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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Spinal cord injury (SCI) is among the most devastating neurological conditions worldwide, imposing substantial clinical, psychological, and socioeconomic burdens on affected individuals and healthcare services. However, a translational gap persists between preclinical findings and therapeutically relevant human applications, partly involving the limitations of conventional two-dimensional culture systems, which inadequately reproduce the complex three-dimensional structure of the spinal cord; and partly due to the fact that animal models differ from humans phylogenetically and physiologically. Recent advances in three-dimensional spinal cord organoids and organoid-on-a-chip microfluidic platforms have provided new opportunities to model human spinal cord biology with greater fidelity. This review discusses the clinical and socioeconomic burden of SCI, identifies the limitations of existing experimental platforms, and explains how microfluidics and scaffold technologies may converge to accelerate the development of regenerative therapies. It also summarizes methodological innovations, recent advances, unresolved challenges, and future prospects in this rapidly evolving field.<\/jats:p>","DOI":"10.3390\/ijms27157060","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:03:27Z","timestamp":1786021407000},"page":"7060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emerging Regenerative Medicine for Spinal Cord Injury: Spinal Cord Organoids-on-a-Chip"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-8025","authenticated-orcid":false,"given":"Manzar","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of MetaBioHealth, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareer","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of MetaBioHealth, Sungkyunkwan University, Suwon 16419, Republic of Korea"},{"name":"Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Republic of Korea"},{"name":"Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-9325","authenticated-orcid":false,"given":"Inbo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam-si 13488, Republic of Korea"},{"name":"Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.14245\/ns.2448546.273","article-title":"Modulation of the LIMK Pathway by Myricetin: A Protective Strategy Against Neurological Impairments in Spinal Cord Injury","volume":"21","author":"Roy","year":"2024","journal-title":"Neurospine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123422","DOI":"10.1016\/j.biomaterials.2025.123422","article-title":"Recent advances in nanotechnology for repairing spinal cord injuries","volume":"323","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41598-024-52210-4","article-title":"Epidemiology features of traumatic and non-traumatic spinal cord injury in China, Wuhan","volume":"14","author":"Khadour","year":"2024","journal-title":"Sci. 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