jacc.2017.08.017","article-title":"Physical activity and mortality in patients with sbrak przerwle coronary heart disease","volume":"70","author":"Stewart","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/eurheartj\/ehab892","article-title":"European Society of Cardiology: Cardiovascular disease statistics 2021","volume":"43","author":"Timmis","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5334\/gh.1139","article-title":"Addressing the global burden of cardiovascular diseases: Need for scalable and sustainable frameworks","volume":"17","author":"Mendis","year":"2022","journal-title":"Glob. Heart"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tips.2017.04.005","article-title":"Targeting free radicals in oxidative stress related human diseases","volume":"38","author":"Poprac","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/1535370215581314","article-title":"Reactive nitrogen species in cellular signaling","volume":"240","author":"Adams","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0005-2728(99)00028-6","article-title":"Biological aspects of reactive nitrogen species","volume":"1411","author":"Patel","year":"1999","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.4049\/jimmunol.1201725","article-title":"Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN \u03b3 and lipopolysaccharide in human pancreatic cancer cell lines","volume":"190","author":"Wu","year":"2013","journal-title":"J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"100029","DOI":"10.1016\/j.dscb.2021.100029","article-title":"Molecular mechanisms of oxidative stress in stroke and cancer","volume":"5","author":"Chavda","year":"2022","journal-title":"Brain Disord."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.mpmed.2020.06.002","article-title":"Stroke: Causes and clinical features","volume":"48","author":"Murphy","year":"2020","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105458","DOI":"10.1016\/j.neuint.2022.105458","article-title":"Stroke: Molecular mechanisms and therapies\u2014Update on recent developments","volume":"162","author":"Shehjar","year":"2022","journal-title":"Neurochem. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1750-1326-6-11","article-title":"Pathophysiology, treatment, and animal and cellular models of human acute ischemic stroke","volume":"6","author":"Woodruff","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: Recent developments","volume":"185","author":"Lusis","year":"2022","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.293.11.1338","article-title":"Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial","volume":"293","author":"Lonn","year":"2005","journal-title":"JAMA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Theofilis, P., Oikonomou, E., Chasikidis, C., Tsioufis, K., and Tousoulis, D. (2023). Inflammasomes in atherosclerosis\u2014From pathophysiology to treatment. Pharmaceuticals, 16.","DOI":"10.3390\/ph16091211"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Jebari Benslaiman, S., Galicia Garc\u00eda, U., Larrea Sebal, A., Olaetxea, J.R., Alloza, I., Vandenbroeck, K., Benito Vicente, A., and Mart\u00edn, C. (2022). Pathophysiology of atherosclerosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063346"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3892\/mmr.2025.13551","article-title":"Eburicoic Acid Inhibits Endothelial Cell Pyroptosis and Retards the Development of Atherosclerosis Through the Keap1\/Nrf2\/HO-1\/ROS Pathway","volume":"32","author":"Ma","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.mpdhp.2017.11.009","article-title":"Pathogenesis of atherosclerosis","volume":"23","author":"Wang","year":"2017","journal-title":"Diagn. Histopathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/STROKEAHA.122.037155","article-title":"Role of inflammatory processes in hemorrhagic stroke","volume":"54","author":"Ohashi","year":"2023","journal-title":"Stroke"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10555-006-9005-3","article-title":"TNF \u03b1 in promotion and progression of cancer","volume":"25","author":"Balkwill","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL 6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jang, D.I., Lee, A.H., Shin, H.Y., Song, H.R., Park, J.H., Kang, T.B., Lee, S.R., and Yang, S.H. (2021). The role of tumor necrosis factor \u03b1 (TNF \u03b1) in autoimmune disease and current TNF \u03b1 inhibitors in therapeutics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052719"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncprheum0338","article-title":"Interleukin 6: From bench to bedside","volume":"2","author":"Nishimoto","year":"2006","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL 6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_66","first-page":"9","article-title":"TNF \u03b1 in the cardiovascular system: From physiology to therapy","volume":"7","author":"Urschel","year":"2015","journal-title":"Int. J. Interferon Cytokine Mediat. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11655-024-4206-6","article-title":"Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1\/Nrf2 Pathway","volume":"31","author":"Li","year":"2025","journal-title":"Chin. J. Integr. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"113418","DOI":"10.1016\/j.intimp.2024.113418","article-title":"Tricetin Attenuates Atherosclerosis by Suppressing Macrophage Ferroptosis via Activation of the NRF2 Pathway","volume":"143","author":"Lin","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2010","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin 1 family: Back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ihim, S.A., Abubakar, S.D., Zian, Z., Sasaki, T., Saffarioun, M., Maleknia, S., and Azizi, G. (2022). Interleukin 18 cytokines in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.919973"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/imr.12616","article-title":"Interleukin 18: Biological properties and role in disease pathogenesis","volume":"281","author":"Kaplanski","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Rivera, K., Andia, M.E., Mart\u00ednez Rodriguez, G., and Gonz\u00e1lez, L. (2023). The IL 1 family and its role in atherosclerosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010017"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"van de Veerdonk, F.L., and Netea, M.G. (2013). New insights in the immunobiology of IL 1 family members. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00167"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin 33 (IL 33): A nuclear cytokine from the IL 1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"155891","DOI":"10.1016\/j.cyto.2022.155891","article-title":"Interleukin 33 (IL 33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine","volume":"156","author":"Cayrol","year":"2022","journal-title":"Cytokine"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev-immunol-101320-124243","article-title":"Emerging functions of IL 33 in homeostasis and immunity","volume":"40","author":"Dwyer","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin 33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL 33 in inflammation and disease","volume":"8","author":"Miller","year":"2011","journal-title":"J. Inflamm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.187.5.787","article-title":"Selective expression of a cell surface molecule on type 2 but not type 1 helper T cells","volume":"187","author":"Xu","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin 1 and the inflammasome as therapeutic targets in cardiovascular disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Schreiber, G.H., and Schreiber, R.D. (2003). Interferon \u03b3. The Cytokine Handbook, Elsevier Inc.","DOI":"10.1016\/B978-012689663-3\/50028-4"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/1078-0432.CCR-11-0482","article-title":"The two faces of interferon \u03b3 in cancer","volume":"17","author":"Zaidi","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"13925","DOI":"10.1074\/jbc.R116.774745","article-title":"Current prospects of type II interferon \u03b3 signaling and autoimmunity","volume":"292","author":"Green","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10715762.2017.1319944","article-title":"Oxidized lipoprotein lipids and atherosclerosis","volume":"51","author":"Ahotupa","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_87","first-page":"e69756","article-title":"Estimation of serum malondialdehyde as a predictive biomarker for severity of coronary artery disease and cardiovascular outcomes","volume":"16","author":"Kamal","year":"2024","journal-title":"Cureus"},{"key":"ref_88","first-page":"e30225","article-title":"Role of high sensitivity C reactive protein (hs CRP) in non communicable diseases: A review","volume":"14","author":"Banait","year":"2022","journal-title":"Cureus"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e001118","DOI":"10.1161\/JAHA.114.001118","article-title":"Soluble urokinase plasminogen activator receptor level is an independent marker of the presence and severity of coronary artery disease and of future adverse events","volume":"3","author":"Eapen","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1161\/01.CIR.0000115516.54550.B1","article-title":"Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: The WISE study","volume":"109","author":"Johnson","year":"2004","journal-title":"Circulation"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta analysis","volume":"375","author":"Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/eurheartj\/eht367","article-title":"Inflammatory cytokines and risk of coronary heart disease: New prospective study and updated meta analysis","volume":"35","author":"Kaptoge","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_93","first-page":"79","article-title":"Inflammation and oxidative stress markers in type 2 diabetes patients with advanced carotid atherosclerosis","volume":"22","author":"Laubriet","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/13547500500216546","article-title":"F2 isoprostanes as markers of oxidative stress in vivo: An overview","volume":"10","author":"Milne","year":"2005","journal-title":"Biomarkers"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.CIR.0000140262.20831.8F","article-title":"Serum myeloperoxidase levels independently predict endothelial dysfunction in humans","volume":"110","author":"Vita","year":"2004","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.06.042","article-title":"Correlation of oxidative stress parameters and inflammatory markers in acute ischemic stroke patients","volume":"25","author":"Chehaibi","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00508-015-0742-6","article-title":"Serum antioxidant enzyme activities and oxidative stress levels in patients with acute acute ischemic stroke: Influence on neurological status and outcome","volume":"128","author":"Milanlioglu","year":"2016","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Poznyak, A.V., Nikiforov, N.G., Markin, A.M., Kashirskikh, D.A., Myasoedova, V.A., Gerasimova, E.V., and Orekhov, A.N. (2021). Overview of OxLDL and its impact on cardiovascular health: Focus on atherosclerosis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.613780"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MOL.0b013e328306a057","article-title":"Glycation as an atherogenic modification of LDL","volume":"19","author":"Younis","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.freeradbiomed.2016.02.028","article-title":"The role of glutathione reductase and related enzymes in cellular redox homeostasis","volume":"95","author":"Couto","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s41983-022-00452-2","article-title":"Plasma glutathione as a risk marker for severity and functional outcome of acute atherothrombotic and cardioembolic stroke","volume":"58","author":"Ivanov","year":"2022","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: Role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1080\/10408398.2021.1913400","article-title":"Superoxide dismutase: An updated review on its health benefits and industrial applications","volume":"62","author":"Islam","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9613090","DOI":"10.1155\/2019\/9613090","article-title":"Role of catalase in oxidative stress and age associated degenerative diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Pei, J., Pan, X., Wei, G., and Hua, Y. (2023). Research progress of glutathione peroxidase family (GPX) in redoxidation. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1147414"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.clinthera.2023.09.020","article-title":"Global trends in atherosclerotic cardiovascular disease","volume":"45","author":"Nedkoff","year":"2023","journal-title":"Clin. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/MOL.0000000000000973","article-title":"Inflammation in atherosclerosis: A big idea that has underperformed so far","volume":"36","author":"Williams","year":"2025","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCRESAHA.107.155838","article-title":"Targeting interferon \u03b3 to treat atherosclerosis","volume":"101","author":"Gotsman","year":"2007","journal-title":"Circ. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ars.2019.7905","article-title":"Regulatory phenomena in the glutathione peroxidase superfamily","volume":"33","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Va\u0161kov\u00e1, J., Ko\u010dan, L., Va\u0161ko, L., and Perj\u00e9si, P. (2023). Glutathione related enzymes and proteins: A review. Molecules, 28.","DOI":"10.3390\/molecules28031447"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"256879","DOI":"10.1155\/2014\/256879","article-title":"Association between oxidative stress and outcome in different subtypes of acute acute ischemic stroke","volume":"2014","author":"Tsai","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Liu, X., Bai, M., Fan, L., and Lou, Z. (2022). Serum 4 hydroxynonenal associates with recurrence in patients with primary cerebral infarction. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.998512"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00204-025-03997-2","article-title":"Antioxidants: A comprehensive review","volume":"99","author":"Gulcin","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/oxygen2020006","article-title":"Free radical properties, sources and targets, antioxidant consumption and health","volume":"2","author":"Martemucci","year":"2022","journal-title":"Oxygen"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12967-023-04361-7","article-title":"Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Rosa, A.C., Corsi, D., Cavi, N., Bruni, N., and Dosio, F. (2021). Superoxide dismutase administration: A review of proposed human uses. Molecules, 26.","DOI":"10.3390\/molecules26071844"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.CIR.0000105720.28086.6C","article-title":"Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study","volume":"109","author":"Juul","year":"2004","journal-title":"Circulation"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1073\/pnas.93.18.9782","article-title":"Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase deficient mice","volume":"93","author":"Lebovitz","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1021\/ja9018572","article-title":"The molecular mechanism of the catalase reaction","volume":"131","author":"Vidossich","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Anwar, S., Alrumaihi, F., Sarwar, T., Babiker, A.Y., Khan, A.A., Prabhu, S.V., Rahmani, A.H., and Sinicropi, S. (2024). Exploring therapeutic potential of catalase: Strategies in disease prevention and management. Biomolecules, 14.","DOI":"10.3390\/biom14060697"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/CIRCHEARTFAILURE.109.864785","article-title":"Cardiac specific overexpression of catalase identifies hydrogen peroxide dependent and independent phases of myocardial remodeling and prevents progression to heart failure in G\u03b1q overexpressing mice","volume":"3","author":"Qin","year":"2010","journal-title":"Circ. Heart Fail."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3892\/br.2022.1576","article-title":"Decrease of glutathione peroxidase in arrhythmic cardiac pathology in young individuals and its therapeutic implications","volume":"17","author":"Bezna","year":"2022","journal-title":"Biomed. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1161\/ATVBAHA.107.142109","article-title":"Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in LDL receptor deficient mice","volume":"27","author":"Qiao","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Carrillo Martinez, E.J., Flores Hern\u00e1ndez, F.Y., Salazar Montes, A.M., Nario Chaidez, H.F., and Hern\u00e1ndez Ortega, L.D. (2024). Quercetin, a flavonoid with great pharmacological capacity. Molecules, 29.","DOI":"10.20944\/preprints202402.0029.v1"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Qi, W., Qi, W., Xiong, D., and Long, M. (2022). Quercetin: Its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy. Molecules, 27.","DOI":"10.3390\/molecules27196545"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/mnfr.201100143","article-title":"Resveratrol and health: A comprehensive review of human clinical trials","volume":"55","author":"Smoliga","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"22586","DOI":"10.1074\/jbc.M101846200","article-title":"Specific structural determinants are responsible for the antioxidant activity and cell cycle effects of resveratrol","volume":"276","author":"Stivala","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"H1876","DOI":"10.1152\/ajpheart.00375.2009","article-title":"Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells","volume":"297","author":"Ungvari","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/01.CIR.0000029925.18593.5C","article-title":"Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase","volume":"106","author":"Wallerath","year":"2002","journal-title":"Circulation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.fct.2017.03.048","article-title":"Quercetin attenuates high fat diet induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase","volume":"105","author":"Xiao","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.nu.10.070190.002041","article-title":"Vitamin E: Antioxidant activity, biokinetics, and bioavailability","volume":"10","author":"Burton","year":"1990","journal-title":"Annu. Rev. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.18295\/2075-0528.1566","article-title":"The role of vitamin E in human health and some diseases","volume":"14","author":"Rizvi","year":"2014","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Alberts, A., Moldoveanu, E.T., Niculescu, A.G., and Grumezescu, A.M. (2025). Vitamin C: A comprehensive review of its role in health, disease prevention, and therapeutic potential. Molecules, 30.","DOI":"10.3390\/molecules30030748"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1016\/j.clnu.2021.08.020","article-title":"The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer\u2019s disease: A Mendelian randomization study","volume":"40","author":"Chen","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/dom.13571","article-title":"Ascorbic Acid Supplementation Improves Postprandial Glycaemic Control and Blood Pressure in Individuals with Type 2 Diabetes: Findings of a Randomized Cross-Over Trial","volume":"21","author":"Mason","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.jacc.2022.09.048","article-title":"Micronutrient supplementation to reduce cardiovascular risk","volume":"80","author":"An","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wan, S., Luo, J., Zhu, Y., An, P., Luo, Y., and Xing, Q. (2024). The effect of antioxidant polyphenol supplementation on cardiometabolic risk factors: A systematic review and meta analysis. Nutrients, 16.","DOI":"10.3390\/nu16234206"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJM200001203420302","article-title":"Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients","volume":"342","author":"Yusuf","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1038\/s41598-020-65528-6","article-title":"The effect of corrected inflammation, oxidative stress and endothelial dysfunction on FMD levels in patients with selected chronic diseases: A quasi-experimental study","volume":"10","author":"Yilmaz","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in Patients With Chronic Coronary Disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and Safety of Low-Dose Colchicine After Myocardial Infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy With Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Calabrese, E.J. (2018). Hormesis: Path and progression to significance. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102871"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pharmtox.43.100901.140223","article-title":"Hormesis: The dose response revolution","volume":"43","author":"Calabrese","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2007.01.029","article-title":"Systemic adaptation to oxidative challenge induced by regular exercise","volume":"44","author":"Radak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"756132","DOI":"10.1155\/2012\/756132","article-title":"Oxidants, antioxidants, and the beneficial roles of exercise induced production of reactive species","volume":"2012","author":"Gomes","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1113\/jphysiol.2013.267419","article-title":"Vitamin C and E supplementation alters protein signalling after exercise","volume":"592","author":"Paulsen","year":"2014","journal-title":"J. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/ajcn\/nqac055","article-title":"Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: The COSMOS randomized clinical trial","volume":"115","author":"Sesso","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(24)01498-3","article-title":"Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: Prespecified analysis of the SELECT trial","volume":"404","author":"Deanfield","year":"2024","journal-title":"Lancet"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00204-023-03492-6","article-title":"Understanding the molecular mechanisms of statin pleiotropic effects","volume":"97","author":"German","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s44161-022-00023-x","article-title":"The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis","volume":"1","author":"Jarr","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"120474","DOI":"10.1016\/j.atherosclerosis.2025.120474","article-title":"Pharmacological activation of Nrf2: Cardioprotective effects of statins and metformin against dyslipidemia-induced oxidative stress","volume":"409","author":"Mthembu","year":"2025","journal-title":"Atherosclerosis"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/14728222.2024.2362644","article-title":"New targets and mechanisms of action for lipid-lowering and anti-inflammatory therapies in atherosclerosis: Where does the field stand?","volume":"28","author":"Nicholls","year":"2024","journal-title":"Expert Opin. Ther. 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