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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Agronomic modulation of secondary metabolism may influence not only crop resilience but also the biological activity of fruit-derived phytochemicals. In this study, we evaluated the impact of exogenous methyl jasmonate (MeJA) application under contrasting water regimes on the selected phenolic compounds and vascular bioactivity of Vaccinium corymbosum L. cv. Legacy. Antioxidant capacity was assessed by FRAP and DPPH assays, phytochemical composition was characterized by HPLC-DAD, and antiplatelet activity was evaluated through inhibition of TRAP-6\u2013induced P-selectin (CD62P) expression in human platelets. Selected phenolic constituents were further examined using molecular docking and molecular dynamics simulations against a platelet receptor model. Although MeJA treatment altered the abundance of selected phenolic compounds identified by HPLC-DAD, total antioxidant capacity remained largely unchanged. Blueberry extracts significantly inhibited platelet activation in a concentration-dependent manner without cytotoxic effects, and antiplatelet potency was not strictly related to global antioxidant indices. Computational analyses revealed stable ligand\u2013receptor interactions and favorable binding free energies for selected phenolics, providing a structural explanation for receptor-level modulation. These findings suggest that elicitor-driven responses in blueberries can influence platelet functional responses and highlight the importance of qualitative phytochemical composition in determining vascular bioactivity. This multiscale approach connects plant stress physiology, natural product chemistry, and human platelet biology, underscoring the translational relevance of agronomic strategies for nutraceutical functionality.<\/jats:p>","DOI":"10.3390\/ijms27167306","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:01:26Z","timestamp":1786968086000},"page":"7306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Water Deficit and Methyl Jasmonate Enhance the Antiplatelet Potential of Blueberries Through Changes in Selected Phenolic Compounds"],"prefix":"10.3390","volume":"27","author":[{"given":"Carlos","family":"Vasquez-Rojas","sequence":"first","affiliation":[{"name":"Multidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Cinco Poniente #1670, Talca 3460787, Chile"},{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago 8580746, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1169-3805","authenticated-orcid":false,"given":"Lyanne","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Thrombosis and Healthy Aging Research Center, VITALIS Longevity Center, Medical Technology School, Faculty of Health Sciences, Interuniversity Center for Healthy Aging, Universidad de Talca, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-2305","authenticated-orcid":false,"given":"Daniel","family":"Bustos","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioinform\u00e1tica y Qu\u00edmica Computacional, Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Cat\u00f3lica del Maule, Talca 3480094, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3478-7726","authenticated-orcid":false,"given":"Valentina","family":"Jara-Villacura","sequence":"additional","affiliation":[{"name":"Multidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Cinco Poniente #1670, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Balbont\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Agropecuarias, INIA Quilamapu, Av. Vicente M\u00e9ndez 515, Chill\u00e1n 3800062, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3871-0261","authenticated-orcid":false,"given":"Gabriela","family":"Urra","sequence":"additional","affiliation":[{"name":"Doctoral Program in Sciences with a Specialization in Modeling of Chemical and Biological Systems, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry, Centre of Biotechnology in Natural Resources, Faculty of Agricultural and Forestry Sciences, Universidad Cat\u00f3lica del Maule, Ave. San Miguel, 3605, Talca 3480112, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-5289","authenticated-orcid":false,"given":"Evelyn","family":"Villagra","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry, Centre of Biotechnology in Natural Resources, Faculty of Agricultural and Forestry Sciences, Universidad Cat\u00f3lica del Maule, Ave. San Miguel, 3605, Talca 3480112, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Laporte","sequence":"additional","affiliation":[{"name":"Laboratory of Plant Physiology and Molecular Biology, Instituto de Ciencias Biom\u00e9dicas, Facultad Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Parra-Palma","sequence":"additional","affiliation":[{"name":"Multidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Cinco Poniente #1670, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-314X","authenticated-orcid":false,"given":"Patricio","family":"Ramos","sequence":"additional","affiliation":[{"name":"Plant Microorganism Interaction Laboratory, Instituto de Ciencias Biol\u00f3gicas, Universidad de Talca, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-4108","authenticated-orcid":false,"given":"Eduardo","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Thrombosis and Healthy Aging Research Center, VITALIS Longevity Center, Medical Technology School, Faculty of Health Sciences, Interuniversity Center for Healthy Aging, Universidad de Talca, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-1989","authenticated-orcid":false,"given":"Luis","family":"Morales-Quintana","sequence":"additional","affiliation":[{"name":"Multidisciplinary Agroindustry Research Laboratory, Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Cinco Poniente #1670, Talca 3460787, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shaito, A., Aramouni, K., Assaf, R., Parenti, A., Orekhov, A., Yazbi, A.E., Pintus, G., and Eid, A.H. 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