{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:02:07Z","timestamp":1790928127505,"version":"4.1.0"},"reference-count":105,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research","award":["P2022JLE99"],"award-info":[{"award-number":["P2022JLE99"]}]},{"award":["P2022JLE99"],"award-info":[{"award-number":["P2022JLE99"]}],"id":[{"id":"https:\/\/ror.org\/0341vw408","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Rare earth elements (REEs) are increasingly recognized as modulators of male reproductive health. This review presents the first comprehensive and critical analysis of the detrimental and potentially beneficial effects of REEs on male vertebrate reproductive function. In vivo and in vitro studies show that elements, particularly Gadolinium, Lanthanum, and Yttrium, share a toxicological profile characterized by oxidative stress, inflammation, mitochondrial dysfunction, endocrine disruption, and impairment of the blood\u2013testis barrier. These mechanisms converge on both somatic and germ cell populations, ultimately compromising spermatogenesis and hormonal balance. Limited epidemiological data in humans are consistent with experimental findings, indicating inverse associations between seminal REE levels and sperm quality. CeO2 nanoparticles represent an exception, showing dose-dependent duality: although some murine studies describe toxic effects, a broader and more consistent body of evidence indicates their protective action by restoring testicular homeostasis in diabetic models, in rats exposed to pesticides, pharmacological agents or irradiation, and in in vitro-treated spermatozoa. Preliminary data on Yttrium (YO) and Gadolinium (GdVO4) nanoparticles similarly point to protective effects under pathological conditions, whereas Neodymium and Samarium show reproductive toxicity, including hormonal disruption and impaired sperm quality. Overall, REEs cannot be considered a homogeneous class: some pose reproductive hazards, others show potential biomedical utility. A systematic, mechanistic research framework is needed to resolve these dualities. It should contextualise reproductive risks in relation to the growing environmental and occupational exposure to REEs, while simultaneously exploring the biomedical potential of those elements that exhibit protective profiles.<\/jats:p>","DOI":"10.3390\/ijms27167298","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:26Z","timestamp":1786968086000},"page":"7298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rare Earth Elements in Testicular Function: Current Knowledge and Future Directions"],"prefix":"10.3390","volume":"27","author":[{"given":"Alessandra","family":"Santillo","sequence":"first","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Falvo","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-5353","authenticated-orcid":false,"given":"Massimo","family":"Venditti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-6729","authenticated-orcid":false,"given":"Maria Maddalena","family":"Di Fiore","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Chieffi Baccari","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"ref_1","unstructured":"(2026, July 06). Guideline for the Prevention, Diagnosis and Treatment of Infertility. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240115774."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.2147\/IJN.S223318","article-title":"ZnO Nanoparticles Induced Male Reproductive Toxicity Based on the Effects on the Endoplasmic Reticulum Stress Signaling Pathway","volume":"14","author":"Tang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e1806","DOI":"10.1002\/wnan.1806","article-title":"The Potential for Nanomaterial Toxicity Affecting the Male Reproductive System","volume":"14","author":"Li","year":"2022","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Venditti, M., Hassine, M.B.H., Messaoudi, I., and Minucci, S. (2023). The Simultaneous Administration of Microplastics and Cadmium Alters Rat Testicular Activity and Changes the Expression of PTMA, DAAM1 and PREP. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1145702"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115067","DOI":"10.1016\/j.ecoenv.2023.115067","article-title":"Evidence of the Protective Role of D-Aspartate in Counteracting\/Preventing Cadmium-Induced Oxidative Stress in the Rat Testis","volume":"259","author":"Venditti","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"116202","DOI":"10.1016\/j.ecoenv.2024.116202","article-title":"Polystyrene Microplastics Impair the Functions of Cultured Mouse Leydig (TM3) and Sertoli (TM4) Cells by Inducing Mitochondrial-Endoplasmic Reticulum Damage","volume":"274","author":"Grillo","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Falvo, S., Grillo, G., Messaoudi, I., Fradi, N., Chieffi Baccari, G., Di Fiore, M.M., Biasi, A., Ambruosi, M.R., Santillo, A., and Venditti, M. (2025). Protective Effects and Potential Mechanisms of D-Aspartate on Testicular Damage Induced by Polystyrene Microplastics. Biomolecules, 15.","DOI":"10.3390\/biom15111484"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/tox.24559","article-title":"Cadmium-Induced Mitochondrial and MAMs Dysregulation in Rat Testis: The Protective Role of D-Aspartate","volume":"41","author":"Latino","year":"2026","journal-title":"Environ. Toxicol."},{"key":"ref_9","unstructured":"(2025). Male Fertility Index\u2019 in IUPAC Compendium of Chemical Terminology, International Union of Pure and Applied Chemistry. [5th ed.]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.gsf.2018.12.005","article-title":"Rare Earth Elements: A Review of Applications, Occurrence, Exploration, Analysis, Recycling, and Environmental Impact","volume":"10","author":"Balaram","year":"2019","journal-title":"Geosci. Front."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.scitotenv.2018.04.235","article-title":"Sources, Behaviour, and Environmental and Human Health Risks of High-Technology Rare Earth Elements as Emerging Contaminants","volume":"636","author":"Gwenzi","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115966","DOI":"10.1016\/j.watres.2020.115966","article-title":"Anthropogenic Gadolinium in Freshwater and Drinking Water Systems","volume":"182","author":"Hofmann","year":"2020","journal-title":"Water Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Blinova, I., Muna, M., Heinlaan, M., Lukjanova, A., and Kahru, A. (2020). Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis. Nanomaterials, 10.","DOI":"10.3390\/nano10020328"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12940-025-01178-3","article-title":"Adverse Effects and Underlying Mechanism of Rare Earth Elements","volume":"24","author":"Wang","year":"2025","journal-title":"Environ. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/ppp3.70010","article-title":"Interactions of Rare Earth Elements with Living Organisms and Emerging Biotechnical Applications","volume":"7","author":"McGaughey","year":"2025","journal-title":"Plants People Planet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10534-016-9931-7","article-title":"Gadolinium-Based Contrast Agent Toxicity: A Review of Known and Proposed Mechanisms","volume":"29","author":"Rogosnitzky","year":"2016","journal-title":"Biometals"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Martino, C., Chianese, T., Chiarelli, R., Roccheri, M.C., and Scudiero, R. (2022). Toxicological Impact of Rare Earth Elements (REEs) on the Reproduction and Development of Aquatic Organisms Using Sea Urchins as Biological Models. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052876"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100457","DOI":"10.1016\/j.emcon.2024.100457","article-title":"Rare Earth Elements on Aquatic Organisms: Toxicity, Detoxification, and Ecological Implications","volume":"11","author":"Banaee","year":"2025","journal-title":"Emerg. Contam."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"112985","DOI":"10.1016\/j.envpol.2019.112985","article-title":"Cerium and Erbium Effects on Daphnia Magna Generations: A Multiple Endpoints Approach","volume":"254","author":"Galdiero","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e31087","DOI":"10.1016\/j.heliyon.2024.e31087","article-title":"Unravelling the Ecotoxicological Impacts of Gadolinium (Gd) on Mytilus Galloprovincialis Embryos and Sperm in Seawater: A Preliminary Study","volume":"10","author":"Spampinato","year":"2024","journal-title":"Heliyon"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00244-015-0143-x","article-title":"Determination of Rare Earth Elements in Human Sperm and Association with Semen Quality","volume":"69","author":"Ludwikowski","year":"2015","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"140582","DOI":"10.1016\/j.chemosphere.2023.140582","article-title":"Exposure to Particulate Matter May Affect Semen Quality via Trace Metals: Evidence from a Retrospective Cohort Study on Fertile Males","volume":"346","author":"Cheng","year":"2024","journal-title":"Chemosphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1007\/s11356-014-3499-y","article-title":"Rare Earths Exposure and Male Infertility: The Injury Mechanism Study of Rare Earths on Male Mice and Human Sperm","volume":"22","author":"Chen","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.btre.2017.11.008","article-title":"Synthesis and Biomedical Applications of Cerium Oxide Nanoparticles\u2014A Review","volume":"17","author":"Rajeshkumar","year":"2018","journal-title":"Biotechnol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jconrel.2021.08.033","article-title":"Nanoceria, the Versatile Nanoparticles: Promising Biomedical Applications","volume":"338","author":"Saifi","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ukwattage, N.L., and Zhiyong, Z. (2025). Impacts of Cerium Dioxide Nanoparticles on the Soil-Plant System and Their Potential Agricultural Applications. Nanomaterials, 15.","DOI":"10.3390\/nano15120950"},{"key":"ref_27","first-page":"947","article-title":"Advances on toxicity of nano-cerium oxide to male reproductive system","volume":"41","author":"Yu","year":"2024","journal-title":"J. Environ. Occup. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/toxsci\/kfs113","article-title":"Tissue Distribution of Inhaled Micro- and Nano-Sized Cerium Oxide Particles in Rats: Results from a 28-Day Exposure Study","volume":"127","author":"Geraets","year":"2012","journal-title":"Toxicol. Sci."},{"key":"ref_29","first-page":"111","article-title":"Cerium Dioxide Nanoparticles Affect in Vitro Fertilization in Mice","volume":"10","author":"Preaubert","year":"2016","journal-title":"Nanotoxicology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tiv.2018.03.013","article-title":"Very Low Concentration of Cerium Dioxide Nanoparticles Induce DNA Damage, but No Loss of Vitality, in Human Spermatozoa","volume":"50","author":"Tassistro","year":"2018","journal-title":"Toxicol. In Vitro"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12920","DOI":"10.1111\/and.12920","article-title":"Cerium Oxide Nanoparticle Elicits Oxidative Stress, Endocrine Imbalance and Lowers Sperm Characteristics in Testes of Balb\/c Mice","volume":"50","author":"Adebayo","year":"2018","journal-title":"Andrologia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12951-019-0474-2","article-title":"SF-1 Mediates Reproductive Toxicity Induced by Cerium Oxide Nanoparticles in Male Mice","volume":"17","author":"Qin","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"ref_33","first-page":"801","article-title":"Detrimental Effects of Cerium Oxide Nanoparticles on Testis, Sperm Parameters Quality, and in Vitro Fertilization in Mice: An Experimental Study","volume":"19","author":"Hosseinalipour","year":"2021","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12011-019-01836-x","article-title":"The Effect of Cerium Oxide During Pregnancy on the Development of the Testicular Tissue of Newborn NMRI Mice","volume":"195","author":"Nemati","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.reprotox.2022.05.014","article-title":"Toxicity of Cerium Oxide Nanoparticles on Neonatal Testicular Development in Mouse Organ Culture","volume":"111","author":"Lee","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"ref_36","first-page":"559","article-title":"Effect of cerium nitrate on activity of the enzyme related to energy metabolism, cell cycle and apoptosis of testiculus cell in male mice","volume":"30","author":"Zhao","year":"2009","journal-title":"J. Xi\u2019an Jiaotong Univ. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15407\/fz60.01.011","article-title":"Morphofunctional state of reproductive system of ageing male rats in case of using nanocerium","volume":"60","author":"Nosenko","year":"2014","journal-title":"Fiziolohichny\u012d Zhurnal"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13167-015-0034-2","article-title":"Antioxidative Effects of Cerium Dioxide Nanoparticles Ameliorate Age-Related Male Infertility: Optimistic Results in Rats and the Review of Clinical Clues for Integrative Concept of Men Health and Fertility","volume":"6","author":"Kobyliak","year":"2015","journal-title":"EPMA J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.theriogenology.2015.12.011","article-title":"Cerium Dioxide Nanoparticles Did Not Alter the Functional and Morphologic Characteristics of Ram Sperm during Short-Term Exposure","volume":"85","author":"Falchi","year":"2016","journal-title":"Theriogenology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12958-018-0339-9","article-title":"Effect of Exposure to CeO2 Nanoparticles on Ram Spermatozoa during Storage at 4 \u00b0C for 96 Hours","volume":"16","author":"Falchi","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_41","first-page":"119","article-title":"Improving Awassi Rams Epididymal Sperms Viability by Adding Zinc and Cerium Oxide Nanoparticles","volume":"56","author":"Hussein","year":"2025","journal-title":"Egy. J. Vet. Sc."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Al-Janabi, G.A., Al-Dulaimi, M.K., and Fadhel, A.A. (2024). Effect of Adding Different Levels of Cerium Oxide Nanoparticles to Tris Extender on Some Parameters of Cooled Semen from Holstein Bulls. Proceedings of the IOP Conference Series: Earth and Environmental Science, IOP Publishing Ltd.","DOI":"10.1088\/1755-1315\/1371\/7\/072046"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.theriogenology.2023.10.022","article-title":"Cerium Oxide Nanoparticles Improve the Post-Thaw Quality and in-Vivo Fertility of Beetal Buck Spermatozoa","volume":"214","author":"Khalique","year":"2024","journal-title":"Theriogenology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1007\/s12011-021-02939-0","article-title":"Effect of Cerium Oxide Nanoparticles on the Expression of Developmental and Apoptosis Genes of Testicular Tissue in 6-Day-Old NMRI Mice Fetuses","volume":"200","author":"Amiri","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_45","first-page":"261","article-title":"Protective Effect of Cerium Oxide Nanoparticle on Sperm Quality and Oxidative Damage in Malathion-Induced Testicular Toxicity in Rats: An Experimental Study","volume":"16","author":"Moridi","year":"2018","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"21069","DOI":"10.1039\/C8NR04640A","article-title":"Engineered Nanoceria Cytoprotection: In Vivo: Mitigation of Reactive Oxygen Species and Double-Stranded DNA Breakage Due to Radiation Exposure","volume":"10","author":"Das","year":"2018","journal-title":"Nanoscale"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/ijpvm.IJPVM_184_18","article-title":"Cerium Oxide Nanoparticles Protect Cyclophosphamide-Induced Testicular Toxicity in Mice","volume":"10","author":"Hamzeh","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Saleh, H., Nassar, A.M.K., Noreldin, A.E., Samak, D., Elshony, N., Wasef, L., Elewa, Y.H.A., Hassan, S.M.A., Saati, A.A., and Hetta, H.F. (2020). Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats. Molecules, 25.","DOI":"10.3390\/molecules25153479"},{"key":"ref_49","first-page":"589","article-title":"Antiapoptotic and Antioxidative Effects of Cerium Oxide Nanoparticles on the Testicular Tissues of Streptozotocin-Induced Diabetic Rats: An Experimental Study","volume":"19","author":"Solgi","year":"2021","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e13089","DOI":"10.1111\/and.13089","article-title":"Amelioration of Diabetes-Induced Testicular and Sperm Damage in Rats by Cerium Oxide Nanoparticle Treatment","volume":"50","author":"Artimani","year":"2018","journal-title":"Andrologia"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17156","DOI":"10.1038\/s41598-026-55900-3","article-title":"Potential Effect of Cerium Oxide Nanoparticles against Boldenone-Induced Oxidative Stress, Inflammation, and Reproductive Dysfunction in Male Albino Rats","volume":"16","author":"Hassan","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_52","first-page":"84","article-title":"Histopathologic Evaluation of Intraperitoneal Administration of Cerium Oxide Nanoparticles on Ischemia Reperfusion Injury in Rat Testicular Torsion and Detorsion Model","volume":"16","author":"Amniattalab","year":"2021","journal-title":"Iran. J. Vet. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e14231","DOI":"10.1111\/and.14231","article-title":"The Therapeutic Effect of Cerium Oxide Nanoparticle on Ischaemia\/Reperfusion Injury in Rat Testis","volume":"53","author":"Mousavi","year":"2021","journal-title":"Andrologia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/etm.2022.11700","article-title":"Protective Effect of Cerium Oxide on Testicular Function and Oxidative Stress after Torsion\/Detorsion in Adult Male Rats","volume":"25","author":"Yesil","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12011-023-03692-2","article-title":"A Two-Generation Reproductive Toxicity Study of Cerium Nitrate in Sprague-Dawley Rats","volume":"202","author":"Ren","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2400269","DOI":"10.1002\/gch2.202400269","article-title":"Gadolinium-Based Contrast Agents (GBCAs) for MRI: A Benefit-Risk Balance Analysis from a Chemical, Biomedical, and Environmental Point of View","volume":"9","author":"Scarciglia","year":"2025","journal-title":"Glob. Chall."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1021\/acsnano.5b05783","article-title":"Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents","volume":"9","author":"Chen","year":"2015","journal-title":"ACS Nano"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.2147\/IJN.S139326","article-title":"Regulation of Apoptosis through Bcl-2\/Bax Proteins Expression and DNA Damage by Nano-Sized Gadolinium Oxide","volume":"12","author":"Alarifi","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/etc.4116","article-title":"Gadolinium as a New Emerging Contaminant of Aquatic Environments","volume":"37","author":"Rogowska","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"146273","DOI":"10.1016\/j.scitotenv.2021.146273","article-title":"What Do We Know about the Ecotoxicological Implications of the Rare Earth Element Gadolinium in Aquatic Ecosystems?","volume":"781","author":"Trapasso","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"124740","DOI":"10.1016\/j.envpol.2024.124740","article-title":"Anthropogenic Gadolinium Contaminations in the Marine Environment and Its Ecological Implications","volume":"359","author":"Zhang","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12405","DOI":"10.1007\/s11356-017-8869-9","article-title":"Bioaccumulation of Gadolinium in Freshwater Bivalves","volume":"24","author":"Perrat","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.scitotenv.2019.01.341","article-title":"Toxicological Assessment of Anthropogenic Gadolinium in Seawater: Biochemical Effects in Mussels Mytilus Galloprovincialis","volume":"664","author":"Henriques","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/and.13031","article-title":"The Effect of Gadolinium-Based Contrast Agents on Rat Testis","volume":"50","author":"Tumkaya","year":"2018","journal-title":"Andrologia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"13950","DOI":"10.1038\/s41598-021-93147-2","article-title":"Repeat and Single Dose Administration of Gadodiamide to Rats to Investigate Concentration and Location of Gadolinium and the Cell Ultrastructure","volume":"11","author":"Davies","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"154270","DOI":"10.1016\/j.tox.2025.154270","article-title":"Prepubertal Exposure to Gadolinium-Based Contrast Agents Impairs Sperm Quality and Elevates Oxidative Stress in Adult Rats","volume":"518","author":"Crepaldi","year":"2025","journal-title":"Toxicology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"154261","DOI":"10.1016\/j.tox.2025.154261","article-title":"Gadolinium Impairs Male Steroidogenesis: In Vivo and in Vitro Evidence","volume":"518","author":"Falvo","year":"2025","journal-title":"Toxicology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"154335","DOI":"10.1016\/j.tox.2025.154335","article-title":"Toxic Effects of Gadolinium on Spermatogenesis Are Associated with Inflammation, Oxidative Stress, Apoptosis and Autophagy","volume":"519","author":"Falvo","year":"2026","journal-title":"Toxicology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"109301","DOI":"10.1016\/j.reprotox.2026.109301","article-title":"Gadolinium Induces Sertoli Cell Damage: Cellular and Molecular Mechanisms","volume":"144","author":"Falvo","year":"2026","journal-title":"Reprod. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/jemt.70015","article-title":"Gadolinium and Its Effects on Nutritional Status, Microscopy and Microanalytical Outcomes: Quantification by ICP-MS and Incidence on Reproductive Tract and Liver of Wistar Rats","volume":"88","author":"Maghraoui","year":"2025","journal-title":"Microsc. Res. Tech."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"127859","DOI":"10.1016\/j.jtemb.2026.127859","article-title":"Effects of Intraperitoneally Administered Gadolinium on Male Reproductive Tissues and Functions in Wistar Rat","volume":"94","author":"Maghraoui","year":"2026","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"296","DOI":"10.54203\/scil.2022.wvj37","article-title":"Effect of Gadolinium Orthovanadate Nanoparticles on Male Rabbits\u2019 Reproductive Performance under Oxidative Stress","volume":"12","author":"Koshevoy","year":"2022","journal-title":"World Vet. J."},{"key":"ref_73","first-page":"951","article-title":"Cell and Molecular Toxicity of Lanthanum Nanoparticles: Are There Possible Risks to Humans?","volume":"15","author":"Malvandi","year":"2021","journal-title":"Nanotoxicology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"106115","DOI":"10.1016\/j.envint.2020.106115","article-title":"Emerging Lanthanum (III)-Containing Materials for Phosphate Removal from Water: A Review towards Future Developments","volume":"145","author":"Zhi","year":"2020","journal-title":"Environ. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1476-5381.1981.tb16798.x","article-title":"Effects of Divalent and Lanthanide Ions on Motility Initiation in Rat Caudal Epididymal Spermatozoa","volume":"73","author":"Lee","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2131\/jts.45.411","article-title":"Effects of Intragastric Administration of La2O3 Nanoparticles on Mouse Testes","volume":"45","author":"Yuan","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.2147\/IJN.S230949","article-title":"La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2\/ARE Signaling Pathway in Kunming Mice","volume":"15","author":"Yuan","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/tox.23046","article-title":"Molecular Mechanisms Associated with Oxidative Damage in the Mouse Testis Induced by LaCl3","volume":"36","author":"Ji","year":"2021","journal-title":"Environ. Toxicol."},{"key":"ref_79","first-page":"471","article-title":"Effects of Lanthanum Chloride on Enzyme Activities of Testes and Sperm Quality of Male Mice","volume":"31","author":"Liu","year":"2012","journal-title":"Sichaun J. Zool."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1007\/s12011-021-02841-9","article-title":"A Two-Generation Reproductive Toxicity Study of Lanthanum Nitrate in SD Rats","volume":"200","author":"Yan","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105670","DOI":"10.1016\/j.yrtph.2024.105670","article-title":"Lanthanum Nitrate Demonstrated No Genotoxicity in the Conducted Tests","volume":"151","author":"Juntao","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-8853(91)90812-O","article-title":"Neodymium-Iron-Boron Permanent Magnets","volume":"100","author":"Herbst","year":"1991","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ahmadi, S., Mohammadi, L., Rahdar, A., Rahdar, S., Dehghani, R., Igwegbe, C.A., and Kyzas, G.Z. (2020). Acid Dye Removal from Aqueous Solution by Using Neodymium(III) Oxide Nanoadsorbents. Nanomaterials, 10.","DOI":"10.3390\/nano10030556"},{"key":"ref_84","first-page":"881","article-title":"Effects of Nd2O3 exposure of rare earth particles on C57 BL\/6J male mice sex hormone secretion and CYP11A1\/PLZF\/STRA8 protein expression","volume":"40","author":"Song","year":"2022","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, S., Bu, N., Yun, Y., Shi, X., Wang, S., and Gao, Y. (2023). RNA-Seq Analysis of Testes from Mice Exposed to Neodymium Oxide. Toxics, 11.","DOI":"10.3390\/toxics11120952"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"124527","DOI":"10.1016\/j.envpol.2024.124527","article-title":"LncRNA SNHG5\/IGF2BP1\/Occludin Axis Regulates Nd2O3 Induced Blood-Testis Barrier Disruption","volume":"358","author":"Wang","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5491\/SHAW.2013.4.1.12","article-title":"Toxicological Evaluations of Rare Earths and Their Health Impacts to Workers: A Literature Review","volume":"4","author":"Rim","year":"2013","journal-title":"Saf. Health Work."},{"key":"ref_88","first-page":"0034","article-title":"Effect of Samarium on Toxicity and Trace Elements of Mice\u2019s Testicle Tissue","volume":"24","author":"Hu","year":"2008","journal-title":"Chin. J. Pub Health-Shenyang"},{"key":"ref_89","first-page":"279","article-title":"Influence of subchronic samarium contamination on organ coefficient and enzyme activity of testis in mice","volume":"25","author":"Chen","year":"2005","journal-title":"China Environ. Sci."},{"key":"ref_90","first-page":"1896","article-title":"Effects of sub-chronic samarium exposure on ultrastructure of mice testis","volume":"31","author":"Yang","year":"2011","journal-title":"China Environ. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.etap.2014.01.007","article-title":"Effects of Subchronic Samarium Exposure on the Histopathological Structure and Apoptosis Regulation in Mouse Testis","volume":"37","author":"Zhang","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhang, D.Y., Shen, X.Y., Xu, X.L., Ruan, Q., Hu, S.S., Chen, Y.Y., and Wang, Z.M. (2016). Effect of Acute\/Subchronic Samarium Exposure on the Concentration, Motility, and Morphology of Sperm in Male Mice. Genet. Mol. Res., 15.","DOI":"10.4238\/gmr.15028807"},{"key":"ref_93","first-page":"648","article-title":"The Influence of Subchronic Samarium Contamination on the Reproductive Ability of Male Mice, and Grow of Embryo and Embryo Rat","volume":"27","author":"Hu","year":"2007","journal-title":"China Environ. Sci. Chin. Ed."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s11356-023-31017-2","article-title":"The Association between Levels of Samarium, Hafnium, Tungsten and Rhenium in Seminal Plasma and the Risk of Idiopathic Oligo-Astheno-Teratozoospermia in Men of Childbearing Age","volume":"31","author":"Jiang","year":"2024","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_95","first-page":"759","article-title":"Er:YAG Laser-Activated Irrigation in Comparison with Different Irrigation Systems for Cleaning the Apical Root Canal Area Beyond Ledge","volume":"39","author":"Aung","year":"2021","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1039\/C9CS00840C","article-title":"The Use of Yttrium in Medical Imaging and Therapy: Historical Background and Future Perspectives","volume":"49","author":"Tickner","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"115262","DOI":"10.1016\/j.ecoenv.2023.115262","article-title":"The Rare-Earth Yttrium Induces Cell Apoptosis and Autophagy in the Male Reproductive System through ROS-Ca2+-CamkII\/Ampk Axis","volume":"263","author":"Hou","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Liu, Z., Ding, Y., Xie, S., Hu, Y., Xiao, H., Liu, X., and Fan, X. (2023). Chronic Exposure to Yttrium Induced Cell Apoptosis in the Testis by Mediating Ca2+\/IP3R1\/CaMKII Signaling. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1104195"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"118720","DOI":"10.1016\/j.ecoenv.2025.118720","article-title":"Yttrium Nitrate Activates the Oxidative Stress-Mediated NF-\u03baB Pathway to Induce Testicular Inflammatory Response and Reduce Sperm Quality in Mice","volume":"302","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"127117","DOI":"10.1016\/j.jtemb.2022.127117","article-title":"The Reproductive Toxicity of Yttrium Nitrate in a Two-Generation Study in Sprague-Dawley Rats","volume":"76","author":"Yan","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.toxrep.2021.05.014","article-title":"Alleviation of Silver Nanoparticle-Induced Sexual Behavior and Testicular Parameters Dysfunction in Male Mice by Yttrium Oxide Nanoparticles","volume":"8","author":"Albetran","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.1021\/acs.est.2c08838","article-title":"Exogenous Metals Atlas in Spermatozoa at Single-Cell Resolution in Relation to Human Semen Quality","volume":"57","author":"Liu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"113859","DOI":"10.1016\/j.envpol.2019.113859","article-title":"New Insights on the Impacts of E-Waste towards Marine Bivalves: The Case of the Rare Earth Element Dysprosium","volume":"260","author":"Freitas","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"172893","DOI":"10.1016\/j.scitotenv.2024.172893","article-title":"Praseodymium and Warming Interactions in Mussels: Comparison between Observed and Predicted Results","volume":"934","author":"Leite","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"177995","DOI":"10.1016\/j.scitotenv.2024.177995","article-title":"Salinity Modulation of Neodymium and Dysprosium Toxicity in Mussels: A Comprehensive Analysis of Adult and Sperm Responses","volume":"959","author":"Leite","year":"2025","journal-title":"Sci. Total Environ."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7298\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:07:01Z","timestamp":1786968421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":105,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167298"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167298","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]}}}