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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Several studies have shown that physical activity is associated with increased life expectancy and the prevention of chronic and neurodegenerative diseases. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on the progression of an experimental model of multiple sclerosis. For this purpose, the murine model of experimental encephalomyelitis (EAE) was used in female C57BL\/6 mice, divided into four groups: negative control (CN), positive control (EAE), HIIT once a day (1-HIIT), and HIIT snacks, three times a day (3-HIIT). The clinical score results demonstrated a significant reduction in the clinical score in mice subjected to 3-HIIT, confirmed by analyses of pro- and anti-inflammatory cytokines and histological analyses. These results provided solid evidence for the potential of HIIT protocols, especially 3-HIIT, to reprogram an autoimmune response in the CNS in mice with the EAE model, favoring a neuroprotective and immunoregulatory environment\u2014evidence that may drive clinical research.<\/jats:p>","DOI":"10.3390\/ijms27156854","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:15:00Z","timestamp":1785428100000},"page":"6854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Intensity Interval Training Snacks Improve Experimental Autoimmune Encephalomyelitis"],"prefix":"10.3390","volume":"27","author":[{"given":"Oswaldo C.","family":"Junior","sequence":"first","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Te\u00f3filo Otoni 39803-371, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jully C. 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