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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>An important role of neuroinflammation in the pathogenesis of Parkinson\u2019s disease (PD) has been proposed. Since some microRNAs (miRNAs), and miR-155 in particular, are involved in neuroinflammatory processes, a previous study reported an association between one of the most common single nucleotide variants (SNVs), rs767649, in the MIR155 gene, and risk for PD. The aim of the current study was to replicate this finding in a larger Spanish population case\u2013control series. We analyzed genotype and allele frequencies of the MIR155 rs767649 SNV in a Spanish Caucasian cohort consisting of 459 PD patients and 460 age- and sex-matched healthy controls, using a TaqMan allelic discrimination assay specifically designed for rs767649. The genotype frequencies of the MIR155 rs767649, under codominant, dominant, recessive, and overdominant inheritance models, as well as allelic frequencies, showed no significant differences between PD patients and healthy controls. Likewise, the age at PD onset did not differ among the three MIR-155 rs767649 genotypes. These data did not identify a statistically significant association between MIR155 rs767649 variants and PD risk. However, the low frequency of the variant allele resulted in limited statistical power, and modest genetic effects cannot be excluded.<\/jats:p>","DOI":"10.3390\/ijms27156943","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:57:56Z","timestamp":1785761876000},"page":"6943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of Association Between MIR155 Gene Variant rs767649 and Risk for Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-2210","authenticated-orcid":false,"given":"Hortensia","family":"Alonso-Navarro","sequence":"first","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0706-0179","authenticated-orcid":false,"given":"Sof\u00eda","family":"Ladera-Navarro","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-4022","authenticated-orcid":false,"given":"Pedro","family":"Ayuso","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7493-8777","authenticated-orcid":false,"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[{"name":"Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol, 08916 Badalona, Spain"},{"name":"Department of Neuroscience, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-3935","authenticated-orcid":false,"given":"Ignacio","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-7093","authenticated-orcid":false,"given":"Miquel","family":"Aguilar","sequence":"additional","affiliation":[{"name":"\u00c0ptima Centre Cl\u00ednic Sant Cugat del Vall\u00e8s, 08174 Sant Cugat del Vall\u00e8s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-046X","authenticated-orcid":false,"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-9160","authenticated-orcid":false,"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7323","authenticated-orcid":false,"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1517\/17425255.2016.1158250","article-title":"Advances in Understanding Genomic Markers and Pharmacogenetics of Parkinson\u2019s Disease","volume":"12","year":"2016","journal-title":"Expert Opin. Drug Metab. 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