{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:29:47Z","timestamp":1787632187445,"version":"build-2736575974"},"reference-count":185,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01v1rak05","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The de novo biosynthesis of two major glycerophospholipids, phosphatidylethanolamine and phosphatidylcholine, occurs through the Kennedy pathway. In this process, ethanolamine or choline is initially phosphorylated to phosphoethanolamine or phosphocholine, respectively, and subsequently converted by cytidylyltransferases into CDP-ethanolamine and CDP-choline. Dysregulation of this pathway has been implicated in various diseases. This review provides a comprehensive overview of the enzymatic components of the Kennedy pathway and their physiological roles. Furthermore, it explores the involvement of these enzymes in diseases, with particular emphasis on cancer, while also considering other conditions such as type II diabetes, obesity, and liver disorders. To assess potential links between Kennedy pathway enzymes and cancer, a bioinformatics analysis was conducted using data from the GEPIA portal, covering 33 different cancer types.<\/jats:p>","DOI":"10.3390\/ijms27177519","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:47:19Z","timestamp":1787572039000},"page":"7519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biosynthesis of Phosphatidylethanolamine and Phosphatidylcholine via the Kennedy Pathway in Cancer and Other Pathological Conditions"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-1259","authenticated-orcid":false,"given":"Jan","family":"Korbecki","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Collegium Medicum, University of Zielona Gora, Zyty 28 St., 65-417 Zielona Gora, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-4329","authenticated-orcid":false,"given":"Mateusz","family":"Bosiacki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Al. Powsta\u0144c\u00f3w Wlkp. 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miko\u0142aj","family":"Chlubek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Al. Powsta\u0144c\u00f3w Wlkp. 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Dzi\u0119cio\u0142owska-Baran","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Pomeranian Medical University in Szczecin, Al. Powsta\u0144c\u00f3w Wlkp. 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4600-8920","authenticated-orcid":false,"given":"Micha\u0142","family":"Lubkowski","sequence":"additional","affiliation":[{"name":"Department of Functional Anatomy, Pomeranian Medical University in Szczecin, Al. 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Rev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Korbecki, J., Bosiacki, M., Kupnicka, P., Barczak, K., Zi\u0119tek, P., Chlubek, D., and Baranowska-Bosiacka, I. (2024). Biochemistry and Diseases Related to the Interconversion of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251910745"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1074\/jbc.M008794200","article-title":"Overexpression of a Mammalian Ethanolamine-Specific Kinase Accelerates the CDP-Ethanolamine Pathway","volume":"276","author":"Lykidis","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0005-2760(90)90120-M","article-title":"Isolation and Characterization of the Human Liver Ethanolamine Kinase","volume":"1045","author":"Draus","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the Human Tissue-Specific Expression by Genome-Wide Integration of Transcriptomics and Antibody-Based Proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-021-03692-z","article-title":"Metabolic Control of TFH Cells and Humoral Immunity by Phosphatidylethanolamine","volume":"595","author":"Fu","year":"2021","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1038\/s41467-020-19721-w","article-title":"ETNK1 Mutations Induce a Mutator Phenotype That Can Be Reverted with Phosphoethanolamine","volume":"11","author":"Fontana","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e19544","DOI":"10.1016\/j.heliyon.2023.e19544","article-title":"miR-708-3p Promotes Gastric Cancer Progression through Downregulating ETNK1","volume":"9","author":"Shang","year":"2023","journal-title":"Heliyon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"152511","DOI":"10.1016\/j.prp.2019.152511","article-title":"miR-199a-3p Targets ETNK1 to Promote Invasion and Migration in Gastric Cancer Cells and Is Associated with Poor Prognosis","volume":"215","author":"Li","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41416-021-01271-7","article-title":"Hepatic Metastasis of Gastric Cancer Is Associated with Enhanced Expression of Ethanolamine Kinase 2 via the P53-Bcl-2 Intrinsic Apoptosis Pathway","volume":"124","author":"Miwa","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5937\/jomb0-39710","article-title":"Lncrna FEZf1-As1 Negatively Regulates ETNK1 to Promote Malignant Progression of Renal Cell Carcinoma","volume":"42","author":"Lou","year":"2023","journal-title":"J. Med. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: A Web Server for Cancer and Normal Gene Expression Profiling and Interactive Analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1743357","DOI":"10.1155\/2023\/1743357","article-title":"ETNK2 Low-Expression Predicts Poor Prognosis in Renal Cell Carcinoma with Immunosuppressive Tumor Microenvironment","volume":"2023","author":"Chu","year":"2023","journal-title":"J. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s12276-020-00547-x","article-title":"Phospholipid Dynamics in Ex Vivo Lung Cancer and Normal Lung Explants","volume":"53","author":"Lesko","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.7150\/jca.65587","article-title":"The ETNK2 Gene Promotes Progression of Papillary Thyroid Carcinoma through the HIPPO Pathway","volume":"13","author":"Zheng","year":"2022","journal-title":"J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/cncr.34616","article-title":"ETNK1 Mutation Occurs in a Wide Spectrum of Myeloid Neoplasms and Is Not Specific for Atypical Chronic Myeloid Leukemia","volume":"129","author":"Shuai","year":"2023","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1097\/HS9.0000000000000497","article-title":"Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia","volume":"4","author":"Fontana","year":"2020","journal-title":"HemaSphere"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.jid.2023.10.040","article-title":"Acquisition of Drug Resistance in Basal Cell Nevus Syndrome Tumors through Basal to Squamous Cell Carcinoma Transition","volume":"144","author":"Jussila","year":"2024","journal-title":"J. Investig. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1074\/jbc.272.14.9567","article-title":"Cloning of a Human cDNA for CTP-Phosphoethanolamine Cytidylyltransferase by Complementation in vivo of a Yeast Mutant","volume":"272","author":"Nakashima","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbrc.2014.04.131","article-title":"Human CTP:Phosphoethanolamine Cytidylyltransferase: Enzymatic Properties and Unequal Catalytic Roles of CTP-Binding Motifs in Two Cytidylyltransferase Domains","volume":"449","author":"Tian","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0005-2760(94)90159-7","article-title":"Substrate Specificity of CTP: Phosphoethanolamine Cytidylyltransferase Purified from Rat Liver","volume":"1211","author":"Vermeulen","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1016\/S0021-9258(18)53196-3","article-title":"Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP: Phosphocholine cytidylyltransferase","volume":"268","author":"Vermeulen","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15415","DOI":"10.1016\/S0021-9258(17)40693-4","article-title":"Ultrastructural Localization of CTP:phosphoethanolamine Cytidylyltransferase in Rat Liver","volume":"269","author":"Slot","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1194\/jlr.M600536-JLR200","article-title":"Alternative Splicing of CTP:Phosphoethanolamine Cytidylyltransferase Produces Two Isoforms That Differ in Catalytic Properties","volume":"48","author":"Tie","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gene.2014.04.005","article-title":"A Novel Murine CTP: Phosphoethanolamine Cytidylyltransferase Splice Variant Is a Post-Translational Repressor and an Indicator That Both Cytidylyltransferase Domains Are Required for Activity","volume":"543","author":"Pavlovic","year":"2014","journal-title":"Gene"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1074\/jbc.M113.544932","article-title":"Isoform-Specific and Protein Kinase C-Mediated Regulation of CTP:Phosphoethanolamine Cytidylyltransferase Phosphorylation","volume":"289","author":"Pavlovic","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gene.2009.07.014","article-title":"Regulation of the Mouse CTP: Phosphoethanolamine Cytidylyltransferase Gene Pcyt2 during Myogenesis","volume":"447","author":"Zhu","year":"2009","journal-title":"Gene"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s42255-023-00766-2","article-title":"PCYT2-Regulated Lipid Biosynthesis Is Critical to Muscle Health and Ageing","volume":"5","author":"Cikes","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1093\/brain\/awz291","article-title":"Mutations in PCYT2 Disrupt Etherlipid Biosynthesis and Cause a Complex Hereditary Spastic Paraplegia","volume":"142","author":"Vaz","year":"2019","journal-title":"Brain J. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e658","DOI":"10.1212\/NXG.0000000000000658","article-title":"Axonal Polyneuropathy in 2 Brothers with a Homozygous Missense Variant in the First Catalytic Domain of PCYT2","volume":"8","author":"Leonardis","year":"2022","journal-title":"Neurol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.celrep.2019.08.087","article-title":"Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2","volume":"29","author":"Osawa","year":"2019","journal-title":"Cell Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/jb\/mvab069","article-title":"PCYT2 Synthesizes CDP-Glycerol in Mammals and Reduced PCYT2 Enhances the Expression of Functionally Glycosylated \u03b1-Dystroglycan","volume":"170","author":"Imae","year":"2021","journal-title":"J. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"12186","DOI":"10.1074\/jbc.RA118.003197","article-title":"CDP-Glycerol Inhibits the Synthesis of the Functional O-Mannosyl Glycan of \u03b1-Dystroglycan","volume":"293","author":"Imae","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Umezawa, F., Natsume, M., Fukusada, S., Nakajima, K., Yamasaki, F., Kawashima, H., Kuo, C.-W., Khoo, K.-H., Shimura, T., and Yagi, H. (2022). Cancer Malignancy Is Correlated with Upregulation of PCYT2-Mediated Glycerol Phosphate Modification of \u03b1-Dystroglycan. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126662"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35387","DOI":"10.1074\/jbc.M113.489237","article-title":"Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism","volume":"288","author":"Gohil","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1177\/0091270011414575","article-title":"Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption","volume":"52","author":"Wang","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhep.2019.11.007","article-title":"The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy","volume":"72","author":"Guan","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/bab.2453","article-title":"Identification of Novel Inhibitor against Human Phosphoethanolamine Cytidylyltransferase from Phytochemicals of Citrus Sinensis Peel Extract by In Vitro and In Silico Approach","volume":"70","author":"Victor","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100337","DOI":"10.1016\/j.jlr.2023.100337","article-title":"Phosphoethanolamine Cytidylyltransferase Ameliorates Mitochondrial Function and Apoptosis in Hepatocytes in T2DM In Vitro","volume":"64","author":"Xu","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1128\/MCB.01527-06","article-title":"Developmental and Metabolic Effects of Disruption of the Mouse CTP: Phosphoethanolamine Cytidylyltransferase Gene (Pcyt2)","volume":"27","author":"Fullerton","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.metabol.2010.03.022","article-title":"Complementation of the Metabolic Defect in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)\u2013Deficient Primary Hepatocytes","volume":"59","author":"Fullerton","year":"2010","journal-title":"Metabolism"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1128\/MCB.00380-15","article-title":"Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice","volume":"35","author":"Basu","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sharma, N.K., Langberg, K.A., Mondal, A.K., and Das, S.K. (2013). Phospholipid Biosynthesis Genes and Susceptibility to Obesity: Analysis of Expression and Polymorphisms. PLoS ONE, 8, Erratum in PLoS ONE\u00a02013, 8, 10. https:\/\/doi.org\/10.1371\/annotation\/7b3edc45-39c7-416b-a7dc-124f4846303d.","DOI":"10.1371\/annotation\/7b3edc45-39c7-416b-a7dc-124f4846303d"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41598-022-05140-y","article-title":"Pcyt2 Deficiency Causes Age-Dependant Development of Nonalcoholic Steatohepatitis and Insulin Resistance That Could Be Attenuated with Phosphoethanolamine","volume":"12","author":"Grapentine","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/bj3390291","article-title":"Cloning and Expression of a Human Choline\/Ethanolaminephosphotransferase: Synthesis of Phosphatidylcholine and Phosphatidylethanolamine","volume":"339","author":"Henneberry","year":"1999","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s11745-002-0947-6","article-title":"PC and PE Synthesis: Mixed Micellar Analysis of the Cholinephosphotransferase and Ethanolaminephosphotransferase Activities of Human Choline\/Ethanolamine Phosphotransferase 1 (CEPT1)","volume":"37","author":"Wright","year":"2002","journal-title":"Lipids"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1194\/jlr.C600019-JLR200","article-title":"Identification and Characterization of Human Ethanolaminephosphotransferase1","volume":"48","author":"Horibata","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1091\/mbc.01-11-0540","article-title":"The Major Sites of Cellular Phospholipid Synthesis and Molecular Determinants of Fatty Acid and Lipid Head Group Specificity","volume":"13","author":"Henneberry","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1194\/jlr.RA120000898","article-title":"Locations and Contributions of the Phosphotransferases EPT1 and CEPT1 to the Biosynthesis of Ethanolamine Phospholipids","volume":"61","author":"Horibata","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1194\/jlr.P081620","article-title":"EPT1 (Selenoprotein I) Is Critical for the Neural Development and Maintenance of Plasmalogen in Humans","volume":"59","author":"Horibata","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"109376","DOI":"10.1016\/j.abb.2022.109376","article-title":"Selenoprotein I (Selenoi) as a Critical Enzyme in the Central Nervous System","volume":"729","author":"Nunes","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_54","first-page":"547","article-title":"A Mutation of EPT1 (SELENOI) Underlies a New Disorder of Kennedy Pathway Phospholipid Biosynthesis","volume":"140","author":"Ahmed","year":"2017","journal-title":"Brain J. Neurol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"101170","DOI":"10.1016\/j.molmet.2021.101170","article-title":"Upregulated Ethanolamine Phospholipid Synthesis via Selenoprotein I Is Required for Effective Metabolic Reprogramming during T Cell Activation","volume":"47","author":"Ma","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/JLB.1A0122-080R","article-title":"Selenoprotein I Deficiency in T Cells Promotes Differentiation into Tolerant Phenotypes While Decreasing Th17 Pathology","volume":"112","author":"Ma","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ygyno.2012.11.018","article-title":"Validated Gene Targets Associated with Curatively Treated Advanced Serous Ovarian Carcinoma","volume":"128","author":"Barlin","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.7314\/APJCP.2013.14.7.4393","article-title":"Gene Expression Profiling of Non-Hodgkin Lymphomas","volume":"14","author":"Zekri","year":"2013","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"126476","DOI":"10.1016\/j.jtemb.2020.126476","article-title":"Accessing the Transcriptional Status of Selenoproteins in Skin Cancer-Derived Cell Lines","volume":"60","author":"Ecker","year":"2020","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2337\/db15-0659","article-title":"Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function","volume":"65","author":"Funai","year":"2016","journal-title":"Diabetes"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/s41467-023-41186-w","article-title":"Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss","volume":"14","author":"Henne","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ijc.35286","article-title":"Choline Kinases: Enzymatic Activity, Involvement in Cancer and Other Diseases, Inhibitors","volume":"156","author":"Korbecki","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0022-2275(20)34484-9","article-title":"Structure and Characterization of the Genes for Murine Choline\/Ethanolamine Kinase Isozymes \u03b1 and \u03921","volume":"41","author":"Aoyama","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Gallego-Ortega, D., Ramirez de Molina, A., Ramos, M.A., Valdes-Mora, F., Barderas, M.G., Sarmentero-Estrada, J., and Lacal, J.C. (2009). Differential Role of Human Choline Kinase Alpha and Beta Enzymes in Lipid Metabolism: Implications in Cancer Onset and Treatment. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007819"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/oxfordjournals.jbchem.a124554","article-title":"Regulation of Choline Kinase R: Analyses of Alternatively Spliced Choline Kinases and the Promoter Region","volume":"116","author":"Uchida","year":"1994","journal-title":"J. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/onc.2011.332","article-title":"Functional Interactions between Choline Kinase \u03b1, Epidermal Growth Factor Receptor and c-Src in Breast Cancer Cell Proliferation","volume":"31","author":"Miyake","year":"2012","journal-title":"Oncogene"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chang, C.C., Few, L.L., Konrad, M., and See Too, W.C. (2016). Phosphorylation of Human Choline Kinase Beta by Protein Kinase A: Its Impact on Activity and Inhibition. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154702"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/msb.2010.52","article-title":"Kinase\/Phosphatase Overexpression Reveals Pathways Regulating Hippocampal Neuron Morphology","volume":"6","author":"Buchser","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e23963","DOI":"10.1016\/j.heliyon.2023.e23963","article-title":"Choline Kinase Alpha Genotype Is Related to Hippocampal Brain Volume and Cognition in Postmenopausal Women","volume":"10","author":"Myers","year":"2024","journal-title":"Heliyon"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/brain\/awac074","article-title":"Bi-Allelic Variants in CHKA Cause a Neurodevelopmental Disorder with Epilepsy and Microcephaly","volume":"145","author":"Tavasoli","year":"2022","journal-title":"Brain J. Neurol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1074\/jbc.M114.567966","article-title":"Choline Kinase \u03b2 Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity, and Low Bone Mass","volume":"290","author":"Kular","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s10038-021-00913-1","article-title":"Megaconial Congenital Muscular Dystrophy Secondary to Novel CHKB Mutations Resemble Atypical Rett Syndrome","volume":"66","author":"Bardhan","year":"2021","journal-title":"J. Hum. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.nmd.2023.06.006","article-title":"Megaconial Congenital Muscular Dystrophy Due to CHKB Gene Variants, the First Report of Thirteen Iranian Patients","volume":"33","author":"Zemorshidi","year":"2023","journal-title":"Neuromuscul. Disord."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jpba.2018.03.062","article-title":"Activation of Choline Kinase Drives Aberrant Choline Metabolism in Esophageal Squamous Cell Carcinomas","volume":"155","author":"Ma","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Kwee, S.A., Hernandez, B., Chan, O., and Wong, L. (2012). Choline Kinase Alpha and Hexokinase-2 Protein Expression in Hepatocellular Carcinoma: Association with Survival. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046591"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1470-2045(07)70279-6","article-title":"Expression of Choline Kinase Alpha to Predict Outcome in Patients with Early-Stage Non-Small-Cell Lung Cancer: A Retrospective Study","volume":"8","author":"Cejas","year":"2007","journal-title":"Lancet Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/jclinpath-2015-202859","article-title":"Exploiting Altered Patterns of Choline Kinase-Alpha Expression on Human Prostate Tissue to Prognosticate Prostate Cancer","volume":"68","author":"Challapalli","year":"2015","journal-title":"J. Clin. Pathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1006\/bbrc.2001.5250","article-title":"Inhibition of ChoK Is an Efficient Antitumor Strategy for Harvey-, Kirsten-, and N-Ras-Transformed Cells","volume":"285","author":"Penalva","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1038\/sj.onc.1205556","article-title":"Increased Choline Kinase Activity in Human Breast Carcinomas: Clinical Evidence for a Potential Novel Antitumor Strategy","volume":"21","author":"Ramos","year":"2002","journal-title":"Oncogene"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.1074\/jbc.M009878200","article-title":"Highly Saturated Endonuclear Phosphatidylcholine Is Synthesizedin Situ and Colocated with CDP-Choline Pathway Enzymes","volume":"276","author":"Hunt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1111\/j.1742-4658.2012.08573.x","article-title":"Balance of Human Choline Kinase Isoforms Is Critical for Cell Cycle Regulation: Implications for the Development of Choline Kinase-Targeted Cancer Therapy","volume":"279","author":"Gruber","year":"2012","journal-title":"FEBS J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1053\/j.gastro.2016.12.033","article-title":"Choline Kinase \u03b1 Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression","volume":"152","author":"Lin","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1476-4598-8-131","article-title":"Regulation of Akt(Ser473) Phosphorylation by Choline Kinase in Breast Carcinoma Cells","volume":"8","author":"Chua","year":"2009","journal-title":"Mol. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"djv371","DOI":"10.1093\/jnci\/djv371","article-title":"Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target","volume":"108","author":"Asim","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bcp.2018.07.004","article-title":"EB-3D a Novel Choline Kinase Inhibitor Induces Deregulation of the AMPK-mTOR Pathway and Apoptosis in Leukemia T-Cells","volume":"155","author":"Mariotto","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Lacal, J.C., Perona, R., de Castro, J., and Cebri\u00e1n, A. (2022). Choline Kinase \u03b1 Inhibitors MN58b and RSM932A Enhances the Antitumor Response to Cisplatin in Lung Tumor Cells. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061143"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wang, N., Brickute, D., Braga, M., Barnes, C., Lu, H., Allott, L., and Aboagye, E.O. (2021). Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13071078"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Molina, P., Sola-Leyva, A., Luque-Navarro, P.M., Laso, A., R\u00edos-Marco, P., R\u00edos, A., Lanari, D., Torretta, A., Parisini, E., and L\u00f3pez-Cara, L.C. (2022). Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020426"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1021\/acs.jmedchem.5b01552","article-title":"Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery","volume":"59","author":"Zech","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"23793","DOI":"10.1038\/srep23793","article-title":"Design, Synthesis, Crystallization and Biological Evaluation of New Symmetrical Biscationic Compounds as Selective Inhibitors of Human Choline Kinase A1 (ChoK\u03b11)","volume":"6","author":"Baglioni","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1016\/j.bmc.2013.09.003","article-title":"New Non-Symmetrical Choline Kinase Inhibitors","volume":"21","author":"Gallo","year":"2013","journal-title":"Bioorganic Med. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0167-4781(94)90056-6","article-title":"Primary Structure and Expression of a Human CTP: Phosphocholine Cytidylyltransferase","volume":"1219","author":"Kalmar","year":"1994","journal-title":"Biochim. Biophys. Acta BBA-Gene Struct. Expr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"14022","DOI":"10.1074\/jbc.273.22.14022","article-title":"Cloning and Characterization of a Second Human CTP:Phosphocholine Cytidylyltransferase","volume":"273","author":"Lykidis","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.1074\/jbc.274.19.13384","article-title":"Enzymatic and Cellular Characterization of a Catalytic Fragment of CTP:Phosphocholine Cytidylyltransferase A","volume":"274","author":"Friesen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1074\/jbc.M113.526970","article-title":"Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-Binding Amphipathic Helix","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1074\/jbc.RA118.002053","article-title":"An Auto-Inhibitory Helix in CTP:Phosphocholine Cytidylyltransferase Hijacks the Catalytic Residue and Constrains a Pliable, Domain-Bridging Helix Pair","volume":"293","author":"Ramezanpour","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10522","DOI":"10.1021\/bi010904c","article-title":"Regulation of CTP: Phosphocholine Cytidylyltransferase Activity by the Physical Properties of Lipid Membranes: An Important Role for Stored Curvature Strain Energy","volume":"40","author":"Davies","year":"2001","journal-title":"Biochemistry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1074\/jbc.M110.201715","article-title":"The Intrinsically Disordered Nuclear Localization Signal and Phosphorylation Segments Distinguish the Membrane Affinity of Two Cytidylyltransferase Isoforms","volume":"286","author":"Dennis","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1091\/mbc.E20-01-0014","article-title":"Differential Dephosphorylation of CTP:Phosphocholine Cytidylyltransferase upon Translocation to Nuclear Membranes and Lipid Droplets","volume":"31","author":"Yue","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/BJ20040105","article-title":"Transcriptional Repression of the CTP:Phosphocholine Cytidylyltransferase Gene by Sphingosine","volume":"382","author":"Ryan","year":"2004","journal-title":"Biochem. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"L108","DOI":"10.1152\/ajplung.2001.281.1.L108","article-title":"CTP:Phosphocholine Cytidylyltransferase Inhibition by Ceramide via PKC-Alpha, P38 MAPK, cPLA2, and 5-Lipoxygenase","volume":"281","author":"Awasthi","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1096\/fj.02-0149fje","article-title":"Phosphatidylcholine Synthesis Is Elevated in Neuronal Models of Gaucher Disease Due to Direct Activation of CTP:Phosphocholine Cytidylyltransferase by Glucosylceramide","volume":"16","author":"Bodennec","year":"2002","journal-title":"FASEB J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"26992","DOI":"10.1074\/jbc.274.38.26992","article-title":"Distribution of CTP:Phosphocholine Cytidylyltransferase (CCT) Isoforms: Identification of a New CCT\u03b2 Splice Variant","volume":"274","author":"Lykidis","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1128\/MCB.01824-08","article-title":"Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase","volume":"29","author":"Chen","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"33494","DOI":"10.1074\/jbc.M706472200","article-title":"Calmodulin Binds and Stabilizes the Regulatory Enzyme, CTP: Phosphocholine Cytidylyltransferase","volume":"282","author":"Chen","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1074\/jbc.275.13.9699","article-title":"Tumor Necrosis Factor-Alpha Inhibits Expression of CTP: Phosphocholine Cytidylyltransferase","volume":"275","author":"Mallampalli","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"26240","DOI":"10.1074\/jbc.274.37.26240","article-title":"Shuttling of CTP:Phosphocholine Cytidylyltransferase between the Nucleus and Endoplasmic Reticulum Accompanies the Wave of Phosphatidylcholine Synthesis during the G(0) \u2192 G(1) Transition","volume":"274","author":"Northwood","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"43688","DOI":"10.1074\/jbc.M108170200","article-title":"Transcription of the CTP:Phosphocholine Cytidylyltransferase Alpha Gene Is Enhanced during the S Phase of the Cell Cycle","volume":"276","author":"Golfman","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_109","first-page":"537","article-title":"Specific Interaction between E2F1 and Sp1 Regulates the Expression of Murine CTP:Phosphocholine Cytidylyltransferase Alpha during the S Phase","volume":"1801","author":"Elena","year":"2010","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Biol. Lipids"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1091\/mbc.e04-10-0874","article-title":"The Rate-Limiting Enzyme in Phosphatidylcholine Synthesis Regulates Proliferation of the Nucleoplasmic Reticulum","volume":"16","author":"Lagace","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1091\/mbc.e07-02-0179","article-title":"Expansion of the Nucleoplasmic Reticulum Requires the Coordinated Activity of Lamins and CTP:Phosphocholine Cytidylyltransferase \u03b1","volume":"19","author":"Gehrig","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1074\/jbc.M112.347682","article-title":"Ras-Induced up-Regulation of CTP:Phosphocholine Cytidylyltransferase \u03b1 Contributes to Malignant Transformation of Intestinal Epithelial Cells","volume":"288","author":"Arsenault","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.22.13.4851-4862.2002","article-title":"Caspase Processing and Nuclear Export of CTP:Phosphocholine Cytidylyltransferase \u03b1 during Farnesol-Induced Apoptosis","volume":"22","author":"Lagace","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1194\/jlr.M041434","article-title":"A Mechanism for Suppression of the CDP-Choline Pathway during Apoptosis","volume":"54","author":"Morton","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(03)00067-2","article-title":"Gene Structure, Expression and Identification of a New CTP:Phosphocholine Cytidylyltransferase Beta Isoform","volume":"1633","author":"Karim","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1080\/15548627.2019.1659608","article-title":"De Novo Phosphatidylcholine Synthesis Is Required for Autophagosome Membrane Formation and Maintenance during Autophagy","volume":"16","author":"Andrejeva","year":"2020","journal-title":"Autophagy"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"47402","DOI":"10.1074\/jbc.M404027200","article-title":"Targeted Deletion of Hepatic CTP:Phosphocholine Cytidylyltransferase Alpha in Mice Decreases Plasma High Density and Very Low Density Lipoproteins","volume":"279","author":"Jacobs","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1074\/jbc.M807338200","article-title":"CTP:Phosphocholine Cytidylyltransferase Alpha Is Required for B-Cell Proliferation and Class Switch Recombination","volume":"284","author":"Fagone","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1194\/jlr.M087056","article-title":"Intestinal de Novo Phosphatidylcholine Synthesis Is Required for Dietary Lipid Absorption and Metabolic Homeostasis","volume":"59","author":"Kennelly","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_120","first-page":"159109","article-title":"De Novo Phosphatidylcholine Synthesis in the Small Intestinal Epithelium Is Required for Normal Dietary Lipid Handling and Maintenance of the Mucosal Barrier","volume":"1867","author":"Carlin","year":"2022","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Biol. Lipids"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Enaw, J.O.E., Zhu, H., Yang, W., Lu, W., Shaw, G.M., Lammer, E.J., and Finnell, R.H. (2006). CHKA and PCYT1A Gene Polymorphisms, Choline Intake and Spina Bifida Risk in a California Population. BMC Med., 4.","DOI":"10.1186\/1741-7015-4-36"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"8901","DOI":"10.1073\/pnas.1408523111","article-title":"Mutations Disrupting the Kennedy Phosphatidylcholine Pathway in Humans with Congenital Lipodystrophy and Fatty Liver Disease","volume":"111","author":"Payne","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ajhg.2013.11.018","article-title":"Mutations in PCYT1A, Encoding a Key Regulator of Phosphatidylcholine Metabolism, Cause Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy","volume":"94","author":"Sobreira","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ajhg.2013.11.022","article-title":"Mutations in PCYT1A Cause Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy","volume":"94","author":"Yamamoto","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ejhg.2017.23","article-title":"Mutations in the PCYT1A Gene Are Responsible for Isolated Forms of Retinal Dystrophy","volume":"25","author":"Testa","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1038\/s41467-020-18153-w","article-title":"Long-Term Autophagy Is Sustained by Activation of CCT\u03b23 on Lipid Droplets","volume":"11","author":"Ogasawara","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bbalip.2011.06.017","article-title":"Involvement of CTP:Phosphocholine Cytidylyltransferase-\u03922 in Axonal Phosphatidylcholine Synthesis and Branching of Neurons","volume":"1811","author":"Strakova","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1074\/jbc.M706531200","article-title":"Phosphatidylcholine Biosynthesis via CTP:Phosphocholine Cytidylyltransferase 2 Facilitates Neurite Outgrowth and Branching","volume":"283","author":"Carter","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1369\/jhc.4A6545.2005","article-title":"Polyploid Formation via Chromosome Duplication Induced by CTP:Phosphocholine Cytidylyltransferase Deficiency and Bcl-2 Overexpression: Identification of Two Novel Endogenous Factors","volume":"53","author":"Shen","year":"2005","journal-title":"J. Histochem. Cytochem. Off. J. Histochem. Soc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nature04217","article-title":"Cytokinesis Failure Generating Tetraploids Promotes Tumorigenesis in P53-Null Cells","volume":"437","author":"Fujiwara","year":"2005","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1242\/jcs.039537","article-title":"The Consequences of Tetraploidy and Aneuploidy","volume":"121","author":"Storchova","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1074\/jbc.M300162200","article-title":"Oncogenic Ha-Ras Transformation Modulates the Transcription of the CTP:Phosphocholine Cytidylyltransferase Alpha Gene via P42\/44MAPK and Transcription Factor Sp3","volume":"278","author":"Bakovic","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1006\/cbir.1999.0430","article-title":"Ha-Ras-Transformation Alters the Metabolism of Phosphatidylethanolamine and Phosphatidylcholine in NIH 3T3 Fibroblasts","volume":"23","author":"Momchilova","year":"1999","journal-title":"Cell Biol. Int."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41419-021-04127-3","article-title":"NSUN2 Modified by SUMO-2\/3 Promotes Gastric Cancer Progression and Regulates mRNA m5C Methylation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/21681805.2018.1439527","article-title":"Choline-Phosphate Cytidylyltransferase-\u03b1 as a Possible Predictor of Survival and Response to Cisplatin Neoadjuvant Chemotherapy in Urothelial Cancer of the Bladder","volume":"52","author":"Hemdan","year":"2018","journal-title":"Scand. J. Urol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbrc.2020.05.164","article-title":"PCYT1A Suppresses Proliferation and Migration via Inhibiting mTORC1 Pathway in Lung Adenocarcinoma","volume":"529","author":"Yu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e171788","DOI":"10.1172\/JCI171788","article-title":"P53 Suppresses Lipid Droplet-Fueled Tumorigenesis through Phosphatidylcholine","volume":"134","author":"Xu","year":"2024","journal-title":"J. Clin. Investig."},{"key":"ref_138","first-page":"254","article-title":"[Expression and potential clinical significance of cytidine triphosphate: Phosphocholine cytidylyltransferase-\u03b1 in oral squamous cell carcinoma]","volume":"53","author":"Lu","year":"2018","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi\/Chin. J. Stomatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1038\/bcj.2017.61","article-title":"MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma","volume":"7","author":"Xiong","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0376-8716(02)00022-4","article-title":"Decreased Activity of Brain Phospholipid Metabolic Enzymes in Human Users of Cocaine and Methamphetamine","volume":"67","author":"Ross","year":"2002","journal-title":"Drug Alcohol Depend."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2018.10.006","article-title":"Localization and Expression of CTP:Phosphocholine Cytidylyltransferase in Rat Brain Following Cocaine Exposure","volume":"96","author":"Pati","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s002130050871","article-title":"Short-Term Treatment with Citicoline (CDP-Choline) Attenuates Some Measures of Craving in Cocaine-Dependent Subjects: A Preliminary Report","volume":"142","author":"Renshaw","year":"1999","journal-title":"Psychopharmacology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(00)00501-7","article-title":"Elevated Activity of Phospholipid Biosynthetic Enzymes in Substantia Nigra of Patients with Parkinson\u2019s Disease","volume":"102","author":"Ross","year":"2001","journal-title":"Neuroscience"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Irigoyen, J., Cartas-Cejudo, P., Iruarrizaga-Lejarreta, M., and Santamar\u00eda, E. (2021). Alteration in the Cerebrospinal Fluid Lipidome in Parkinson\u2019s Disease: A Post-Mortem Pilot Study. Biomedicines, 9.","DOI":"10.20944\/preprints202104.0324.v1"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1074\/jbc.RA118.002780","article-title":"Effects of Phosphatidylcholine Membrane Fluidity on the Conformation and Aggregation of N-Terminally Acetylated \u03b1-Synuclein","volume":"293","author":"Jiang","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1021\/acschemneuro.2c00355","article-title":"Phosphatidylcholine and Phosphatidylserine Uniquely Modify the Secondary Structure of \u03b1-Synuclein Oligomers Formed in Their Presence at the Early Stages of Protein Aggregation","volume":"13","author":"Dou","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20050834","article-title":"Effects of Hypoxia, Glucose Deprivation and Acidosis on Phosphatidylcholine Synthesis in HL-1 Cardiomyocytes. CTP: Phosphocholine Cytidylyltransferase Activity Correlates with Sarcolemmal Disruption","volume":"394","author":"Sarri","year":"2006","journal-title":"Biochem. J."},{"key":"ref_148","first-page":"101037","article-title":"Cardiac Phospholipidome Is Altered during Ischemia and Reperfusion in an Ex Vivo Rat Model","volume":"27","author":"Aveiro","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13058-020-01308-4","article-title":"Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer","volume":"22","author":"Maliniak","year":"2020","journal-title":"Breast Cancer Res."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Li, X., Ren, Y., Chang, K., Wu, W., Griffiths, H.R., Lu, S., and Gao, D. (2023). Adipose tissue macrophages as potential targets for obesity and metabolic diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1153915"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bbalip.2011.06.021","article-title":"Phosphatidylcholine Protects against Steatosis in Mice but Not Non-Alcoholic Steatohepatitis","volume":"1811","author":"Niebergall","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1038\/srep08421","article-title":"The Metabolic Responses to Hepatitis B Virus Infection Shed New Light on Pathogenesis and Targets for Treatment","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"12989","DOI":"10.1038\/s41598-019-49367-8","article-title":"Stimulated Phospholipid Synthesis Is Key for Hepatitis B Virus Replications","volume":"9","author":"Huang","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/1061186X.2021.2009841","article-title":"Significant Metabolic Alterations in Patients with Hepatitis B Virus Replication Observed via Serum Untargeted Metabolomics Shed New Light on Hepatitis B Virus Infection","volume":"30","author":"Yu","year":"2022","journal-title":"J. Drug Target."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"29808","DOI":"10.1074\/jbc.M005786200","article-title":"Cloning, Genomic Organization, and Characterization of a Human Cholinephosphotransferase","volume":"275","author":"Henneberry","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1074\/jbc.M109.017350","article-title":"Cross-Talk between Remodeling and De Novo Pathways Maintains Phospholipid Balance through Ubiquitination","volume":"285","author":"Butler","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.2147\/IJGM.S343426","article-title":"Identification of a Lipid Metabolism-Associated Gene Signature Predicting Survival in Breast Cancer","volume":"14","author":"Gong","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1158\/0008-5472.CAN-15-2910","article-title":"Estrogen Receptor \u03b1 Promotes Breast Cancer by Reprogramming Choline Metabolism","volume":"76","author":"Jia","year":"2016","journal-title":"Cancer Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1038\/s41388-020-01456-z","article-title":"Aberrant Activation of Super Enhancer and Choline Metabolism Drive Antiandrogen Therapy Resistance in Prostate Cancer","volume":"39","author":"Wen","year":"2020","journal-title":"Oncogene"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: An Update to the Integrated Cancer Data Analysis Platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1007271915160","article-title":"Modulation of Biosynthesis of Phosphatidylcholine via CDP-Choline in Rat Liver: Influence of Ethanol on the Microsomal Cholinephosphotransferase Activity","volume":"217","author":"Carrasco","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2011.05.022","article-title":"Lipidomic Changes in Rat Liver after Long-Term Exposure to Ethanol","volume":"255","author":"Fernando","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Tong, R., Ding, X., Liu, F., Li, H., Liu, H., Song, H., Wang, Y., Zhang, X., Liu, S., and Sun, T. (2023). Classification of Subtypes and Identification of Dysregulated Genes in Sepsis. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1226159"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10753-016-0500-6","article-title":"Alteration of Lysophosphatidylcholine-Related Metabolic Parameters in the Plasma of Mice with Experimental Sepsis","volume":"40","author":"Ahn","year":"2017","journal-title":"Inflammation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.200706152","article-title":"Cytokine Secretion Requires Phosphatidylcholine Synthesis","volume":"181","author":"Tian","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jlb.48.1.38","article-title":"Lipopolysaccharide (LPS) Alters Phosphatidylcholine Metabolism in Elicited Peritoneal Macrophages","volume":"48","author":"Grove","year":"1990","journal-title":"J. Leukoc. Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00226188","article-title":"Effect of Escherichia Coli Lipopolysaccharide on Phosphatidylcholine Biosynthesis by Rat Lung and Alveolar Type II Cells","volume":"93","author":"Bosch","year":"1990","journal-title":"Mol. Cell. Biochem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jat.1752","article-title":"Effect of Lipopolysaccharide on Alteration of Phospholipids and Their Fatty Acid Composition in Spleen and Thymus by In Vitro Metabolic Labeling","volume":"33","author":"Sabarirajan","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000368546","article-title":"Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses","volume":"41","author":"Feng","year":"2016","journal-title":"Kidney Blood Press. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"F1136","DOI":"10.1152\/ajprenal.00100.2016","article-title":"Early Lipid Changes in Acute Kidney Injury Using SWATH Lipidomics Coupled with MALDI Tissue Imaging","volume":"310","author":"Rao","year":"2016","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.cmet.2023.04.003","article-title":"Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals","volume":"35","author":"Kenny","year":"2023","journal-title":"Cell Metab."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-024-07444-7","article-title":"Molecular mechanism of choline and ethanolamine transport in humans","volume":"630","author":"Ri","year":"2024","journal-title":"Nature"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41586-024-07374-4","article-title":"Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1","volume":"629","author":"Son","year":"2024","journal-title":"Nature"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/ejh.12599","article-title":"Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia","volume":"96","author":"Mercurio","year":"2016","journal-title":"Eur. J. Haematol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ajhg.2010.10.013","article-title":"Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa","volume":"87","author":"Rajadhyaksha","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"101273","DOI":"10.1016\/j.gim.2024.101273","article-title":"Biallelic variation in the choline and ethanolamine transporter FLVCR1 underlies a severe developmental disorder spectrum","volume":"27","author":"Calame","year":"2025","journal-title":"Genet. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3324\/haematol.13359","article-title":"Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis","volume":"93","author":"Rey","year":"2008","journal-title":"Haematologica"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbagrm.2014.02.010","article-title":"Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2\u03b1 and ETS1","volume":"1839","author":"Fiorito","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Gao, Q., Fan, L., Chen, Y., and Cai, J. (2022). Identification of the hub and prognostic genes in liver hepatocellular carcinoma via bioinformatics analysis. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.1000847"},{"key":"ref_181","first-page":"1559","article-title":"FLVCR1 promotes the proliferation and tumorigenicity of synovial sarcoma through inhibiting apoptosis and autophagy","volume":"52","author":"Peng","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Zhou, S., Zhang, M., Zhou, C., Meng, Y., Yang, H., and Ye, W. (2021). FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma via Upregulating CSE1L. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.660955"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network, Weinstein, J.N., Collisson, E.A., Mills, G.B., Shaw, K.R.M., Ozenberger, B.A., Ellrott, K., Shmulevich, I., Sander, C., and Stuart, J.M. (2013). The Cancer Genome Atlas Pan-Cancer Analysis Project. Nat. Genet., 45, 1113\u20131120.","DOI":"10.1038\/ng.2764"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"16856","DOI":"10.1016\/S0021-9258(18)37470-2","article-title":"Specificity of Rat Hepatic Phosphatidylethanolamine N-Methyltransferase for Molecular Species of Diacyl Phosphatidylethanolamine","volume":"263","author":"Ridgway","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1016\/S0021-9258(18)38127-4","article-title":"A Cloned Gene Encoding Phosphatidylserine Decarboxylase Complements the Phosphatidylserine Biosynthetic Defect of a Chinese Hamster Ovary Cell Mutant","volume":"266","author":"Kuge","year":"1991","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7519\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:14:59Z","timestamp":1787631299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":185,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177519"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177519","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]}}}