{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:32:38Z","timestamp":1787045558213,"version":"build-2736575974"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002568","name":"2023 Research Fund of the University of Ulsan","doi-asserted-by":"publisher","award":["2023-0380"],"award-info":[{"award-number":["2023-0380"]}],"id":[{"id":"10.13039\/501100002568","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2023-0380"],"award-info":[{"award-number":["2023-0380"]}],"id":[{"id":"https:\/\/ror.org\/02c2f8975","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Combination therapy has emerged as an effective strategy to enhance anticancer efficacy while overcoming the limitations of conventional cancer treatment, including systemic toxicity and therapeutic resistance. Among marine-derived bioactive compounds, fucoidan, a sulfated polysaccharide isolated from brown seaweeds, has attracted considerable attention because of its multitarget biological activities, favorable safety profile, and ability to enhance therapeutic responses. Increasing evidence suggests that fucoidan may be particularly valuable as a multifunctional combination partner rather than as a standalone anticancer agent, capable of potentiating the efficacy of conventional chemotherapy, targeted therapy, and, to a much lesser extent, natural bioactive compounds. In this review, we summarize the biological characteristics that make fucoidan an attractive combination partner and provide a comprehensive overview of current evidence regarding fucoidan-based combination strategies for cancer therapy. We further discuss the molecular mechanisms underlying these combination effects, including the regulation of apoptosis, autophagy, tumor microenvironment remodeling, and oncogenic signaling pathways associated with therapeutic resistance. Although combinations with conventional anticancer therapies have been extensively investigated, studies involving natural bioactive compounds remain remarkably limited, highlighting an important opportunity for future research. Collectively, current evidence, derived largely from preclinical studies, supports the potential of fucoidan as a promising multifunctional adjuvant for cancer combination therapy, while further standardization, mechanistic studies, and clinical validation will be essential for its successful translation into clinical practice.<\/jats:p>","DOI":"10.3390\/ijms27167370","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:06:41Z","timestamp":1787044001000},"page":"7370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fucoidan-Based Combination Strategies in Cancer Therapy: Biological Basis, Current Evidence, and Future Perspectives"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5948-5802","authenticated-orcid":false,"given":"Yumi","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, University of Ulsan, Ulsan 44610, Republic of Korea"},{"name":"Basic-Clinical Convergence Research Institute, University of Ulsan, Ulsan 44610, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sung, H., Filho, A.M., Laversanne, M., Ferlay, J., Siegel, R.L., Soerjomataram, I., Jemal, A., and Bray, F. (2026). Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries. CA Cancer J. Clin., 76.","DOI":"10.3322\/caac.70090"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural Products as Sources of New Drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Choudhari, A.S., Mandave, P.C., Deshpande, M., Ranjekar, P., and Prakash, O. (2019). Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Front. Pharmacol., 10, Corrigendum in Front Pharmacol. 2020, 11, 175.","DOI":"10.3389\/fphar.2020.00175"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.7150\/jca.34374","article-title":"The Power of Phytochemicals Combination in Cancer Chemoprevention","volume":"11","author":"Rizeq","year":"2020","journal-title":"J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Talib, W.H., Awajan, D., Hamed, R.A., Azzam, A.O., Mahmod, A.I., and Al-Yasari, I.H. (2022). Combination Anticancer Therapies Using Selected Phytochemicals. Molecules, 27.","DOI":"10.3390\/molecules27175452"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Casta\u00f1eda, A.M., Mel\u00e9ndez, C.M., Uribe, D., and Pedroza-D\u00edaz, J. (2022). Synergistic effects of natural compounds and conventional chemotherapeutic agents: Recent insights for the development of cancer treatment strategies. Heliyon, 8.","DOI":"10.1016\/j.heliyon.2022.e09519"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1039\/D2NP00083K","article-title":"Marine natural products","volume":"40","author":"Carroll","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ahmad, M., Tahir, M., Hong, Z., Zia, M.A., Rafeeq, H., Ahmad, M.S., Rehman, S.U., and Sun, J. (2024). Plant and marine-derived natural products: Sustainable pathways for future drug discovery and therapeutic development. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1497668"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Khalifa, S.A.M., Elias, N., Farag, M.A., Chen, L., Saeed, A., Hegazy, M.F., Moustafa, M.S., Abd El-Wahed, A., Al-Mousawi, S.M., and Musharraf, S.G. (2019). Marine Natural Products: A Source of Novel Anticancer Drugs. Mar. Drugs, 17.","DOI":"10.3390\/md17090491"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Apostolova, E., Lukova, P., Baldzhieva, A., Katsarov, P., Nikolova, M., Iliev, I., Peychev, L., Trica, B., Oancea, F., and Delattre, C. (2020). Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review. Polymers, 12.","DOI":"10.3390\/polym12102338"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Turrini, E., Maffei, F., and Fimognari, C. (2023). Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects. Mar. Drugs, 21.","DOI":"10.3390\/md21050307"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yu, H., Zhang, Q., Farooqi, A.A., Wang, J., Yue, Y., Geng, L., and Wu, N. (2024). Opportunities and challenges of fucoidan for tumors therapy. Carbohydr. Polym., 324.","DOI":"10.1016\/j.carbpol.2023.121555"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kim, E.J., Park, S.Y., Lee, J.Y., and Park, J.H. (2010). Fucoidan present in brown algae induces apoptosis of human colon cancer cells. BMC Gastroenterol., 10.","DOI":"10.1186\/1471-230X-10-96"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., Liu, Y., Sun, L., and Li, Q. (2012). Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043483"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.3892\/mmr.2015.3804","article-title":"Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase\/Akt\/mechanistic target of rapamycin pathways","volume":"12","author":"Han","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lee, H., Kim, J.S., and Kim, E. (2012). Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050624"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bai, X., Wang, Y., Hu, B., Cao, Q., Xing, M., Song, S., and Ji, A. (2020). Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway. Mar. Drugs, 18.","DOI":"10.3390\/md18040220"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.3390\/md13042327","article-title":"Fucoidan and cancer: A multifunctional molecule with anti-tumor potential","volume":"13","author":"Atashrazm","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"748","DOI":"10.2174\/1389201018666171115115112","article-title":"Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines","volume":"18","author":"Abudabbus","year":"2017","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Huang, C.W., Chen, Y.C., Yin, T.C., Chen, P.J., Chang, T.A.-O., Su, W.C., Ma, C.J., Li, C.C., Tsai, H.L., and Wang, J.A.-O. (2021). Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158041"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Abdollah, M.R.A., Ali, A.A., Elgohary, H.H., and Elmazar, M.M. (2023). Antiangiogenic drugs in combination with seaweed fucoidan: A mechanistic in vitro and in vivo study exploring the VEGF receptor and its downstream signaling molecules in hepatic cancer. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1108992"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Deng, Z., Qishan, S., Zhang, Q., Wang, J., Yue, Y., Geng, L., and Wu, N. (2024). Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin. Biomed. Pharmacother., 173, Corrigendum in Biomed Pharmacother. 2026, 197, 119213.","DOI":"10.1016\/j.biopha.2026.119213"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/md11010194","article-title":"The effect of sulfated (1\u21923)-\u03b1-l-fucan from the brown alga Saccharina cichorioides Miyabe on resveratrol-induced apoptosis in colon carcinoma Cells","volume":"11","author":"Vishchuk","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Al Monla, R., Dassouki, Z., Sari-Chmayssem, N., Mawlawi, H., and Gali-Muhtasib, H. (2022). Fucoidan and Alginate from the Brown Algae Colpomenia sinuosa and Their Combination with Vitamin C Trigger Apoptosis in Colon Cancer. Molecules, 27.","DOI":"10.3390\/molecules27020358"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhong, J., Chung, S.K., Han, X., Huang, R., Xu, B., and Wong, I.N. (2025). Harnessing marine algal polysaccharides for combination cancer therapy: Pharmacological mechanisms and clinical perspectives. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1682025"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.3390\/md13095920","article-title":"Therapies from Fucoidan: An Update","volume":"13","author":"Fitton","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Jin, J.O., Chauhan, P.S., Arukha, A.P., Chavda, V., Dubey, A., and Yadav, D.A.-O. (2021). The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles. Mar. Drugs, 19.","DOI":"10.3390\/md19050265"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.31557\/APJCP.2020.21.8.2469","article-title":"Antitumor Effects of Fucoidan Via Apoptotic and Autophagic Induction on HSC-3 Oral Squamous CellCarcinoma","volume":"21","author":"Chantree","year":"2020","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Nguyen, A.N., Van Ngo, Q., Quach, T.T.M., Ueda, S., Yuguchi, Y., Matsumoto, Y., Kitamura, S., Ho, C.D., and Thanh, T.T.T. (2024). Fucoidan from brown seaweed Tubinaria decurrens: Structure and structure\u2014Anticancer activity relationship. Int. J. Biol. Macromol., 259.","DOI":"10.1016\/j.ijbiomac.2024.129326"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lin, Y., Qi, X., Liu, H., Xue, K., Xu, S., and Tian, Z. (2020). The anti-cancer effects of fucoidan: A review of both in vivo and in vitro investigations. Cancer Cell Int., 20.","DOI":"10.1186\/s12935-020-01233-8"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3892\/ol.2011.254","article-title":"Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer","volume":"2","author":"Ikeguchi","year":"2011","journal-title":"Oncol. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/1534735416684014","article-title":"The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients with Breast Cancer","volume":"17","author":"Tocaciu","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Critelli, S., and Celano, M. (2026). Fucoidan: An Update on Function, Role in Human Health and Applications. Chem. Biol. Drug Des., 107.","DOI":"10.1111\/cbdd.70310"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lakshmikanthan, M., and Muthu, S. (2026). Fucoidan: Structure\u2013activity relationships, molecular mechanisms, and nanotherapeutic applications with perspectives from Traditional Chinese Medicine. Pharmacol. Res. Mod. Chin. Med., 20.","DOI":"10.1016\/j.prmcm.2026.100838"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1002\/ptr.7303","article-title":"Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Oh, B., Kim, J., Lu, W., and Rosenthal, D. (2014). Anticancer effect of fucoidan in combination with tyrosine kinase inhibitor lapatinib. Evid. Based Complement. Altern. Med., 2014.","DOI":"10.1155\/2014\/865375"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yang, J., Yang, X., Pan, W., Wang, M., Lu, Y., Zhang, J., Fang, Z., Zhang, X., Ji, Y., and Bei, J.X. (2021). Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.733246"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1039\/D3FO04807A","article-title":"Fucoidan enhances the anti-tumor effect of anti-PD-1 immunotherapy by regulating gut microbiota","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhang, W., Park, H.B., An, E.K., Kim, S.J., Ryu, D., Kim, D., Lim, D., Hwang, J., Kwak, M., and You, S. (2024). Fucoidan from Durvillaea Antarctica enhances the anti-cancer effect of anti-PD-L1 antibody by activating dendritic cells and T cells. Int. J. Biol. Macromol., 280.","DOI":"10.1016\/j.ijbiomac.2024.135922"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Miyata, Y.A.-O., Matsuo, T.A.-O., Ohba, K.A.-O., Mitsunari, K.A.-O., Mukae, Y., Otsubo, A., Harada, J., Matsuda, T., Kondo, T., and Sakai, H. (2020). Present Status, Limitations and Future Directions of Treatment Strategies Using Fucoidan-Based Therapies in Bladder Cancer. Cancers, 12.","DOI":"10.3390\/cancers12123776"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yang, F., Xiao, D., Dissanayake, D.S., Jayawardhana, H., Song, J.Y., Ko, K.Y., and Jeon, Y.J. (2026). Ethnopharmacological basis and combined protection of intestinal barrier function by fucoidan from Sargassum thunbergii and chito-oligosaccharides in DSS-induced colitis. J. Ethnopharmacol., 365.","DOI":"10.1016\/j.jep.2026.121599"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Fang, S., Liu, N., Zhang, T., Huang, Y., Li, L., Tian, Y., Hu, X., Ji, Y., and Guo, Y. (2025). Fucoidan in cancer therapy: From biomedical application to medicinal chemistry approach. J. Mater. Sci. Mater. Med., 36.","DOI":"10.1007\/s10856-025-06962-8"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"T77","DOI":"10.1111\/j.1750-3841.2011.02099.x","article-title":"Antiproliferative activity of fucoidan was associated with the induction of apoptosis and autophagy in AGS human gastric cancer cells","volume":"76","author":"Park","year":"2011","journal-title":"J. Food Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tsai, H.L., Tai, C.J., Huang, C.W., Chang, F.R., and Wang, J.Y. (2017). Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial. Mar. Drugs, 15.","DOI":"10.3390\/md15040122"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zou, Y., Wu, S.Y., Zhang, W., Zhang, W., Shen, X., Qu, X., and Yao, Q. (2025). Fucoidan Improves Tumour Control and Liver Function in TACE for Unresectable Hepatocellular Carcinoma: A Random-ised Trial. Liver Int., 45.","DOI":"10.1111\/liv.70347"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Tsai, H.L., Yeh, Y.S., Chen, P.J., Chang, Y.T., Chen, Y.C., Su, W.C., Chang, T.K., Huang, C.W., and Wang, J.Y. (2023). The Auxiliary Effects of Low-Molecular-Weight Fucoidan in Locally Advanced Rectal Cancer Patients Receiving Neoad-juvant Concurrent Chemoradiotherapy Before Surgery: A Double-Blind, Randomized, Placebo-Controlled Study. Integr. Cancer Ther., 22.","DOI":"10.1177\/15347354231187153"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7370\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:08:28Z","timestamp":1787044108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":48,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167370"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167370","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]}}}