{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:27:13Z","timestamp":1786685233565,"version":"build-2736575974"},"reference-count":16,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02t4ekc95","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Short episodes of intradialytic hypoxemia (IDH) are a common but still under-recognized complication of hemodialysis with clinically significant consequences. The aim of the study was to analyze the effect of IDH on the secretion of hypoxia-inducible factors 1 and 2 and sirtuin 1. The study group consisted of 49 chronic hemodialysis patients, mean age 58.8 \u00b1 15.3 years. Pulse oximetry was continuously recorded throughout hemodialysis. Blood was collected three times during a single mid-week hemodialysis session and at the start of the next mid-week session to assess levels of sirtuin 1 (SIRT1), hypoxia-inducible factor 1 (HIF-1), and hypoxia-inducible factor 2 (HIF-2). IDH, defined as a decrease in blood oxygen saturation below 90%, occurred in 22 (45%) patients. The mean time of hypoxemia during dialysis was 0.52% of the total hemodialysis session time. Plasma SIRT1 and HIF-2 concentrations did not change significantly during hemodialysis, whereas plasma HIF-1 levels decreased significantly. Multiple regression analysis showed that pre-dialysis plasma SIRT1 and HIF-1 explained a significant portion of the variability of blood oxygen saturation during hemodialysis. Pre-dialysis plasma levels of sirtuin 1 and HIF-1 could be considered predictors of the decline in blood oxygen saturation during hemodialysis sessions; they also determine the degree of variability of this parameter during the procedure.<\/jats:p>","DOI":"10.3390\/ijms27167207","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:53:48Z","timestamp":1786539228000},"page":"7207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-Term Effects of Intradialytic Hypoxemia on Plasma Markers of Hypoxia"],"prefix":"10.3390","volume":"27","author":[{"given":"Joanna","family":"Korzycka","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hypertension, Transplantation and Internal Medicine, Central University Hospital, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"P\u0119czek-Bartyzel","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension, Transplantation and Internal Medicine, Central University Hospital, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-5440","authenticated-orcid":false,"given":"Micha\u0142","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension, Transplantation and Internal Medicine, Central University Hospital, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2215\/CJN.08510815","article-title":"Intradialytic Hypoxemia and Clinical Outcomes in Patients on Hemodialysis","volume":"11","author":"Zhang","year":"2016","journal-title":"Clin. 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