{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:34:28Z","timestamp":1792690468479,"version":"4.5.0"},"reference-count":319,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Considered a global public health priority, sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Its heterogeneous clinical presentation arises, in part, from pre-existing chronic conditions such as hypertension, metabolic syndrome, diabetes, alcohol exposure, psychosocial stress, and periodontitis, which induce persistent systemic changes even before the infectious event. This narrative review synthesizes evidence from experimental models and clinical studies to clarify the molecular and immunological mechanisms by which chronic conditions influence the septic state. We discuss how these conditions converge on common pathophysiological mechanisms, including low-grade chronic inflammation, oxidative stress, endothelial and mitochondrial dysfunction, and changes in the microbiota and neuroimmune regulation. Pathways such as TLR-NF-\u03baB signaling and the NLRP3 inflammasome are maintained in a basal state of activation, lowering the threshold for hyperinflammatory responses and increasing the risk of multiple organ dysfunction syndrome. In conclusion, understanding these phenotypes can guide the identification of biomarkers and the development of personalized therapeutic strategies, thereby moving beyond one-size-fits-all approaches to the management of sepsis and septic shock.<\/jats:p>","DOI":"10.3390\/ijms27167395","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:58:23Z","timestamp":1787126303000},"page":"7395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comorbidities and Inflammation: How Chronic Diseases Prime the Host Response in Sepsis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0963-8864","authenticated-orcid":false,"given":"Maria Vit\u00f3ria Oliveira","family":"Miguel","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina 86055-970, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-6007","authenticated-orcid":false,"given":"Rayssa Menon","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina 86055-970, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4085-8500","authenticated-orcid":false,"given":"Matheus Marques de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina 86055-970, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-178X","authenticated-orcid":false,"given":"Gislaine Garcia","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina 86055-970, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-7742","authenticated-orcid":false,"given":"Andressa","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina 86055-970, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of Global Incidence and Mortality of Hospital-Treated Sepsis. Current Estimates and Limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, Regional, and National Sepsis Incidence and Mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Guarino, M., Perna, B., Cesaro, A.E., Maritati, M., Spampinato, M.D., Contini, C., and De Giorgio, R. (2023). 2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department. J. Clin. Med., 12.","DOI":"10.3390\/jcm12093188"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chang, Z., Lu, J., Zhang, Q., Wu, H., Liang, Z., Pan, X., Li, B., Cheng, Z.J., and Sun, B. (2024). Clinical Biomarker Profiles Reveals Gender Differences and Mortality Factors in Sepsis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1413729"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13054-025-05516-2","article-title":"Harnessing Adiponectin for Sepsis: Current Knowledge, Clinical Insights and Future Therapies","volume":"29","author":"Gianoli","year":"2025","journal-title":"Crit. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2337\/dc10-1185","article-title":"Diabetes and Sepsis: Preclinical Findings and Clinical Relevance","volume":"34","author":"Schuetz","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"l5784","DOI":"10.1136\/bmj.l5784","article-title":"Stress Related Disorders and Subsequent Risk of Life Threatening Infections: Population Based Sibling Controlled Cohort Study","volume":"367","author":"Song","year":"2019","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chest.2017.11.041","article-title":"The Effect of Alcohol Consumption on the Risk of ARDS","volume":"154","author":"Simou","year":"2017","journal-title":"Chest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00063-023-01037-4","article-title":"Sepsis and Underlying Comorbidities in Intensive Care Unit Patients","volume":"119","author":"Schwarzkopf","year":"2024","journal-title":"Med. Klin. Intensivmed. Notfmed."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3071","article-title":"Macrophage-Mediated Inflammation in Metabolic Disease","volume":"11","author":"Chawla","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zheng, H., Yu, F., Bei, C., Zhou, Y., Mo, Z., and Wei, B. (2026). Diabetes Mellitus and Mortality in Patients Admitted to ICU with Sepsis: A Meta-Analysis. Front. Med., 13.","DOI":"10.3389\/fmed.2026.1743706"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Meydan, C., Bekenstein, U., and Soreq, H. (2018). Molecular Regulatory Pathways Link Sepsis with Metabolic Syndrome: Non-Coding RNA Elements Underlying the Sepsis\/Metabolic Cross-Talk. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00189"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a Link between Obesity, Metabolic Syndrome and Type 2 Diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41569-023-00964-1","article-title":"Immune and Inflammatory Mechanisms in Hypertension","volume":"21","author":"Guzik","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1530-0277.2007.00355.x","article-title":"Alcohol Binge before Trauma\/Hemorrhage Impairs Integrity of Host Defense Mechanisms during Recovery","volume":"31","author":"Greiffenstein","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2018.02.008","article-title":"Chronic Ethanol Consumption Increases Vascular Oxidative Stress and the Mortality Induced by Sub-Lethal Sepsis: Potential Role of INOS","volume":"825","author":"Ceron","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Garc\u00eda, M., and Hern\u00e1ndez-Lemus, E. (2024). The Molecular Comorbidity Network of Periodontal Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810161"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3748\/wjg.v16.i11.1321","article-title":"Alcoholic Liver Disease and the Gut-Liver Axis","volume":"16","author":"Szabo","year":"2010","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.4049\/jimmunol.1303468","article-title":"Moderate Alcohol Induces Stress Proteins HSF1 and Hsp70 and Inhibits Pro-Inflammatory Cytokines Resulting in Endotoxin Tolerance","volume":"193","author":"Muralidharan","year":"2014","journal-title":"J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e58855","DOI":"10.7554\/eLife.58855","article-title":"Chronic Ethanol Consumption Compromises Neutrophil Function in Acute Pulmonary Aspergillus Fumigatus Infection","volume":"9","author":"Souza","year":"2020","journal-title":"eLife"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: From Microbial Immune Subversion to Systemic Inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/toxsci\/kfg146","article-title":"Immune Changes during Acute Cold\/Restraint Stress-Induced Inhibition of Host Resistance to Listeria","volume":"74","author":"Cao","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbi.2005.09.006","article-title":"Role of Early Stress in the Individual Differences in Host Response to Viral Infection","volume":"20","author":"Avitsur","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maydych, V., Claus, M., Watz, C., and Kleinsorge, T. (2018). Attention to Emotional Information Is Associated with Cytokine Responses to Psychological Stress. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00687"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Scanzano, A., and Cosentino, M. (2015). Adrenergic Regulation of Innate Immunity: A Review. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2015.00171"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/JLB.3A1017-398RR","article-title":"\u03922 -Adrenoceptors Inhibit Neutrophil Extracellular Traps in Human Polymorphonuclear Leukocytes","volume":"104","author":"Marino","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of Microorganisms and Activation of the Immune Response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen Recognition and Innate Immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern Recognition Receptors and Inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The Role of Pattern-Recognition Receptors in Innate Immunity: Update on Toll-like Receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS Signaling in C3H\/HeJ and C57BL\/10ScCr Mice: Mutations in Tlr4 Gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2024.03.004","article-title":"Decoding Toll-like Receptors: Recent Insights and Perspectives in Innate Immunity","volume":"57","author":"Kawai","year":"2024","journal-title":"Immunity"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen Recognition by the Innate Immune System","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The Inflammasomes: Guardians of the Body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The Inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41392-023-01687-y","article-title":"The Role of Inflammasomes in Human Diseases and Their Potential as Therapeutic Targets","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1189\/jlb.3AB1214-590R","article-title":"Metabolic Danger Signals, Uric Acid and ATP, Mediate Inflammatory Cross-Talk between Hepatocytes and Immune Cells in Alcoholic Liver Disease","volume":"98","author":"Petrasek","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.00031.2016","article-title":"Role of the Immune System in Hypertension","volume":"97","author":"Pons","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the Site of Inflammation: The Leukocyte Adhesion Cascade Updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil Recruitment and Function in Health and Inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of Chemokine Receptor by Toll-like Receptor 2 Is Critical to Neutrophil Migration and Resistance to Polymicrobial Sepsis","volume":"106","author":"Freitas","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil Extracellular Traps in Immunity and Disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ccm.2008.06.010","article-title":"The Compensatory Anti-Inflammatory Response Syndrome (CARS) in Critically Ill Patients","volume":"29","author":"Ward","year":"2008","journal-title":"Clin. Chest Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-Induced Immunosuppression: From Cellular Dysfunctions to Immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nm.2156","article-title":"Interleukin-33 Attenuates Sepsis by Enhancing Neutrophil Influx to the Site of Infection","volume":"16","author":"Souto","year":"2010","journal-title":"Nat. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The Immunopathology of Sepsis and Potential Therapeutic Targets","volume":"17","author":"Scicluna","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","article-title":"Biomarkers of Sepsis: Time for a Reappraisal","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit. Care"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Candelli, M., Sacco Fernandez, M., Rozzi, G., Sodero, G., Piccioni, A., Pignataro, G., Rigante, D., and Franceschi, F. (2025). The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications. Diagnostics, 15.","DOI":"10.3390\/diagnostics15222927"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The Blood-Brain Barrier in Systemic Inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_51","first-page":"150","article-title":"Endothelial dysfunction in sepsis","volume":"11","author":"Kremer","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ddmod.2011.05.004","article-title":"Protease Activity and the Role of the Endothelial Glycocalyx in Inflammation","volume":"8","author":"Lipowsky","year":"2011","journal-title":"Drug Discov. Today Dis. Models"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/SHK.0000000000000473","article-title":"The Endothelium in Sepsis","volume":"45","author":"Ince","year":"2016","journal-title":"Shock"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/rccm.201910-1911TR","article-title":"Endothelial Responses in Sepsis","volume":"202","author":"Joffre","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/cc1864","article-title":"Bench-to-Bedside Review: Endothelial Cell Dysfunction in Severe Sepsis: A Role in Organ Dysfunction?","volume":"7","author":"Vallet","year":"2003","journal-title":"Crit. Care"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular Histones Are Major Mediators of Death in Sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s10753-020-01232-x","article-title":"Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis","volume":"43","author":"Luo","year":"2020","journal-title":"Inflammation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/cvr\/cvv144","article-title":"Soluble VE-Cadherin Is Involved in Endothelial Barrier Breakdown in Systemic Inflammation and Sepsis","volume":"107","author":"Flemming","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ajpath.2019.11.016","article-title":"Endothelial Glycocalyx Impairment in Disease: Focus on Hyaluronan Shedding","volume":"190","author":"Flamion","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/CM9.0000000000000177","article-title":"Endothelial Glycocalyx as a Potential Theriapeutic Target in Organ Injuries","volume":"132","author":"Cao","year":"2019","journal-title":"Chin. Med. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11739-012-0859-9","article-title":"Disseminated Intravascular Coagulation: A Review for the Internist","volume":"8","author":"Levi","year":"2013","journal-title":"Intern. Emerg. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0891-5520(05)70085-4","article-title":"Nitric oxide in the pathogenesis of sepsis","volume":"13","author":"Symeonides","year":"1999","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/315682","article-title":"Role of Nitric Oxide in the Failure of Neutrophil Migration in Sepsis","volume":"182","author":"Benjamim","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1128\/IAI.70.7.3602-3610.2002","article-title":"Inhibition of Leukocyte Rolling by Nitric Oxide during Sepsis Leads to Reduced Migration of Active Microbicidal Neutrophils","volume":"70","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1177\/0885066619871452","article-title":"Multiple Organ Dysfunction Syndrome","volume":"35","author":"Gourd","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Misrani, A., Tabassum, S., and Yang, L. (2021). Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.617588"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s40635-024-00694-9","article-title":"Assessment of Mitochondrial Function and Its Prognostic Role in Sepsis: A Literature Review","volume":"12","author":"Nedel","year":"2024","journal-title":"Intensive Care Med. Exp."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2018.07.014","article-title":"Mitochondria in Innate Immune Signaling","volume":"202","author":"Banoth","year":"2018","journal-title":"Transl. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jiao, Y., Yan, Z., and Yang, A. (2023). Mitochondria in Innate Immunity Signaling and Its Therapeutic Implications in Autoimmune Diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1160035"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/SHK.0b013e31820e1ef0","article-title":"Divergent Role of Heme Oxygenase Inhibition in the Pathogenesis of Sepsis","volume":"35","author":"Freitas","year":"2011","journal-title":"Shock"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"102968","DOI":"10.1016\/j.redox.2023.102968","article-title":"Restoring the Infected Powerhouse: Mitochondrial Quality Control in Sepsis","volume":"68","author":"Gartzke","year":"2023","journal-title":"Redox Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/2110-5820-1-41","article-title":"Mitochondrial Dysfunction and Biogenesis: Do ICU Patients Die from Mitochondrial Failure?","volume":"1","author":"Kozlov","year":"2011","journal-title":"Ann. Intensive Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03985","article-title":"A Network-Based Analysis of Systemic Inflammation in Humans","volume":"437","author":"Calvano","year":"2005","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00018-022-04490-0","article-title":"Metabolic Reprogramming Consequences of Sepsis: Adaptations and Contradictions","volume":"79","author":"Liu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_75","first-page":"1234567890","article-title":"Sepsis and the immunometabolic inflammatory response","volume":"4","author":"Paul","year":"2026","journal-title":"Metab. Health Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between Mitochondrial Dysfunction and Severity and Outcome of Septic Shock","volume":"360","author":"Brealey","year":"2002","journal-title":"Lancet"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"21029","DOI":"10.1038\/s41598-020-78195-4","article-title":"Mitochondrial Dysfunction in Sepsis Is Associated with Diminished Intramitochondrial TFAM despite Its Increased Cellular Expression","volume":"10","author":"Rahmel","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cmet.2012.04.023","article-title":"The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism","volume":"15","author":"Haschemi","year":"2012","journal-title":"Cell Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cmet.2014.07.011","article-title":"Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Tipping the Balance of Macrophage-Osteoclast Polarization","volume":"20","author":"Jin","year":"2014","journal-title":"Cell Metab."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Shamriz, O., Bar-On, Z., Yosef, O., Cohen-Daniel, L., Sheer, A., Reuven, O., Salaymeh, W., Saragovi, A., Somech, R., and Lev, A. (2026). NDUFS4, a Mitochondrial Complex I Subunit, Is Essential for T-Cell Metabolic Fitness and Immune Function. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1734203"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen Radicals, Nitric Oxide, and Peroxynitrite: Redox Pathways in Molecular Medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13054-024-05069-w","article-title":"Mitochondrial Dysfunction in Sepsis: Mechanisms and Therapeutic Perspectives","volume":"28","author":"Hu","year":"2024","journal-title":"Crit. Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molmed.2014.11.008","article-title":"Mitochondria: Diversity in the Regulation of NLRP3 Inflammasome","volume":"21","author":"Gurung","year":"2014","journal-title":"Trends Mol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical Role for Calcium Mobilization in Activation of the NLRP3 Inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New Mitochondrial DNA Synthesis Enables NLRP3 Inflammasome Activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/viru.26907","article-title":"The Role of Mitochondrial Dysfunction in Sepsis-Induced Multi-Organ Failure","volume":"5","author":"Singer","year":"2014","journal-title":"Virulence"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of Mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhu, C.L., Yao, R.Q., Li, L.X., Li, P., Xie, J., Wang, J.F., and Deng, X.M. (2021). Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.664896"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1097\/01.CCM.0000230240.02216.21","article-title":"Carbamoyl Phosphate Synthase-1: A Marker of Mitochondrial Damage and Depletion in the Liver during Sepsis","volume":"34","author":"Crouser","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1172\/JCI130996","article-title":"Inhibition of Mitophagy Drives Macrophage Activation and Antibacterial Defense during Sepsis","volume":"130","author":"Patoli","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-03424-1","article-title":"Sepsis Is Associated with Mitochondrial DNA Damage and a Reduced Mitochondrial Mass in the Kidney of Patients with Sepsis-AKI","volume":"25","author":"Star","year":"2021","journal-title":"Crit. Care"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.chest.2019.07.014","article-title":"Circulating Mitochondrial DNA as Predictor of Mortality in Critically Ill Patients: A Systematic Review of Clinical Studies","volume":"156","author":"Harrington","year":"2019","journal-title":"Chest"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11306-024-02089-z","article-title":"Circulating N-Lactoyl-Amino Acids and N-Formyl-Methionine Reflect Mitochondrial Dysfunction and Predict Mortality in Septic Shock","volume":"20","author":"Rogers","year":"2024","journal-title":"Metabolomics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5492\/wjccm.v12.i3.139","article-title":"Sepsis-Induced Mitochondrial Dysfunction: A Narrative Review","volume":"12","author":"Nedel","year":"2023","journal-title":"World J. Crit. Care Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1093\/hmg\/ddae031","article-title":"Mitochondrial DNA Release and Sensing in Innate Immune Responses","volume":"33","author":"Vanportfliet","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-Related Organ Failure Assessment) Score to Describe Organ Dysfunction\/Failure. On Behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.injury.2011.05.032","article-title":"The Role of Toll-like Receptor-4 in the Development of Multi-Organ Failure Following Traumatic Haemorrhagic Shock and Resuscitation","volume":"43","author":"McGhan","year":"2012","journal-title":"Injury"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.phrs.2009.09.008","article-title":"PD98059, a Specific MAP Kinase Inhibitor, Attenuates Multiple Organ Dysfunction Syndrome\/Failure (MODS) Induced by Zymosan in Mice","volume":"61","author":"Galuppo","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_100","first-page":"31","article-title":"Identification of Genes and Pathways Associated with Multiple Organ Dysfunction Syndrome by Microarray Analysis","volume":"18","author":"Gu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol Metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Frydrych, L.M., Fattahi, F., He, K., Ward, P.A., and Delano, M.J. (2017). Diabetes and Sepsis: Risk, Recurrence, and Ruination. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00271"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/PSY.0000000000000545","article-title":"Psychological Stress and Mitochondria: A Systematic Review","volume":"80","author":"Picard","year":"2018","journal-title":"Psychosom. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Deng, Y., Xiao, J., Ma, L., Wang, C., Wang, X., Huang, X., and Cao, Z. (2024). Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021024"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.201003-0416OC","article-title":"Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis","volume":"183","author":"Souto","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Liu, Z., Ting, Y., Li, M., Li, Y., Tan, Y., and Long, Y. (2024). From Immune Dysregulation to Organ Dysfunction: Understanding the Enigma of Sepsis. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1415274"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1757-7241-22-16","article-title":"Interleukin-6 as Inflammatory Marker Referring to Multiple Organ Dysfunction Syndrome in Severely Injured Children","volume":"22","author":"Andruszkow","year":"2014","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_108","first-page":"161","article-title":"Cytokines in the Systemic Inflammatory Response Syndrome: A Reviwe","volume":"2","author":"Jaffer","year":"2010","journal-title":"HSR Proc. Intensive Care Cardiovasc. Anesth."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13054-016-1341-2","article-title":"Early Changes within the Lymphocyte Population Are Associated with the Development of Multiple Organ Dysfunction Syndrome in Trauma Patients","volume":"20","author":"Manson","year":"2016","journal-title":"Crit. Care"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/IAI.00031-20","article-title":"Role of 2 Integrins in Neutrophils and Sepsis","volume":"88","author":"Yuki","year":"2020","journal-title":"Infect. Immun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/sur.2017.298","article-title":"Multiple Organ Dysfunction: The Defining Syndrome of Sepsis","volume":"19","author":"Ziesmann","year":"2018","journal-title":"Surg. Infect."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and Neutrophil Extracellular Traps Collaborate to Promote Intravascular Coagulation during Sepsis in Mice","volume":"129","author":"McDonald","year":"2017","journal-title":"Blood"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0749-0704(03)00069-1","article-title":"ARDS and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process","volume":"18","author":"Khadaroo","year":"2002","journal-title":"Crit. Care Clin."},{"key":"ref_114","first-page":"273","article-title":"Multiple Organ Dysfunction Syndrome","volume":"43","year":"2013","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/01.CCM.0000266683.64081.02","article-title":"Mechanisms of Sepsis-Induced Cardiac Dysfunction","volume":"35","author":"Rudiger","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/SHK.0b013e31824c3238","article-title":"Structural Changes of the Heart during Severe Sepsis or Septic Shock","volume":"37","author":"Smeding","year":"2012","journal-title":"Shock"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI6709","article-title":"Toll4 (TLR4) Expression in Cardiac Myocytes in Normal and Failing Myocardium","volume":"104","author":"Frantz","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cardiores.2006.09.011","article-title":"Toll-like Receptor Stimulation in Cardiomyoctes Decreases Contractility and Initiates an NF-KappaB Dependent Inflammatory Response","volume":"72","author":"Boyd","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Li, H., and Xia, N. (2021). The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.650214"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/sdi.12022","article-title":"Periodontal Diseases and Systemic Inflammation","volume":"26","author":"Craig","year":"2013","journal-title":"Semin. Dial."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/bmj.1.4667.1383","article-title":"Stress and the General Adaptation Syndrome","volume":"1","author":"Selye","year":"1950","journal-title":"Br. Med. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","article-title":"Sepsis-Associated Encephalopathy","volume":"8","author":"Gofton","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13054-017-1643-z","article-title":"Neuroanatomy of Sepsis-Associated Encephalopathy","volume":"21","author":"Heming","year":"2017","journal-title":"Crit. Care"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of Stress on Immune Function: The Good, the Bad, and the Beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10072-021-05810-1","article-title":"Structural and Functional Connections between the Autonomic Nervous System, Hypothalamic-Pituitary-Adrenal Axis, and the Immune System: A Context and Time Dependent Stress Response Network","volume":"43","author":"Mueller","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1378\/chest.08-1149","article-title":"Critical Illness-Related Corticosteroid Insufficiency","volume":"135","author":"Marik","year":"2009","journal-title":"Chest"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/1479164110383723","article-title":"Coagulation and Fibrinolysis in Diabetes","volume":"7","author":"Alzahrani","year":"2010","journal-title":"Diab. Vasc. Dis. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The Global Epidemiology of Hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/advan.00027.2016","article-title":"Central Neural Control of the Cardiovascular System: Current Perspectives","volume":"40","author":"Dampney","year":"2016","journal-title":"Adv. Physiol. Educ."},{"key":"ref_130","first-page":"R865","article-title":"Long-Term Arterial Pressure Control: An Analysis from Animal Experiments and Computer and Graphic Models","volume":"259","author":"Guyton","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.115.018526","article-title":"Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced Hypertension","volume":"133","author":"Hall","year":"2016","journal-title":"Circulation"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/hr.2010.258","article-title":"Serum Levels of the Th1 Chemoattractant Interferon-Gamma-Inducible Protein (IP) 10 Are Elevated in Patients with Essential Hypertension","volume":"34","author":"Stumpf","year":"2011","journal-title":"Hypertens. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11906-016-0628-7","article-title":"Role of Inflammation and Immunity in Hypertension: Recent Epidemiological, Laboratory, and Clinical Evidence","volume":"18","author":"Caillon","year":"2016","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/jcp.31019","article-title":"Inflammation and Hypertension: Underlying Mechanisms and Emerging Understandings","volume":"238","author":"Aboukhater","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/10641963.2016.1226888","article-title":"Homocysteine Levels and Risk of Essential Hypertension: A Meta-Analysis of Published Epidemiological Studies","volume":"39","author":"Zhong","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11906-018-0900-0","article-title":"Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure","volume":"20","author":"Satou","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","article-title":"Oxidative Stress and Hypertension","volume":"128","author":"Griendling","year":"2021","journal-title":"Circ. Res."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Gallo, G., Volpe, M., and Savoia, C. (2022). Endothelial Dysfunction in Hypertension: Current Concepts and Clinical Implications. Front. Med., 8.","DOI":"10.3389\/fmed.2021.798958"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.vph.2012.02.012","article-title":"Targeting NADPH Oxidases in Vascular Pharmacology","volume":"56","author":"Schramm","year":"2012","journal-title":"Vasc. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40292-017-0245-9","article-title":"Essential Hypertension and Functional Microvascular Ageing","volume":"25","author":"Bruno","year":"2018","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T Cell in the Genesis of Angiotensin II Induced Hypertension and Vascular Dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"C596","DOI":"10.1152\/ajpcell.00088.2016","article-title":"Toll-like Receptor 4 Mutation Suppresses Hyperhomocysteinemia-Induced Hypertension","volume":"311","author":"Familtseva","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3892\/ijmm.2016.2476","article-title":"P120 Catenin Attenuates the Angiotensin II-Induced Apoptosis of Human Umbilical Vein Endothelial Cells by Suppressing the Mitochondrial Pathway","volume":"37","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/HYPERTENSIONAHA.110.163576","article-title":"Inflammation, Immunity, and Hypertension","volume":"57","author":"Harrison","year":"2011","journal-title":"Hypertension"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.110.217299","article-title":"Central and Peripheral Mechanisms of T-Lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-Induced Hypertension","volume":"107","author":"Marvar","year":"2010","journal-title":"Circ. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI80761","article-title":"Immune Activation Caused by Vascular Oxidation Promotes Fibrosis and Hypertension","volume":"126","author":"Wu","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"H184","DOI":"10.1152\/ajpheart.00328.2013","article-title":"Toll-like Receptors and Damage-Associated Molecular Patterns: Novel Links between Inflammation and Hypertension","volume":"306","author":"McCarthy","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/cvr\/cvab302","article-title":"Neutrophils in Cardiovascular Disease: Warmongers, Peacemakers, or Both?","volume":"118","author":"Sreejit","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1097\/HJH.0000000000003543","article-title":"The ATP Connection: A New Therapeutic Promise of P2X7 Targeting in Hypertension and Vascular Injury","volume":"41","author":"Guzik","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/cvr\/cvaa257","article-title":"Role of Interleukin-23\/Interleukin-17 Axis in T-Cell-Mediated Actions in Hypertension","volume":"117","author":"Higaki","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Wang, Y., Chen, S., Yao, T., Li, D.Q., Wang, Y.X., Li, Y.Q., Wu, S.L., and Cai, J. (2014). Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108223"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e021103","DOI":"10.1136\/bmjopen-2017-021103","article-title":"Association of Total Homocysteine with Blood Pressure in a General Population of Chinese Adults: A Cross-Sectional Study in Jiangsu Province, China","volume":"8","author":"Wu","year":"2018","journal-title":"BMJ Open"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.RES.0000108264.67601.2C","article-title":"Hyperhomocysteinemia Activates Nuclear Factor-KappaB in Endothelial Cells via Oxidative Stress","volume":"94","author":"Woo","year":"2004","journal-title":"Circ. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory Mechanisms Linking Obesity and Metabolic Disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and Metabolic Disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and Insulin Resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00709-017-1082-3","article-title":"Lymphocytes and Macrophages in Adipose Tissue in Obesity: Markers or Makers of Subclinical Inflammation?","volume":"254","year":"2017","journal-title":"Protoplasma"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/01.ATV.19.4.972","article-title":"C-Reactive Protein in Healthy Subjects: Associations with Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating from Adipose Tissue?","volume":"19","author":"Yudkin","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_161","first-page":"3338","article-title":"Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss","volume":"85","author":"Bastard","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"The Diabetes Prevention Program Research Group (2005). Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants with Impaired Glucose Tolerance. Diabetes, 54, 1566\u20131572.","DOI":"10.2337\/diabetes.54.5.1566"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.2337\/db08-1475","article-title":"Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice","volume":"58","author":"Fujisaka","year":"2009","journal-title":"Diabetes"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity Induces a Phenotypic Switch in Adipose Tissue Macrophage Polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 Links Innate Immunity and Fatty Acid-Induced Insulin Resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ Effector T Cells Contribute to Macrophage Recruitment and Adipose Tissue Inflammation in Obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41574-023-00908-2","article-title":"Macrophage and T Cell Networks in Adipose Tissue","volume":"20","author":"Jacks","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nm.2002","article-title":"Lean, but Not Obese, Fat Is Enriched for a Unique Population of Regulatory T Cells That Affect Metabolic Parameters","volume":"15","author":"Feuerer","year":"2009","journal-title":"Nat. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 Inflammasome Instigates Obesity-Induced Inflammation and Insulin Resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-051X.2008.01282.x","article-title":"Effects of Diabetes Mellitus Onperiodontal and Peri-Implantconditions: Update Onassociations and Risks","volume":"35","author":"Salvi","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1570161112666140423221008","article-title":"Endothelial Dysfunction, Obesity and Insulin Resistance","volume":"12","author":"Prieto","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"185","DOI":"10.35946\/arcr.v37.2.04","article-title":"Impact of Alcohol Abuse on the Adaptive Immune System","volume":"37","author":"Pasala","year":"2015","journal-title":"Alcohol Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pnpbp.2015.09.001","article-title":"Opposing Effects of Alcohol on the Immune System","volume":"65","author":"Barr","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vph.2015.04.002","article-title":"Angiotensin Type 1 Receptor Mediates Chronic Ethanol Consumption-Induced Hypertension and Vascular Oxidative Stress","volume":"74","author":"Passaglia","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/j.gastro.2006.11.016","article-title":"Chronic Ethanol Consumption Impairs Cellular Immune Responses Against HCV NS5 Protein Due to Dendritic Cell Dysfunction","volume":"132","author":"Aloman","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_177","first-page":"1719","article-title":"\u03b2-Endorphin Modulation of Lymphocyte Proliferation: Effects of Ethanol","volume":"26","author":"Boyadjieva","year":"2002","journal-title":"Alcohol Clin. Exp. Res."},{"key":"ref_178","first-page":"230","article-title":"Alcohol-Induced Alterations on Host Defense after Traumatic Injury","volume":"64","author":"Greiffenstein","year":"2008","journal-title":"J. Trauma"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/toxsci\/kfq215","article-title":"Innate Immunity and Inflammation in Sepsis: Mechanisms of Suppressed Host Resistance in Mice Treated with Ethanol in a Binge-Drinking Model","volume":"117","author":"Pruett","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1006\/bbrc.2000.3738","article-title":"Tolerance and Sensitization to Endotoxin in Kupffer Cells Caused by Acute Ethanol Involve Interleukin-1 Receptor-Associated Kinase","volume":"277","author":"Yamashina","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_181","first-page":"10","article-title":"The Effect of Stress on the Defense Systems","volume":"3","year":"2010","journal-title":"J. Med. Life"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/0033-2909.130.4.601","article-title":"Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry","volume":"130","author":"Segerstrom","year":"2004","journal-title":"Psychol. Bull."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/JLB.3MA0517-194RR","article-title":"Activation of the Sympathetic Nervous System Modulates Neutrophil Function","volume":"103","author":"Nicholls","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"112","DOI":"10.31594\/commagene.1641548","article-title":"The Relationship between Stress and Immune Function: A Review Article","volume":"9","author":"Kahya","year":"2025","journal-title":"Commagene J. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/brbi.1997.0508","article-title":"Acute Stress Enhances While Chronic Stress Suppresses Cell-Mediated Immunity in Vivo: A Potential Role for Leukocyte Trafficking","volume":"11","author":"Dhabhar","year":"1997","journal-title":"Brain Behav. Immun."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.4049\/jimmunol.158.9.4200","article-title":"Differential Expression of the Beta2-Adrenergic Receptor by Th1 and Th2 Clones: Implications for Cytokine Production and B Cell Help","volume":"158","author":"Sanders","year":"1997","journal-title":"J. Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2011.08.001","article-title":"The Beta2-Adrenergic Receptor on T and B Lymphocytes: Do We Understand It Yet?","volume":"26","author":"Sanders","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0031-6997(24)01510-2","article-title":"Norepinephrine and Beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in vitro and in vivo","volume":"53","author":"Kohm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.crimmu.2021.11.001","article-title":"Role of Adrenergic Receptor Signalling in Neuroimmune Communication","volume":"2","author":"Chhatar","year":"2021","journal-title":"Curr. Res. Immunol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.imlet.2005.05.008","article-title":"Beta2-Adrenergic Receptor Stimulation Inhibits LPS-Induced IL-18 and IL-12 Production in Monocytes","volume":"101","author":"Mizuno","year":"2005","journal-title":"Immunol. Lett."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12931-017-0613-y","article-title":"Human Lung and Monocyte-Derived Macrophages Differ with Regard to the Effects of \u03922-Adrenoceptor Agonists on Cytokine Release","volume":"18","author":"Victoni","year":"2017","journal-title":"Respir. Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/j.2040-4603.2014.tb00574.x","article-title":"Autonomic Nervous System and Immune System Interactions","volume":"4","author":"Kenney","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"e996","DOI":"10.1002\/ctm2.996","article-title":"Manipulating Adrenergic Stress Receptor Signalling to Enhance Immunosuppression and Prolong Survival of Vascularized Composite Tissue Transplants","volume":"12","author":"Kim","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s13075-014-0504-2","article-title":"The Sympathetic Nervous Response in Inflammation","volume":"16","author":"Pongratz","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_195","first-page":"55","article-title":"How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory Action of Glucocorticoids\u2014New Mechanisms for Old Drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2008.03.017","article-title":"A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-\u039aB Signaling","volume":"64","author":"Miller","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk","volume":"109","author":"Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e01960","DOI":"10.1002\/brb3.1960","article-title":"Molecular Links between Endocrine, Nervous and Immune System during Chronic Stress","volume":"11","author":"Zefferino","year":"2021","journal-title":"Brain Behav."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1016\/S0091-6749(99)70272-1","article-title":"Molecular and Genetic Basis of \u03b22-adrenergic Receptor Function","volume":"104","author":"Liggett","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1164\/ajrccm.152.3.7663795","article-title":"Beta-Adrenergic Receptors and Their Regulation","volume":"152","author":"Barnes","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jaci.2005.11.012","article-title":"Molecular Mechanisms of \u03922-Adrenergic Receptor Function, Response, and Regulation","volume":"117","author":"Johnson","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neubiorev.2021.06.013","article-title":"Glucocorticoid Resistance and \u03922-Adrenergic Receptor Signaling Pathways Promote Peripheral Pro-Inflammatory Conditions Associated with Chronic Psychological Stress: A Systematic Review Across Species","volume":"128","author":"Walsh","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.autneu.2014.01.006","article-title":"Autonomic Regulation of Cellular Immune Function","volume":"182","author":"Bellinger","year":"2014","journal-title":"Auton. Neurosci."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM199801153380307","article-title":"Protective and Damaging Effects of Stress Mediators","volume":"338","author":"McEwen","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.psych.60.110707.163551","article-title":"Health Psychology: Developing Biologically Plausible Models Linking the Social World and Physical Health","volume":"60","author":"Miller","year":"2009","journal-title":"Annu. Rev. Psychol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"978","DOI":"10.14219\/jada.archive.2009.0307","article-title":"Periodontitis: An Archetypical Biofilm Disease","volume":"140","author":"Schaudinn","year":"2009","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/jcpe.12935","article-title":"A New Classification Scheme for Periodontal and Peri-Implant Diseases and Conditions\u2014Introduction and Key Changes from the 1999 Classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: A Polymicrobial Disruption of Host Homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Neurath, N., and Kesting, M. (2024). Cytokines in Gingivitis and Periodontitis: From Pathogenesis to Therapeutic Targets. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1435054"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tem.2009.12.004","article-title":"Prostaglandins in Bone: Bad Cop, Good Cop?","volume":"21","author":"Blackwell","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0765.1991.tb01649.x","article-title":"The Role of Inflammatory Mediators in the Pathogenesis of Periodontal Disease","volume":"26","author":"Page","year":"1991","journal-title":"J. Periodontal Res."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Zhang, M., Liu, Y., Afzali, H., and Graves, D.T. (2024). An Update on Periodontal Inflammation and Bone Loss. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1385436"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","article-title":"Osteoimmunology in Periodontitis and Orthodontic Tooth Movement","volume":"21","author":"Alghamdi","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1902\/jop.2008.080233","article-title":"Inflammation and Bone Loss in Periodontal Disease","volume":"79","author":"Cochran","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034510385236","article-title":"Critical Review in Oral Biology & Medicine: Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss","volume":"90","author":"Graves","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Zhou, M., and Graves, D.T. (2022). Impact of the Host Response and Osteoblast Lineage Cells on Periodontal Disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.998244"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1902\/jop.1998.69.10.1139","article-title":"Neutrophil Migration into the Gingival Sulcus Is Associated with Transepithelial Gradients of Interleukin-8 and ICAM-1","volume":"69","author":"Tonetti","year":"1998","journal-title":"J. Periodontol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2197779","DOI":"10.1080\/20002297.2023.2197779","article-title":"Current Concepts in the Pathogenesis of Periodontitis: From Symbiosis to Dysbiosis","volume":"15","author":"Abdulkareem","year":"2023","journal-title":"J. Oral Microbiol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/0022034509339889","article-title":"The Involvement of IL-23 and the Th17 Pathway in Periodontitis","volume":"88","author":"Ohyama","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Bunte, K., and Beikler, T. (2019). Th17 Cells and the IL-23\/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143394"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Tang, Z., Jin, L., and Yang, Y. (2025). The Dual Role of IL-17 in Periodontitis Regulating Immunity and Bone Homeostasis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1578635"},{"key":"ref_224","first-page":"235","article-title":"Pathogenesis of Inflammatory Periodontal Disease. A Summary of Current Work\u2014PubMed","volume":"34","author":"Page","year":"1976","journal-title":"Lab. Investig."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of Periodontitis and Endothelial Function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/jcpe.12732","article-title":"Impact of the Global Burden of Periodontal Diseases on Health, Nutrition and Wellbeing of Mankind: A Call for Global Action","volume":"44","author":"Tonetti","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral Diseases: A Global Public Health Challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Saavedra-Torres, J.S., Nati-Castillo, H.A., Gaibor-Pazmi\u00f1o, A., Ortiz Erazo, W.F., Mart\u00ednez Casta\u00f1o, M.A., Nieto Brandon, C.C., Parra Ramos, D.C., Villamil, J., S\u00e1nchez, S.L., and L\u00f3pez-Cort\u00e9s, A. (2026). Sepsis in Multimorbidity: A Domain-Based Framework for Systemic Vulnerability and Precision Care. Front. Med., 13.","DOI":"10.3389\/fmed.2026.1827818"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1097\/01.CCM.0000239114.50519.0E","article-title":"The Role of Infection and Comorbidity: Factors That Influence Disparities in Sepsis","volume":"34","author":"Esper","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009\u20132014","volume":"318","author":"Rhee","year":"2017","journal-title":"JAMA"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13054-019-2486-6","article-title":"Multimorbidity States Associated with Higher Mortality Rates in Organ Dysfunction and Sepsis: A Data-Driven Analysis in Critical Care","volume":"23","author":"Zador","year":"2019","journal-title":"Crit. Care"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1378\/chest.09-1425","article-title":"Alcohol-Use Disorders in the Critically Ill Patient","volume":"138","author":"Jones","year":"2010","journal-title":"Chest"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1097\/01.CCM.0000057845.77458.25","article-title":"Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction","volume":"31","author":"Moss","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/S0140-6736(06)69490-7","article-title":"Alcohol Abuse in the Critically Ill Patient","volume":"368","author":"Moss","year":"2006","journal-title":"Lancet"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-Induced Immune Dysfunction: Implications for Health","volume":"5","author":"Glaser","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and Systemic Mechanisms Linking Periodontal Disease and Inflammatory Comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.2337\/db08-0564","article-title":"High Glucose Induces Toll-like Receptor Expression in Human Monocytes: Mechanism of Activation","volume":"57","author":"Dasu","year":"2008","journal-title":"Diabetes"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0757.2006.00168.x","article-title":"Diabetic Periodontitis: A Model for Activated Innate Immunity and Impaired Resolution of Inflammation","volume":"43","author":"Nassar","year":"2007","journal-title":"Periodontology 2000"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.4049\/jimmunol.1202907","article-title":"Histamine H2 Receptor Signaling in the Pathogenesis of Sepsis: Studies in a Murine Diabetes Model","volume":"191","author":"Carlos","year":"2013","journal-title":"J. Immunol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2337\/db11-0825","article-title":"A1-Acid Glycoprotein Decreases Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice","volume":"61","author":"Spiller","year":"2012","journal-title":"Diabetes"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1677\/joe.1.06438","article-title":"Diabetes Causes Marked Changes in Function and Metabolism of Rat Neutrophils","volume":"188","author":"Hirabara","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1590\/S0100-879X2006005000143","article-title":"Neutrophil Function and Metabolism in Individuals with Diabetes Mellitus","volume":"40","author":"Munhoz","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes Primes Neutrophils to Undergo NETosis, Which Impairs Wound Healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1128\/IAI.71.7.4182-4185.2003","article-title":"Leptin Modulates Neutrophil Phagocytosis of Klebsiella Pneumoniae","volume":"71","author":"Moore","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.174.11.6820","article-title":"Leptin Promotes Differentiation and Survival of Human Dendritic Cells and Licenses Them for Th1 Priming","volume":"174","author":"Mattioli","year":"2005","journal-title":"J. Immunol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.pupt.2012.04.006","article-title":"Obesity and Respiratory Infections: Does Excess Adiposity Weigh down Host Defense?","volume":"26","author":"Mancuso","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/CS20110523","article-title":"Toll like Receptor 4 Contributes to Blood Pressure Regulation and Vascular Contraction in Spontaneously Hypertensive Rat","volume":"122","author":"Bomfim","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/cvr\/cvt265","article-title":"Damage-Associated Molecular Pattern Activated Toll-like Receptor 4 Signalling Modulates Blood Pressure in L-NAME-Induced Hypertension","volume":"101","author":"Sollinger","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1111\/bph.12876","article-title":"IL-1\u03b2 and IL-18: Inflammatory Markers or Mediators of Hypertension?","volume":"171","author":"Krishnan","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Gandhi, J.A., Ekhar, V.V., Asplund, M.B., Abdulkareem, A.F., Ahmadi, M., Coelho, C., and Martinez, L.R. (2014). Alcohol Enhances Acinetobacter Baumannii-Associated Pneumonia and Systemic Dissemination by Impairing Neutrophil Antimicrobial Activity in a Murine Model of Infection. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095707"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.4049\/jimmunol.0803206","article-title":"The Opposite Effects of Acute and Chronic Alcohol on Lipopolysaccharide-Induced Inflammation Are Linked to IRAK-M in Human Monocytes","volume":"183","author":"Mandrekar","year":"2009","journal-title":"J. Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s10571-010-9540-x","article-title":"Repeated Stress Down-Regulates \u03922- and A2C-Adrenergic Receptors and Up-Regulates Gene Expression of IL-6 in the Rat Spleen","volume":"30","author":"Laukova","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful Molecular Mechanisms in Sepsis","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrcardio.2012.45","article-title":"Stress and Cardiovascular Disease","volume":"9","author":"Steptoe","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Bermejo-Martin, J.F., Mart\u00edn-Fernandez, M., L\u00f3pez-Mestanza, C., Duque, P., and Almansa, R. (2018). Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease). J. Clin. Med., 7.","DOI":"10.3390\/jcm7110400"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jcrc.2012.11.002","article-title":"Inflammatory and Endothelial Activation Biomarkers and Risk of Sepsis: A Nested Case-Control Study","volume":"28","author":"Wang","year":"2013","journal-title":"J. Crit. Care"},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Takeda, Y., Matoba, K., Sekiguchi, K., Nagai, Y., Yokota, T., Utsunomiya, K., and Nishimura, R. (2020). Endothelial Dysfunction in Diabetes. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070182"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial Dysfunction Due to ENOS Uncoupling: Molecular Mechanisms as Potential Therapeutic Targets","volume":"28","author":"Dobrucki","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric Oxide and Peroxynitrite in Health and Disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"P50","DOI":"10.1186\/cc6029","article-title":"Peroxynitrite Mediates Neutrophil Migration Failure in Severe Polymicrobial Sepsis","volume":"11","author":"Freitas","year":"2007","journal-title":"Crit. Care"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, Metaflammation and Immunometabolic Disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Srdi\u0107, T., \u0110ura\u0161evi\u0107, S., Laki\u0107, I., Ru\u017ei\u010di\u0107, A., Vujovi\u0107, P., Jev\u0111ovi\u0107, T., Daki\u0107, T., \u0110or\u0111evi\u0107, J., Tosti, T., and Glumac, S. (2024). From Molecular Mechanisms to Clinical Therapy: Understanding Sepsis-Induced Multiple Organ Dysfunction. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147770"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, Stress, and Diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.dsx.2012.02.026","article-title":"Sepsis in Diabetes: A Bad Duo","volume":"5","author":"Tiwari","year":"2011","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Insight Review Articles","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4239\/wjd.v6.i4.598","article-title":"Type 2 Diabetes Mellitus: From a Metabolic Disorder to an Inflammatory Condition","volume":"6","author":"Hameed","year":"2015","journal-title":"World J. Diabetes"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2337\/diacare.24.6.1044","article-title":"Diabetes and the Risk of Infection-Related Mortality in the U.S","volume":"24","author":"Bertoni","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1525-1381.1999.99220.x","article-title":"Free Fatty Acids, Insulin Resistance, and Type 2 Diabetes Mellitus","volume":"111","author":"Boden","year":"1999","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"ref_269","first-page":"1245","article-title":"Insulin Resistance and Chronic Inflammation","volume":"70","author":"Matulewicz","year":"2016","journal-title":"Postep. Hig. Med. Dosw."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.taap.2006.01.003","article-title":"Diabetes and Mitochondrial Function: Role of Hyperglycemia and Oxidative Stress","volume":"212","author":"Rolo","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.3390\/ijms141121525","article-title":"Oxidative Stress in Diabetes: Implications for Vascular and Other Complications","volume":"14","author":"Pitocco","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"H1417","DOI":"10.1152\/ajpheart.00089.2013","article-title":"Role of Mitochondrial Oxidative Stress in Hypertension","volume":"305","author":"Dikalov","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Torres, J.S.S., Tamayo-Giraldo, F.J., Bejarano-Zuleta, A., Nati-Castillo, H.A., Quintero, D.A., Ospina-Mej\u00eda, M.J., Salazar-Santoliva, C., Su\u00e1rez-Sangucho, I., Ortiz-Prado, E., and Izquierdo-Condoy, J.S. (2025). Sepsis and Post-Sepsis Syndrome: A Multisystem Challenge Requiring Comprehensive Care and Management\u2014A Review. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1560737"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11481-012-9432-6","article-title":"Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective","volume":"8","author":"Ippoliti","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","article-title":"Intestinal Permeability, Gut-Bacterial Dysbiosis, and Behavioral Markers of Alcohol-Dependence Severity","volume":"111","author":"Leclercq","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11906-017-0795-1","article-title":"The Role of Sympatho-Inhibition in Combination Treatment of Obesity-Related Hypertension","volume":"19","author":"Carnagarin","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The Gut Microbiota-Brain Axis in Behaviour and Brain Disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11906-023-01254-4","article-title":"Sympathetic Neural Mechanisms in Hypertension: Recent Insights","volume":"25","author":"Grassi","year":"2023","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_279","first-page":"56","article-title":"Physiological Changes in the Autonomic Nervous System Under Chronic Stress: A Systematic Review","volume":"3","author":"Taha","year":"2025","journal-title":"J. Sci. Med. Life"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The Inflammatory Reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The Cholinergic Anti-Inflammatory Pathway: A Missing Link in Neuroimmunomodulation","volume":"9","author":"Pavlov","year":"2003","journal-title":"Mol. Med."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbi.2019.03.015","article-title":"Apical Splenic Nerve Electrical Stimulation Discloses an Anti-Inflammatory Pathway Relying on Adrenergic and Nicotinic Receptors in Myeloid Cells","volume":"80","author":"Guyot","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbi.2019.04.042","article-title":"Anti-Inflammatory Effect of \u03922 Adrenergic Stimulation on Circulating Monocytes with a pro-Inflammatory State in High-Fat Diet-Induced Obesity","volume":"80","author":"Hinchado","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00011-014-0791-8","article-title":"Adrenergic Modulation of Migration, CD11b and CD18 Expression, ROS and Interleukin-8 Production by Human Polymorphonuclear Leukocytes","volume":"64","author":"Scanzano","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00003246-199301000-00010","article-title":"Impaired \u03b2-Adrenergic Receptor Stimulation of Cyclic Adenosine Monophosphate in Human Septic Shock: Association with Myocardial Hyporesponsiveness to Catecholamines","volume":"21","author":"Silverman","year":"1993","journal-title":"Crit. Care Med."},{"key":"ref_286","first-page":"638","article-title":"Changes of Alpha 1-Adrenergic Receptors in Human Liver during Intraabdominal Sepsis","volume":"20","author":"Hwang","year":"1994","journal-title":"Hepatology"},{"key":"ref_287","doi-asserted-by":"crossref","unstructured":"Petitjeans, F., Geloen, A., Pichot, C., Leroy, S., Ghignone, M., and Quintin, L. (2021). Is the Sympathetic System Detrimental in the Setting of Septic Shock, with Antihypertensive Agents as a Counterintuitive Approach? A Clinical Proposition. J. Clin. Med., 10.","DOI":"10.3390\/jcm10194569"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13613-021-00869-7","article-title":"The Autonomic Nervous System in Septic Shock and Its Role as a Future Therapeutic Target: A Narrative Review","volume":"11","author":"Carrara","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Mohammad, S., and Thiemermann, C. (2021). Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.594150"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic Endotoxemia Initiates Obesity and Insulin Resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/gmic.19625","article-title":"Involvement of Gut Microbiota in the Development of Low-Grade Inflammation and Type 2 Diabetes Associated with Obesity","volume":"3","author":"Cani","year":"2012","journal-title":"Gut Microbes"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"223","DOI":"10.35946\/arcr.v37.2.07","article-title":"The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota","volume":"37","author":"Engen","year":"2015","journal-title":"Alcohol Res."},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Sansores-Espa\u00f1a, L.D., Melgar-Rodr\u00edguez, S., Olivares-Sagredo, K., Cafferata, E.A., Mart\u00ednez-Aguilar, V.M., Vernal, R., Paula-Lima, A.C., and D\u00edaz-Z\u00fa\u00f1iga, J. (2021). Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis with Neurodegenerative Diseases. Front. Aging, 2.","DOI":"10.3389\/fragi.2021.781582"},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Gan, G., Chen, R., Zheng, P., Long, K., Cheng, K.K.Y., Sulaiman, J.E., and Huang, X. (2026). Oral Pathogens Meet the Gut Microbiome: New Mechanistic Insights on Systemic Disease. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1673512"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2009.07.031","article-title":"The Blood-Brain Barrier and Immune Function and Dysfunction","volume":"37","author":"Banks","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Silva, Y.P., Bernardi, A., and Frozza, R.L. (2020). The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00025"},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Janeiro, M.H., Ram\u00edrez, M.J., Milagro, F.I., Mart\u00ednez, J.A., and Solas, M. (2018). Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target. Nutrients, 10.","DOI":"10.3390\/nu10101398"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S2468-1253(16)30119-4","article-title":"The Role of the Gut Microbiota in Sepsis","volume":"2","author":"Haak","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The Pathophysiology and Treatment of Sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cellsig.2017.01.014","article-title":"GRK2 as Negative Modulator of NO Bioavailability: Implications for Cardiovascular Disease","volume":"41","author":"Cannavo","year":"2017","journal-title":"Cell. Signal."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.200601-103OC","article-title":"Down-Regulation of CXCR2 on Neutrophils in Severe Sepsis Is Mediated by Inducible Nitric Oxide Synthase-Derived Nitric Oxide","volume":"175","author":"Souto","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe Sepsis and Septic Shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_303","first-page":"775","article-title":"Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial","volume":"335","author":"Kotsaki","year":"2025","journal-title":"JAMA"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3803\/EnM.2023.1621","article-title":"Association between Serum Amyloid A Levels and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"38","author":"Liu","year":"2023","journal-title":"Endocrinol. Metab."},{"key":"ref_305","first-page":"G696","article-title":"Effects of Chronic Ethanol Consumption on Cytokine Regulation of Liver Regeneration","volume":"275","author":"Yang","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cyto.2012.06.006","article-title":"Analysis of IL1 Gene Polymorphisms and Transcript Levels in Periodontal and Chronic Kidney Disease","volume":"60","author":"Braosi","year":"2012","journal-title":"Cytokine"},{"key":"ref_307","first-page":"775","article-title":"Relationship between Stress and the Immune System-Related Disorders","volume":"11","author":"Aghayan","year":"2024","journal-title":"Int. J. Med. Rev."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","article-title":"Colonic Microbiome Is Altered in Alcoholism","volume":"302","author":"Mutlu","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1177\/0022034520924633","article-title":"The Bacterial Connection between the Oral Cavity and the Gut Diseases","volume":"99","author":"Kitamoto","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nm0505-475","article-title":"Do-All Receptor Takes on Coagulation, Inflammation","volume":"11","author":"Esmon","year":"2005","journal-title":"Nat. Med."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/cvr\/cvt343","article-title":"Pleiotropic Effects of Factor Xa and Thrombin: What to Expect from Novel Anticoagulants","volume":"101","author":"Spronk","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: The Diverse Biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41416-018-0333-1","article-title":"Immunosuppression Mediated by Myeloid-Derived Suppressor Cells (MDSCs) during Tumour Progression","volume":"120","author":"Groth","year":"2019","journal-title":"Br. J. Cancer"},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Boyko, A.A., Troyanova, N.I., Kovalenko, E.I., and Sapozhnikov, A.M. (2017). Similarity and Differences in Inflammation-Related Haracteristics of the Peripheral Immune System of Patients with Parkinson\u2019s and Alzheimer\u2019s Diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122633"},{"key":"ref_315","first-page":"576","article-title":"Inflammaging: A New Immune\u2013Metabolic Viewpoint for Age-Related Diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nature"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"516","DOI":"10.5005\/jp-journals-10071-24986","article-title":"Machine Learning and Deep Learning Models for Early Sepsis Prediction: A Scoping Review","volume":"29","author":"Rawat","year":"2025","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Papathanakos, G., Andrianopoulos, I., Xenikakis, M., Papathanasiou, A., Koulenti, D., Blot, S., and Koulouras, V. (2023). Clinical Sepsis Phenotypes in Critically Ill Patients. Microorganisms, 11.","DOI":"10.3390\/microorganisms11092165"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"797","DOI":"10.21037\/atm.2020.04.11","article-title":"Continuous Cardiac Output Assessment or Serial Echocardiography during Septic Shock Resuscitation?","volume":"8","author":"Vignon","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.2019.5791","article-title":"Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis","volume":"321","author":"Seymour","year":"2019","journal-title":"JAMA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7395\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:15:52Z","timestamp":1787285752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/16\/7395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":319,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ijms27167395"],"URL":"https:\/\/doi.org\/10.3390\/ijms27167395","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]}}}