{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:30:52Z","timestamp":1786595452014,"version":"build-2736575974"},"reference-count":13,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007817","name":"University of Rzesz\u00f3w","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007817","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/03pfsnq21","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The amplification of KMT2A, a gene involved in hematopoietic stem cell function, is extremely rare in acute leukemias, especially in mixed-phenotype acute leukemia. We present the case of a 62-year-old patient diagnosed with acute myeloid leukemia, myelodysplasia-related (AML-MR) with immunophenotypic features suggestive of B\/myeloid mixed-phenotype acute leukemia (MPAL), with the presence of multiple KMT2A gene amplifications and a very aggressive and complicated clinical course ending in failure despite intensive treatment. KMT2A amplification in MPAL could be a risk factor suggesting adverse outcomes.<\/jats:p>","DOI":"10.3390\/ijms27167170","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:32:16Z","timestamp":1786444336000},"page":"7170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) with Immunophenotypic Features Suggestive of B\/Myeloid Mixed-Phenotype Acute Leukemia (MPAL), Harboring Multiple KMT2A Gene Amplifications"],"prefix":"10.3390","volume":"27","author":[{"given":"Jakub","family":"\u0141\u0105czak","sequence":"first","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Szarawarska","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudycz","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Bie\u0144ko","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0432-7662","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Grzyb","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"},{"name":"Department of Hematology, Faculty of Medicine, Collegium Medicum, University of Rzesz\u00f3w, 35-310 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Skoczylas","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Blajer-Olszewska","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. Chopin University Clinical Hospital, 35-055 Rzesz\u00f3w, Poland"},{"name":"Department of Hematology, Faculty of Medicine, Collegium Medicum, University of Rzesz\u00f3w, 35-310 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Kopacz","sequence":"additional","affiliation":[{"name":"Department of Hematology, F. 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Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood.2019004551","article-title":"MYC and KMT2A multiple extra copies in acute myeloid leukemia","volume":"135","author":"Klein","year":"2020","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/bjh.19520","article-title":"A CD10-negative adult B-lymphoblastic leukaemia with amplification of KMT2A without rearrangement: A case report and review of the English literature","volume":"205","author":"Wang","year":"2024","journal-title":"Br. J. Haematol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00277-018-3297-6","article-title":"An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL)","volume":"97","author":"Khan","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pantrangi, M., Barone, P.D., Leeman-Neill, R.J., and Bao, L. (2026). KMT2A Amplification in Mixed-Phenotype Acute Leukemia: Immunophenotyping, Cytogenomic Features, and Clinical Correlation. Arch. Pathol. Lab. Med.","DOI":"10.5858\/arpa.2025-0485-OA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4103\/joah.joah_81_24","article-title":"Mixed-phenotype acute leukemia with trilineage differentiation in a 3-year-8-month-old child","volume":"15","author":"Mardewi","year":"2024","journal-title":"J. Appl. Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.2169\/internalmedicine.4898-24","article-title":"Therapy-related Trilineage Mixed Phenotype Acute Leukemia Treated with Venetoclax and Azacitidine","volume":"64","author":"Yamamoto","year":"2025","journal-title":"Intern. 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