{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:57:55Z","timestamp":1785560275849,"version":"3.56.0"},"reference-count":222,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Bone metastasis is often treated clinically as a late complication of advanced cancer, yet accumulating evidence indicates that it is also a spatial evolutionary process shaped by clonal selection, niche adaptation, dormancy, and reseeding. This review examines BoM through a phylogeographic framework that links tumor ancestry with anatomical location and time. We discuss how heterogeneous primary tumors generate bone-tropic subclones, how circulating tumor cells pass through dissemination bottlenecks, and how disseminated tumor cells enter perivascular and endosteal niches that either maintain dormancy or support early micrometastatic outgrowth. We then compare clonal architectures across breast, prostate, lung, and renal cell carcinomas, emphasizing both lineage-specific programs and convergent bone-adaptive states, including osteomimicry, immune evasion, metabolic plasticity, and epigenetic remodeling. Methodological platforms such as multiregion sequencing, single-cell and spatial transcriptomics, lineage tracing, and liquid biopsy are evaluated with attention to the technical limitations imposed by mineralized tissue. Finally, we consider how bone lesions may function as reservoirs for secondary dissemination and how evolutionary thinking could improve biomarker development, dormancy prediction, trial design, and therapy selection. Viewing BoM as an evolving ecosystem may help shift the field from reactive skeletal management toward earlier, biology-informed intervention.<\/jats:p>","DOI":"10.3390\/ijms27156805","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:53:31Z","timestamp":1785333211000},"page":"6805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phylogeography of Bone Metastasis: Clonal Evolution, Skeletal Niche Adaptation, and Clinical Implications"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1821-7983","authenticated-orcid":false,"given":"Samaa","family":"Alotab","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2356-9069","authenticated-orcid":false,"given":"Rasha","family":"Alissa","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7729-9920","authenticated-orcid":false,"given":"Mariam","family":"Zainab","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9663-1232","authenticated-orcid":false,"given":"Labibah Labib","family":"Khamies","sequence":"additional","affiliation":[{"name":"Department of Clinical Skills, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9708-2111","authenticated-orcid":false,"given":"Khalid Said","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.21037\/atm.2020.03.55","article-title":"Incidence of patients with bone metastases at diagnosis of solid tumors in adults: A large population-based study","volume":"8","author":"Huang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_2","first-page":"100513","article-title":"Incidence of Bone Metastases and Skeletal-Related Events in Patients with EGFR-Mutated NSCLC Treated with Osimertinib","volume":"4","author":"Brouns","year":"2023","journal-title":"JTO Clin. Res. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e069908","DOI":"10.1136\/bmjopen-2022-069908","article-title":"Prevalence and prognosis of bone metastases in common solid cancers at initial diagnosis: A population-based study","volume":"13","author":"Zhang","year":"2023","journal-title":"BMJ Open"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.cell.2021.03.011","article-title":"The bone microenvironment invigorates metastatic seeds for further dissemination","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Feng, Y., Zhang, X., Wang, G., Yang, F., Li, R., Yin, L., Chen, D., Wang, W., Wang, M., and Hu, Z. (2025). Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer. Biomedicines, 13.","DOI":"10.3390\/biomedicines13040909"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41586-022-05425-2","article-title":"Spatial genomics maps the structure, nature and evolution of cancer clones","volume":"611","author":"Lomakin","year":"2022","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"eabc1944","DOI":"10.1126\/science.abc1944","article-title":"Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts","volume":"371","author":"Quinn","year":"2021","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"eabf4408","DOI":"10.1126\/sciadv.abf4408","article-title":"The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile","volume":"7","author":"Berthelet","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115788","DOI":"10.1016\/j.bone.2020.115788","article-title":"Cancer cell foraging to explain bone-specific metastatic progression","volume":"158","author":"Mallin","year":"2022","journal-title":"Bone"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.cell.2022.04.015","article-title":"Lineage Tracing Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gofrit, O.N., Gofrit, B., Roditi, Y., Popovtzer, A., Frank, S., Sosna, J., and Goldberg, S.N. (2022). Patterns of metastases progression- The linear parallel ratio. PLoS ONE, 17.","DOI":"10.2139\/ssrn.4001467"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1158\/0008-5472.CAN-24-3687","article-title":"Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer","volume":"85","author":"Hosseini","year":"2025","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41568-021-00406-5","article-title":"Evolving cancer\u2013niche interactions and therapeutic targets during bone metastasis","volume":"22","author":"Satcher","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1038\/s41467-020-16995-y","article-title":"Looking backward in time to define the chronology of metastasis","volume":"11","author":"Hu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41413-023-00260-1","article-title":"Bone serves as a transfer station for secondary dissemination of breast cancer","volume":"11","author":"Huang","year":"2023","journal-title":"Bone Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1200\/JCO.2022.40.6_suppl.287","article-title":"Molecular alterations across sites of metastasis in patients with renal cell carcinoma (RCC)","volume":"40","author":"McKay","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.15586\/jkcvhl.v8i4.202","article-title":"Evolving Patterns of Metastasis in Renal Cell Carcinoma","volume":"8","author":"Lin","year":"2021","journal-title":"J. Kidney Cancer VHL"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/s41416-021-01329-6","article-title":"Bone marrow niches in the regulation of bone metastasis","volume":"124","author":"Chen","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2013.07.036","article-title":"Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma","volume":"154","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13578-023-01171-8","article-title":"Predictive and prognostic biomarkers of bone metastasis in breast cancer: Current status and future directions","volume":"13","author":"Wang","year":"2023","journal-title":"Cell Biosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41388-019-1064-3","article-title":"PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells","volume":"39","author":"Clements","year":"2019","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"bqae022","DOI":"10.1210\/endocr\/bqae022","article-title":"Dissemination of Circulating Tumor Cells in Breast and Prostate Cancer: Implications for Early Detection","volume":"165","author":"Bae","year":"2024","journal-title":"Endocrinology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"216870","DOI":"10.1016\/j.canlet.2024.216870","article-title":"Circulating tumor cells with metastasis-initiating competence survive fluid shear stress during hematogenous dissemination through CXCR4-PI3K\/AKT signaling","volume":"590","author":"Xin","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/HEP.0000000000000934","article-title":"Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT","volume":"81","author":"Sun","year":"2025","journal-title":"Hepatology"},{"key":"ref_25","first-page":"166","article-title":"Monascin accelerates anoikis in circulating tumor cells and prevents breast cancer metastasis","volume":"20","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1111\/jcmm.13867","article-title":"Disseminated tumour cells in bone marrow are the source of cancer relapse after therapy","volume":"22","author":"Sai","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13059-016-1109-7","article-title":"Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing","volume":"17","author":"Demeulemeester","year":"2016","journal-title":"Genome Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"So, K.W.L., Su, Z., Cheung, J.P.Y., and Choi, S.W. (2024). Single-Cell Analysis of Bone-Marrow-Disseminated Tumour Cells. Diagnostics, 14.","DOI":"10.3390\/diagnostics14192172"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, Y., Liu, J., Gong, Y., Hu, B., Xie, J., Cheng, J., and Huang, Q. (2024). Bone Marrow Disseminated Tumor Cell Detection Is Beneficial for the Early Finding of Bone Metastasis and Prognosis. Diagnostics, 14.","DOI":"10.3390\/diagnostics14151629"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e143764","DOI":"10.1172\/JCI143764","article-title":"Exploiting bone niches: Progression of disseminated tumor cells to metastasis","volume":"131","author":"Muscarella","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41556-018-0267-0","article-title":"Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy","volume":"21","author":"Carlson","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ijc.32933","article-title":"A perivascular niche in the bone marrow hosts quiescent and proliferating tumorigenic colorectal cancer cells","volume":"147","author":"Zowada","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ccell.2014.11.017","article-title":"The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells","volume":"27","author":"Wang","year":"2015","journal-title":"Cancer Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1091\/mbc.9.7.1903","article-title":"Osteoblastic responses to TGF-beta during bone remodeling","volume":"9","author":"Erlebacher","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.canlet.2020.06.004","article-title":"Hypoxia in Bone Metastasis and Osteolysis","volume":"489","author":"Todd","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kolb, A.D., and Bussard, K.M. (2019). The Bone Extracellular Matrix as an Ideal Milieu for Cancer Cell Metastases. Cancers, 11.","DOI":"10.3390\/cancers11071020"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2009.04964.x","article-title":"Functional Heterogeneity of the Bone Marrow Vascular Niche","volume":"1176","author":"Kopp","year":"2009","journal-title":"Ann. NY Acad. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100598","DOI":"10.1016\/j.jbo.2024.100598","article-title":"Macrophage heterogeneity in bone metastasis","volume":"45","author":"Guo","year":"2024","journal-title":"J. Bone Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s42003-023-04652-1","article-title":"A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration","volume":"6","author":"Noom","year":"2023","journal-title":"Commun. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.devcel.2021.03.008","article-title":"The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells","volume":"56","author":"Bado","year":"2021","journal-title":"Dev. Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11914-025-00934-1","article-title":"Cancer Cell Dormancy in the Bone Microenvironment","volume":"23","author":"Harris","year":"2025","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41413-020-00105-1","article-title":"Molecular mechanisms and clinical management of cancer bone metastasis","volume":"8","author":"Wang","year":"2020","journal-title":"Bone Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.breast.2016.09.017","article-title":"Breast cancer osteomimicry and its role in bone specific metastasis; an integrative, systematic review of preclinical evidence","volume":"30","author":"Awolaran","year":"2016","journal-title":"Breast"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.1038\/s41467-025-66704-w","article-title":"Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer","volume":"16","author":"Mikutenaite","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1158\/2159-8290.CD-22-0220","article-title":"Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells","volume":"13","author":"Zhang","year":"2023","journal-title":"Cancer Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1038\/s41467-021-26556-6","article-title":"Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis","volume":"12","author":"Yip","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100888","DOI":"10.1016\/j.xgen.2025.100888","article-title":"Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization","volume":"5","author":"Liu","year":"2025","journal-title":"Cell Genom."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1152\/physrev.00012.2019","article-title":"Bone metastasis: Mechanisms, therapies, and biomarkers","volume":"101","author":"Coleman","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bendinelli, P., Maroni, P., Dall\u2019olio, V., Matteucci, E., and Desiderio, M.A. (2019). Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGF\u03b21-Type I Receptor Blockade. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102520"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6886","DOI":"10.1158\/0008-5472.CAN-13-0991","article-title":"A novel model of dormancy for bone metastatic breast cancer cells","volume":"73","author":"Marlow","year":"2013","journal-title":"Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13046-023-02849-0","article-title":"Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase","volume":"42","author":"Liu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1158\/0008-5472.CAN-17-1051","article-title":"Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGF\u03b2RIII-p38MAPK-pS249\/T252RB Pathway","volume":"78","author":"Yu","year":"2018","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s43018-021-00179-8","article-title":"Bone marrow NG2+\/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF\u03b22","volume":"2","author":"Nobre","year":"2021","journal-title":"Nat. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bakir, M., Dabaliz, A., Dawalibi, A., and Mohammad, K.S. (2025). Microenvironmental and Molecular Pathways Driving Dormancy Escape in Bone Metastases. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262411893"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/ncb2767","article-title":"The perivascular niche regulates breast tumour dormancy","volume":"15","author":"Ghajar","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/nm.2830","article-title":"Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape","volume":"18","author":"Bidwell","year":"2012","journal-title":"Nat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s43018-021-00291-9","article-title":"A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy","volume":"3","author":"Nobre","year":"2021","journal-title":"Nat. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e70092","DOI":"10.1002\/iub.70092","article-title":"Hypoxia-Inducible Factors as Guardians of Cancer Stem Cell Fate: Implications for Novel Therapies","volume":"78","author":"Abuhassan","year":"2026","journal-title":"IUBMB Life"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1158\/2159-8290.CD-23-1161","article-title":"Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells","volume":"14","author":"Rosano","year":"2024","journal-title":"Cancer Discov."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cels.2020.08.018","article-title":"The stress-like cancer cell state is a consistent component of tumorigenesis","volume":"11","author":"Baron","year":"2020","journal-title":"Cell Syst."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Russo, S., Scotto di Carlo, F., and Gianfrancesco, F. (2022). The Osteoclast Traces the Route to Bone Tumors and Metastases. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.886305"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e10125","DOI":"10.1002\/jbm4.10125","article-title":"Tumor Cell Dormancy and Reactivation in Bone: Skeletal Biology and Therapeutic Opportunities","volume":"3","author":"Byrne","year":"2019","journal-title":"JBMR Plus"},{"key":"ref_63","first-page":"19","article-title":"The genetic architecture of bone metastases: Unveiling the role of epigenetic and genetic modifications in drug resistance","volume":"8","author":"Dawalibi","year":"2025","journal-title":"Cancer Drug Resist."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"a036848","DOI":"10.1101\/cshperspect.a036848","article-title":"Bone Tropism in Cancer Metastases","volume":"10","author":"Wang","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41422-023-00810-6","article-title":"SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches","volume":"33","author":"Wu","year":"2023","journal-title":"Cell Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e00485","DOI":"10.1002\/adbi.202500485","article-title":"Dormancy and Recurrence in Breast Cancer Bone Metastasis: From Mechanisms to Clinical Translation","volume":"10","author":"Sun","year":"2026","journal-title":"Adv. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"903","DOI":"10.21037\/atm.2020.02.177","article-title":"Epigenetic plasticity in metastatic dormancy: Mechanisms and therapeutic implications","volume":"8","author":"Robinson","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.trecan.2022.03.002","article-title":"Ecology and evolution of dormant metastasis","volume":"8","author":"Blasco","year":"2022","journal-title":"Trends Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/modpathol.2017.95","article-title":"Estrogen receptor (ESR1) mutation in bone metastases from breast cancer","volume":"31","author":"Bartels","year":"2018","journal-title":"Mod. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101261","DOI":"10.1016\/j.genrep.2021.101261","article-title":"Clinical significance of estrogen receptor 1 gene mutations in hormonal resistant breast cancer patients","volume":"24","author":"Aboelwafa","year":"2021","journal-title":"Gene Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41698-018-0047-0","article-title":"Organotropism: New insights into molecular mechanisms of breast cancer metastasis","volume":"2","author":"Chen","year":"2018","journal-title":"npj Precis. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40164-021-00223-4","article-title":"The metabolic adaptation mechanism of metastatic organotropism","volume":"10","author":"Wang","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ring, A., Spataro, M., Wicki, A., and Aceto, N. (2022). Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.929893"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejca.2021.06.028","article-title":"Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis","volume":"154","author":"Hartkopf","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1038\/s41591-024-03215-z","article-title":"A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features","volume":"30","author":"Klughammer","year":"2024","journal-title":"Nat. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3892\/ol.2023.13749","article-title":"Prostate cancer bone metastases biology and clinical management (Review)","volume":"25","author":"Goode","year":"2023","journal-title":"Oncol. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bone.2013.07.006","article-title":"Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice\u2014A quantitative study using microCT and Raman spectroscopy","volume":"56","author":"Bi","year":"2013","journal-title":"Bone"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1158\/1078-0432.CCR-18-1229","article-title":"The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications","volume":"24","author":"Thysell","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"107669","DOI":"10.1016\/j.celrep.2020.107669","article-title":"Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress","volume":"31","author":"Nyquist","year":"2020","journal-title":"Cell Rep."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"H\u00f6rnberg, E., Ylitalo, E.B., Crnalic, S., Antti, H., Stattin, P., Widmark, A., Bergh, A., and Wikstr\u00f6m, P. (2011). Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019059"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1158\/2159-8290.CD-24-1509","article-title":"High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes","volume":"15","author":"Sharifi","year":"2025","journal-title":"Cancer Discov."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative Genomic Profiling of Human Prostate Cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"a000752","DOI":"10.1101\/mcs.a000752","article-title":"Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer","volume":"2","author":"Bova","year":"2016","journal-title":"Mol. Case Stud."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.7150\/ijbs.100960","article-title":"New insights into non-small cell lung cancer bone metastasis: Mechanisms and therapies","volume":"20","author":"Xue","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5306\/wjco.v5.i2.149","article-title":"Bone metastases: When and how lung cancer interacts with bone","volume":"5","author":"Roato","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"17588359241239293","DOI":"10.1177\/17588359241239293","article-title":"Bone metastasis in non-small-cell lung cancer: Genomic characterization and exploration of potential targets","volume":"16","author":"Gong","year":"2024","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Corral de la Fuente, E., Olmedo Garcia, M.E., Gomez Rueda, A., Lage, Y., and Garrido, P. (2022). Targeting KRAS in Non-Small Cell Lung Cancer. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.792635"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Moldvay, J., and T\u00edm\u00e1r, J. (2024). KRASG12C mutant lung adenocarcinoma: Unique biology, novel therapies and new challenges. Pathol. Oncol. Res., 29.","DOI":"10.3389\/pore.2023.1611580"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhou, X., Zheng, J., Ai, H., Yang, C., Wang, J., Sun, Y., and Jin, L. (2025). MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: An exploratory study. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1673498"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"117625","DOI":"10.1016\/j.bone.2025.117625","article-title":"The microstructure of metastatic bone lesions suggests tumor mediated alterations in bone mineralization","volume":"201","author":"Fan","year":"2025","journal-title":"Bone"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s42003-024-05772-y","article-title":"Single-cell profiling of the microenvironment in human bone metastatic renal cell carcinoma","volume":"7","author":"Ma","year":"2024","journal-title":"Commun. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.7150\/jca.88612","article-title":"Clinical Implications of a Six-Protein Signature in Bone Metastasis of Renal Cell Carcinoma","volume":"15","author":"Liu","year":"2024","journal-title":"J. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chen, S.-C., and Kuo, P.-L. (2016). Bone Metastasis from Renal Cell Carcinoma. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060987"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ijc.35181","article-title":"New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities","volume":"156","author":"Cesana","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-023-01272-6","article-title":"Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions","volume":"16","author":"Mei","year":"2024","journal-title":"Genome Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1158\/1078-0432.CCR-10-2507","article-title":"Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL\/RANK\/OPG Pathway in Tumorigenesis and Metastasis","volume":"18","author":"Dougall","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_97","first-page":"641","article-title":"Validity of Osteoprotegerin and Receptor Activator of NF-\u03baB Ligand for the Detection of Bone Metastasis in Breast Cancer","volume":"25","author":"Elfar","year":"2017","journal-title":"Oncol. Res. Featur. Preclin. Clin. Cancer Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/gcc.22116","article-title":"Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma","volume":"53","author":"Gossage","year":"2014","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2217\/fon.11.112","article-title":"Mechanisms of Cancer Cell Metastasis to the Bone: A Multistep Process","volume":"7","author":"Patel","year":"2011","journal-title":"Future Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrc.2017.126","article-title":"Genetic insights into the morass of metastatic heterogeneity","volume":"18","author":"Hunter","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kan, C., Vargas, G., Pape, F., and Cl\u00e9zardin, P. (2016). Cancer Cell Colonisation in the Bone Microenvironment. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101674"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Schmid-Alliana, A., Schmid-Antomarchi, H., Al-Sahlanee, R., Lagadec, P., Scimeca, J.-C., and Verron, E. (2018). Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010148"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.21037\/apm-21-1595","article-title":"Mutational characteristics of bone metastasis of lung cancer","volume":"10","author":"Huang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41523-021-00303-y","article-title":"Comprehensive characterization of distinct genetic alterations in metastatic breast cancer across various metastatic sites","volume":"7","author":"Cha","year":"2021","journal-title":"npj Breast Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/1724600817753576","article-title":"Circulating tumor DNA as prognostic markers for late stage NSCLC with bone metastasis","volume":"33","author":"Jia","year":"2018","journal-title":"Int. J. Biol. Markers"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9455","DOI":"10.1038\/s41598-022-12500-1","article-title":"Model-based inference of metastatic seeding rates in de novo metastatic breast cancer reveals the impact of secondary seeding and molecular subtype","volume":"12","author":"Vitos","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s11538-019-00597-x","article-title":"A Mathematical Framework for Modelling the Metastatic Spread of Cancer","volume":"81","author":"Franssen","year":"2019","journal-title":"Bull. Math. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"151277","DOI":"10.1016\/j.soncn.2022.151277","article-title":"Bone Metastases: From Mechanisms to Treatment","volume":"38","author":"Riffel","year":"2022","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1470-2045(09)70088-9","article-title":"Imaging bone metastases in breast cancer: Techniques and recommendations for diagnosis","volume":"10","author":"Costelloe","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Ouvrard, E., Kaseb, A., Poterszman, N., Porot, C., Somme, F., and Imperiale, A. (2024). Nuclear medicine imaging for bone metastases assessment: What else besides bone scintigraphy in the era of personalized medicine?. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1320574"},{"key":"ref_111","first-page":"202","article-title":"Treatment of bone metastases from solid tumors with bone-modifying agents: A web survey of Italian oncologists investigating patterns of practice drug prescription and prevention of side effects","volume":"32","author":"Fusco","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cllc.2023.08.015","article-title":"Stereotactic Body Radiation Therapy for Oligoprogressive and Oligorecurrent Non\u2013Small-Cell Lung Cancer","volume":"24","author":"Ebadi","year":"2023","journal-title":"Clin. Lung Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.3390\/curroncol28050290","article-title":"Current Overview of Treatment for Metastatic Bone Disease","volume":"28","author":"Tsukamoto","year":"2021","journal-title":"Curr. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/jcb.25159","article-title":"Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies","volume":"116","author":"Xi","year":"2015","journal-title":"J. Cell Biochem."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Hinz, N., and J\u00fccker, M. (2021). AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review. Cancers, 13.","DOI":"10.3390\/cancers13102287"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"115676","DOI":"10.1016\/j.biopha.2023.115676","article-title":"Exploring the role of PI3K\/AKT\/mTOR inhibitors in hormone-related cancers: A focus on breast and prostate cancer","volume":"168","author":"Kaczmarska","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/onc.2013.2","article-title":"Site-specific activation of AKT protects cells from death induced by glucose deprivation","volume":"33","author":"Gao","year":"2014","journal-title":"Oncogene"},{"key":"ref_118","first-page":"3109","article-title":"Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl-2-like protein 11 and cyclin-dependent kinase inhibitor 1B","volume":"17","author":"Yan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1158\/1541-7786.MCR-08-0568","article-title":"Parathyroid Hormone-Related Protein Regulates Cell Survival Pathways via Integrin \u03b16\u03b24-Mediated Activation of Phosphatidylinositol 3-Kinase\/Akt Signaling","volume":"7","author":"Bhatia","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3892\/ijo.2013.1825","article-title":"Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145","volume":"42","author":"Ren","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e23199","DOI":"10.1002\/gcc.23199","article-title":"Frequency of genetic alterations differs in advanced breast cancer between metastatic sites","volume":"63","author":"Grote","year":"2024","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.canlet.2018.08.027","article-title":"TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases","volume":"438","author":"Delliaux","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41416-021-01564-x","article-title":"ESR1 mutations and therapeutic resistance in metastatic breast cancer: Progress and remaining challenges","volume":"126","author":"Herzog","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/ng.2823","article-title":"Activating ESR1 mutations in hormone-resistant metastatic breast cancer","volume":"45","author":"Robinson","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"102583","DOI":"10.1016\/j.xcrm.2025.102583","article-title":"A pan-cancer single-cell transcriptomic atlas of human bone metastases","volume":"7","author":"Wang","year":"2026","journal-title":"Cell Rep. Med."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Wu, R., Roy, A.M., Tokumaru, Y., Gandhi, S., Asaoka, M., Oshi, M., Yan, L., Ishikawa, T., and Takabe, K. (2022). NR2F1, a Tumor Dormancy Marker, Is Expressed Predominantly in Cancer-Associated Fibroblasts and Is Associated with Suppressed Breast Cancer Cell Proliferation. Cancers, 14.","DOI":"10.3390\/cancers14122962"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1158\/0008-5472.CAN-22-2108","article-title":"Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma","volume":"82","author":"Borgenvik","year":"2022","journal-title":"Cancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e20210836","DOI":"10.1084\/jem.20210836","article-title":"An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy","volume":"219","author":"Khalil","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1158\/1541-7786.MCR-18-0956","article-title":"Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures","volume":"17","author":"McGrath","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4252\/wjsc.v12.i6.481","article-title":"Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy","volume":"12","author":"Xiao","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Canciello, A., Cerver\u00f3-Varona, A., Peserico, A., Mauro, A., Russo, V., Morrione, A., Giordano, A., and Barboni, B. (2022). \u201cIn medio stat virtus\u201d: Insights into hybrid E\/M phenotype attitudes. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1038841"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Waryah, C., Alves, E., Mazzieri, R., Dolcetti, R., Thompson, E.W., Redfern, A., and Blancafort, P. (2023). Unpacking the Complexity of Epithelial Plasticity: From Master Regulator Transcription Factors to Non-Coding RNAs. Cancers, 15.","DOI":"10.3390\/cancers15123152"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41423-023-00980-8","article-title":"Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy","volume":"20","author":"Gu","year":"2023","journal-title":"Cell Mol. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/jbmr.4386","article-title":"Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice","volume":"36","author":"Qin","year":"2020","journal-title":"J. Bone Mineral. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"eabg2564","DOI":"10.1126\/sciadv.abg2564","article-title":"In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer","volume":"7","author":"Bock","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ucci, A., Giacchi, L., and Rucci, N. (2024). Primary Bone Tumors and Breast Cancer-Induced Bone Metastases: In Vivo Animal Models and New Alternative Approaches. Biomedicines, 12.","DOI":"10.3390\/biomedicines12112451"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bone.2003.09.001","article-title":"Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia","volume":"34","author":"Nakamura","year":"2004","journal-title":"Bone"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","article-title":"Pre-metastatic niche: Formation, characteristics and therapeutic implication","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Ren, Y., B\u00e4cker, H., M\u00fcller, M., and Kienzle, A. (2023). The role of myeloid derived suppressor cells in musculoskeletal disorders. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1139683"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Ansbro, M.R., Shukla, S., Ambudkar, S.V., Yuspa, S.H., and Li, L. (2013). Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060334"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Wium, M., Ajayi-Smith, A.F., Paccez, J.D., and Zerbini, L.F. (2021). The Role of the Receptor Tyrosine Kinase Axl in Carcinogenesis and Development of Therapeutic Resistance: An Overview of Molecular Mechanisms and Future Applications. Cancers, 13.","DOI":"10.3390\/cancers13071521"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"eado7225","DOI":"10.1126\/scitranslmed.ado7225","article-title":"In vivo CRISPR activation screen identifies acyl-CoA\u2013binding protein as a driver of bone metastasis","volume":"17","author":"Teng","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.18632\/aging.204885","article-title":"Single-cell sequencing analysis reveals the relationship between tumor microenvironment cells and oxidative stress in breast cancer bone metastases","volume":"15","author":"Zhang","year":"2023","journal-title":"Aging"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"eadn0220","DOI":"10.1126\/sciadv.adn0220","article-title":"Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissues","volume":"10","author":"Sanghvi","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.semcdb.2022.11.002","article-title":"Epigenetic regulation of bone remodeling and bone metastasis","volume":"154","author":"Sharma","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"eabj9123","DOI":"10.1126\/sciimmunol.abj9123","article-title":"Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells","volume":"7","author":"Ford","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"27764","DOI":"10.1074\/jbc.M312870200","article-title":"Smad3 Interacts with JunB and Cbfa1\/Runx2 for Transforming Growth Factor-\u03b21-stimulated Collagenase-3 Expression in Human Breast Cancer Cells","volume":"279","author":"Selvamurugan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"109519","DOI":"10.1016\/j.exer.2023.109519","article-title":"Heparanase-mediated histone 3 acetylation regulates VEGF gene transcription in the hyperglycemia and hypoxia human retinal endothelial cells","volume":"233","author":"Leng","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bone.2018.01.035","article-title":"YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism","volume":"110","author":"Zhao","year":"2018","journal-title":"Bone"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/cas.14884","article-title":"Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer","volume":"112","author":"Okabe","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1073\/pnas.1324290111","article-title":"Up-regulation of glycolytic metabolism is required for HIF1\u03b1-driven bone formation","volume":"111","author":"Regan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.molcel.2019.09.019","article-title":"KDM3A Senses Oxygen Availability to Regulate PGC-1\u03b1-Mediated Mitochondrial Biogenesis","volume":"76","author":"Qian","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1038\/ncomms7170","article-title":"NR2F1 controls tumour cell dormancy via SOX9- and RAR\u03b2-driven quiescence programmes","volume":"6","author":"Sosa","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/path.5925","article-title":"Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone","volume":"257","author":"Giesche","year":"2022","journal-title":"J. Pathol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/pros.24476","article-title":"SOX9 and HMGB3 co-operatively transactivate NANOG and promote prostate cancer progression","volume":"83","author":"Xu","year":"2023","journal-title":"Prostate"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e12963","DOI":"10.1111\/cpr.12963","article-title":"Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells","volume":"54","author":"Zhang","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.gendis.2018.06.003","article-title":"Epigenetic mechanisms as a new approach in cancer treatment: An updated review","volume":"5","author":"Fardi","year":"2018","journal-title":"Genes Dis."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/emph\/eov006","article-title":"Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites","volume":"2015","author":"Cunningham","year":"2015","journal-title":"Evol. Med. Public Health"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12013-014-0433-3","article-title":"Effect of PI3K\/Akt Signaling Pathway on the Process of Prostate Cancer Metastasis to Bone","volume":"72","author":"Zhu","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2353\/ajpath.2010.090885","article-title":"PTEN, PIK3CA, p-AKT, and p-p70S6K Status","volume":"177","author":"Esteva","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Nirala, B.K., and Yustein, J.T. (2025). The Role of MYC in Tumor Immune Microenvironment Regulation: Insights and Future Directions. Front. Biosci.-Landmark, 30.","DOI":"10.31083\/FBL37304"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Baxevanis, C.N., and Gritzapis, A.D. (2025). Targeting of Tumor Dormancy Pathways: An Editorial to the Special Issue. Onco, 5.","DOI":"10.3390\/onco5040048"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e2507203122","DOI":"10.1073\/pnas.2507203122","article-title":"CDKN1B (p27\/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors","volume":"122","author":"Horwitz","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10549-024-07431-6","article-title":"Receptor Discordance in Metastatic Breast Cancer; a review of clinical and genetic subtype alterations from primary to metastatic disease","volume":"207","author":"Dowling","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Ferrer-Diaz, A.I., Sinha, G., Petryna, A., Gonzalez-Bermejo, R., Kenfack, Y., Adetayo, O., Patel, S.A., Nehra, A.H., and Rameshwar, P. (2024). Role of KMT2B and KMT2D histone 3, lysine 4 methyltransferases and DNA oxidation status in circulating breast cancer cells provide insights into cell-autonomous regulation of cancer stem cells 2024. Res. Sq.","DOI":"10.21203\/rs.3.rs-3822758\/v1"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1038\/s41467-024-51424-4","article-title":"Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution","volume":"15","author":"Nadalin","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41592-025-02924-8","article-title":"Inferring cancer type-specific patterns of metastatic spread using Metient","volume":"23","author":"Koyyalagunta","year":"2026","journal-title":"Nat. Methods"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Nikolouzakis, T.K., Souglakos, J., Kantidakis, E.E., Achilleos, K., van Staden, T., and Chrysos, E. (2026). Metastatic Odyssey: Decoding the Genomic Journey from Primary Colorectal Cancer to Disseminated Disease. Cancers, 18.","DOI":"10.3390\/cancers18071062"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cell.2022.01.003","article-title":"Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients","volume":"185","author":"Nguyen","year":"2022","journal-title":"Cell"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.annonc.2022.06.005","article-title":"Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine","volume":"33","author":"Ding","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13058-022-01503-5","article-title":"Gene expression predicts dormant metastatic breast cancer cell phenotype","volume":"24","author":"Ren","year":"2022","journal-title":"Breast Cancer Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1007\/s12672-025-04085-8","article-title":"Epigenetic reprogramming as the nexus of cancer stemness and therapy resistance: Implications for biomarker discovery","volume":"16","author":"Ng","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/1878-0261.13158","article-title":"Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C","volume":"16","author":"Thysell","year":"2022","journal-title":"Mol. Oncol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Thangaretnam, K., Islam, M.O., Lv, J., Chen, L., Ballout, F., Zhu, S., Lu, H., Peng, D., El-Rifai, W., and Chen, Z. (2026). Architectural Refuges: Mapping Spatial Heterogeneity and Niche-Mediated Drug Resistance in Gastric and Esophageal Adenocarcinomas. Cancers, 18.","DOI":"10.3390\/cancers18111748"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"eadw4871","DOI":"10.1126\/sciadv.adw4871","article-title":"Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML 2025","volume":"11","author":"Gui","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"100741","DOI":"10.1016\/j.jbo.2026.100741","article-title":"Digital spatial profiling of \u03b1-PD-1 treated breast cancer bone metastases reveals region-specific signaling and enrichment of immune-suppressive markers","volume":"57","author":"Grant","year":"2026","journal-title":"J. Bone Oncol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1158\/2159-8290.CD-23-1332","article-title":"Clonal Lineage Tracing with Somatic Delivery of Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer","volume":"14","author":"Serio","year":"2024","journal-title":"Cancer Discov."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cac2.12078","article-title":"Single-cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy","volume":"40","author":"Ding","year":"2020","journal-title":"Cancer Commun."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1002\/jbmr.4041","article-title":"Circulating Osteocalcin-Positive Cells as a Novel Diagnostic Biomarker for Bone Metastasis in Breast Cancer Patients","volume":"35","author":"Lee","year":"2020","journal-title":"J. Bone Mineral. Res."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Trapp, E.K., Fasching, P.A., Fehm, T., Schneeweiss, A., Mueller, V., Harbeck, N., Lorenz, R., Schumacher, C., Heinrich, G., and Schochter, F. (2022). Does the Presence of Circulating Tumor Cells in High-Risk Early Breast Cancer Patients Predict the Site of First Metastasis\u2014Results from the Adjuvant SUCCESS A Trial. Cancers, 14.","DOI":"10.3390\/cancers14163949"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e2400577","DOI":"10.1200\/PO-24-00577","article-title":"Personalized Circulating Tumor DNA Testing for Detection of Progression and Treatment Response Monitoring in Patients with Metastatic Invasive Lobular Carcinoma of the Breast","volume":"9","author":"Foldi","year":"2025","journal-title":"JCO Precis. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Sivapalan, L., Thorn, G.J., Gadaleta, E., Kocher, H.M., Ross-Adams, H., and Chelala, C. (2022). Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09387-6"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"13353","DOI":"10.1007\/s00432-023-05162-7","article-title":"Radiomics-Clinical model based on 99mTc-MDP SPECT\/CT for distinguishing between bone metastasis and benign bone disease in tumor patients","volume":"149","author":"Wang","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pathol.2025.10.003","article-title":"Spatial transcriptomics in bone research: Navigating hype and hurdles","volume":"58","author":"Sokolowskei","year":"2026","journal-title":"Pathology"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Laranga, R., Duchi, S., Ibrahim, T., Guerrieri, A.N., Donati, D.M., and Lucarelli, E. (2020). Trends in Bone Metastasis Modeling. Cancers, 12.","DOI":"10.3390\/cancers12082315"},{"key":"ref_186","first-page":"7","article-title":"Tumor dormancy and relapse: Understanding the molecular mechanisms of cancer recurrence","volume":"12","author":"Tufail","year":"2025","journal-title":"Mil. Med. Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"e70604","DOI":"10.1002\/mco2.70604","article-title":"Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets","volume":"7","author":"Wen","year":"2026","journal-title":"MedComm"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41419-019-1594-1","article-title":"IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis","volume":"10","author":"Liang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e157917","DOI":"10.1172\/JCI157917","article-title":"IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer","volume":"132","author":"He","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e2307094120","DOI":"10.1073\/pnas.2307094120","article-title":"MDA-9\/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis","volume":"120","author":"Maji","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.trecan.2020.09.006","article-title":"Emerging Players in Prostate Cancer\u2013Bone Niche Communication","volume":"7","author":"Furesi","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"16172","DOI":"10.18632\/aging.103599","article-title":"Leptin promotes bone metastasis of breast cancer by activating the SDF-1\/CXCR4 axis","volume":"12","author":"Duan","year":"2020","journal-title":"Aging"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Lin, T.-C., and Hsiao, M. (2021). Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062870"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.7150\/thno.29617","article-title":"CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes\/macrophages","volume":"9","author":"Jiang","year":"2019","journal-title":"Theranostics"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e20191820","DOI":"10.1084\/jem.20191820","article-title":"Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth","volume":"217","author":"Ma","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"101224","DOI":"10.1016\/j.neo.2025.101224","article-title":"Contribution of the immune bone marrow microenvironment to tumor growth and bone deconstruction: Implications for improving immunotherapeutic strategies in bone metastasis","volume":"69","author":"Massy","year":"2025","journal-title":"Neoplasia"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"10732748261427063","DOI":"10.1177\/10732748261427063","article-title":"Denosumab Plus Immune Checkpoint Inhibitors in Bone Metastases From Solid Tumors","volume":"33","author":"Wang","year":"2026","journal-title":"Cancer Control"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41413-025-00429-w","article-title":"Advances in spatial transcriptomics and its application in the musculoskeletal system","volume":"13","author":"Wang","year":"2025","journal-title":"Bone Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s40425-019-0753-3","article-title":"Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients","volume":"7","author":"Ihle","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Abbott, A.G., Meyers, D.E., Elmi-Assadzadeh, G., Stukalin, I., Marro, A., Puloski, S.K.T., Morris, D.G., Cheung, W.Y., and Monument, M.J. (2024). Effectiveness of immune checkpoint inhibitor therapy on bone metastases in non-small-cell lung cancer. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1379056"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Chen, S., Lei, J., Mou, H., Zhang, W., Jin, L., Lu, S., Yinwang, E., Xue, Y., Shao, Z., and Chen, T. (2024). Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1335366"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"101619","DOI":"10.1016\/j.bonr.2022.101619","article-title":"The road of NSCLC stem cells toward bone metastases","volume":"17","author":"Bertolini","year":"2022","journal-title":"Bone Rep."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Iuliani, M., Simonetti, S., Ribelli, G., Napolitano, A., Pantano, F., Vincenzi, B., Tonini, G., and Santini, D. (2020). Current and Emerging Biomarkers Predicting Bone Metastasis Development. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00789"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"9840962","DOI":"10.1155\/2018\/9840962","article-title":"Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients","volume":"2018","author":"Scimeca","year":"2018","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"(2021). Erratum for: CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion. Cell. Physiol. Biochem., 55, 235\u2013237.","DOI":"10.33594\/000000362"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12943-022-01697-4","article-title":"Targeting SOST using a small-molecule compound retards breast cancer bone metastasis","volume":"21","author":"Sun","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1038\/s41467-019-12108-6","article-title":"The CXCL5\/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis","volume":"10","author":"Curtis","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Wang, X., Yu, J., Yan, J., Peng, K., and Zhou, H. (2022). Single-cell sequencing reveals MYC targeting gene MAD2L1 is associated with prostate cancer bone metastasis tumor dormancy. BMC Urol., 22.","DOI":"10.1186\/s12894-022-00991-z"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Boral, D., Liu, H.N., Kenney, S.R., and Marchetti, D. (2020). Molecular Interplay between Dormant Bone Marrow-Resident Cells (BMRCs) and CTCs in Breast Cancer. Cancers, 12.","DOI":"10.3390\/cancers12061626"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Chen, S., Yang, M., Zhong, N., Yu, D., Jian, J., Jiang, D., Xiao, Y., Wei, W., Wang, T., and Lou, Y. (2021). Quantified CIN Score From Cell-free DNA as a Novel Noninvasive Predictor of Survival in Patients with Spinal Metastasis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.767340"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10555-022-10075-x","article-title":"Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors","volume":"42","author":"Heidrich","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1158\/0008-5472.CAN-20-0571","article-title":"Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment","volume":"81","author":"Dhimolea","year":"2021","journal-title":"Cancer Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"100608","DOI":"10.1016\/j.jbo.2024.100608","article-title":"The role of IL-1B in breast cancer bone metastasis","volume":"46","author":"Zhou","year":"2024","journal-title":"J. Bone Oncol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1158\/2159-8290.CD-23-0762","article-title":"Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity","volume":"14","author":"Monteran","year":"2024","journal-title":"Cancer Discov."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"101809","DOI":"10.1016\/j.neuchi.2026.101809","article-title":"Systemic management of spinal metastases: Current strategies and future directions","volume":"72","author":"Collin","year":"2026","journal-title":"Neurochirurgie"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.ccell.2025.03.036","article-title":"Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts","volume":"43","author":"Cheng","year":"2025","journal-title":"Cancer Cell"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Teja, M., Berenguer Frances, M.A., L\u00f3pez Campos, F., Feltes Ben\u00edtez, N., Stoica, A., Puertas, A., Marvaso, G., Murthy, V., and Cou\u00f1ago, F. (2026). The Role of SBRT in Oligometastatic Prostate Cancer: Where We Are and Where We Are Heading. Life, 16.","DOI":"10.3390\/life16040550"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Elshimy, Y., Alkhatib, A.R., Atassi, B., and Mohammad, K.S. (2025). Biomarker-Driven Approaches to Bone Metastases: From Molecular Mechanisms to Clinical Applications. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051160"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Ban, J., Fock, V., Aryee, D.N.T., and Kovar, H. (2021). Mechanisms, Diagnosis and Treatment of Bone Metastases. Cells, 10.","DOI":"10.3390\/cells10112944"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/gtc.13103","article-title":"C9orf10\/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L-BO4in a mouse model","volume":"29","author":"Uekita","year":"2024","journal-title":"Genes Cells"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"100374","DOI":"10.1016\/j.jbo.2021.100374","article-title":"A predictive biomarker panel for bone metastases: Liquid biopsy approach","volume":"29","author":"Bhadresha","year":"2021","journal-title":"J. Bone Oncol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.2147\/CMAR.S369910","article-title":"Clinical Characteristics, Prognostic Factors and Treatment Outcomes of Patients with Bone-Only Metastatic Breast Cancer","volume":"14","author":"Marie","year":"2022","journal-title":"Cancer Manag. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/6805\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:12:57Z","timestamp":1785557577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/6805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":222,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27156805"],"URL":"https:\/\/doi.org\/10.3390\/ijms27156805","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]}}}