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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Hypophosphatasia (HPP) is a rare inherited disorder caused by deficient tissue-nonspecific alkaline phosphatase (TNSALP) activity and classically characterized by impaired mineralization processes, although growing evidence suggests broader systemic involvement beyond bone. This cross-sectional study aimed to characterize circulating levels of osteoglycin and sclerostin in patients with HPP and to explore their relationships with TNSALP activity and systemic clinical\u2013biochemical profiles. This cross-sectional study included 25 genetically confirmed HPP patients and 25 age- and sex-matched controls without cardiovascular disease. Circulating osteoglycin and sclerostin were measured by ELISA, and clinical, metabolic, renal, inflammatory, cardiovascular, and bone-related variables were assessed. HPP patients showed lower osteoglycin and higher sclerostin levels compared with controls. Osteoglycin was mainly associated with ALP activity and mineral-related variables, while sclerostin showed broader associations involving glycemic, inflammatory, renal, and cardiovascular domains. In multivariable analyses, osteoglycin was linked to ALP, renal and inflammatory markers, whereas sclerostin was associated with glycemic, mineral, inflammation, and circulatory markers. Overall, osteoglycin variability appeared mainly driven by mineral-related factors, while sclerostin was more influenced by metabolic and inflammatory domains. In conclusion, HPP is associated with an imbalance in circulating bone-derived proteins, characterized by reduced osteoglycin and increased sclerostin, suggesting systemic alterations in bone-related signaling beyond impaired mineralization.<\/jats:p>","DOI":"10.3390\/ijms27157048","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:46:38Z","timestamp":1786009598000},"page":"7048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteoglycin and Sclerostin Imbalance in Hypophosphatasia: Bone-Derived Markers of Mineralization and Systemic Involvement"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9330-8108","authenticated-orcid":false,"given":"Luis","family":"Mart\u00ednez-Heredia","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. 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Granada), 18012 Granada, Spain"},{"name":"Clinical Analysis Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7452-4387","authenticated-orcid":false,"given":"Mar\u00eda Carmen","family":"Andreo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. Granada), 18012 Granada, Spain"},{"name":"Endocrinology and Nutrition Unit, University Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Contreras-Bol\u00edvar","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada (Ibs. 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Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9832","DOI":"10.1038\/s41467-024-53623-5","article-title":"Effect of Genetically Predicted Sclerostin on Cardiovascular Biomarkers, Risk Factors, and Disease Outcomes","volume":"15","author":"Xie","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/ATVBAHA.113.302070","article-title":"Inflammatory, Metabolic, and Genetic Mechanisms of Vascular Calcification","volume":"34","author":"Demer","year":"2014","journal-title":"ATVB"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12933-024-02406-9","article-title":"Bone Proteins Are Associated with Cardiovascular Risk According to the SCORE2-Diabetes Algorithm","volume":"23","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12933-023-02043-8","article-title":"Cardioprotective Function of Sclerostin by Reducing Calcium Deposition, Proliferation, and Apoptosis in Human Vascular Smooth Muscle Cells","volume":"22","author":"Lacal","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18843","DOI":"10.1074\/jbc.274.27.18843","article-title":"The Biology of the Small Leucine-Rich Proteoglycans: Functional Network of Interactive Proteins","volume":"274","author":"Iozzo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11914-019-00523-z","article-title":"Osteoglycin and Bone\u2014A Systematic Review","volume":"17","author":"Viggers","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1096\/fj.201500096R","article-title":"The Diverse Functions of Osteoglycin: A Deceitful Dwarf, or a Master Regulator of Disease?","volume":"30","author":"Deckx","year":"2016","journal-title":"FASEB J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molmet.2018.05.004","article-title":"Osteoglycin, a Novel Coordinator of Bone and Glucose Homeostasis","volume":"13","author":"Lee","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Salvatierra, S., Garc\u00eda-Fontana, C., And\u00fajar-Vera, F., Grau-Perales, A.B., Mart\u00ednez-Heredia, L., Avil\u00e9s-P\u00e9rez, M.D., Hay\u00f3n-Ponce, M., Iglesias-Baena, I., Riquelme-Gallego, B., and Mu\u00f1oz-Torres, M. (2021). Osteoglycin as a Potential Biomarker of Mild Kidney Function Impairment in Type 2 Diabetes Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102209"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sanabria-de la Torre, R., Gonz\u00e1lez-Salvatierra, S., Garc\u00eda-Fontana, C., And\u00fajar-Vera, F., Garc\u00eda-Fontana, B., Mu\u00f1oz-Torres, M., and Riquelme-Gallego, B. (2022). Exploring the Role of Sclerostin as a Biomarker of Cardiovascular Disease and Mortality: A Scoping Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192315981"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Catalano, A., Bellone, F., Morabito, N., and Corica, F. (2020). Sclerostin and Vascular Pathophysiology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134779"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e3069","DOI":"10.1002\/dmrr.3069","article-title":"Sclerostin Is Expressed in the Atherosclerotic Plaques of Patients Who Undergoing Carotid Endarterectomy","volume":"35","author":"Leto","year":"2019","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/0886022X.2020.1741386","article-title":"Association of Sclerostin with Cardiovascular Events and Mortality in Dialysis Patients","volume":"42","author":"Zou","year":"2020","journal-title":"Ren. Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.advms.2025.10.003","article-title":"The Role of Sclerostin in the Development and Progression of Cardiovascular Diseases- a Potential Biomarker?","volume":"70","author":"Stelmaszek","year":"2025","journal-title":"Adv. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1038\/s41467-022-31997-8","article-title":"Targeting Loop3 of Sclerostin Preserves Its Cardiovascular Protective Action and Promotes Bone Formation","volume":"13","author":"Yu","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11914-020-00652-w","article-title":"Romosozumab: A Review of Efficacy, Safety, and Cardiovascular Risk","volume":"19","author":"Fixen","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kvist, A.V., Faruque, J., Vallejo-Yag\u00fce, E., Weiler, S., Winter, E.M., and Burden, A.M. (2021). Cardiovascular Safety Profile of Romosozumab: A Pharmacovigilance Analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS). J. Clin. Med., 10.","DOI":"10.3390\/jcm10081660"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-2-40","article-title":"Hypophosphatasia","volume":"2","author":"Mornet","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1172\/JCI112031","article-title":"Markedly Increased Circulating Pyridoxal-5\u2019-Phosphate Levels in Hypophosphatasia. Alkaline Phosphatase Acts in Vitamin B6 Metabolism","volume":"76","author":"Whyte","year":"1985","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrendo.2016.14","article-title":"Hypophosphatasia\u2014Aetiology, Nosology, Pathogenesis, Diagnosis and Treatment","volume":"12","author":"Whyte","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00198-023-06844-1","article-title":"Hypophosphatasia Diagnosis: Current State of the Art and Proposed Diagnostic Criteria for Children and Adults","volume":"35","author":"Khan","year":"2024","journal-title":"Osteoporos. Int."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Andreo-L\u00f3pez, M.C., Contreras-Bol\u00edvar, V., Mart\u00ednez-Heredia, L., And\u00fajar-Vera, F., Becerra-Garc\u00eda, D., Gonz\u00e1lez-Cejudo, T., Gonz\u00e1lez-Salvatierra, S., Garc\u00eda-Fontana, C., Garc\u00eda-Fontana, B., and Mu\u00f1oz-Torres, M. (2025). Alkaline Phosphatase as a Potential Biomarker of Muscle Function: A Pilot Study in Patients with Hypophosphatasia. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136153"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Heredia, L., Mu\u00f1oz-Torres, M., Sanabria-de La Torre, R., Jim\u00e9nez-Ortas, \u00c1., And\u00fajar-Vera, F., Gonz\u00e1lez-Cejudo, T., Contreras-Bol\u00edvar, V., Gonz\u00e1lez-Salvatierra, S., G\u00f3mez-Vida, J.M., and Garc\u00eda-Fontana, C. (2024). Systemic Effects of Hypophosphatasia Characterization of Two Novel Variants in the ALPL Gene. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1320516"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liedtke, D., Hofmann, C., Jakob, F., Klopocki, E., and Graser, S. (2020). Tissue-Nonspecific Alkaline Phosphatase\u2014A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease. Biomolecules, 10.","DOI":"10.3390\/biom10121648"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1272\/jnms.77.4","article-title":"The Mechanism of Mineralization and the Role of Alkaline Phosphatase in Health and Disease","volume":"77","author":"Orimo","year":"2010","journal-title":"J. Nippon. Med. Sch."},{"key":"ref_27","first-page":"1555","article-title":"Matrix Vesicles in Osteomalacic Hypophosphatasia Bone Contain Apatite-like Mineral Crystals","volume":"151","author":"Anderson","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbagen.2017.11.005","article-title":"Matrix Vesicles from Chondrocytes and Osteoblasts: Their Biogenesis, Properties, Functions and Biomimetic Models","volume":"1862","author":"Bottini","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) -General. Subj."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.31662\/jmaj.2024-0138","article-title":"High Prevalence of Nephrocalcinosis in Hypophosphatasia Patients with the ALPL c.1559del Gene Variant","volume":"8","author":"Kawashima","year":"2025","journal-title":"JMA J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1111\/febs.12136","article-title":"The Regulatory Roles of Small Leucine-Rich Proteoglycans in Extracellular Matrix Assembly","volume":"280","author":"Chen","year":"2013","journal-title":"FEBS J."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nulali, J., Zhan, M., Zhang, K., Tu, P., Liu, Y., and Song, H. (2022). Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis. Biomolecules, 12.","DOI":"10.3390\/biom12111674"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bone.2016.11.007","article-title":"Association of Osteoglycin and FAM5C with Bone Turnover Markers, Bone Mineral Density, and Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus","volume":"95","author":"Tanaka","year":"2017","journal-title":"Bone"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.7150\/thno.27372","article-title":"Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6\/GSK3\u03b2 Complex in Hypophosphatasia","volume":"8","author":"Liu","year":"2018","journal-title":"Theranostics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41536-025-00404-3","article-title":"Fibroblast-Derived Osteoglycin Promotes Epithelial Cell Repair","volume":"10","author":"Woest","year":"2025","journal-title":"npj Regen. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bone.2016.11.024","article-title":"Sclerostin Expression and Functions beyond the Osteocyte","volume":"96","author":"Weivoda","year":"2017","journal-title":"Bone"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbmr.217","article-title":"Relation of Age, Gender, and Bone Mass to Circulating Sclerostin Levels in Women and Men","volume":"26","author":"Hoey","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/jc.2011-2152","article-title":"Sclerostin and Its Association with Physical Activity, Age, Gender, Body Composition, and Bone Mineral Content in Healthy Adults","volume":"97","author":"Amrein","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E1854","DOI":"10.1210\/jc.2014-2042","article-title":"Serum Sclerostin and Adverse Outcomes in Nondialyzed Chronic Kidney Disease Patients","volume":"99","author":"Kanbay","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Donham, C., Chicana, B., Robling, A.G., Mohamed, A., Elizaldi, S., Chi, M., Freeman, B., Millan, A., Murugesh, D.K., and Hum, N.R. (2021). Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179111"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/7048\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:47:23Z","timestamp":1786009643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/7048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":39,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27157048"],"URL":"https:\/\/doi.org\/10.3390\/ijms27157048","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}