{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:18:59Z","timestamp":1787635139886,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research was supported by grants from Central Public-interest Scientific Institution Basal Research Fund, Freshwater Fisheries Research Center, CAFS","award":["NO.2026SJXT0201"],"award-info":[{"award-number":["NO.2026SJXT0201"]}]},{"award":["NO.2026SJXT0201"],"award-info":[{"award-number":["NO.2026SJXT0201"]}],"id":[{"id":"https:\/\/ror.org\/02h2xja52","id-type":"ROR","asserted-by":"publisher"}]},{"name":"The earmarked fund for China Agriculture Research System","award":["CARS-47-07"],"award-info":[{"award-number":["CARS-47-07"]}]},{"award":["CARS-47-07"],"award-info":[{"award-number":["CARS-47-07"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Macrobrachium nipponense is an economically important freshwater crustacean in China, and growth-related traits are major determinants of its commercial value. Identifying single nucleotide polymorphisms (SNPs) associated with growth-related traits may provide useful molecular markers for the genetic improvement of growth performance. Previous studies have suggested that the cAMP-dependent protein kinase type I regulatory subunit-like gene (Mn-PKA-R1) is involved in the regulation of growth and molting in M. nipponense. In the present study, a cultured full-sib family comprising 120 females and 120 males was used to screen SNPs within the coding region of Mn-PKA-R1, and evaluate their associations with body weight, body length, full length, and abdominal width. Seven SNPs were identified in exon 12, including five nonsynonymous missense variants and two synonymous variants, whereas no SNPs were detected in the other exons examined. The mean effective number of alleles (Ne), observed heterozygosity (Ho), expected heterozygosity (He), Nei\u2019s gene diversity (Nei), and polymorphic information content (PIC) were 1.3561, 0.3048, 0.2350, 0.2340, and 0.1962, respectively, in females, compared with 1.3118, 0.2714, 0.1868, 0.1861, and 0.1512, respectively, in males. Four SNPs were significantly associated with growth-related traits in females: C+82748G and A+82750G were associated with body weight and abdominal width, T+82810G was associated with abdominal width, and A+83324G was associated with body weight, full length, and abdominal width (p &lt; 0.05). No significant genotype\u2013trait associations were detected among the SNP loci that could be statistically evaluated in males. Pairwise r2 values ranged from 0.001 to 0.693 in females and from 0.000 to 0.351 in males, with generally higher values observed in females within the investigated full-sib family. Females also showed slightly higher mean genetic polymorphism parameters than males, while significant SNP\u2013trait associations were detected only in females within this family. These findings provide candidate SNPs for further validation of their potential utility in marker-assisted selection in M. nipponense.<\/jats:p>","DOI":"10.3390\/ijms27167500","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:51:05Z","timestamp":1787327465000},"page":"7500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Growth-Related Single-Nucleotide Polymorphisms in the cAMP-Dependent Protein Kinase Type I Regulatory Subunit-like Gene of the Oriental River Prawn, Macrobrachium nipponense"],"prefix":"10.3390","volume":"27","author":[{"given":"Yuefan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1869-4414","authenticated-orcid":false,"given":"Xiaofan","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"},{"name":"Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"},{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"},{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"},{"name":"Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"},{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-9268","authenticated-orcid":false,"given":"Shubo","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture & Stock Enhancement in North China\u2019s Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian 116023, China"},{"name":"Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China"},{"name":"Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1365-2109.2011.03085.x","article-title":"Current status and prospects of farming the giant river prawn (Macrobrachium rosenbergii) and the oriental river prawn (Macrobrachium nipponense) in China","volume":"43","author":"Fu","year":"2012","journal-title":"Aquac. 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