{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:49:06Z","timestamp":1785764946826,"version":"3.56.0"},"reference-count":183,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Lavender essential oil (LEO) possesses broad therapeutic potential, yet translating empirical knowledge into evidence-based medicine is hindered by the descriptive literature that conflates isolated monoterpene mechanisms with whole-oil efficacy. Addressing these critical shortcomings, this review presents a target-centric synthesis that explicitly delineates the molecular pathways of pure constituents (e.g., linalool, linalyl acetate) versus intact LEO matrices and standardized oral preparations (Silexan\u2122). We systematically integrate LEO\u2019s multi-target signaling networks across neuroregulatory, analgesic, anti-inflammatory, and skin-regenerative domains, while critically examining how genetic taxonomy, environmental stress, and green extraction technologies dictate chemotype diversity. Furthermore, we candidly address current evidence limitations, including pre-clinical predominance, publication bias, and clinical trial narrowness. Finally, we outline actionable translational strategies centered on chemotype-driven standardization, smart delivery systems, and a dual pharmacological paradigm that valorizes non-volatile processing byproducts. This synthesis establishes a rigorous theoretical foundation for LEO\u2019s clinical translation and pharmaceutical standardization.<\/jats:p>","DOI":"10.3390\/ijms27156931","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:57:56Z","timestamp":1785761876000},"page":"6931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Constituents and Pharmacological Properties of Lavender Essential Oil: Molecular Mechanisms, Current Evidence, and Future Perspectives"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2327-8322","authenticated-orcid":false,"given":"Ketong","family":"Chen","sequence":"first","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of New Materials and Future Technologies, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-8187","authenticated-orcid":false,"given":"Junsong","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-1596","authenticated-orcid":false,"given":"Hua","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"ref_1","first-page":"1934578X1801301037","article-title":"Plants of the Genus Lavandula: From Farm to Pharmacy","volume":"13","author":"Salehi","year":"2018","journal-title":"Nat. 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