{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:30:56Z","timestamp":1786437056297,"version":"build-2736575974"},"reference-count":82,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Education and Science","award":["613\/2023"],"award-info":[{"award-number":["613\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Thanks to the rapid development of advanced analytical methods, researchers can now identify new, so far unknown applications for existing drugs. This expanding knowledge about the mechanisms of drug action, including interactions with various molecules and molecular pathways, not only enables more effective use of available therapies but also reduces both the time and cost of developing new therapeutic options. One of the proteins reported to interact with numerous drugs and chemicals is Translationally Controlled Tumor Protein (TCTP). Numerous studies have demonstrated that TCTP plays a crucial role in diverse biological processes, including cell growth, cell cycle regulation, cellular proliferation, allergic reactions, stress response, inhibition of apoptosis, calcium ion binding, interacting with microtubules and actin microfilaments, the progression of various cancers, and tumor reversion. Therefore, this review article aims to compile a list of drugs and substances shown to interact with TCTP and that, given TCTP\u2019s numerous cellular functions, could be repurposed for other therapies.<\/jats:p>","DOI":"10.3390\/ijms27167161","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:09:36Z","timestamp":1786435776000},"page":"7161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological Modulators of TCTP: Opportunities and Challenges for Drug Repurposing"],"prefix":"10.3390","volume":"27","author":[{"given":"Weronika","family":"Andrzejczyk","sequence":"first","affiliation":[{"name":"Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"},{"name":"BioMedChem Doctoral School, University of Lodz, Lodz Institutes of the Polish Academy of Sciences, Jana Matejki 21\/23, 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Por\u0119bska","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-8970","authenticated-orcid":false,"given":"Thananjeyan","family":"Balasubramaniyam","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Synowiec","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-8584","authenticated-orcid":false,"given":"Malgorzata","family":"Kloc","sequence":"additional","affiliation":[{"name":"Transplant Immunology, The Houston Methodist Research Institute, Houston, TX 77030, USA"},{"name":"Department of Surgery, The Houston Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-8289","authenticated-orcid":false,"given":"Pawe\u0142","family":"St\u0105czek","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, University of Lodz, Banacha 12\/16, 90-237 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-5127","authenticated-orcid":false,"given":"Jacek Z.","family":"Kubiak","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine\u2014National Research Institute, Szaser\u00f3w 128, 04-141 Warsaw, Poland"},{"name":"Dynamics and Mechanics of Epithelia Group, Institute of Genetics and Development of Rennes (IGDR), Faculty of Medicine, UMR 6290 CNRS, Univeristy of Rennes, 35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12935-024-03355-9","article-title":"Biological Role and Expression of Translationally Controlled Tumor Protein (TCTP) in Tumorigenesis and Development and Its Potential for Targeted Tumor Therapy","volume":"24","author":"Liu","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.abb.2007.08.021","article-title":"Solution Structure and Mapping of a Very Weak Calcium-Binding Site of Human Translationally Controlled Tumor Protein by NMR","volume":"467","author":"Feng","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1357-2725(03)00213-9","article-title":"The Translationally Controlled Tumour Protein (TCTP)","volume":"36","author":"Bommer","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1111\/j.1742-4658.2007.06069.x","article-title":"Induction of Translationally Controlled Tumor Protein (TCTP) by Transcriptional and Post-Transcriptional Mechanisms","volume":"274","author":"Schmidt","year":"2007","journal-title":"FEBS J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biochi.2023.03.011","article-title":"Inhibitors of Dimerized Translationally Controlled Tumor Protein, a Histamine Releasing Factor, May Serve as Anti-Allergic Drug Candidates","volume":"211","author":"Maeng","year":"2023","journal-title":"Biochimie"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1242\/jcs.112.8.1257","article-title":"The Growth-Related, Translationally Controlled Protein P23 Has Properties of a Tubulin Binding Protein and Associates Transiently with Microtubules during the Cell Cycle","volume":"112","author":"Gachet","year":"1999","journal-title":"J. Cell Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/carcin\/bgp022","article-title":"Complex Relationship between TCTP, Microtubules and Actin Microfilaments Regulates Cell Shape in Normal and Cancer Cells","volume":"30","author":"Bazile","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6839","DOI":"10.1038\/onc.2017.289","article-title":"Identification of Translationally Controlled Tumor Protein in Promotion of DNA Homologous Recombination Repair in Cancer Cells by Affinity Proteomics","volume":"36","author":"Li","year":"2017","journal-title":"Oncogene"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nm.2546","article-title":"Reciprocal Repression between P53 and TCTP","volume":"18","author":"Amson","year":"2012","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19725","DOI":"10.1038\/srep19725","article-title":"TCTP Contains a BH3-like Domain, Which Instead of Inhibiting, Activates Bcl-XL","volume":"6","author":"Thebault","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104830","DOI":"10.1016\/j.jbc.2023.104830","article-title":"Structural Transitions in TCTP Tumor Protein upon Binding to the Anti-Apoptotic Protein Family Member Mcl-1","volume":"299","author":"Malard","year":"2023","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101303","DOI":"10.1016\/j.tranon.2021.101303","article-title":"Sertraline Repositioning: An Overview of Its Potential Use as a Chemotherapeutic Agent after Four Decades of Tumor Reversal Studies","volume":"16","author":"Gallon","year":"2022","journal-title":"Transl. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/cdd.2008.18","article-title":"TCTP Protects from Apoptotic Cell Death by Antagonizing Bax Function","volume":"15","author":"Susini","year":"2008","journal-title":"Cell Death Differ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41467-022-29611-y","article-title":"Targeting TCTP Sensitizes Tumor to T Cell-Mediated Therapy by Reversing Immune-Refractory Phenotypes","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nature05528","article-title":"Drosophila TCTP Is Essential for Growth and Proliferation through Regulation of DRheb GTPase","volume":"445","author":"Hsu","year":"2007","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.febslet.2008.07.057","article-title":"Biochemical Characterisation of TCTP Questions Its Function as a Guanine Nucleotide Exchange Factor for Rheb","volume":"582","author":"Rehmann","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41419-022-05438-9","article-title":"GOLPH3 Protein Controls Organ Growth by Interacting with TOR Signaling Proteins in Drosophila","volume":"13","author":"Frappaolo","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.cellsig.2015.04.011","article-title":"Growth-Factor Dependent Expression of the Translationally Controlled Tumour Protein TCTP Is Regulated through the PI3-K\/Akt\/MTORC1 Signalling Pathway","volume":"27","author":"Bommer","year":"2015","journal-title":"Cell. Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1080\/15548627.2017.1287650","article-title":"TPT1 (Tumor Protein, Translationally-Controlled 1) Negatively Regulates Autophagy through the BECN1 Interactome and an MTORC1-Mediated Pathway","volume":"13","author":"Bae","year":"2017","journal-title":"Autophagy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41467-017-00029-1","article-title":"Fortilin Binds IRE1\u03b1 and Prevents ER Stress from Signaling Apoptotic Cell Death","volume":"8","author":"Pinkaew","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41366-021-00821-6","article-title":"Overexpression of Translationally Controlled Tumor Protein Ameliorates Metabolic Imbalance and Increases Energy Expenditure in Mice","volume":"45","author":"Jeon","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/biomedicines10112722","article-title":"Role of Translationally Controlled Tumor Protein (TCTP) in the Development of Hypertension and Related Diseases in Mouse Models","volume":"10","author":"Maeng","year":"2022","journal-title":"Biomedicines"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1038\/srep08061","article-title":"Translationally Controlled Tumor Protein Induces Epithelial to Mesenchymal Transition and Promotes Cell Migration, Invasion and Metastasis","volume":"5","author":"Bae","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.2147\/OTT.S184555","article-title":"TCTP Promotes Epithelial\u2014Mesenchymal Transition in Lung Adenocarcinoma","volume":"12","author":"Sun","year":"2019","journal-title":"Onco. Targets. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1804877","DOI":"10.3389\/fphar.2026.1804877","article-title":"Small Extracellular Vesicles as System-Level Regulators and Predictive Biomarkers in Breast Cancer Progression and Chemoresistance","volume":"17","author":"Li","year":"2026","journal-title":"Front. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/s44319-024-00108-7","article-title":"TCTP Regulates Genotoxic Stress and Tumorigenicity via Intercellular Vesicular Signaling","volume":"25","author":"Amson","year":"2024","journal-title":"EMBO Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1128\/MCB.22.17.6209-6221.2002","article-title":"Plk Phosphorylation Regulates the Microtubule-Stabilizing Protein TCTP","volume":"22","author":"Yarm","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_28","first-page":"4973","article-title":"Phosphorylation of TCTP as a Marker for Polo-like Kinase-1 Activity In Vivo","volume":"30","author":"Cucchi","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20812","DOI":"10.1038\/s41598-021-00247-0","article-title":"TCTP Protein Degradation by Targeting MTORC1 and Signaling through S6K, Akt, and Plk1 Sensitizes Lung Cancer Cells to DNA-Damaging Drugs","volume":"11","author":"Jeong","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.2200276","article-title":"Histamine-Releasing Factor Is a Novel Alarmin Induced by House Dust Mite Allergen, Cytokines, and Cell Death","volume":"209","author":"Kasakura","year":"2022","journal-title":"J. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41590-021-00967-5","article-title":"Orchestration of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Ubiquitous Cellular Protein TCTP Released by Tumor Cells","volume":"22","author":"Hangai","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41598-019-57064-9","article-title":"Flexible Loop and Helix 2 Domains of TCTP Are the Functional Domains of Dimerized TCTP","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114072","DOI":"10.1016\/j.biopha.2022.114072","article-title":"Meclizine, a Piperazine-Derivative Antihistamine, Binds to Dimerized Translationally Controlled Tumor Protein and Attenuates Allergic Reactions in a Mouse Model","volume":"157","author":"Jang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jung, J., Lee, J.S., Lee, Y.S., and Lee, K. (2019). Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein. Cancers, 11.","DOI":"10.3390\/cancers11030386"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-019-1787-7","article-title":"Translationally Controlled Tumor Protein (TCTP) Plays a Pivotal Role in Cardiomyocyte Survival through a Bnip3-Dependent Mechanism","volume":"10","author":"Cai","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ijc.33965","article-title":"Repurposing Autophagy Regulators in Brain Tumors","volume":"151","author":"Petrosyan","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/FPC.0000000000000392","article-title":"PharmGKB Summary: Sertraline Pathway, Pharmacokinetics","volume":"30","author":"Huddart","year":"2020","journal-title":"Pharmacogenet. Genom."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15364","DOI":"10.1073\/pnas.0406776101","article-title":"Translationally Controlled Tumor Protein Is a Target of Tumor Reversion","volume":"101","author":"Tuynder","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70168","DOI":"10.1002\/prp2.70168","article-title":"Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms","volume":"13","author":"Blum","year":"2025","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/bjc.2017.230","article-title":"TCTP as a Therapeutic Target in Melanoma Treatment","volume":"117","author":"Hamasaki","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_41","first-page":"2043","article-title":"Repurposing Antidepressant sertraline as a Pharmacological Drug to Target Prostate Stem Cells: Dual Activation of apoptosis and Autophagy Signaling by Deregulating Redox Balance","volume":"10","author":"Chinnapaka","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1039\/D5MO00039D","article-title":"Thioridazine Induces Phospholipid Accumulation and Necroptosis in Parental and Tamoxifen-Resistant Breast Cancer Cells","volume":"21","author":"Mythri","year":"2025","journal-title":"Mol. Omics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16818","DOI":"10.18632\/oncotarget.7605","article-title":"Interaction of Antihistaminic Drugs with Human Translationally Controlled Tumor Protein (TCTP) as Novel Approach for Differentiation Therapy","volume":"7","author":"Seo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s13770-023-00599-w","article-title":"Understanding the Multi-Functional Role of TCTP in the Regeneration Process of Earthworm, Perionyx Excavatus","volume":"21","author":"Rajagopalan","year":"2023","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/molecules15031705","article-title":"The Molecular Mechanism of Action of Artemisinin\u2014The Debate Continues","volume":"15","author":"Barton","year":"2010","journal-title":"Molecules"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1021\/acs.bioconjchem.6b00556","article-title":"Characterization of the Artemisinin Binding Site for Translationally Controlled Tumor Protein (TCTP) by Bioorthogonal Click Chemistry","volume":"27","author":"Li","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bcp.2012.10.006","article-title":"Molecular Interaction of Artemisinin with Translationally Controlled Tumor Protein (TCTP) of Plasmodium Falciparum","volume":"85","author":"Eichhorn","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26314","DOI":"10.1074\/jbc.M114.568253","article-title":"Translationally Controlled Tumor Protein Is a Novel Biological Target for Neurofibromatosis Type 1-Associated Tumors","volume":"289","author":"Kobayashi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.febslet.2008.02.055","article-title":"Human Fortilin Is a Molecular Target of Dihydroartemisinin","volume":"582","author":"Fujita","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.7314\/APJCP.2014.15.6.2511","article-title":"Targeted Eficacy of Dihydroartemisinin for Translationally Controlled Protein Expression in a Lung Cancer Model","volume":"15","author":"Liu","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"D\u2019amico, S., Krasnowska, E.K., Manni, I., Toietta, G., Baldari, S., Piaggio, G., Ranalli, M., Gambacurta, A., Vernieri, C., and Di Giacinto, F. (2020). Dihydroartemisinin (DHA) Affects Microtubule Dynamics through Reduction of Phospho-Translationally Controlled Tumour Protein (TCTP) Levels and Enhances the Antiproliferative Effect of Trastuzumab Emtansine (T-DM1) in Trastuzumab-Resistant Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Cell Lines. Cells, 9.","DOI":"10.3390\/cells9051260"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/gerona\/glw090","article-title":"Rapamycin: An InhibiTOR of Aging Emerges from the Soil of Easter Island","volume":"71","author":"Lamming","year":"2016","journal-title":"J. Gerontol.-Ser. A Biol. Sci. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2165\/00003495-200060040-00005","article-title":"Oxaliplatin","volume":"60","author":"Culy","year":"2000","journal-title":"Drugs"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.bbapap.2009.06.005","article-title":"Comparative Proteomic Analysis of Colon Cancer Cells in Response to Oxaliplatin Treatment","volume":"1794","author":"Yao","year":"2009","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12964-017-0164-3","article-title":"Translationally Controlled Tumour Protein TCTP Is Induced Early in Human Colorectal Tumours and Contributes to the Resistance of HCT116 Colon Cancer Cells to 5-FU and Oxaliplatin","volume":"15","author":"Bommer","year":"2017","journal-title":"Cell Commun. Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.burns.2013.10.012","article-title":"Amentoflavone Inhibits Angiogenesis of Endothelial Cells and Stimulates Apoptosis in Hypertrophic Scar Fibroblasts","volume":"40","author":"Zhang","year":"2014","journal-title":"Burns"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41401-020-0383-9","article-title":"Research Progress on the Protective Effects of Licorice-Derived 18\u03b2-Glycyrrhetinic Acid against Liver Injury","volume":"42","author":"Wu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"33429","DOI":"10.1038\/s41598-025-18912-z","article-title":"18\u03b2-Glycyrrhetinic Acid Inhibits the Proliferation and Metastasis of Gastric Cancer by Inhibiting the TCTP\/AKT\/P53 Signaling Pathway","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e42642","DOI":"10.1371\/journal.pone.0042642","article-title":"Binding of Translationally Controlled Tumour Protein to the N-Terminal Domain of HDM2 Is Inhibited by Nutlin-3","volume":"7","author":"Funston","year":"2012","journal-title":"PLoS ONE"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3892\/ijmm.2013.1369","article-title":"Sann-Joong-Kuey-Jian-Tang Decreases the Protein Expression of Mcl-1 and TCTP and Increases That of TNF-\u03b1 and Bax in BxPC-3 Pancreatic Carcinoma Cells","volume":"32","author":"Chien","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3892\/mmr.2013.1381","article-title":"Sann-Joong-Kuey-Jian-Tang Inhibits Hepatocellular Carcinoma Hep-G2 Cell Proliferation by Increasing TNF-\u03b1, Caspase-8, Caspase- 3 and Bax but by Decreasing TCTP and Mcl-1 Expression In Vitro","volume":"7","author":"Chen","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1186\/s12885-020-07256-8","article-title":"Clinical Effects of Curcumin in Enhancing Cancer Therapy: A Systematic Review","volume":"20","author":"Mansouri","year":"2020","journal-title":"BMC Cancer"},{"key":"ref_63","first-page":"673","article-title":"Curcumin Inhibits the Proliferation of Human Hepatocellular Carcinoma J5 Cells by Inducing Endoplasmic Reticulum Stress and Mitochondrial Dysfunction","volume":"26","author":"Cheng","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-0042-1758791","article-title":"Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)","volume":"49","year":"2023","journal-title":"Semin. Thromb. Hemostasis"},{"key":"ref_65","first-page":"11","article-title":"PAI-1 Induces Cell Detachment, Downregulates Nucleophosmin (B23) and Fortilin (TCTP) in LnCAP Prostate Cancer Cells","volume":"20","author":"Jankun","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e5732","DOI":"10.1371\/journal.pone.0005732","article-title":"Proton Pump Inhibitors Exert Anti-Allergic Effects by Reducing TCTP Secretion","volume":"4","author":"Choi","year":"2009","journal-title":"PLoS ONE"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"112316","DOI":"10.1016\/j.biopha.2021.112316","article-title":"DTBP2 Attenuates Severe Airway Inflammation by Blocking Inflammatory Cellular Network Mediated by DTCTP","volume":"144","author":"Cho","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.4049\/jimmunol.161.11.6356","article-title":"Macrophage Colony-Stimulating Factor Stimulates Synthesis and Secretion of a Mouse Homolog of a Human IgE-Dependent Histamine-Releasing by Macrophages In Vitro and In Vivo","volume":"161","author":"Teshima","year":"1998","journal-title":"J. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1152\/ajplung.00118.2003","article-title":"Stimulation of Human Bronchial Epithelial Cells by IgE-Dependent Histamine-Releasing Factor","volume":"286","author":"Yoneda","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1006\/bbrc.2001.6302","article-title":"Dioxin Stimulates Synthesis and Secretion of IgE-Dependent Histamine-Releasing Factor","volume":"290","author":"Oikawa","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"50057","DOI":"10.18632\/oncotarget.10315","article-title":"Extracellular Translationally Controlled Tumor Protein Promotes Colorectal Cancer Invasion and Metastasis through Cdc42\/JNK\/MMP9 Signaling","volume":"7","author":"Xiao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9571","DOI":"10.7150\/thno.61711","article-title":"The Polo-like Kinase 1 Inhibitor Onvansertib Represents a Relevant Treatment for Head and Neck Squamous Cell Carcinoma Resistant to Cisplatin and Radiotherapy","volume":"11","author":"Hagege","year":"2021","journal-title":"Theranostics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1158\/1078-0432.CCR-20-2586","article-title":"A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia","volume":"26","author":"Zeidan","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"152486","DOI":"10.1016\/j.comppsych.2024.152486","article-title":"Off-Label Higher Doses of Serotonin Reuptake Inhibitors in the Treatment of Obsessive-Compulsive Disorder: Safety and Tolerability","volume":"133","author":"Levy","year":"2024","journal-title":"Compr. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1470-2045(07)70148-1","article-title":"Effect of Sertraline on Symptoms and Survival in Patients with Advanced Cancer, but without Major Depression: A Placebo-Controlled Double-Blind Randomised Trial","volume":"8","author":"Stockler","year":"2007","journal-title":"Lancet Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"603","DOI":"10.7150\/ijbs.50364","article-title":"Dihydroartemisinin: A Potential Natural Anticancer Drug","volume":"17","author":"Dai","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-024-01808-1","article-title":"Drug Repurposing for Cancer Therapy","volume":"9","author":"Xia","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-2407-14-165","article-title":"Interaction of Translationally Controlled Tumor Protein with Apaf-1 Is Involved in the Development of Chemoresistance in HeLa Cells","volume":"14","author":"Jung","year":"2014","journal-title":"BMC Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1021\/acsanm.3c05543","article-title":"Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release","volume":"7","author":"Ganguly","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1158\/0008-5472.CAN-09-4072","article-title":"The Antidepressant Sertraline Inhibits Translation Initiation by Curtailing Mammalian Target of Rapamycin Signaling","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Duarte, D., Cardoso, A., and Vale, N. (2021). Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147408"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbagrm.2014.11.002","article-title":"Stress-Mediated Translational Control in Cancer Cells","volume":"1849","author":"Leprivier","year":"2015","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:12:54Z","timestamp":1786435974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":82,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167161"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167161","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]}}}