{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:44:16Z","timestamp":1786164256724,"version":"build-2736575974"},"reference-count":119,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372994"],"award-info":[{"award-number":["32372994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32372994"],"award-info":[{"award-number":["32372994"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2020MH279"],"award-info":[{"award-number":["ZR2020MH279"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>As an important member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, ADAMTS16 participates in various physiological and pathological processes through the regulation of extracellular matrix (ECM) components. This review systematically delineates the expression profiles of ADAMTS16 in different tissues and cell types, as well as its diverse roles in reproductive development, cardiovascular diseases, ocular diseases, skeletal disorders, malignancies, and other pathological conditions, revealing significant differences in its expression patterns and mechanisms of action across various tissues. Cumulatively, current evidence suggests that ADAMTS16 may engage in direct or indirect interactions with ECM constituents to regulate cell proliferation, differentiation, and migration, and may also influence a range of cellular activities via synergistic cooperation with other cytokines.<\/jats:p>","DOI":"10.3390\/ijms27157050","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:46:38Z","timestamp":1786009598000},"page":"7050","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Advances in the Physiological Roles and Disease-Associated Mechanisms of ADAMTS16"],"prefix":"10.3390","volume":"27","author":[{"given":"Linxiu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan 250022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan 250022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2520-5055","authenticated-orcid":false,"given":"Yuying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan 250022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1074\/jbc.272.1.556","article-title":"Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene","volume":"272","author":"Kuno","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Th\u00e9ret, N., Bouezzedine, F., Azar, F., Diab-Assaf, M., and Legagneux, V. (2021). ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment. Cancers, 13.","DOI":"10.3390\/cancers13071563"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/112_2021_67","article-title":"The Biochemistry and Physiology of A Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies","volume":"184","author":"Sharma","year":"2023","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhou, R., Zhao, T., Xiang, D., and Gong, X. (2026). The ADAM Family of Proteases: Structure, Substrates, and Roles in Liver Diseases. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27041626"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"120137","DOI":"10.1016\/j.bbamcr.2026.120137","article-title":"ADAM proteases in cytokine biology: Modulators of immune signaling, inflammation and cancer","volume":"1873","author":"Khattab","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.mucimm.2025.09.003","article-title":"Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling","volume":"18","author":"Fuhr","year":"2025","journal-title":"Mucosal Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e113\u20132025","DOI":"10.1152\/function.113.2025","article-title":"Endothelial CD44 cleavage by ADAM17 impairs shear stress mechanotransduction","volume":"7","author":"Power","year":"2026","journal-title":"Function"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2023.07.010","article-title":"AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation","volume":"675","author":"Baek","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/HYPERTENSIONAHA.122.19411","article-title":"Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway","volume":"80","author":"Aujla","year":"2023","journal-title":"Hypertension"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41420-023-01744-z","article-title":"Role of ADAM and ADAMTS proteases in pathological tissue remodeling","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mohamedi, Y., Fontanil, T., Cal, S., Cobo, T., and Obaya, \u00c1.J. (2021). ADAMTS-12: Functions and Challenges for a Complex Metalloprotease. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.686763"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"147169","DOI":"10.1016\/j.gene.2023.147169","article-title":"Secreted protease ADAMTS18 in development and disease","volume":"858","author":"Nie","year":"2023","journal-title":"Gene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"200333","DOI":"10.1098\/rsob.200333","article-title":"ADAMTS proteases in cardiovascular physiology and disease","volume":"10","author":"Santamaria","year":"2020","journal-title":"Open Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s11033-026-11493-8","article-title":"TNF-\u03b1 orchestrates ADAM metallopeptidase with thrombospondin type 1 motif 2 upregulation and extracellular matrix remodeling through multimodal signaling in osteosarcoma cells","volume":"53","author":"Aymaz","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100186","DOI":"10.1016\/j.mbplus.2025.100186","article-title":"Generation of a conditional Adamts6 mouse allele reveals roles in lung maturation in addition to cardiac and musculoskeletal development","volume":"28","author":"Sirek","year":"2025","journal-title":"Matrix Biol. Plus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000521498","article-title":"The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities","volume":"59","author":"Novak","year":"2022","journal-title":"J. Vasc. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.2147\/OTT.S248085","article-title":"ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"Onco Targets Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2020.01.020","article-title":"ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor","volume":"524","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1089\/dna.2020.6053","article-title":"ADAMTS8 Inhibits Progression of Esophageal Squamous Cell Carcinoma","volume":"39","author":"Wu","year":"2020","journal-title":"DNA Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yang, S., Cheng, M., Zhang, S., Wang, H., Wang, J., Zhang, X., Mi, Y., and Li, S. (2025). DNMT3A facilitates breast cancer progression via regulating ADAMTS8 mediated EGFR-MEK-ERK activation. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0321889"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/00220345211029270","article-title":"Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice","volume":"101","author":"Yang","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"112144","DOI":"10.1016\/j.cellsig.2025.112144","article-title":"Fibroblast-secreted ADAMTSL2 promotes cardiac repair after myocardial infarction by activating LRP6\/\u03b2-catenin signaling","volume":"136","author":"Wang","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112319","DOI":"10.1016\/j.cellsig.2025.112319","article-title":"ADAMTSL2 facilitates ACLY-mediated lipid metabolism in colorectal cancer by activating Notch signaling pathway","volume":"139","author":"He","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-1119(01)00861-7","article-title":"Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains","volume":"283","author":"Cal","year":"2002","journal-title":"Gene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13059-015-0676-3","article-title":"The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family","volume":"16","author":"Kelwick","year":"2015","journal-title":"Genome Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41598-025-29549-3","article-title":"Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: Applications in osteoarthritis and ovarian cancer models","volume":"16","author":"Cuffaro","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biochi.2022.06.001","article-title":"Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5","volume":"201","author":"Yu","year":"2022","journal-title":"Biochimie"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.joca.2021.08.012","article-title":"Pharmacological characterization of GLPG1972\/S201086, a potent and selective small-molecule inhibitor of ADAMTS5","volume":"30","author":"Little","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119190","DOI":"10.1016\/j.atherosclerosis.2025.119190","article-title":"Loss of ADAMTS5 promotes vascular calcification via versican\/integrin \u03b21\/FAK signal","volume":"404","author":"Zhu","year":"2025","journal-title":"Atherosclerosis"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1111\/febs.70080","article-title":"The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25","volume":"292","author":"Yuan","year":"2025","journal-title":"FEBS J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"C651","DOI":"10.1152\/ajpcell.00443.2025","article-title":"Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regeneration","volume":"330","author":"Dulos","year":"2026","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jiang, L., Lin, J., Zhao, S., Wu, J., Jin, Y., Yu, L., Wu, N., Wu, Z., Wang, Y., and Lin, M. (2021). ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.703110"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101686","DOI":"10.1016\/j.gendis.2025.101686","article-title":"ADAMTS2: More than a procollagen N-proteinase","volume":"12","author":"Vanlerberghe","year":"2025","journal-title":"Genes Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112450","DOI":"10.1016\/j.cellsig.2026.112450","article-title":"Silencing Adamts2 attenuates fibroblast-mediated fibrosis and promotes axonal regeneration in an in vitro model","volume":"143","author":"Chen","year":"2026","journal-title":"Cell. Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101132","DOI":"10.1016\/j.jbc.2021.101132","article-title":"Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity","volume":"297","author":"Ercig","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/17474086.2024.2356763","article-title":"Novel mechanisms of action of emerging therapies of hereditary thrombotic thrombocytopenic purpura","volume":"17","author":"Zheng","year":"2024","journal-title":"Expert Rev. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1182\/blood.2025030791","article-title":"Thrombotic thrombocytopenic purpura: Celebrating 25 years of ADAMTS13","volume":"147","author":"Scully","year":"2026","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bja.2025.07.092","article-title":"A novel role for ADAMTS13 in hyperfibrinolysis after trauma-induced shock\u2606","volume":"136","author":"Sloos","year":"2026","journal-title":"Br. J. Anaesth."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1136\/annrheumdis-2013-203561","article-title":"ADAMTS-7 forms a positive feedback loop with TNF-\u03b1 in the pathogenesis of osteoarthritis","volume":"73","author":"Lai","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"801546","DOI":"10.1155\/2015\/801546","article-title":"The Function and Roles of ADAMTS-7 in Inflammatory Diseases","volume":"2015","author":"Zhang","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e187451","DOI":"10.1172\/JCI187451","article-title":"ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis","volume":"136","author":"Chung","year":"2026","journal-title":"J. Clin. Investig."},{"key":"ref_42","first-page":"100288","article-title":"ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration","volume":"11","author":"Mead","year":"2025","journal-title":"J. Mol. Cell. Cardiol. Plus"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Karoulias, S.Z., Taye, N., Stanley, S., and Hubmacher, D. (2020). The ADAMTS\/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases. Biomolecules, 10.","DOI":"10.3390\/biom10040596"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35956","DOI":"10.1038\/srep35956","article-title":"ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions","volume":"6","author":"Cain","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e71142","DOI":"10.7554\/eLife.71142","article-title":"Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development","volume":"11","author":"Mead","year":"2022","journal-title":"eLife"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.matbio.2018.09.004","article-title":"Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage","volume":"77","author":"Wang","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1074\/mcp.RA118.000676","article-title":"A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis","volume":"17","author":"Schnellmann","year":"2018","journal-title":"Mol. Cell. Proteom."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"41871","DOI":"10.1038\/srep41871","article-title":"Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease","volume":"7","author":"Hubmacher","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"110844","DOI":"10.1016\/j.jbc.2025.110844","article-title":"A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) cleaves fibronectin and negatively regulates its fibrillogenesis","volume":"301","author":"Barbiera","year":"2025","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Rose, K.W.J., Taye, N., Karoulias, S.Z., and Hubmacher, D. (2021). Regulation of ADAMTS Proteases. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.701959"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100542","DOI":"10.1016\/j.repbio.2021.100542","article-title":"ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice","volume":"21","author":"Lin","year":"2021","journal-title":"Reprod. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jpedsurg.2019.12.019","article-title":"Interplay between collagenase and undescended testes in Adamts16 knockout rats","volume":"55","author":"Sarila","year":"2020","journal-title":"J. Pediatr. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/cvr\/cvz187","article-title":"ADAMTS16 activates latent TGF-\u03b2, accentuating fibrosis and dysfunction of the pressure-overloaded heart","volume":"116","author":"Yao","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"111347","DOI":"10.1016\/j.cellsig.2024.111347","article-title":"A novel role of ADAMTS16 in renal fibrosis through activating TGF-\u03b2\/Smad signaling","volume":"122","author":"Zhao","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s42003-025-08320-4","article-title":"The secreted protease ADAMTS18 is a novel activator of latent TGF-\u03b2 to exacerbate renal fibrosis","volume":"8","author":"Wang","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Xu, B., Zhang, J.E., Ye, L., and Yuan, C.W. (2024). The Role of the ADAMTS18 Gene-Induced Immune Microenvironment in Mouse Kidney Development. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020396"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ydbio.2019.06.012","article-title":"Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease","volume":"454","author":"Rutledge","year":"2019","journal-title":"Dev. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/s41467-020-15357-y","article-title":"The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche","volume":"11","author":"Ataca","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_59","first-page":"2173","article-title":"Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta","volume":"54","author":"Bonnier","year":"2011","journal-title":"Hepatology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1074\/jbc.RA119.007492","article-title":"Proteomic discovery of substrates of the cardiovascular protease ADAMTS7","volume":"294","author":"Colige","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/molehr\/gam037","article-title":"FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles","volume":"13","author":"Gao","year":"2007","journal-title":"Mol. Hum. Reprod."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kordowski, F., Kolarova, J., Schafmayer, C., Buch, S., Goldmann, T., Marwitz, S., Kugler, C., Scheufele, S., Gassling, V., and N\u00e9meth, C.G. (2018). Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4701-2"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/art.11433","article-title":"Expression profiling of metalloproteinases and their inhibitors in cartilage","volume":"50","author":"Kevorkian","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/j.1349-7006.2009.01477.x","article-title":"Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma","volume":"101","author":"Sakamoto","year":"2010","journal-title":"Cancer Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/hmg\/ddp218","article-title":"Positional identification of variants of Adamts16 linked to inherited hypertension","volume":"18","author":"Joe","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1134\/S1022795423140120","article-title":"Screening and analysis of twin genes in ovarian tissue of Yanshan cashmere goat","volume":"59","author":"Xie","year":"2023","journal-title":"Russ. J. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"18811","DOI":"10.1074\/jbc.M113.464644","article-title":"Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development","volume":"288","author":"Jacobi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17195","DOI":"10.1038\/s41598-019-53900-0","article-title":"Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight","volume":"9","author":"Livermore","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1745-7580-4-5","article-title":"Expression analysis of G Protein-Coupled Receptors in mouse macrophages","volume":"4","author":"Lattin","year":"2008","journal-title":"Immunome Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/ar2013","article-title":"Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage","volume":"8","author":"Davidson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"ref_71","first-page":"425","article-title":"The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections","volume":"62","author":"Akpinar","year":"2016","journal-title":"Clin. Lab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41419-024-07226-z","article-title":"ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-\u03b21 activation in lung adenocarcinoma","volume":"15","author":"Xiao","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_73","first-page":"255","article-title":"The Investigation of ADAMTS16 in Insulin-Induced Human Chondrosarcoma Cells","volume":"30","author":"Cakmak","year":"2015","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Li, T., Zhou, J., Jiang, Y., Zhao, Y., Huang, J., Li, W., Huang, Z., Chen, Z., Tang, X., and Chen, H. (2022). The Novel Protein ADAMTS16 Promotes Gastric Carcinogenesis by Targeting IFI27 through the NF-\u03bab Signaling Pathway. Int. J. Mol. Sci., 23.","DOI":"10.21203\/rs.3.rs-1792512\/v1"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bbagen.2006.01.013","article-title":"Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18","volume":"1760","author":"Zeng","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/CIRCULATIONAHA.123.065458","article-title":"Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation","volume":"149","author":"Lin","year":"2024","journal-title":"Circulation"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1038\/s41598-019-47494-w","article-title":"Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis","volume":"9","author":"Santamaria","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5653\/cerm.2014.41.3.120","article-title":"Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure","volume":"41","author":"Pyun","year":"2014","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/GME.0000000000000172","article-title":"Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure","volume":"21","author":"Pyun","year":"2014","journal-title":"Menopause"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/hmg\/ddy325","article-title":"Epigenetic changes in preterm birth placenta suggest a role for ADAMTS genes in spontaneous preterm birth","volume":"28","author":"Mani","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"204023","DOI":"10.1016\/j.cdev.2025.204023","article-title":"Extracellular matrix in cardiac morphogenesis, fibrosis, and regeneration","volume":"182","author":"Punde","year":"2025","journal-title":"Cells Dev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"20555","DOI":"10.1073\/pnas.1211290109","article-title":"Targeted disruption of Adamts16 gene in a rat genetic model of hypertension","volume":"109","author":"Gopalakrishnan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s12012-022-09745-7","article-title":"Bone Marrow Mesenchymal Stem Cell-Derived Exosomal microRNA-29b-3p Promotes Angiogenesis and Ventricular Remodeling in Rats with Myocardial Infarction by Targeting ADAMTS16","volume":"22","author":"Zheng","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Chan, B.H.C., Moosajee, M., and Rainger, J. (2021). Closing the Gap: Mechanisms of Epithelial Fusion During Optic Fissure Closure. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.620774"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1167\/iovs.17-22827","article-title":"Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure","volume":"59","author":"Cao","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"100092","DOI":"10.1016\/j.mcpro.2021.100092","article-title":"The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development","volume":"20","author":"Cirksena","year":"2021","journal-title":"Mol. Cell. Proteom."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1074\/jbc.M008073200","article-title":"C-mannosylation and O-fucosylation of the thrombospondin type 1 module","volume":"276","author":"Hofsteenge","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/glycob\/cwad006","article-title":"O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules","volume":"33","author":"Berardinelli","year":"2023","journal-title":"Glycobiology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s43657-022-00082-x","article-title":"A Genome-Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes","volume":"3","author":"Lu","year":"2022","journal-title":"Phenomics"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Michelacci, Y.M., Baccarin, R.Y.A., and Rodrigues, N.N.P. (2023). Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions. Life, 13.","DOI":"10.3390\/life13071460"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"120555","DOI":"10.1016\/j.biomaterials.2020.120555","article-title":"The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration","volume":"268","author":"Peng","year":"2021","journal-title":"Biomaterials"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"320","DOI":"10.22203\/eCM.v023a25","article-title":"Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells","volume":"23","author":"Boeuf","year":"2012","journal-title":"Eur. Cell Mater."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.matbio.2009.07.001","article-title":"Characterization and regulation of ADAMTS-16","volume":"28","author":"Surridge","year":"2009","journal-title":"Matrix Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/jbmr.3698","article-title":"Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry","volume":"34","author":"Hsu","year":"2019","journal-title":"J. Bone Min. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1186\/s13018-021-02658-1","article-title":"Potential genes and pathways associated with heterotopic ossification derived from analyses of gene expression profiles","volume":"16","author":"Yang","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zhang, D., Qian, C., Wei, H., and Qian, X. (2020). Identification of the Prognostic Value of Tumor Microenvironment-Related Genes in Esophageal Squamous Cell Carcinoma. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.599475"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"88410","DOI":"10.18632\/oncotarget.11120","article-title":"ADAMTS16 mutations sensitize ovarian cancer cells to platinum-based chemotherapy","volume":"8","author":"Yasukawa","year":"2016","journal-title":"Oncotarget"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/pin.13327","article-title":"ADAM metallopeptidase with thrombospondin type 1 motif 16 is a potential marker for prognosis in clear cell renal cell carcinoma","volume":"73","author":"Bai","year":"2023","journal-title":"Pathol. Int."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2174\/0113862073321326240718063755","article-title":"ADAMTS16 Suppression by MicroRNA-25 Leads to Oncogenic Properties in Renal Cell Carcinoma","volume":"28","author":"Huang","year":"2025","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"108640","DOI":"10.1016\/j.pharmthera.2024.108640","article-title":"Therapeutic targeting of DNA methylation alterations in cancer","volume":"258","author":"Lee","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3892\/ol.2022.13352","article-title":"Cancer stem cell marker expression and methylation status in patients with colorectal cancer","volume":"24","author":"Mersakova","year":"2022","journal-title":"Oncol. Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"119563","DOI":"10.1016\/j.envpol.2022.119563","article-title":"Epigenome-wide DNA methylation signature of plasma zinc and their mediation roles in the association of zinc with lung cancer risk","volume":"307","author":"Meng","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Titmarsh, H.F., von Kriegsheim, A., Wills, J.C., O\u2019Connor, R.A., Dhaliwal, K., Frame, M.C., Pattle, S.B., Dorward, D.A., Byron, A., and Akram, A.R. (2023). Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1194515"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3892\/ol.2023.13842","article-title":"Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma","volume":"25","author":"Jiang","year":"2023","journal-title":"Oncol. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e7383","DOI":"10.1002\/cam4.7383","article-title":"Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules","volume":"13","author":"Zhou","year":"2024","journal-title":"Cancer Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ajmg.b.32190","article-title":"Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia","volume":"162","author":"McGrath","year":"2013","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Garcia, J.P.T., and Tayo, L.L. (2024). Codes between Poles: Linking Transcriptomic Insights into the Neurobiology of Bipolar Disorder. Biology, 13.","DOI":"10.3390\/biology13100787"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s00125-025-06395-6","article-title":"As members of the H3Africa AWI-Gen study. Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort","volume":"68","author":"Chebii","year":"2025","journal-title":"Diabetologia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.jhsa.2008.04.002","article-title":"Metalloproteinase gene expression correlates with clinical outcome in Dupuytren\u2019s disease","volume":"33","author":"Johnston","year":"2008","journal-title":"J. Hand Surg. Am."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Hu, C., Feng, X., Ma, Y., Wei, D., Zhang, L., Wang, S., and Ma, Y. (2023). CircADAMTS16 Inhibits Differentiation and Promotes Proliferation of Bovine Adipocytes by Targeting miR-10167-3p. Cells, 12.","DOI":"10.3390\/cells12081175"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"124797","DOI":"10.1016\/j.jchromb.2025.124797","article-title":"ADAMTS16 and TRPV5: New targets of Zhenwu decoction on renal fibrosis investigated by chemomics and transcriptomics","volume":"1267","author":"Ren","year":"2025","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10120-018-0866-2","article-title":"ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer","volume":"22","author":"Huang","year":"2019","journal-title":"Gastric Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41419-021-03628-5","article-title":"DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/cam4.1076","article-title":"Epigenetic silencing of ADAMTS18 promotes cell migration and invasion of breast cancer through AKT and NF-\u03baB signaling","volume":"6","author":"Xu","year":"2017","journal-title":"Cancer Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1159\/000485534","article-title":"ADAMTS9 is Silenced by Epigenetic Disruption in Colorectal Cancer and Inhibits Cell Growth and Metastasis by Regulating Akt\/p53 Signaling","volume":"44","author":"Chen","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.matbio.2022.11.001","article-title":"ADAMTS6 cleaves the large latent TGF\u03b2 complex and increases the mechanotension of cells to activate TGF\u03b2","volume":"114","author":"Cain","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41586-019-1064-z","article-title":"Genetic compensation triggered by mutant mRNA degradation","volume":"568","author":"Kontarakis","year":"2019","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"dev186452","DOI":"10.1242\/dev.186452","article-title":"Transcriptional adaptation: A mechanism underlying genetic robustness","volume":"147","author":"Sztal","year":"2020","journal-title":"Development"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Mead, T.J. (2022). ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.1023511"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/7050\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:25:53Z","timestamp":1786163153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/15\/7050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":119,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27157050"],"URL":"https:\/\/doi.org\/10.3390\/ijms27157050","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}