{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:34:35Z","timestamp":1786354475927,"version":"build-2736575974"},"reference-count":146,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Metabolic syndrome (MetS) is a complex multisystem disorder characterized by insulin resistance, central obesity, dyslipidemia, hypertension, and chronic low-grade inflammation, all of which substantially increase the risk of type 2 diabetes mellitus and cardiovascular disease. The aim of this narrative review is to examine the role of vitamin D in the pathophysiology of MetS from a multisystem perspective. Specifically, it synthesizes current evidence on the molecular mechanisms through which vitamin D may influence inter-organ communication, insulin resistance, adipose tissue dysfunction, hepatic metabolism, skeletal muscle function, chronic inflammation, oxidative stress, and mitochondrial homeostasis, highlighting its potential contribution to the prevention and management of MetS. Current evidence indicates that MetS should not be regarded merely as a cluster of isolated metabolic abnormalities but rather as a disorder characterized by disrupted molecular signaling and impaired communication among metabolically active organs. In this context, experimental and preclinical evidence suggests that vitamin D, through activation of the vitamin D receptor (VDR), modulates key signaling pathways, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), nuclear factor kappa B (NF-\u03baB), and peroxisome proliferator-activated receptor gamma (PPAR-\u03b3), thereby influencing insulin sensitivity, inflammation, oxidative stress, mitochondrial function, and metabolic homeostasis. Nevertheless, clinical evidence remains heterogeneous due, in part, to the lack of consensus regarding serum 25-hydroxyvitamin D thresholds for defining vitamin D status, as well as differences in baseline vitamin D concentrations, supplementation regimens, study populations, and methodological designs. Overall, the available evidence suggests that vitamin D should be considered an adjunct to lifestyle-based interventions rather than a stand-alone therapeutic strategy. Future research is warranted to clarify its clinical utility in the prevention and management of MetS.<\/jats:p>","DOI":"10.3390\/ijms27167101","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:24:53Z","timestamp":1786353893000},"page":"7101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D and Metabolic Syndrome: Molecular Mechanisms and Clinical Implications: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-0848","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Fuentes-Barr\u00eda","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CEIMA), Universidad Arturo Prat, Iquique 1110939, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4123-4255","authenticated-orcid":false,"given":"Ra\u00fal","family":"Aguilera-Egu\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica, Facultad de Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 3349001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alarc\u00f3n-Rivera","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de investigaci\u00f3n, Universidad Bernardo O\u2019Higgins, Santiago 8370993, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-7157","authenticated-orcid":false,"given":"Cherie","family":"Flores-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Gesti\u00f3n de la Informaci\u00f3n, Universidad Tecnol\u00f3gica Metropolitana, Santiago 7550000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21501319241309168","DOI":"10.1177\/21501319241309168","article-title":"Metabolic Syndrome: An Updated Review on Diagnosis and Treatment for Primary Care Clinicians","volume":"15","author":"Peterseim","year":"2024","journal-title":"J. Prim. Care Community Health"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Theodorakis, N., and Nikolaou, M. (2025). From Cardiovascular-Kidney-Metabolic Syndrome to Cardiovascular-Renal-Hepatic-Metabolic Syndrome: Proposing an Expanded Framework. Biomolecules, 15.","DOI":"10.3390\/biom15020213"},{"key":"ref_3","first-page":"e67428","article-title":"A Comprehensive Review of Metabolic Syndrome and Its Role in Cardiovascular Disease and Type 2 Diabetes Mellitus: Mechanisms, Risk Factors, and Management","volume":"16","author":"Dhondge","year":"2024","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-63657-8_1","article-title":"The Definition and Prevalence of Obesity and Metabolic Syndrome: Correlative Clinical Evaluation Based on Phenotypes","volume":"1460","author":"Engin","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s40256-025-00761-w","article-title":"Definition, Classification, Diagnosis, and Management of an Emerging Threat: Cardio-Renal-Metabolic Syndrome","volume":"26","author":"Koufakis","year":"2026","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.nefro.2024.05.001","article-title":"Cardiovascular-kidney-metabolic syndrome definition and its role in the prevention, risk staging, and treatment. An opportunity for the Nephrology","volume":"44","author":"Cases","year":"2024","journal-title":"Nefrol. (Engl. Ed.)"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12933-025-02854-x","article-title":"Association of novel triglyceride-glucose-related indices with incident stroke in early-stage cardiovascular-kidney-metabolic syndrome","volume":"24","author":"Yue","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000545032","article-title":"Clinical Investigations and Therapeutic Perspectives on Metabolic Syndrome following Kidney Transplantation","volume":"50","author":"Zhu","year":"2025","journal-title":"Kidney Blood Press. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.dsx.2020.06.006","article-title":"Skeletal muscle\u2014A bystander or influencer of metabolic syndrome?","volume":"14","author":"Fenning","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-3-031-63657-8_8","article-title":"Adipose Tissue Dysfunction Determines Lipotoxicity and Triggers the Metabolic Syndrome: Current Challenges and Clinical Perspectives","volume":"1460","author":"Carobbio","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00784-025-06161-3","article-title":"Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review","volume":"29","author":"Zhu","year":"2025","journal-title":"Clin. Oral Investig."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Todosenko, N., Khaziakhmatova, O., Malashchenko, V., Yurova, K., Bograya, M., Beletskaya, M., Vulf, M., Gazatova, N., and Litvinova, L. (2023). Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512012"},{"key":"ref_13","first-page":"384","article-title":"From Metabolic Syndrome to Cardiovascular-Kidney-Metabolic Syndrome and Systemic Metabolic Disorder: A Call to Recognize the Progressive Multisystemic Dysfunction","volume":"29","author":"Erol","year":"2025","journal-title":"Anatol. J. Cardiol."},{"key":"ref_14","first-page":"E18715303385742","article-title":"The Inflammatory Response in Metabolic Syndrome","volume":"26","year":"2026","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41590-023-01479-0","article-title":"Macrophage function in adipose tissue homeostasis and metabolic inflammation","volume":"24","author":"Chavakis","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Apaza, C.J., Cerezo, J.F., Garc\u00eda-Tejedor, A., Gim\u00e9nez-Bastida, J.A., and Laparra-Llopis, J.M. (2024). Revisiting the Immunometabolic Basis for the Metabolic Syndrome from an Immunonutritional View. Biomedicines, 12.","DOI":"10.3390\/biomedicines12081825"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fuentes-Barr\u00eda, H., Aguilera-Egu\u00eda, R., Flores-Fern\u00e1ndez, C., Angarita-Davila, L., and Alarc\u00f3n-Rivera, M. (2026). Exercise as a Molecular Therapeutic Tool in MASLD: From Signaling Pathways to Clinical Translation\u2014A Narrative Review. Biomedicines, 14.","DOI":"10.3390\/biomedicines14030577"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7570\/jomes23052","article-title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review","volume":"32","author":"Chan","year":"2023","journal-title":"J. Obes. Metab. Syndr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/CIRCRESAHA.125.325497","article-title":"In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome","volume":"136","author":"Juguilon","year":"2025","journal-title":"Circ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1172\/JCI129193","article-title":"Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome","volume":"129","author":"Kita","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Burganova, G., Bridges, C., Thorn, P., and Landsman, L. (2021). The Role of Vascular Cells in Pancreatic Beta-Cell Function. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.667170"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2023.11.019","article-title":"Associations between metabolic syndrome and anxiety, and the mediating role of inflammation: Findings from the UK Biobank","volume":"116","author":"Cen","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chen, Y., Ju, H., Xie, K., and Zhao, X. (2024). Association of inflammatory score with all-cause and cardiovascular mortality in patients with metabolic syndrome: NHANES longitudinal cohort study. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1410871"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Feng, Z., Tan, Z., and Lu, D. (2025). Mitochondrial bioenergetics dysfunction in T2DM: Linking oxidative stress to insulin resistance. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1674477"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Acierno, C., Nevola, R., Barletta, F., Rinaldi, L., Sasso, F.C., Adinolfi, L.E., and Caturano, A. (2025). Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship. Biomedicines, 13.","DOI":"10.3390\/biomedicines13061343"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"174079","DOI":"10.1016\/j.ejphar.2021.174079","article-title":"JNK signaling pathway in metabolic disorders: An emerging therapeutic target","volume":"901","author":"Garg","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tcb.2017.01.006","article-title":"Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-\u03baB","volume":"27","author":"Catrysse","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI67227","article-title":"AMPK, insulin resistance, and the metabolic syndrome","volume":"123","author":"Ruderman","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fuentes-Barr\u00eda, H., Aguilera-Egu\u00eda, R., Angarita-Davila, L., Rojas-G\u00f3mez, D., Alarc\u00f3n-Rivera, M., L\u00f3pez-Soto, O., Maureira-S\u00e1nchez, J., Berm\u00fadez, V., Rivera-Porras, D., and Contreras-Vel\u00e1zquez, J.C. (2025). Vitamin D and Sarcopenia: Implications for Muscle Health. Biomedicines, 13.","DOI":"10.3390\/biomedicines13081863"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fuentes-Barr\u00eda, H., Aguilera-Egu\u00eda, R., Flores-Fern\u00e1ndez, C., Angarita-Davila, L., Rojas-G\u00f3mez, D., Alarc\u00f3n-Rivera, M., L\u00f3pez-Soto, O., and Maureira-S\u00e1nchez, J. (2025). Vitamin D and Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Implications\u2014A Narrative Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052153"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Fuentes-Barr\u00eda, H., Aguilera-Egu\u00eda, R., Alarc\u00f3n-Rivera, M., Angarita-Davila, L., and Flores-Fern\u00e1ndez, C. (2026). Vitamin D and Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms and Clinical Implications\u2014A Narrative Review. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27062532"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/ibd\/izy092","article-title":"Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation","volume":"24","author":"Bakke","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12944-017-0477-7","article-title":"VDR Gene variation and insulin resistance related diseases","volume":"16","author":"Han","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"103062","DOI":"10.1016\/j.redox.2024.103062","article-title":"VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats","volume":"70","author":"Chen","year":"2024","journal-title":"Redox Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/10715762.2022.2094791","article-title":"VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury","volume":"56","author":"Lan","year":"2022","journal-title":"Free Radic. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cimini, F.A., Sentinelli, F., Oldani, A., Barchetta, I., and Cavallo, M.G. (2025). Adipose Tissue Dysfunction and Metabolic Diseases: The Role of Vitamin D\/Vitamin D Receptor Axis. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202509.1434.v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4162\/nrp.2021.15.3.329","article-title":"Serum vitamin D status and metabolic syndrome: A systematic review and dose-response meta-analysis","volume":"15","author":"Lee","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/er.2012-1000","article-title":"The nonskeletal effects of vitamin D: An Endocrine Society scientific statement","volume":"33","author":"Rosen","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Greco, E.A., Lenzi, A., and Migliaccio, S. (2019). Role of Hypovitaminosis D in the Pathogenesis of Obesity-Induced Insulin Resistance. Nutrients, 11.","DOI":"10.3390\/nu11071506"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Herti\u0161 Petek, T., Hom\u0161ak, E., Svetej, M., and Mar\u010dun Varda, N. (2024). Metabolic Syndrome, Inflammation, Oxidative Stress, and Vitamin D Levels in Children and Adolescents with Obesity. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910599"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsbmb.2019.02.001","article-title":"Vitamin D receptor: A critical regulator of inter-organ communication between skeletal and hematopoietic systems","volume":"190","author":"Katayama","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1080\/10408398.2018.1437022","article-title":"Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions","volume":"59","author":"Fenwick","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chomiuk, T., Niezgoda, N., Mamcarz, A., and \u015ali\u017c, D. (2024). Physical activity in metabolic syndrome. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1365761"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s11154-021-09644-2","article-title":"Education-based, lifestyle intervention programs with unsupervised exercise improve outcomes in adults with metabolic syndrome. A systematic review and meta-analysis","volume":"22","author":"Peiris","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jnutbio.2016.03.017","article-title":"The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy","volume":"33","author":"Masquio","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/endrev\/bnz007","article-title":"Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism","volume":"41","author":"Scheele","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-3-031-63657-8_10","article-title":"Reappraisal of Adipose Tissue Inflammation in Obesity","volume":"1460","author":"Engin","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1556\/2060.2026.00780","article-title":"Exercise intervention for obesity via modulating metabolic flexibility: A molecular perspective (review)","volume":"113","author":"Liu","year":"2026","journal-title":"Physiol. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113101","DOI":"10.1016\/j.exger.2026.113101","article-title":"Metabolic flexibility following resistance exercise and a high protein diet in older men: Results from a 12-week randomized controlled trial","volume":"217","author":"Griffen","year":"2026","journal-title":"Exp. Gerontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jesf.2025.07.005","article-title":"Compared to moderate-intensity continuous training, short-term high-intensity interval training demonstrates enhanced effects on metabolic flexibility in adult males with obesity","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Exerc. Sci. Fit."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e0203223","DOI":"10.1128\/mbio.02032-23","article-title":"Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases","volume":"15","author":"Zeng","year":"2024","journal-title":"mBio"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1017\/S0007114520000380","article-title":"Microbial dysbiosis-induced obesity: Role of gut microbiota in homoeostasis of energy metabolism","volume":"123","author":"Amabebe","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1159\/000534174","article-title":"A Role for Sodium-Glucose Cotransporter 2 Inhibitors in the Treatment of Chronic Kidney Disease: A Mini Review","volume":"48","author":"Song","year":"2023","journal-title":"Kidney Blood Press. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.7150\/ijbs.120980","article-title":"Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets","volume":"21","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lee, H., and Jose, P.A. (2021). Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.670076"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., and Hsu, C.N. (2022). Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress. Antioxidants, 11.","DOI":"10.3390\/antiox11112108"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s10741-021-10109-6","article-title":"Mitochondrial abnormalities: A hub in metabolic syndrome-related cardiac dysfunction caused by oxidative stress","volume":"27","author":"Li","year":"2022","journal-title":"Heart Fail. Rev."},{"key":"ref_59","unstructured":"Feingold, K.R., Adler, R.A., Ahmed, S.F., Anawalt, B., Blackman, M.R., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., and Dungan, K. (2000). Metabolic Syndrome. 2019 Feb 11. Endotext [Internet], MDText.com, Inc."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Tarc\u0103u, B.M., Vica\u0219, L.G., Filip, L., Maghiar, F., \u0218andor, M., Pallag, A., Jurca, T., Mure\u0219an, M.E., and Marian, E. (2023). Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome. J. Pers. Med., 14.","DOI":"10.3390\/jpm14010032"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ha, S., Choi, H.R., and Lee, Y.H. (2017). Clustering of four major lifestyle risk factors among Korean adults with metabolic syndrome. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174567"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.advnut.2022.10.002","article-title":"Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review","volume":"14","author":"Thomas","year":"2023","journal-title":"Adv. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Masenga, S.K., Kabwe, L.S., Chakulya, M., and Kirabo, A. (2023). Mechanisms of Oxidative Stress in Metabolic Syndrome. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097898"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s42000-018-0051-3","article-title":"Metabolic syndrome: An update on diagnostic criteria, pathogenesis, and genetic links","volume":"17","author":"Zafar","year":"2018","journal-title":"Hormones"},{"key":"ref_66","first-page":"29","article-title":"Effectiveness of Vitamin D2 Compared with Vitamin D3 Replacement Therapy in a Primary Healthcare Setting: A Retrospective Cohort Study","volume":"2022","author":"Albarri","year":"2022","journal-title":"Qatar Med. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1024\/0300-9831\/a000733","article-title":"Sources of Vitamin D for Humans","volume":"92","author":"Benedik","year":"2022","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Argano, C., Mirarchi, L., Amodeo, S., Orlando, V., Torres, A., and Corrao, S. (2023). The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.0595.v1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.dsx.2020.08.018","article-title":"Association of 25-hydroxyvitamin D levels and metabolic syndrome in Thai postmenopausal women","volume":"14","author":"Jeenduang","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Shan, X., Zhao, X., Li, S., Song, P., Man, Q., Liu, Z., Hu, Y., and Yang, L. (2022). Association of Serum 25(OH)D with Metabolic Syndrome in Chinese Women of Childbearing Age. Nutrients, 14.","DOI":"10.3390\/nu14112301"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6671823","DOI":"10.1155\/2021\/6671823","article-title":"Association between 25-Hydroxyvitamin D and Metabolic Syndrome in Older Adults: The Health, Aging and Body Composition Study","volume":"2021","author":"Agarwal","year":"2021","journal-title":"Int. J. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.3892\/mmr.2016.5531","article-title":"Vitamin D induces autophagy of pancreatic \u03b2-cells and enhances insulin secretion","volume":"14","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e13223","DOI":"10.1111\/obr.13223","article-title":"Serum vitamin D levels in relation to metabolic syndrome: A systematic review and dose-response meta-analysis of epidemiologic studies","volume":"22","author":"Hajhashemy","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Li, Z., Liu, S., Li, X., Liu, J., Li, X., Zhao, Y., and Feng, Y. (2024). The association between the triglyceride-glucose index and vitamin D status: A systematic review and meta-analysis. BMC Endocr. Disord., 24.","DOI":"10.1186\/s12902-024-01743-w"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e13314","DOI":"10.1111\/obr.13314","article-title":"Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose-response meta-analysis of epidemiologic studies","volume":"22","author":"Rouhani","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/2211536604666150414203919","article-title":"An Association Between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease","volume":"4","author":"Sheane","year":"2015","journal-title":"MicroRNA"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Melnik, B.C., John, S.M., Carrera-Bastos, P., and Schmitz, G. (2020). MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors. Cancers, 12.","DOI":"10.3390\/cancers12082111"},{"key":"ref_79","first-page":"251","article-title":"Vitamin D and miRNA-155 in Beh\u00e7et\u2019s Disease: Possible Association with the Disease and Disease Activity","volume":"12","author":"Eissa","year":"2023","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.4049\/jimmunol.1203273","article-title":"1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages","volume":"190","author":"Chen","year":"2013","journal-title":"J. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Ao, T., Kikuta, J., and Ishii, M. (2021). The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules, 11.","DOI":"10.3390\/biom11111624"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Komisarenko, Y.I., and Bobryk, M.I. (2018). Vitamin D Deficiency and Immune Disorders in Combined Endocrine Pathology. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00600"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8193523","DOI":"10.1155\/2018\/8193523","article-title":"Vitamin D3 Protects Against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS\/TXNIP\/NLRP3 Inflammasome Pathway","volume":"2018","author":"Lu","year":"2018","journal-title":"J. Diabetes Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9013904","DOI":"10.1155\/2019\/9013904","article-title":"Active Vitamin D and Vitamin D Receptor Help Prevent High Glucose-Induced Oxidative Stress of Renal Tubular Cells via AKT\/UCP2 Signaling Pathway","volume":"2019","author":"Zhu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_85","first-page":"179","article-title":"Recommendations for the rational use of the 25-hydroxyvitamin D test Policy Brief","volume":"6","author":"Castillo","year":"2019","journal-title":"Rev. Colomb. Nefrol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1210\/clinem\/dgae290","article-title":"Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline","volume":"109","author":"Demay","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Karrow, N.A., Leuschner, S.E., Shandilya, U.K., Mallard, B.A., Wagter-Lesperance, L., and Bridle, B.W. (2025). Genetic Variants Influencing Individual Vitamin D Status. Nutrients, 17.","DOI":"10.3390\/nu17162673"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Wimalawansa, S.J., Pludowski, P., and Cheng, R.Z. (2025). Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines. Nutrients, 17.","DOI":"10.3390\/nu17020277"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-030-46227-7_2","article-title":"Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?","volume":"1268","author":"Holick","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijpp.2018.01.005","article-title":"The roles of vitamin D and cutaneous vitamin D production in human evolution and health","volume":"23","author":"Jablonski","year":"2018","journal-title":"Int. J. Paleopathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7556\/jaoa.2017.089","article-title":"Effect of Latitude on Vitamin D Levels","volume":"117","author":"Leary","year":"2017","journal-title":"J. Osteopath. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Kift, R.C., and Webb, A.R. (2024). Globally Estimated UVB Exposure Times Required to Maintain Sufficiency in Vitamin D Levels. Nutrients, 16.","DOI":"10.3390\/nu16101489"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Delrue, C., and Speeckaert, M.M. (2023). Vitamin D and Vitamin D-Binding Protein in Health and Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054642"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The Vitamin D Deficiency Pandemic: Approaches for Diagnosis, Treatment, and Prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Bennour, I., Haroun, N., Sicard, F., Mounien, L., and Landrier, J.F. (2022). Vitamin D and Obesity\/Adiposity-A Brief Overview of Recent Studies. Nutrients, 14.","DOI":"10.3390\/nu14102049"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.afnr.2023.12.006","article-title":"Vitamin D and obesity","volume":"109","author":"Park","year":"2024","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nrendo.2016.123","article-title":"Vitamin D and falls\u2014The dosage conundrum","volume":"12","author":"Gallagher","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"T\u00f3th, B.E., Tak\u00e1cs, I., K\u00e1d\u00e1r, K., Mirani, S., Vecserny\u00e9s, M., and Lakatos, P. (2024). Safety and Efficacy of Loading Doses of Vitamin D: Recommendations for Effective Repletion. Pharmaceuticals, 17.","DOI":"10.3390\/ph17121620"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s11914-016-0331-2","article-title":"Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis","volume":"22","author":"Bellavia","year":"2024","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2174\/1871530320666200805101302","article-title":"Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (MetS): A Meta-Analysis","volume":"21","author":"Totonchi","year":"2021","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/15548627.2021.1962681","article-title":"Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway","volume":"18","author":"Li","year":"2022","journal-title":"Autophagy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e02367","DOI":"10.1016\/j.heliyon.2019.e02367","article-title":"VDR agonists down regulate PI3K\/Akt\/mTOR axis and trigger autophagy in Kaposi\u2019s sarcoma cells","volume":"5","author":"Suares","year":"2019","journal-title":"Heliyon"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"172761","DOI":"10.1016\/j.ejphar.2019.172761","article-title":"VDR regulates energy metabolism by modulating remodeling in adipose tissue","volume":"865","author":"Xu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Lu, S., and Cao, Z.B. (2023). Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function. Nutrients, 15.","DOI":"10.3390\/nu15224832"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s11914-019-00546-6","article-title":"The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications","volume":"17","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"105925","DOI":"10.1016\/j.jsbmb.2021.105925","article-title":"Can vitamin D be considered an adiponectin secretagogue? A systematic review and meta-analysis","volume":"212","author":"Nikooyeh","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1017\/S0954422419000064","article-title":"Mechanisms of vitamin D action in skeletal muscle","volume":"32","author":"Montenegro","year":"2019","journal-title":"Nutr. Res. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"113647","DOI":"10.3748\/wjg.v32.i4.113647","article-title":"Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytes","volume":"32","author":"Gao","year":"2026","journal-title":"World J. Gastroenterol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"105663","DOI":"10.1016\/j.jsbmb.2020.105663","article-title":"Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation","volume":"200","author":"Fakhoury","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"110450","DOI":"10.1016\/j.jnutbio.2026.110450","article-title":"Vitamin D attenuates metabolic dysfunction-associated steatotic liver disease (MASLD) and downregulates hepatic gluconeogenesis in obesity","volume":"157","author":"Cordeiro","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Aggeletopoulou, I., Tsounis, E.P., and Triantos, C. (2024). Vitamin D and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Novel Mechanistic Insights. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094901"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12937-024-00911-x","article-title":"Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: An exploratory randomized clinical trial","volume":"23","author":"Sohrabpour","year":"2024","journal-title":"Nutr. J."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Dogay Us, G., Innocenti, F., Koc, O.M., Yumuk, V.D., Gungor, Z.B., and Koek, G.H. (2026). Vitamin D Sufficiency Revisited: Evidence of a Dose-Response Effect for MASLD in Adults at Risk. Nutrients, 18.","DOI":"10.3390\/nu18040599"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e47436","DOI":"10.1097\/MD.0000000000047436","article-title":"Effects of different vitamin D supplements on body fat distribution and glucolipid metabolism in patients with obesity-associated metabolic syndrome: A meta-analysis","volume":"105","author":"Huang","year":"2026","journal-title":"Medicine"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molmet.2018.06.010","article-title":"The role of kidney in the inter-organ coordination of endogenous glucose production during fasting","volume":"16","author":"Kaneko","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"104866","DOI":"10.1016\/j.yexmp.2023.104866","article-title":"A review of the critical role of vitamin D axis on the immune system","volume":"132\u2013133","author":"Daryabor","year":"2023","journal-title":"Exp. Mol. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103053","DOI":"10.1016\/j.ceca.2025.103053","article-title":"Dietary calcium intake controls epithelial expression of TRPV6 independent of 1,25(OH)2D3 endocrine signaling","volume":"130","author":"Tanishige","year":"2025","journal-title":"Cell Calcium"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jare.2021.01.011","article-title":"Vitamin D\/VDR regulates peripheral energy homeostasis via central renin-angiotensin system","volume":"33","author":"Su","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Shu, J., Zhao, Y., Wu, X., He, Z., Lyu, X., Zhou, Y., and Ma, L. (2025). Vitamin D3 promotes white fat beige through IL-27\/P38MAPK\/PGC-1\u03b1 pathway. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1661072"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"27480","DOI":"10.1038\/s41598-025-10921-2","article-title":"Vitamin D and lipopolysaccharide jointly induce a distinct epigenetic and transcriptional program in human monocytes","volume":"15","author":"Jankowski","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1159\/000524855","article-title":"Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4\/NF-\u03baB Pathway in Human Respiratory Epithelial Cells","volume":"183","author":"Wang","year":"2022","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"153777","DOI":"10.1016\/j.bbrc.2026.153777","article-title":"Vitamin D receptor overexpression promotes differentiation and lipogenesis in 3T3-L1 preadipocytes by increasing peroxisome proliferator-activated receptor gamma expression under vitamin D deficiency","volume":"818","author":"Liang","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Pop, T.L., S\u00eerbe, C., Ben\u0163a, G., Mititelu, A., and Grama, A. (2022). The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810705"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"AlAnouti, F., Abboud, M., Papandreou, D., Mahboub, N., Haidar, S., and Rizk, R. (2020). Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 12.","DOI":"10.3390\/nu12113352"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1055\/a-0651-4842","article-title":"The Effects of Vitamin D Supplementation on Markers Related to Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"50","author":"Tabrizi","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Holick, M.F., Mazzei, L., Garc\u00eda Men\u00e9ndez, S., Mart\u00edn Gim\u00e9nez, V.M., Al Anouti, F., and Manucha, W. (2023). Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases. Nutrients, 15.","DOI":"10.3390\/nu15030767"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1038\/s41366-024-01629-w","article-title":"1,25-Dihydroxyvitamin D3 Mitigates the Adipogenesis Induced by Bisphenol A in 3T3-L1 and hAMSC Through miR-27-3p Regulation","volume":"48","author":"Provvisiero","year":"2024","journal-title":"Int. J. Obes."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/WNR.0000000000000328","article-title":"Expression of CYP2R1 and VDR in human brain pericytes: The neurovascular vitamin D autocrine\/paracrine model","volume":"26","author":"Dreyfus","year":"2015","journal-title":"Neuroreport"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00240-019-01163-9","article-title":"Expression of vitamin D receptor, CYP27B1 and CYP24A1 hydroxylases and 1,25-dihydroxyvitamin D3 levels in stone formers","volume":"48","author":"Melo","year":"2020","journal-title":"Urolithiasis"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1002\/mgg3.1618","article-title":"Vitamin D status and CYP27B1-1260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus","volume":"9","author":"Fakhfakh","year":"2021","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_132","first-page":"631","article-title":"Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters, and the vitamin D and leptin receptor genes on mice colon cancer","volume":"22","author":"Ranji","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Garcia, P.M., Moore, J., Kahan, D., and Hong, M.Y. (2020). Effects of Vitamin D Supplementation on Inflammation, Colonic Cell Kinetics, and Microbiota in Colitis: A Review. Molecules, 25.","DOI":"10.3390\/molecules25102300"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Sukik, A., Alalwani, J., and Ganji, V. (2023). Vitamin D, Gut Microbiota, and Cardiometabolic Diseases\u2014A Possible Three-Way Axis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020940"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"An, J.H., Cho, D.H., Lee, G.Y., Kang, M.S., Kim, S.J., and Han, S.N. (2021). Effects of Vitamin D Supplementation on CD4+ T Cell Subsets and mTOR Signaling Pathway in High-Fat-Diet-Induced Obese Mice. Nutrients, 13.","DOI":"10.3390\/nu13030796"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7941861","DOI":"10.1155\/2020\/7941861","article-title":"Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy","volume":"2020","author":"Khodir","year":"2020","journal-title":"Int. J. Nephrol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109516","DOI":"10.1016\/j.jnutbio.2023.109516","article-title":"Low Vitamin D During Pregnancy Is Associated with Infantile Eczema by Up-Regulation of PI3K\/AKT\/mTOR Signaling Pathway and Affecting FOXP3 Expression: A Bidirectional Cohort Study","volume":"124","author":"Ding","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"ref_138","first-page":"105","article-title":"A High Dose of Calcitriol Inhibits Glycolysis and M2 Macrophage Polarization in the Tumor Microenvironment by Repressing mTOR Activation: In Vitro and Molecular Docking Studies","volume":"57","author":"Munir","year":"2023","journal-title":"Cell Physiol. Biochem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr. Rev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000518826","article-title":"Influence of Ethnicities and Skin Color Variations in Different Populations: A Review","volume":"35","author":"Naik","year":"2022","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"106272","DOI":"10.1016\/j.jsbmb.2023.106272","article-title":"Estimation of the Vitamin D Status of Pregnant Japanese Women Based on Food Intake and VD Synthesis by Solar UV-B Radiation Using a Questionnaire and UV-B Observations","volume":"229","author":"Nakajima","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1093\/milmed\/usac258","article-title":"Relation of Vitamin D Level, BMI, and Location of Lower Extremity Stress Fractures in Military Trainees","volume":"188","author":"Zalneraitis","year":"2023","journal-title":"Mil. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e2324465","DOI":"10.1001\/jamanetworkopen.2023.24465","article-title":"Effects of Exercise Alone or Combined with Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults with Mild Cognitive Impairment: A Randomized Clinical Trial","volume":"6","author":"Zou","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"105545","DOI":"10.1016\/j.jsbmb.2019.105545","article-title":"The Relationship of 25-Hydroxyvitamin D Concentrations and Individual-Level Socioeconomic Status","volume":"197","author":"Thacher","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Mesquita, M.C.C., de Castro, R.M., Mendes, T.V., do Carmo, M.A.V., Sampaio, E.S., Corona, L.P., Lima, D.B., Raposo, A., Alasqah, I., and Alqarawi, N. (2024). Relationship Between Vitamin D Insufficiency and Anemia in Older Adults: An Approach Considering Clinical Aspects and Food Insecurity. Nutrients, 16.","DOI":"10.3390\/nu16213669"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1007\/s00467-022-05513-5","article-title":"Hypervitaminosis D and Nephrocalcinosis: Too Much of a Good Thing?","volume":"37","author":"Wan","year":"2022","journal-title":"Pediatr. Nephrol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7101\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:27:09Z","timestamp":1786354029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":146,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167101"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167101","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]}}}