{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:09:16Z","timestamp":1785506956633,"version":"3.56.0"},"reference-count":230,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Cerebral strokes have been a global problem for many decades. Interest in saliva as a diagnostic material has grown substantially. The ease of collection, minimal invasiveness and low storage costs make saliva particularly well suited for diagnostic and therapeutic applications. Research shows that markers detected in blood can also be found in saliva, opening up the possibility of using this biofluid for clinical purposes. The aim of this paper is to review current knowledge on salivary biomarkers in stroke patients. Among the markers detected in the saliva of stroke patients are indicators of antioxidant capacity (e.g., reduced glutathione and uric acid), oxidative (e.g., malondialdehyde, advanced oxidation protein products) and nitrosative stress (e.g., peroxynitrite), inflammation (pro- and anti-inflammatory cytokines) and others. The levels of many salivary biomarkers correlate with the severity of disease, organ complications and may serve as valuable tools for the differential stroke diagnosis. The collective findings of these studies underscore the potential clinical applications of salivary biomarkers in stroke. However, considerable obstacles such as methodological heterogeneity, limited differential diagnostic studies, small cohorts, and insufficient standardization of saliva collection and oral health assessment impede their clinical implementation. Establishing standardized saliva collection protocols and reference values for key parameters is crucial. Identifying biomarkers in saliva lays the groundwork for developing innovative tools to analyze and accurately assess stroke patients.<\/jats:p>","DOI":"10.3390\/ijms27156871","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:23:20Z","timestamp":1785504200000},"page":"6871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of Saliva in Stroke Patients: A Review"],"prefix":"10.3390","volume":"27","author":[{"given":"Dominika","family":"Forszt","sequence":"first","affiliation":[{"name":"Department of Risk Group Dentistry, Chair of Pediatric Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Greater Poland Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Gerreth","sequence":"additional","affiliation":[{"name":"Department of Risk Group Dentistry, Chair of Pediatric Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Greater Poland Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Bielas","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Poznan University of Medical Sciences, 60-512 Poznan, Greater Poland Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-3187","authenticated-orcid":false,"given":"Mateusz","family":"Maciejczyk","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Environmental Health, Medical University of Bialystok, 15-222 Bialystok, Podlaskie Voivodeship, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"ref_1","first-page":"e299","article-title":"Salivary biomarkers for diagnosis of systemic diseases and malignant tumors. A systematic review","volume":"25","author":"Meleti","year":"2020","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1128\/CMR.00021-13","article-title":"Salivary biomarkers: Toward future clinical and diagnostic utilities","volume":"26","author":"Yoshizawa","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","first-page":"ZC56","article-title":"Estimation of salivary and serum biomarkers in diabetic and non diabetic patients\u2013a comparative study","volume":"10","author":"Ladgotra","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21260","DOI":"10.1038\/s41598-020-78209-1","article-title":"Dynamics of salivary markers of kidney functions in acute and chronic kidney diseases","volume":"10","author":"Pavlov","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/1535370216681550","article-title":"Saliva diagnostics\u2013current views and directions","volume":"242","author":"Aro","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2014.08.046","article-title":"Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: The Suita study","volume":"237","author":"Kosaka","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"72S","DOI":"10.1177\/0022034514537522","article-title":"Utility of salivary biomarkers for demonstrating acute myocardial infarction","volume":"93","author":"Miller","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Klimiuk, A., Zalewska, A., Sawicki, R., Knapp, M., and Maciejczyk, M. (2020). Salivary oxidative stress increases with the progression of chronic heart failure. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030769"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9996958","DOI":"10.1155\/2021\/9996958","article-title":"Comparison of ischemic and hemorrhagic stroke in the medical ward of Dessie Referral Hospital, Northeast Ethiopia: A retrospective study","volume":"2021","author":"Abdu","year":"2021","journal-title":"Neurol. Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood\u2013brain barrier dysfunction, and imaging modalities","volume":"53","author":"Dijkhuizen","year":"2022","journal-title":"Stroke"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Janigro, D., Bailey, D.M., Lehmann, S., Badaut, J., O\u2019Flynn, R., Hirtz, C., and Marchi, N. (2021). Peripheral blood and salivary biomarkers of blood\u2013brain barrier permeability and neuronal damage: Clinical and applied concepts. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.577312"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17185","DOI":"10.1038\/s41598-021-96739-0","article-title":"Salivary cytokine profile in patients with ischemic stroke","volume":"11","author":"Maciejczyk","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gerreth, P., Maciejczyk, M., Zalewska, A., Gerreth, K., and Hojan, K. (2020). Comprehensive evaluation of the oral health status, salivary gland function, and oxidative stress in the saliva of patients with subacute phase of stroke: A case-control study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9072252"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ncl.2008.07.003","article-title":"Epidemiology of ischemic and hemorrhagic stroke: Incidence, prevalence, mortality, and risk factors","volume":"26","author":"Grysiewicz","year":"2008","journal-title":"Neurol. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/CIRCRESAHA.116.308398","article-title":"Stroke risk factors, genetics, and prevention","volume":"120","author":"Boehme","year":"2017","journal-title":"Circ. Res."},{"key":"ref_16","first-page":"e41","article-title":"2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"ref_17","unstructured":"(2024). GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol., 23, 973\u20131003."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s11883-022-01067-x","article-title":"A contemporary review of epidemiology, risk factors, etiology, and outcomes of premature stroke","volume":"24","author":"Potter","year":"2022","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STR.0b013e318296aeca","article-title":"An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals From the American Heart Association\/American Stroke Association","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Biomarkers Definitions Working Group (2001). Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin. Pharmacol. Ther., 69, 89\u201395.","DOI":"10.1067\/mcp.2001.113989"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bennett, M.R., and Devarajan, P. (2017). Characteristics of an ideal biomarker of kidney diseases. Biomark. Kidney Dis., 1\u201320.","DOI":"10.1016\/B978-0-12-803014-1.00001-7"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/COH.0b013e32833ed177","article-title":"What are biomarkers?","volume":"5","author":"Strimbu","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13311-011-0050-4","article-title":"Blood biomarkers of ischemic stroke","volume":"8","author":"Jickling","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1747-4949.2012.00784.x","article-title":"Blood biomarkers in stroke: Research and clinical practice","volume":"7","author":"Whiteley","year":"2012","journal-title":"Int. J. Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.forsciint.2004.10.026","article-title":"The physiology of saliva and transfer of drugs into saliva","volume":"150","author":"Aps","year":"2005","journal-title":"Forensic Sci. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/ar.23569","article-title":"Overview of Human Salivary Glands: Highlights of Morphology and Developing Processes","volume":"300","author":"Teshima","year":"2017","journal-title":"Anat. Rec."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Porcheri, C., and Mitsiadis, T.A. (2019). Physiology, pathology and regeneration of salivary glands. Cells, 8.","DOI":"10.3390\/cells8090976"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000358776","article-title":"Anatomy, biogenesis and regeneration of salivary glands","volume":"24","author":"Holmberg","year":"2014","journal-title":"Monogr. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.archoralbio.2016.05.012","article-title":"Minor salivary glands function is decreased in hyposalivation-related diseases","volume":"69","author":"Wang","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26502\/jrci.2809038","article-title":"Minor Salivary Glands and \u2018Tubarial Glands\u2019-Anatomy, Physiology, and Pathology Relevant to Radiology","volume":"4","author":"Sainudeen","year":"2021","journal-title":"J. Radiol. Clin. Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcdb.2013.12.001","article-title":"Salivary gland development: A template for regeneration","volume":"25\u201326","author":"Patel","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4161\/org.25224","article-title":"Interactions between developing nerves and salivary glands","volume":"9","author":"Ferreira","year":"2013","journal-title":"Organogenesis"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bechir, F., Pacurar, M., Tohati, A., and Bataga, S.M. (2021). Comparative study of salivary pH, buffer capacity, and flow in patients with and without gastroesophageal reflux disease. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19010201"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jdent.2018.08.010","article-title":"The role of natural salivary defences in maintaining a healthy oral microbiota","volume":"80","year":"2019","journal-title":"J. Dent."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.11613\/BM.2015.018","article-title":"Clinical and diagnostic utility of salivaas a non-invasive diagnostic fluid: A systematic review","volume":"25","author":"Nunes","year":"2015","journal-title":"Med. Biochem."},{"key":"ref_36","first-page":"246178","article-title":"Comparison of biomarkers in blood and saliva in healthy adults","volume":"2012","author":"Williamson","year":"2012","journal-title":"Nurs. Res. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood\u2013brain barrier dysfunction and recovery after ischemic stroke","volume":"163\u2013164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol. J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Qiu, Y.M., Zhang, C.L., Chen, A.Q., Wang, H.L., Zhou, Y.F., Li, Y.N., and Hu, B. (2021). Immune Cells in the, B.BB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.678744"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3804979","DOI":"10.1155\/2018\/3804979","article-title":"Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy","volume":"2018","author":"Sun","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lakhan, S.E., Kirchgessner, A., Tepper, D., and Leonard, A. (2013). Matrix metalloproteinases and blood\u2013brain barrier disruption in acute ischemic stroke. Front. Neurol., 4, Erratum in Front. Neurol. 2018, 9, 202. https:\/\/doi.org\/10.3389\/fneur.2013.00032.","DOI":"10.3389\/fneur.2013.00032"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1212\/WNL.0b013e3182697e70","article-title":"Blood\u2013brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke","volume":"79","author":"Khatri","year":"2012","journal-title":"Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: Friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood\u2013brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1742-2094-7-74","article-title":"The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia","volume":"7","author":"Ceulemans","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4356386","DOI":"10.1155\/2020\/4356386","article-title":"Oxidative stress-mediated blood\u2013brain barrier disruption in neurological diseases","volume":"2020","author":"Song","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2147\/CIA.S233909","article-title":"The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke","volume":"15","author":"Pawluk","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-7-97","article-title":"Inflammatory mechanisms in ischemic stroke: Therapeutic approaches","volume":"7","author":"Lakhan","year":"2009","journal-title":"J. Transl. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/jcbfm.2015.60","article-title":"Diverse functions of pericytes in cerebral blood flow regulation and ischemia","volume":"35","author":"Priller","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wu, L., Xiong, X., Wu, X., Ye, Y., Jian, Z., Zhi, Z., and Gu, L. (2020). Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.00028"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2217\/bmm.09.30","article-title":"Molecular biomarkers in stroke diagnosis and prognosis","volume":"3","author":"Maas","year":"2009","journal-title":"Biomark. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1756286418789340","DOI":"10.1177\/1756286418789340","article-title":"Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management","volume":"11","author":"Ramiro","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41587-019-0045-y","article-title":"Wearable biosensors for healthcare monitoring","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/154411130201300209","article-title":"The diagnostic applications of saliva--A review","volume":"13","author":"Kaufman","year":"2002","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/oem.2006.026567","article-title":"The use of salivary biomarkers in occupational and environmental medicine","volume":"64","year":"2007","journal-title":"Occup. Environ. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"110","DOI":"10.17305\/bjbms.2008.2962","article-title":"Daily fluctuation of cortisol in saliva and serum of Healthy Persons","volume":"8","author":"Sapcanin","year":"2008","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1373\/clinchem.2010.153767","article-title":"Diagnostic Potential of Saliva: Current State and Future Applications","volume":"57","author":"Pfaffe","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4239\/wjd.v5.i6.730","article-title":"Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance","volume":"5","author":"Desai","year":"2014","journal-title":"World J. Diabetes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.24191\/jchs.v4i1.7280","article-title":"CRP and IL-6 levels of Gingival Crevicular Fluid in stroke survivors: A pilot study","volume":"4","author":"Yatim","year":"2019","journal-title":"J. Clin. Health Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bbi.2012.01.019","article-title":"Assessing salivary C-reactive protein: Longitudinal associations with systemic inflammation and cardiovascular disease risk in women exposed to intimate partner violence","volume":"26","author":"Out","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.archoralbio.2018.10.026","article-title":"Salivary biomarkers of inflammation and oxidative stress in healthy adults","volume":"97","author":"Nam","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6619439","DOI":"10.1155\/2020\/6619439","article-title":"Salivary Gland Dysfunction in Stroke Patients Is Associated with Increased Protein Glycoxidation and Nitrosative Stress","volume":"2020","author":"Maciejczyk","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jobcr.2015.08.006","article-title":"Saliva as a diagnostic tool for oral and systemic diseases","volume":"6","author":"Javaid","year":"2016","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_63","first-page":"4360612","article-title":"Diagnostic value of salivary markers in neuropsychiatric disorders","volume":"2019","author":"Waszkiewicz","year":"2019","journal-title":"Dis. Markers"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"\u010ci\u017em\u00e1rov\u00e1, B., Tome\u010dkov\u00e1, V., Hubkov\u00e1, B., Hurajtov\u00e1, A., Ohlasov\u00e1, J., and Birkov\u00e1, A. (2022). Salivary Redox Homeostasis in Human Health and Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231710076"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-013-7231-5","article-title":"Cortisol levels and the severity and outcomes of acute stroke: A systematic review","volume":"261","author":"Barugh","year":"2014","journal-title":"J. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antiox3030472","article-title":"Oxidative Stress and the Use of Antioxidants in Stroke","volume":"3","author":"Shirley","year":"2014","journal-title":"Antioxidants"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11357-997-0012-2","article-title":"Xanthine dehydrogenase\/xanthine oxidase and oxidative stress","volume":"20","author":"Chung","year":"1997","journal-title":"Age"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102623","DOI":"10.1016\/j.redox.2023.102623","article-title":"The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke","volume":"60","author":"Yu","year":"2023","journal-title":"Redox Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Maciejczyk, M., Nesterowicz, M., Zalewska, A., Biedrzycki, G., Gerreth, P., Hojan, K., and Gerreth, K. (2022). Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.897413"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of Illness in the Aged: The Index of ADL: A Standardized Measure of Biological and Psychosocial Function","volume":"185","author":"Katz","year":"1963","journal-title":"J. Am. Med. Assoc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2340\/16501977-2280","article-title":"Berg Balance Scale score at admission can predict walking suitable for community ambulation at discharge from inpatient stroke rehabilitation","volume":"50","author":"Louie","year":"2018","journal-title":"J. Rehabil. Med"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.2147\/NDT.S212328","article-title":"Comparative diagnostic accuracy of ACE-III and MoCA for detecting mild cognitive impairment","volume":"15","author":"Wang","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wiero\u0144ska, J.M., Cie\u015blik, P., and Kalinowski, L. (2021). Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia. Biomolecules, 11.","DOI":"10.3390\/biom11081097"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000026342","article-title":"Role of nitric oxide in salivary secretion","volume":"5","author":"Lomniczi","year":"1998","journal-title":"Neuroimmunomodulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1016\/S0021-9258(20)64313-7","article-title":"Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide","volume":"266","author":"Radi","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1590\/S0100-40422009000100032","article-title":"Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification","volume":"32","author":"Grotto","year":"2009","journal-title":"Quim. Nova"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1089\/ars.2015.6317","article-title":"Clinical Relevance of Biomarkers of Oxidative Stress","volume":"23","author":"Frijhoff","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Twarda-Clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6501046","DOI":"10.1155\/2017\/6501046","article-title":"Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans","volume":"2017","author":"Marrocco","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1279250","DOI":"10.1155\/2019\/1279250","article-title":"Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field","volume":"2019","author":"Katerji","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Song, Y.R., Kim, J.K., Lee, H.S., Kim, S.G., and Choi, E.K. (2020). Serum levels of protein carbonyl, a marker of oxidative stress, are associated with overhydration, sarcopenia and mortality in hemodialysis patients. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-01937-z"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00726-003-0011-2","article-title":"Free radical-mediated oxidation of free amino acids and amino acid residues in proteins","volume":"25","author":"Stadtman","year":"2003","journal-title":"Amino Acids"},{"key":"ref_83","first-page":"661","article-title":"Is there a halo-enzymopathy in Parkinson\u2019s disease?","volume":"37","year":"2019","journal-title":"Neurologia"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/iub.2519","article-title":"Homeostatic control of redox status and health","volume":"74","author":"Sies","year":"2022","journal-title":"IUBMB Life"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/jeb.01022","article-title":"Oxidants, antioxidants and the ischemic brain","volume":"207","author":"Warner","year":"2004","journal-title":"J. Exp. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zi\u0144czuk, J., Maciejczyk, M., Zar\u0119ba, K., Pryczynicz, A., Dymicka-Piekarska, V., Kami\u0144ska, J., Koper-Lenkiewicz, O., Matowicka-Karna, J., K\u0119dra, B., and Zalewska, A. (2020). Pro-Oxidant Enzymes, Redox Balance and Oxidative Damage to Proteins, Lipids and, DNA in Colorectal Cancer Tissue. Is Oxidative Stress. Dependent on Tumour Budding and Inflammatory Infiltration?. Cancers, 12.","DOI":"10.3390\/cancers12061636"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1440-1819.2009.02004.x","article-title":"Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment","volume":"63","author":"Cumurcu","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Rog, J., \u0141obejko, \u0141., Hordejuk, M., Marciniak, W., Derkacz, R., Kilja\u0144czyk, A., Matuszczak, M., Lubi\u0144ski, J., Nesterowicz, M., and \u017bendzian-Piotrowska, M. (2024). Pro\/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1441575"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Arteaga, O., \u00c1lvarez, A., Revuelta, M., Santaolalla, F., Urtasun, A., and Hilario, E. (2017). Role of Antioxidants in Neonatal Hypoxic\u2013Ischemic Brain Injury: New Therapeutic Approaches. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020265"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Lee, K.H., Cha, M., and Lee, B.H. (2020). Neuroprotective Effect of Antioxidants in the Brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197152"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004647-200101000-00002","article-title":"Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain","volume":"21","author":"Chan","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0891-5849(01)00806-1","article-title":"Characterization of the differentiated antioxidant profile of human saliva","volume":"32","author":"Nagler","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.foodchem.2009.02.035","article-title":"Potential applications of peroxidases","volume":"115","author":"Hamid","year":"2009","journal-title":"Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1399-302X.1992.tb00595.x","article-title":"Inhibition of Candida albicans by the Peroxidase\/SCN-\/H2O2 system","volume":"7","year":"1992","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_95","first-page":"2","article-title":"Assessment of salivary and serum oxidative stress and antioxidants as plausible parameters in prediction of ischemic stroke among Iraqi Samples","volume":"7","author":"Jaber","year":"2008","journal-title":"Internet J. Third World Med."},{"key":"ref_96","first-page":"57","article-title":"Salivary Lipid Peroxidation and Lipid Profile Levels in Patients with Recent Ischemic Stroke","volume":"3","year":"2010","journal-title":"J. Int. Dent. Med. Res."},{"key":"ref_97","first-page":"14","article-title":"Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia","volume":"2015","author":"Hassan","year":"2016","journal-title":"Qatar Med. J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1161\/01.STR.0000103140.52838.45","article-title":"Iron and iron-handling proteins in the brain after intracerebral hemorrhage","volume":"34","author":"Wu","year":"2003","journal-title":"Stroke"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1515\/cclm-2019-0899","article-title":"Obtaining information from the brain in a non-invasive way: Determination of iron in nasal exudate to differentiate hemorrhagic and ischemic strokes","volume":"58","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_100","first-page":"8423105","article-title":"The Impact of Health Resort Treatment on the Nonenzymatic Endogenous Antioxidant System","volume":"2020","author":"Kasperczak","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/DMSO.S346648","article-title":"Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology","volume":"15","author":"Liu","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","article-title":"Metabolism and functions of glutathione in brain","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Didier, A.J., Stiene, J., Fang, L., Watkins, D., Dworkin, L.D., and Creeden, J.F. (2023). Antioxidant and Anti-Tumor Effects of Dietary Vitamins A.C. and E. Antioxidants, 12.","DOI":"10.3390\/antiox12030632"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Napolitano, G., Fasciolo, G., and Venditti, P. (2021). Mitochondrial Management of Reactive Oxygen Species. Antioxidants, 10.","DOI":"10.3390\/antiox10111824"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.2147\/NDT.S373493","article-title":"Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke","volume":"18","author":"Liu","year":"2022","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ashok, A., Andrabi, S.S., Mansoor, S., Kuang, Y., Kwon, B.K., and Labhasetwar, V. (2022). Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation. Antioxidants, 11.","DOI":"10.3390\/antiox11020408"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/10715769409056594","article-title":"Antioxidant Activity of Saliva and Periodontal Disease","volume":"21","author":"Moore","year":"1994","journal-title":"Free Radic. Res."},{"key":"ref_109","first-page":"e19649","article-title":"Salivary uric acid: A noninvasive wonder for clinicians?","volume":"13","author":"Jaiswal","year":"2021","journal-title":"Cureus"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Otani, N., Hoshiyama, E., Ouchi, M., Takekawa, H., and Suzuki, K. (2023). Uric acid and neurological disease: A narrative review. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1164756"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jth.14759","article-title":"Cytokine and chemokine regulation of venous thromboembolism","volume":"18","author":"Najem","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.nrl.2021.10.003","article-title":"Relationship between inflammation and oxidative stress and its effect on multiple sclerosis","volume":"39","author":"Ortiz","year":"2024","journal-title":"Neurologia"},{"key":"ref_113","first-page":"294","article-title":"Cytokines: Their role in stroke and potential use as biomarkers and therapeutic targets","volume":"5","author":"Doll","year":"2014","journal-title":"Aging Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.7150\/ijms.110452","article-title":"The screening assessment of pro-inflammatory, anti-inflammatory, Th1, Th2 and Th17 cytokines in saliva of patients with ischemic stroke","volume":"22","author":"Forszt","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1038\/s41598-025-97974-5","article-title":"Salivary chemokines and growth factors in patients with ischemic stroke","volume":"15","author":"Forszt","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.it.2017.08.004","article-title":"Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes","volume":"38","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/j.1582-4934.2009.00987.x","article-title":"Growth factors in ischemic stroke","volume":"15","author":"Lanfranconi","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_119","first-page":"1243","article-title":"Evaluation of serum and gingival crevicular fluid C-reactive protein and IL-6 levels in patients with periodontitis and transient ischemic attacks","volume":"52","author":"Haba","year":"2011","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/prd.12109","article-title":"Clinical and technical considerations in the analysis of gingival crevicular fluid","volume":"70","author":"Wassall","year":"2016","journal-title":"Periodontol. 2000"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/jcpe.13630","article-title":"Discovery, validation, and diagnostic ability of multiple protein-based biomarkers in saliva and gingival crevicular fluid to distinguish between health and periodontal diseases","volume":"49","author":"Grant","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12118","article-title":"Gingival crevicular fluid and saliva","volume":"70","author":"Taylor","year":"2016","journal-title":"Periodontol. 2000"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1002\/jssc.202100384","article-title":"Saliva, a bodily fluid with recognized and potential diagnostic applications","volume":"44","author":"Boroumand","year":"2021","journal-title":"J. Sep. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Romano, F., Iaderosa, G., Corana, M., Perotto, S., Baima, G., Di Scipio, F., Abbadessa, G., Mariani, G.M., Aimetti, M., and Berta, G.N. (2022). Comparing Ionic Profile of Gingival Crevicular Fluid and Saliva as Distinctive Signature of Severe Periodontitis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10030687"},{"key":"ref_125","first-page":"8","article-title":"The Mini-Mental State Examination (MMSE)","volume":"25","author":"Kurlowicz","year":"1999","journal-title":"J. Gerontol. Nurs."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Pawlukowska, W., Baumert, B., Meller, A., Dziewulska, A., Zawi\u015blak, A., Grocholewicz, K., Nowacki, P., and Masztalewicz, M. (2022). The Influence of Periodontal Diseases and the Stimulation of Saliva Secretion on the Course of the Acute Phase of Ischemic Stroke. J. Clin. Med., 11.","DOI":"10.3390\/jcm11154321"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/1753425913501214","article-title":"Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study","volume":"20","author":"Palm","year":"2014","journal-title":"Innate Immun."},{"key":"ref_128","first-page":"1519","article-title":"Salivary neuron specific enolase: An indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients","volume":"47","author":"Atiyah","year":"2009","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11011-016-9801-6","article-title":"Neuron specific enolase: A promising therapeutic target in acute spinal cord injury","volume":"31","author":"Haque","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.20517\/2347-8659.2017.59","article-title":"Neuron specific enolase is a potential target for regulating neuronal cell survival and death: Implications in neurodegeneration and regeneration","volume":"4","author":"Polcyn","year":"2017","journal-title":"Neuroimmunol. Neuroinflamm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s11064-017-2291-z","article-title":"Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats","volume":"42","author":"Haque","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Haque, A., Polcyn, R., Matzelle, D., and Banik, N.L. (2018). New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection. Brain Sci., 8.","DOI":"10.3390\/brainsci8020033"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Cheng, F., Yuan, Q., Yang, J., Wang, W., and Liu, H. (2014). The Prognostic Value of Serum Neuron-Specific Enolase in Traumatic Brain Injury: Systematic Review and Meta-Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106680"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"504","DOI":"10.4103\/0972-2327.120442","article-title":"Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke","volume":"16","author":"Zaheer","year":"2013","journal-title":"Ann. Indian. Acad. Neurol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.17691\/stm2021.13.2.08","article-title":"Prognostic Value of Investigating Neuron-Specific Enolase in Patients with Ischemic Stroke","volume":"13","author":"Kurakina","year":"2021","journal-title":"Sovrem. Tekhnologii Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12291-011-0172-9","article-title":"Correlation of Brain Biomarker Neuron Specific Enolase (NSE) with Degree of Disability and Neurological Worsening in Cerebrovascular Stroke","volume":"27","author":"Bharosay","year":"2012","journal-title":"Indian. J. Clin. Biochem."},{"key":"ref_137","first-page":"227","article-title":"Serum Neuron Specific Enolase as predictor of neurological disability and short term outcome in Ischemic Stroke","volume":"2","author":"Pandey","year":"2013","journal-title":"J. Sci. Innov. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3803\/EnM.2022.1549","article-title":"Clinical and Technical Aspects in Free Cortisol Measurement","volume":"37","author":"Choi","year":"2022","journal-title":"Endocrinol. Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2522\/ptj.20130597","article-title":"Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation","volume":"94","author":"Hannibal","year":"2014","journal-title":"Phys. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000079943","article-title":"Salivary cortisol, a biological marker of stress, is positively associated with 24-hour systolic blood pressure in patients with acute ischaemic stroke","volume":"18","author":"Ahmed","year":"2004","journal-title":"Cerebrovasc. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1044\/1092-4388(2007\/034)","article-title":"Assessing cortisol reactivity to a linguistic task as a marker of stress in individuals with left-hemisphere stroke and aphasia","volume":"50","author":"Heim","year":"2007","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/13803395.2012.658356","article-title":"Aphasia severity and salivary cortisol over time","volume":"34","year":"2012","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e19180494","DOI":"10.1590\/1678-4324-2019180494","article-title":"The Psychophysiological Responses of the Chronic Ischemic Stroke Patients to the Acute Stress were Changed","volume":"62","author":"Mirzaee","year":"2019","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3233\/JAD-180486","article-title":"The Price of Stress: High Bedtime Salivary Cortisol Levels Are Associated with Brain Atrophy and Cognitive Decline in Stroke Survivors. Results from the TABASCO Prospective Cohort Study","volume":"65","author":"Tene","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s10143-020-01256-9","article-title":"The potential predictive value of salivary cortisol on the occurrence of secondary cognitive impairment after ischemic stroke","volume":"44","author":"Wang","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.3390\/cimb44120429","article-title":"Development of Post-Stroke Cognitive and Depressive Disturbances: Associations with Neurohumoral Indices","volume":"44","author":"Zhanina","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_148","first-page":"271","article-title":"Salivary \u03b1-amylase and cortisol as stress biomarkers\u2013Literature Review","volume":"50","author":"Stefaniak","year":"2013","journal-title":"Dent. Med. Probl."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"709230","DOI":"10.1155\/2015\/709230","article-title":"The Cortisol Awakening Response in Patients with Poststroke Depression Is Blunted and Negatively Correlated with Depressive Mood","volume":"2015","author":"Kwon","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.psyneuen.2008.10.002","article-title":"Altered tonic and phasic cortisol secretion following unilateral stroke","volume":"34","author":"Lueken","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_151","first-page":"e89222","article-title":"Association of Circadian Rhythm Biomarkers and Ambulatory Blood Pressure Monitoring With Prognosis and Outcome in People With Acute Ischemic Stroke: A Case-Control Study","volume":"17","author":"Atam","year":"2025","journal-title":"Cureus"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Chen, Y.L., Bai, L., Dilimulati, D., Shao, S., Qiu, C., Liu, T., Xu, S., Bai, X.B., Du, L.J., and Zhou, L.J. (2022). Periodontitis Salivary Microbiota Aggravates Ischemic Stroke Through IL-17A. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.876582"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/aian.AIAN_483_19","article-title":"Gut microbiota and stroke","volume":"23","author":"Tan","year":"2020","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_154","first-page":"1019","article-title":"May the force be with you: The light and dark sides of the microbiota\u2013gut\u2013brain axis in neuropsychiatry","volume":"30","author":"Sherwin","year":"2016","journal-title":"Cent. Nerv. Syst. Drugs"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e012330","DOI":"10.1161\/JAHA.119.012330","article-title":"Oral bacterial signatures in cerebral thrombi of patients with acute ischemic stroke treated with thrombectomy","volume":"8","author":"Patrakka","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncomms1491","article-title":"The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke","volume":"2","author":"Nakano","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Cieplik, F., Wiedenhofer, A.M., Pietsch, V., Hiller, K.A., Hiergeist, A., Wagner, A., Baldaranov, D., Linker, R.A., Jantsch, J., and Buchalla, W. (2020). Oral Health, Oral Microbiota, and Incidence of Stroke-Associated Pneumonia-A Prospective Observational Study. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.528056"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/j.wneu.2018.01.158","article-title":"A Potential New Risk Factor for Stroke: Streptococcus Mutans With Collagen-Binding Protein","volume":"113","author":"Inenaga","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"ycae088","DOI":"10.1093\/ismeco\/ycae088","article-title":"Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke","volume":"4","author":"Manzoor","year":"2024","journal-title":"ISME Commun."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1038\/s41598-025-95728-x","article-title":"Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale","volume":"15","author":"Manzoor","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1253\/circj.CJ-24-0872","article-title":"Oral Pathobiont Streptococcus Anginosus Is Enriched in the Gut of Stroke Patients and Predicts 2-Year Cardiovascular Outcome","volume":"89","author":"Tonomura","year":"2025","journal-title":"Circ. J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Roongpiboonsopit, D., Wairit, S., Nithisathienchai, C., Pakdee, A., Cheibchalard, T., Sayasathid, J., Wilantho, A., Tongsima, S., and Somboonna, N. (2025). Oral microbiome dysbiosis in acute ischemic stroke and transient ischemic attack patients. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0333676"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/mp.2011.121","article-title":"BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity","volume":"17","author":"Rakofsky","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/mp.2017.144","article-title":"BDNF at the synapse: Why location matters","volume":"22","author":"Song","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3892\/br.2012.48","article-title":"The neuroprotective roles of, B.DNF in hypoxic ischemic brain injury","volume":"1","author":"Chen","year":"2013","journal-title":"Biomed. Rep."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/15459683221096391","article-title":"Genetic and Neurophysiological Biomarkers of Neuroplasticity Inform Post-Stroke Language Recovery","volume":"36","author":"Dresang","year":"2022","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Kertesz, A. (2007). Western Aphasia Battery\u2013Revised, The Psychological Corporation.","DOI":"10.1037\/t15168-000"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"Goode","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Lorente, L., Mart\u00edn, M.M., Almeida, T., P\u00e9rez-Cejas, A., Ramos, L., Argueso, M., Ria\u00f1o-Ruiz, M., Sol\u00e9-Viol\u00e1n, J., and Hern\u00e1ndez, M. (2016). Serum levels of substance P and mortality in patients with a severe acute ischemic stroke. Int. J. Mol., 17.","DOI":"10.3390\/ijms17060991"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"29","DOI":"10.29245\/2572.942X\/2016\/2.1020","article-title":"Substance P and antagonists of the neurokinin-1 receptor in neuroinflammation associated with infectious and neurodegenerative diseases of the central nervous system","volume":"1","author":"Martinez","year":"2016","journal-title":"J. Neurol. Neuromedicine"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000482002","article-title":"Increase of Substance P Concentration in Saliva after Pharyngeal Electrical Stimulation in Severely Dysphagic Stroke Patients\u2014An Indicator of Decannulation Success?","volume":"25","author":"Muhle","year":"2017","journal-title":"Neurosignals"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00455-017-9867-2","article-title":"Relationship Between Frequency of Spontaneous Swallowing and Salivary Substance P Level in Patients with Acute Stroke","volume":"33","author":"Niimi","year":"2018","journal-title":"Dysphagia"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00455-022-10451-3","article-title":"Spontaneous Swallowing Frequency in Post-Stroke Patients with and Without Oropharyngeal Dysphagia: An Observational Study","volume":"38","author":"Tomsen","year":"2023","journal-title":"Dysphagia"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1161\/01.STR.0000190056.76543.eb","article-title":"Dysphagia after stroke: Incidence, diagnosis, and pulmonary complications","volume":"36","author":"Martino","year":"2005","journal-title":"Stroke"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Sun, Q., Guo, C.W., Chen, S.N., Ding, Y., Chen, R., and Li, J. (2026). Exploration of circadian rhythm characteristics and its impact on prognosis and neuroinflammation in acute ischemic stroke patients. Neurol. Res., 1\u201314.","DOI":"10.1080\/01616412.2026.2614348"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/bph.14116","article-title":"New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation","volume":"175","author":"Zisapel","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Sadanandan, N., Cozene, B., Cho, J., Park, Y.J., Saft, M., Gonzales-Portillo, B., and Borlongan, C.V. (2020). Melatonin\u2014A potent therapeutic for stroke and stroke-related dementia. Antioxidants, 9.","DOI":"10.3390\/antiox9080672"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Ko\u0142odziejska, R., Wo\u017aniak, A., Bilski, R., Weso\u0142owski, R., Kupczyk, D., Porzych, M., Wr\u00f3blewska, W., and Pawluk, H. (2025). Melatonin\u2014A powerful antioxidant in neurodegenerative diseases. Antioxidants, 14.","DOI":"10.3390\/antiox14070819"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/JAD-160357","article-title":"Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer\u2019s Disease","volume":"55","author":"Tong","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9150(98)00142-7","article-title":"Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: Involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover","volume":"140","author":"Yu","year":"1998","journal-title":"Atherosclerosis"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-3-7091-6499-0_19","article-title":"Deamination of methylamine and angiopathy: Toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes","volume":"52","author":"Yu","year":"1998","journal-title":"J. Neural Transm. Suppl."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"35857","DOI":"10.1038\/srep35857","article-title":"Formaldehyde impairs transepithelial sodium transport","volume":"6","author":"Cui","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0009-8981(77)90462-4","article-title":"The action of human pancreatic and salivary isoamylases on starch and glycogen","volume":"79","author":"Kaczmarek","year":"1977","journal-title":"Clin. Chim. Acta"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11892-016-0794-7","article-title":"Salivary amylase: Digestion and metabolic syndrome","volume":"16","author":"Breslin","year":"2016","journal-title":"Curr. Diab. Rep."},{"key":"ref_186","first-page":"20","article-title":"Inhibition of Neisseria gonorrhoeae by normal human saliva","volume":"55","author":"Mellersh","year":"1979","journal-title":"Br. J. Vener. Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/iai.41.1.44-49.1983","article-title":"Effects of alpha-amylase on in vitro growth of Legionella pneumophila","volume":"41","author":"Bortner","year":"1983","journal-title":"Infect. Immun."},{"key":"ref_188","first-page":"365","article-title":"Alpha-amylase activity in supragingival dental plaque in humans","volume":"91","author":"Fiehn","year":"1983","journal-title":"Scand. J. Dent. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1128\/iai.57.9.2853-2863.1989","article-title":"Characterization of salivary alpha-amylase binding to Streptococcus sanguis","volume":"57","author":"Scannapieco","year":"1989","journal-title":"Infect. Immun."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/10454411930040030701","article-title":"Salivary alpha-amylase: Role in dental plaque and caries formation","volume":"4","author":"Scannapieco","year":"1993","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_191","first-page":"S141","article-title":"Proteomics of human teeth and saliva","volume":"63","author":"Eckhardt","year":"2014","journal-title":"Physiol. Res."},{"key":"ref_192","first-page":"6141845","article-title":"Protein-based salivary profiles as novel biomarkers for oral diseases","volume":"2018","author":"Bravo","year":"2018","journal-title":"Dis. Markers."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1621S","DOI":"10.1093\/jn\/131.5.1621S","article-title":"Human saliva as a diagnostic specimen","volume":"131","author":"Hofman","year":"2001","journal-title":"J. Nutr."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7150\/ijms.11280","article-title":"Can saliva proteins be used to predict the onset of acute myocardial infarction among high-risk patients?","volume":"12","author":"Rahim","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"ref_195","first-page":"158786","article-title":"Salivary diagnostics: A brief review","volume":"2014","author":"Malathi","year":"2014","journal-title":"ISRN Dent."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"39073","DOI":"10.1038\/srep39073","article-title":"The proteomic profile of whole and glandular saliva in healthy pain-free subjects","volume":"6","author":"Jasim","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3126\/jcmsn.v16i4.31073","article-title":"Assessment and correlation of uric acid concentration in saliva and serum of patients attending tertiary care centre","volume":"16","author":"Gautam","year":"2020","journal-title":"J. Coll. Med. Sci. Nepal."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Jung, J.Y., Kim, J.W., Kim, H.A., and Suh, C.H. (2021). Salivary biomarkers in patients with Sj\u00f6gren\u2019s syndrome: A systematic review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312903"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4155\/bio-2017-0010","article-title":"Saliva: A reliable sample matrix in bioanalytics","volume":"9","year":"2017","journal-title":"Bioanalysis"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Khurshid, Z., Zohaib, S., Najeeb, S., Zafar, M.S., Slowey, P.D., and Almas, K. (2016). Human saliva collection devices for proteomics: An update. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060846"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Campanati, A., Martina, E., Diotallevi, F., Radi, G., Marani, A., Sartini, D., Emanuelli, M., Kontochristopoulos, G., Rigopoulos, D., and Gregoriou, S. (2021). Saliva proteomics as fluid signature of inflammatory and immune-mediated skin diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137018"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.7150\/thno.78872","article-title":"Saliva-based microfluidic point-of-care diagnostic","volume":"13","author":"Pittman","year":"2023","journal-title":"Theranostics"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1177\/0022034511420721","article-title":"Whole-saliva proteolysis and its impact on salivary diagnostics","volume":"90","author":"Thomadaki","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: Normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J. Prosthet. Dent."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12160-015-9753-9","article-title":"Use of salivary diurnal cortisol as an outcome measure in randomised controlled trials: A systematic review","volume":"50","author":"Ryan","year":"2016","journal-title":"Ann. Behav. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.psyneuen.2017.05.018","article-title":"Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis","volume":"83","author":"Adam","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Kang, J.H., Lee, Y.H., and Kho, H.S. (2018). Clinical factors affecting salivary transferrin level, a marker of blood contamination in salivary analysis. BMC Oral Health, 18.","DOI":"10.1186\/s12903-018-0510-x"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"96","DOI":"10.9790\/0853-1169699","article-title":"Saliva\u2014A diagnostic tool","volume":"11","author":"Madalli","year":"2013","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.prosdent.2021.05.009","article-title":"Novel impacts of saliva with regard to oral health","volume":"127","author":"Uchida","year":"2022","journal-title":"J. Prosthet. Dent."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40520-022-02292-9","article-title":"Associations between saliva and plasma cytokines in cognitively normal, older adults","volume":"35","author":"Parkin","year":"2023","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Militello, R., Pinto, G., Illiano, A., Luti, S., Magherini, F., Amoresano, A., Modesti, P.A., and Modesti, A. (2022). Modulation of plasma proteomic profile by regular training in male and female basketball players: A preliminary study. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.813447"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Ntovas, P., Loumprinis, N., Maniatakos, P., Margaritidi, L., and Rahiotis, C. (2022). The effects of physical exercise on saliva composition: A comprehensive review. Dent. J., 10.","DOI":"10.3390\/dj10010007"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/jtxs.12356","article-title":"Aging-related changes in quantity and quality of saliva: Where do we stand in our understanding?","volume":"50","author":"Xu","year":"2019","journal-title":"J. Texture Stud."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Toan, N.K., and Ahn, S.G. (2021). Aging-related metabolic dysfunction in the salivary gland: A review of the literature. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115835"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40120-019-00168-1","article-title":"Salivary biomarkers for Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ashton","year":"2019","journal-title":"Neurol. Ther."},{"key":"ref_216","first-page":"841","article-title":"Hyposalivation in elderly patients","volume":"72","author":"Gupta","year":"2006","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2147\/TCRM.S76282","article-title":"Diagnosis and management of xerostomia and hyposalivation","volume":"11","author":"Villa","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_218","first-page":"80","article-title":"Salivary biomarkers: A review of powerful diagnostic tool","volume":"14","author":"Goswami","year":"2015","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jobcr.2015.12.004","article-title":"Role of salivary malondialdehyde in assessment of oxidative stress among diabetics","volume":"6","author":"Smriti","year":"2016","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Maciejczyk, M., Szulimowska, J., Skutnik, A., Taranta-Janusz, K., Wasilewska, A., Wi\u015bniewska, N., and Zalewska, A. (2018). Salivary biomarkers of oxidative stress in children with chronic kidney disease. J. Clin. Med., 7.","DOI":"10.3390\/jcm7080209"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Finamore, A., Peluso, I., and Cauli, O. (2020). Salivary stress\/immunological markers in Crohn\u2019s disease and ulcerative colitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228562"},{"key":"ref_222","first-page":"82","article-title":"Estimation of the level of salivary interleukin-6 (IL-6) and its correlation with the clinical parameters in patients with periodontal diseases","volume":"14","author":"Alwan","year":"2015","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"e4710","DOI":"10.7717\/peerj.4710","article-title":"IL-6 and TNF-\u03b1 salivary levels according to the periodontal status in Portuguese pregnant women","volume":"6","author":"Machado","year":"2018","journal-title":"PeerJ"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.4103\/0976-237X.166816","article-title":"Estimation of salivary tumor necrosis factor-alpha in chronic and aggressive periodontitis patients","volume":"6","author":"Varghese","year":"2015","journal-title":"Contemp. Clin. Dent."},{"key":"ref_225","first-page":"151","article-title":"C-reactive protein levels in patients with periodontal disease and normal subjects","volume":"2","author":"Shojaee","year":"2013","journal-title":"Int. J. Mol. Cell Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"9179632","DOI":"10.1155\/2016\/9179632","article-title":"Salivary markers for periodontal and general diseases","volume":"2016","author":"Podzimek","year":"2016","journal-title":"Dis. Markers"},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"T\u00f3thov\u00e1, L., Kamodyov\u00e1, N., \u010cervenka, T., and Celec, P. (2015). Salivary markers of oxidative stress in oral diseases. Front. Cell. Infect. Microbiol., 5.","DOI":"10.3389\/fcimb.2015.00073"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1097\/PRS.0b013e3181f44abc","article-title":"Observational studies: Cohort and case-control studies","volume":"126","author":"Song","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.chest.2020.03.012","article-title":"Cross-sectional studies: Strengths, weaknesses, and recommendations","volume":"158","author":"Wang","year":"2020","journal-title":"Chest"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1742-1241.2009.02056.x","article-title":"Observational studies: A review of study designs, challenges and strategies to reduce confounding","volume":"63","author":"Lu","year":"2009","journal-title":"Int. J. Clin. Pract."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/6871\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:27:54Z","timestamp":1785504474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/6871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":230,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27156871"],"URL":"https:\/\/doi.org\/10.3390\/ijms27156871","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}