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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Despite the traditional application of Sophora moorcroftiana (Benth.) Baker seeds for liver disorders, the capacity of its 70% ethanol extract (SMS) to alleviate metabolic dysfunction-associated steatotic liver disease (MASLD) and the underlying gut\u2013liver axis mechanisms remain unclear. In this study, a high-fat diet (HFD)-induced MASLD mouse model was established to investigate the protective effects of SMS and its regulatory role in the interplay among gut microbiota, short-chain fatty acids (SCFAs), and inflammation. Serum, intestinal, and hepatic samples were collected to evaluate inflammatory responses, intestinal barrier integrity, and hepatic lipid metabolism. Gut microbiota composition and SCFA profiles were analyzed using 16S rRNA sequencing and metabolomics. In LPS-stimulated Caco-2 cells, SMS reduced inflammatory cytokines and TLR4\/MyD88\/NF-\u03baB-associated signaling. The results demonstrated that SMS markedly alleviated hepatic steatosis by reducing triglyceride synthesis and hepatocellular lipid accumulation. In addition, SMS promoted the proliferation of beneficial bacteria, including Bifidobacterium and Akkermansia, and increased the production of SCFAs, particularly butyrate. SMS also restored intestinal barrier integrity through upregulation of Occludin and Claudin-1, thereby reducing circulating lipopolysaccharide (LPS) levels. Furthermore, SMS attenuated inflammation by inhibiting activation of the TLR4\/NF-\u03baB signaling pathway. Collectively, these findings demonstrate that SMS alleviates MASLD through coordinated modulation of gut microbiota composition, SCFA metabolism, intestinal barrier function, and inflammatory responses, highlighting its potential as a therapeutic strategy targeting the gut\u2013liver axis.<\/jats:p>","DOI":"10.3390\/ijms27167368","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:06:41Z","timestamp":1787044001000},"page":"7368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sophora moorcroftiana Seeds Ethanol Extract Against Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice by Modulating Gut Microbiota Dysbiosis, SCFAs, and Related Inflammation"],"prefix":"10.3390","volume":"27","author":[{"given":"Xiaotong","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxue","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Medicine, Tibet University, Lhasa 850001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Medicine, Tibet University, Lhasa 850001, China"},{"name":"College of Pharmacy, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-8398","authenticated-orcid":false,"given":"Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-1076","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Pharmacy, School of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China"},{"name":"Department of Pharmacy, College of Medicine, Tibet University, Lhasa 850001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s42255-024-00985-1","article-title":"From NAFLD to MASLD: Implications of the New Nomenclature for Preclinical and Clinical Research","volume":"6","author":"Hsu","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zazueta, A., Valenzuela-P\u00e9rez, L., Ortiz-L\u00f3pez, N., Pinto-Le\u00f3n, A., Torres, V., Gui\u00f1ez, D., Aliaga, N., Merino, P., Sandoval, A., and Covarrubias, N. (2024). Alteration of Gut Microbiota Composition in the Progression of Liver Damage in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084387"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and Resolution of Inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.31518","article-title":"Multiple Parallel Hits Hypothesis in Nonalcoholic Fatty Liver Disease: Revisited After a Decade","volume":"73","author":"Tilg","year":"2021","journal-title":"Hepatology"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Burz, S.D., Monnoye, M., Philippe, C., Farin, W., Ratziu, V., Strozzi, F., Paillarse, J.-M., Ch\u00eane, L., Blotti\u00e8re, H.M., and G\u00e9rard, P. (2021). Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD). Microorganisms, 9.","DOI":"10.3390\/microorganisms9010199"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"lxae125","DOI":"10.1093\/jambio\/lxae125","article-title":"Coprococcus Protects against High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice","volume":"135","author":"Lu","year":"2024","journal-title":"J. Appl. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"20584","DOI":"10.1038\/s41598-023-47905-z","article-title":"Characterization of Gut Microbiome Composition in Iranian Patients with Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"13","author":"Abdollahiyan","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"22385","DOI":"10.1038\/s41598-024-72909-8","article-title":"Altered Gut Microbial Profile Accompanied by Abnormal Short Chain Fatty Acid Metabolism Exacerbates Nonalcoholic Fatty Liver Disease Progression","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mitrovi\u0107, M., Stankovi\u0107 Popovi\u0107, V., Erceg, S., Peri\u0161i\u0107 Mitrovi\u0107, M., Dobrosavljevi\u0107, A., Stupar, A., Vukovi\u0107, P., Zlatkovi\u0107, D., and Svorcan, P. (2025). Exploring the Potential of Oral Butyrate Supplementation in Metabolic Dysfunction-Associated Steatotic Liver Disease: Subgroup Insights from an Interventional Study. Int. J. Mol. Sci., 26.","DOI":"10.20944\/preprints202504.0157.v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","article-title":"Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14","volume":"182","author":"Guo","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Forlano, R., Mullish, B.H., Roberts, L.A., Thursz, M.R., and Manousou, P. (2022). The Intestinal Barrier and Its Dysfunction in Patients with Metabolic Diseases and Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020662"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.2147\/DDDT.S514498","article-title":"The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease","volume":"19","author":"Song","year":"2025","journal-title":"Drug Devel Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13567-018-0596-9","article-title":"Therapeutic and Immunoregulatory Effects of Water-Soluble Alkaloids E2-a from Sophora Moorcroftiana Seeds as a Novel Potential Agent against Echinococcosis in Experimentally Protoscolex-Infected Mice","volume":"49","author":"Luo","year":"2018","journal-title":"Vet. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1080\/01480545.2021.1962692","article-title":"Hepatoprotective Effect of Sophora m Oorcroftiana (Benth.) Benth.Ex Baker Seeds in vivo and in vitro","volume":"45","author":"Yuan","year":"2022","journal-title":"Drug Chem. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yuan, R., Gui, M., Huang, S., Ciren, Y., Zhuoma, D., Yang, G., Zhang, W., Wang, S., and Li, B. (2025). Sophora Moocroftiana Seeds Ethanol Extract Regulates NLRP3 Inflammasome Activation and Pyroptosis via ROS\/TXNIP Pathway to Amelioration of NAFLD in Vitro and in Vivo. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1622178"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chen, X., Cui, M., Sun, X., Gao, L., Liu, H., Yuan, R., Wang, S., Huang, S., and Li, B. (2025). Sophora Moorcroftiana Seeds Ethanol Extract Alleviates Non-Alcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via LKB1\/AMPK Signalling Pathway. Nat. Prod. Res. Product., 1\u201310.","DOI":"10.1080\/14786419.2025.2597514"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The Gut-Liver Axis in Liver Disease: Pathophysiological Basis for Therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bahitham, W., Banoun, Y., Aljahdali, M., Almuaiqly, G., Bahshwan, S.M., Aljahdali, L., Sanai, F.M., Rosado, A.S., and Sergi, C.M. (2025). \u201cTrust Your Gut\u201d: Exploring the Connection between Gut Microbiome Dysbiosis and the Advancement of Metabolic Associated Steatosis Liver Disease (MASLD)\/Metabolic Associated Steatohepatitis (MASH): A Systematic Review of Animal and Human Studies. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1637071"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hui, D., Liu, L., Azami, N.L.B., Song, J., Huang, Y., Xu, W., Wu, C., Xie, D., Jiang, Y., and Bian, Y. (2023). The Spleen-Strengthening and Liver-Draining Herbal Formula Treatment of Non-Alcoholic Fatty Liver Disease by Regulation of Intestinal Flora in Clinical Trial. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1107071"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"19355","DOI":"10.18632\/oncotarget.8466","article-title":"Distinctly Altered Gut Microbiota in the Progression of Liver Disease","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Xu, B., Hao, K., Chen, X., Wu, E., Nie, D., Zhang, G., and Si, H. (2022). Broussonetia Papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora. Nutrients, 14.","DOI":"10.3390\/nu14132636"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.transproceed.2016.01.077","article-title":"Profile of Gut Microbiota Associated With the Presence of Hepatocellular Cancer in Patients With Liver Cirrhosis","volume":"48","author":"Wronka","year":"2016","journal-title":"Transplant. Proc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Luo, D., Yang, L., Pang, H., Zhao, Y., Li, K., Rong, X., and Guo, J. (2022). Tianhuang Formula Reduces the Oxidative Stress Response of NAFLD by Regulating the Gut Microbiome in Mice. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.984019"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00535-022-01909-0","article-title":"Pathogenic Effects of Desulfovibrio in the Gut on Fatty Liver in Diet-Induced Obese Mice and Children with Obesity","volume":"57","author":"Lin","year":"2022","journal-title":"J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jcmgh.2023.08.001","article-title":"Escherichia Coli Promotes Endothelial to Mesenchymal Transformation of Liver Sinusoidal Endothelial Cells and Exacerbates Nonalcoholic Fatty Liver Disease Via Its Flagellin","volume":"16","author":"Shen","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/gutjnl-2012-304119","article-title":"Western Diet Induces Dysbiosis with Increased E Coli in CEABAC10 Mice, Alters Host Barrier Function Favouring AIEC Colonisation","volume":"63","author":"Denizot","year":"2014","journal-title":"Gut"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00253-019-10304-4","article-title":"Effects of a Probiotic Intervention on Escherichia Coli and High-Fat Diet-Induced Intestinal Microbiota Imbalance","volume":"104","author":"Sun","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e26991","DOI":"10.1016\/j.heliyon.2024.e26991","article-title":"Short-Chain Fatty Acids in Nonalcoholic Fatty Liver Disease: New Prospects for Short-Chain Fatty Acids as Therapeutic Targets","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1039\/D4FO02390K","article-title":"Limosilactobacillus Fermentum HNU312 Alleviates Lipid Accumulation and Inflammation Induced by a High-Fat Diet: Improves Lipid Metabolism Pathways and Increases Short-Chain Fatty Acids in the Gut Microbiome","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, A., and Van Sinderen, D. (2016). Bifidobacteria and Their Role as Members of the Human Gut Microbiota. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00925"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1002\/fsn3.4279","article-title":"Bifidobacterium Longum BL -19 Inhibits Oxidative Stress and Inflammatory Damage in the Liver of Mice with NAFLD by Regulating the Production of Butyrate in the Intestine","volume":"12","author":"Zhang","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/JOE-20-0018","article-title":"SCFAs Alleviated Steatosis and Inflammation in Mice with NASH Induced by MCD","volume":"245","author":"Deng","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1096\/fj.202000455R","article-title":"Propionic Acid and Not Caproic Acid, Attenuates Nonalcoholic Steatohepatitis and Improves (Cerebro) Vascular Functions in Obese Ldlr\u2212\/\u2212 .Leiden Mice","volume":"34","author":"Tengeler","year":"2020","journal-title":"FASEB J."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ye, J., Lv, L., Wu, W., Li, Y., Shi, D., Fang, D., Guo, F., Jiang, H., Yan, R., and Ye, W. (2018). Butyrate Protects Mice Against Methionine\u2013Choline-Deficient Diet-Induced Non-Alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01967"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v23.i1.60","article-title":"Sodium Butyrate Attenuates High-Fat Diet-Induced Steatohepatitis in Mice by Improving Gut Microbiota and Gastrointestinal Barrier","volume":"23","author":"Zhou","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10675","DOI":"10.1039\/D0FO01954B","article-title":"Amelioration of Non-Alcoholic Fatty Liver Disease by Sodium Butyrate Is Linked to the Modulation of Intestinal Tight Junctions in Db\/Db Mice","volume":"11","author":"Yang","year":"2020","journal-title":"Food Funct."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2500099","DOI":"10.1080\/19490976.2025.2500099","article-title":"Advances in the Acting Mechanism and Treatment of Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease","volume":"17","author":"Wu","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2331460","DOI":"10.1080\/19490976.2024.2331460","article-title":"Breaking the Barriers: The Role of Gut Homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)","volume":"16","author":"Cubero","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases","volume":"26","author":"An","year":"2022","journal-title":"J. Gastrointest. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Vallianou, N.G., Kounatidis, D., Psallida, S., Vythoulkas-Biotis, N., Adamou, A., Zachariadou, T., Kargioti, S., Karampela, I., and Dalamaga, M. (2024). NAFLD\/MASLD and the Gut\u2013Liver Axis: From Pathogenesis to Treatment Options. Metabolites, 14.","DOI":"10.3390\/metabo14070366"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"104912","DOI":"10.1016\/j.cellimm.2024.104912","article-title":"Sodium Butyrate Prevents Lipopolysaccharide Induced Inflammation and Restores the Expression of Tight Junction Protein in Human Epithelial Caco-2 Cells","volume":"408","author":"Bakshi","year":"2025","journal-title":"Cell. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, Y., Deng, H., Xiao, L., and Pan, Y. (2024). Escherichia Coli Nissle 1917 Protects against Sepsis-Induced Intestinal Damage by Regulating the SCFA\/GPRs Signaling Pathway. Microorganisms, 12.","DOI":"10.3390\/microorganisms12081622"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"157249","DOI":"10.1016\/j.phymed.2025.157249","article-title":"Siweixizangmaoru Decoction Attenuates Collagen-Induced Arthritis via Gut Microbiota-Dependent SCFA Restoration and Immunomodulation","volume":"148","author":"Sun","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"156833","DOI":"10.1016\/j.phymed.2025.156833","article-title":"Sophocarpine Suppresses MAPK-Mediated Inflammation by Restoring Gut Microbiota in Colorectal Cancer","volume":"143","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cao, G., Li, J., Mao, Z., and Zhang, Y. (2023). Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells. Molecules, 28.","DOI":"10.3390\/molecules28155879"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"117262","DOI":"10.1016\/j.biopha.2024.117262","article-title":"Oral Matrine Alleviates CCl4-Induced Liver Fibrosis via Preserved HSP72 from Modulated Gut Microbiota","volume":"178","author":"Zhu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose Translation from Animal to Human Studies Revisited","volume":"22","author":"Nihal","year":"2008","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112960","DOI":"10.1016\/j.envpol.2019.112960","article-title":"Bisphenol A Increases Intestinal Permeability through Disrupting Intestinal Barrier Function in Mice","volume":"254","author":"Feng","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7368\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:08:14Z","timestamp":1787044094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":49,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167368"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167368","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}