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J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The aryl hydrocarbon receptor (AhR) is highly expressed in keratinocytes and functions as an environmental sensor regulating xenobiotic metabolism, epidermal differentiation, and inflammatory responses. Particulate matter (PM), a major environmental pollutant containing reactive oxygen species (ROS), transition metals, and polycyclic aromatic hydrocarbons (PAHs), induces oxidative stress and inflammation, leading to skin barrier dysfunction. Transition metals generate ROS via Fenton-type reactions, whereas PAHs undergo AhR-mediated metabolism that further amplifies oxidative stress. Excessive ROS promotes inflammatory cytokine expression and disrupts barrier-related protein expression. In response, activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway induces antioxidant enzymes, including heme oxygenase-1 (HO-1), to counteract oxidative damage. However, sustained PM exposure may overwhelm these defense mechanisms, resulting in impaired cellular homeostasis. Although the roles of AhR and Nrf2 have been extensively investigated individually, their coordinated regulation in PM-induced skin injury remains underexplored. This review summarizes current evidence on the functional interplay between AhR and Nrf2 and discusses how coordinated activation of these pathways integrates xenobiotic metabolism, antioxidant defense, and barrier-associated functions. Overall, the available evidence supports a dual-pathway framework for maintaining epidermal homeostasis under PM-induced environmental stress.<\/jats:p>","DOI":"10.3390\/ijms27177573","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:49:34Z","timestamp":1787582974000},"page":"7573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Particulate Matter-Induced Skin Injury: A Dual-Pathway AhR\u2013Nrf2 Framework for Epidermal Homeostasis and Therapeutic Targeting"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-6495","authenticated-orcid":false,"given":"Chia-Hsuan","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Yen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-2107","authenticated-orcid":false,"given":"Yu-Tse","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2745-139X","authenticated-orcid":false,"given":"Hsun-Shuo","family":"Chang","sequence":"additional","affiliation":[{"name":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-0200","authenticated-orcid":false,"given":"Horng-Huey","family":"Ko","sequence":"additional","affiliation":[{"name":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Pharmacy, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812012, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-1319","authenticated-orcid":false,"given":"Yih-Fung","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"University Center of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100603","DOI":"10.1016\/j.envadv.2024.100603","article-title":"An update on adverse health effects from exposure to PM2.5","volume":"18","author":"Sangkham","year":"2024","journal-title":"Environ. Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12989-022-00507-5","article-title":"A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence","volume":"19","author":"Li","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"ref_3","unstructured":"U.S. EPA (2025, November 19). Particulate Matter (PM) Basics, Available online: https:\/\/www.epa.gov\/pm-pollution\/particulate-matter-pm-basics."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s13181-011-0203-1","article-title":"Clearing the air: A review of the effects of particulate matter air pollution on human health","volume":"8","author":"Anderson","year":"2012","journal-title":"J. Med. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0045-6535(02)00241-2","article-title":"Combustion sources of particles. 1. Health relevance and source signatures","volume":"49","author":"Morawska","year":"2002","journal-title":"Chemosphere"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","article-title":"Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles","volume":"113","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11837-006-0147-0","article-title":"The potential toxicity of nanomaterials\u2014The role of surfaces","volume":"58","author":"Karakoti","year":"2006","journal-title":"JOM"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.bbagen.2016.03.019","article-title":"Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution","volume":"1860","author":"Chen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101147","DOI":"10.1016\/j.gsf.2021.101147","article-title":"Sources, characteristics, toxicity, and control of ultrafine particles: An overview","volume":"13","year":"2022","journal-title":"Geosci. Front."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1289\/ehp.1408387","article-title":"Effects of ambient coarse, fine, and ultrafine particles and their biological constituents on systemic biomarkers: A controlled human exposure study","volume":"123","author":"Liu","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41598-023-31215-5","article-title":"The dependence of particle size on cell toxicity for modern mining dust","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1289\/ehp.6000","article-title":"Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage","volume":"111","author":"Li","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/ar3000647","article-title":"The role of surface functionality in determining nanoparticle cytotoxicity","volume":"46","author":"Kim","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00128-022-03510-w","article-title":"Recent developments in the determination of PM2.5 chemical composition","volume":"108","author":"Pan","year":"2022","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"116913","DOI":"10.1016\/j.taap.2024.116913","article-title":"Redox-activity and in vitro effects of regional atmospheric aerosol pollution: Seasonal differences and correlation between oxidative potential and in vitro toxicity of PM1","volume":"485","author":"Melzi","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.envint.2014.10.005","article-title":"A review on the human health impact of airborne particulate matter","volume":"74","author":"Kim","year":"2015","journal-title":"Environ. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15342","DOI":"10.1007\/s11356-025-36624-9","article-title":"Emissions characteristics of polycyclic aromatic hydrocarbons, water-soluble heavy metals, and oxidative potential from indoor non-energy combustion sources","volume":"32","author":"Zhao","year":"2025","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.tox.2017.01.017","article-title":"Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter","volume":"380","author":"Wei","year":"2017","journal-title":"Toxicology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/envhealth.3c00060","article-title":"Influence of exposure pathways on tissue distribution and health impact of polycyclic aromatic hydrocarbon derivatives","volume":"1","author":"Zhang","year":"2023","journal-title":"Environ. Health"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Menichetti, A., Mordini, D., and Montalti, M. (2025). Penetration of microplastics and nanoparticles through skin: Effects of size, shape, and surface chemistry. J. Xenobiot., 15.","DOI":"10.3390\/jox15010006"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1016\/S2542-5196(22)00090-0","article-title":"Pollution and health: A progress update","volume":"6","author":"Fuller","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"ref_22","unstructured":"WHO (2025, November 20). Air Pollution. Available online: https:\/\/www.who.int\/health-topics\/air-pollution#tab=tab_2."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/08958378.2011.593587","article-title":"Health effects of particulate air pollution: A review of epidemiological evidence","volume":"23","author":"Ruckerl","year":"2011","journal-title":"Inhal. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ngoc, L.T.N., Park, D., Lee, Y., and Lee, Y.C. (2017). Systematic review and meta-analysis of human skin diseases due to particulate matter. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14121458"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12982-025-00502-z","article-title":"Association between fine particulate matter (PM2.5) and atopic dermatitis\u2014A systematic review","volume":"22","author":"Weslock","year":"2025","journal-title":"Discov. Public Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.freeradbiomed.2025.03.040","article-title":"Evidence that the aryl hydrocarbon receptor orchestrates oxinflammatory responses and contributes to airborne particulate matter-induced skin aging","volume":"233","author":"Hartung","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2017.01.029","article-title":"Sunlight damage to cellular DNA: Focus on oxidatively generated lesions","volume":"107","author":"Schuch","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105121","DOI":"10.1016\/j.chemphyslip.2021.105121","article-title":"Effects of ozone on stratum corneum lipid integrity and assembly","volume":"240","author":"Petracca","year":"2021","journal-title":"Chem. Phys. Lipids"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Manisalidis, I., Stavropoulou, E., Stavropoulos, A., and Bezirtzoglou, E. (2020). Environmental and health impacts of air pollution: A review. Front. Public Health, 8.","DOI":"10.3389\/fpubh.2020.00014"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1083\/jcb.100.4.1295","article-title":"Cellular uptake and intracellular localization of benzo(a)pyrene by digital fluorescence imaging microscopy","volume":"100","author":"Plant","year":"1985","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.combustflame.2014.03.014","article-title":"Laser induced fluorescence spectroscopy of aromatic species produced in atmospheric sooting flames using UV and visible excitation wavelengths","volume":"161","author":"Bejaoui","year":"2014","journal-title":"Combust. Flame"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"117559","DOI":"10.1016\/j.taap.2025.117559","article-title":"Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction","volume":"505","author":"Lin","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Drakaki, E., Dessinioti, C., and Antoniou, C.V. (2014). Air pollution and the skin. Front. Environ. Sci., 2.","DOI":"10.3389\/fenvs.2014.00011"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"de Szalay, S., and Wertz, P.W. (2023). Protective barriers provided by the epidermis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043145"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/JDN.0b013e3182274a98","article-title":"Anatomy and physiology of the skin","volume":"3","author":"Kolarsick","year":"2011","journal-title":"J. Dermatol. Nurses\u2019 Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1210\/er.2002-0021","article-title":"Epidermal homeostasis: The role of the growth hormone and insulin-like growth factor systems","volume":"24","author":"Edmondson","year":"2003","journal-title":"Endocr. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41574-025-01107-x","article-title":"Neuro-immuno-endocrinology of the skin: How environment regulates body homeostasis","volume":"21","author":"Slominski","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1396-0296.2004.04S1005.x","article-title":"Moisturization and skin barrier function","volume":"17","author":"Rawlings","year":"2004","journal-title":"Dermatol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cocis.2012.02.001","article-title":"Penetration of drugs through skin, a complex rate-controlling membrane","volume":"17","author":"Bolzinger","year":"2012","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/jdv.19745","article-title":"Epidermal barrier function in dry, flaky and sensitive skin: A narrative review","volume":"38","author":"Fluhr","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: An indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.01235","article-title":"Barriers built on claudins","volume":"117","author":"Turksen","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2016.08.007","article-title":"The role of tight junctions in skin barrier function and dermal absorption","volume":"242","author":"Bergmann","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lefevre-Utile, A., Braun, C., Haftek, M., and Aubin, F. (2021). Five functional aspects of the epidermal barrier. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111676"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.1523-1747.2002.01710.x","article-title":"Functional expression of AQP3 in human skin epidermis and reconstructed epidermis","volume":"118","author":"Sougrat","year":"2002","journal-title":"J. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-94-024-1057-0_11","article-title":"Aquaporins in the skin","volume":"969","author":"Patel","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/BC20040104","article-title":"Aquaporin-3 functions as a glycerol transporter in mammalian skin","volume":"97","author":"Verkman","year":"2005","journal-title":"Biol. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/ics.12994","article-title":"Influence of particle parameters on deposition onto healthy and damaged human hair","volume":"47","author":"Tham","year":"2025","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jdermsci.2018.04.015","article-title":"Urban particulate matter in air pollution penetrates into the barrier-disrupted skin and produces ROS-dependent cutaneous inflammatory response in vivo","volume":"91","author":"Jin","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1111\/ijd.17867","article-title":"Impact of air pollution on skin pigmentation: Mechanisms and protective strategies","volume":"64","author":"Khunger","year":"2025","journal-title":"Int. J. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejpb.2008.11.001","article-title":"Follicular transport route\u2014Research progress and future perspectives","volume":"71","author":"Knorr","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"119118","DOI":"10.1016\/j.envres.2024.119118","article-title":"Polycyclic aromatic hydrocarbon skin permeation efficiency in vitro is lower through human than pigskin and decreases with lipophilicity","volume":"255","author":"Simon","year":"2024","journal-title":"Environ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/jdv.17780","article-title":"The skin redoxome","volume":"36","author":"Schalka","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1017\/erm.2024.5","article-title":"The role of the cytochrome P450 superfamily in the skin","volume":"26","author":"Chen","year":"2024","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Paik, K., Na, J.I., Huh, C.H., and Shin, J.W. (2024). Particulate matter and its molecular effects on skin: Implications for various skin diseases. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25189888"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"167111","DOI":"10.1016\/j.scitotenv.2023.167111","article-title":"Particulate matter and inflammatory skin diseases: From epidemiological and mechanistic studies","volume":"905","author":"Chao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_57","first-page":"908","article-title":"Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor","volume":"60","author":"Burczynski","year":"2000","journal-title":"Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00204-018-2197-9","article-title":"Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis","volume":"92","author":"Piao","year":"2018","journal-title":"Arch. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2629079","DOI":"10.1080\/13510002.2026.2629079","article-title":"Mitigating PM2.5-induced skin injury and aging: Botanical strategies targeting redox and inflammatory pathways","volume":"31","author":"Maunjumpon","year":"2026","journal-title":"Redox Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tips.2022.12.003","article-title":"Advances and challenges in therapeutic targeting of Nrf2","volume":"44","author":"Copple","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lee, E.S., Kim, S., Lee, S.W., Jung, J., Lee, S.H., Na, H.W., Kim, H.J., Hong, Y.D., Park, W.S., and Lee, T.G. (2021). Molecule-resolved visualization of particulate matter on human skin using multimodal nonlinear optical imaging. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105199"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"117122","DOI":"10.1016\/j.taap.2024.117122","article-title":"PM10 dysregulates epithelial barrier function in human corneal epithelial cells that is restored by antioxidant SKQ1","volume":"492","author":"Somayajulu","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e15048","DOI":"10.1111\/exd.15048","article-title":"The cross-linking between DNA damage, oxidative stress and epidermal barrier in keratinocytes after exposure to particulate matters and carbon black","volume":"33","author":"Tang","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.jid.2020.03.971","article-title":"Air particulate matter induces skin barrier dysfunction and water transport alteration on a reconstructed human epidermis model","volume":"140","author":"Hieda","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"59199","DOI":"10.1021\/acsami.3c14377","article-title":"Anti-inflammatory artificial extracellular vesicles with notable inhibition of particulate matter-induced skin inflammation and barrier function impairment","volume":"15","author":"Park","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00281-013-0394-4","article-title":"Functions of the aryl hydrocarbon receptor in the skin","volume":"35","author":"Esser","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Li, Y., Zeng, Y., Chen, Z., Tan, X., Mei, X., and Wu, Z. (2024). The role of aryl hydrocarbon receptor in vitiligo: A review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1291556"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1021\/acs.est.5c08535","article-title":"Oxidative potential of atmospheric particulate matter: A review of the role of metal-organic interactions, mechanistic insights, and key determinants","volume":"60","author":"Lin","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.4081\/jphr.2021.2372","article-title":"Glutathione (GSH) and superoxide dismutase (SOD) levels among junior high school students induced by indoor particulate matter 2.5 (PM2.5) and nitrogen dioxide (NO2) exposure","volume":"10","author":"Wispriyono","year":"2021","journal-title":"J. Public Health Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/acs.chemrestox.0c00007","article-title":"Particulate matter toxicity is Nrf2 and mitochondria dependent: The roles of metals and polycyclic aromatic hydrocarbons","volume":"33","author":"Pardo","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e23425","DOI":"10.4161\/psb.23425","article-title":"Transition metals: A double edge sward in ROS generation and signaling","volume":"8","author":"Poschenrieder","year":"2013","journal-title":"Plant Signal. Behav."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.freeradbiomed.2008.01.028","article-title":"The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles","volume":"44","author":"Li","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"101080","DOI":"10.1016\/j.redox.2018.101080","article-title":"Particulate matter induces inflammatory cytokine production via activation of NF-\u03baB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin","volume":"21","author":"Ryu","year":"2019","journal-title":"Redox Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"168475","DOI":"10.1016\/j.scitotenv.2023.168475","article-title":"Effects of personal exposure to the oxidative potential of PM2.5 on oxidative stress biomarkers in pregnant women","volume":"911","author":"Marsal","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/biof.1513","article-title":"Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage","volume":"45","author":"Pecorelli","year":"2019","journal-title":"BioFactors"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/ars.2023.0252","article-title":"Pathological impact of redox post-translational modifications","volume":"41","author":"Chahla","year":"2024","journal-title":"Antioxid. Redox Signal"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/s12276-022-00822-z","article-title":"8-Oxoguanine: From oxidative damage to epigenetic and epitranscriptional modification","volume":"54","author":"Hahm","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/es803337c","article-title":"PM2.5 constituents and oxidative DNA damage in humans","volume":"43","author":"Wei","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2008.02.030","article-title":"Air pollution, oxidative damage to DNA, and carcinogenesis","volume":"266","author":"Folkmann","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2544014","DOI":"10.1080\/26395940.2025.2544014","article-title":"Apigenin prevents oxidative stress and mitochondrial damage caused by particulate matter 2.5 in skin cells","volume":"37","author":"Fernando","year":"2025","journal-title":"Environ. Pollut. Bioavailab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2004.07.015","article-title":"Genotoxicity of airborne particulate matter: The role of cell-particle interaction and of substances with adduct-forming and oxidizing capacity","volume":"565","author":"Karlsson","year":"2004","journal-title":"Mutat. Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Herath, H., Piao, M.J., Kang, K.A., Zhen, A.X., Fernando, P., Kang, H.K., Yi, J.M., and Hyun, J.W. (2022). Hesperidin exhibits protective effects against PM2.5-mediated mitochondrial damage, cell cycle arrest, and cellular senescence in human HaCaT keratinocytes. Molecules, 27.","DOI":"10.3390\/molecules27154800"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhen, A.X., Piao, M.J., Kang, K.A., Fernando, P.D., Herath, H.M., Cho, S.J., and Hyun, J.W. (2023). 3-Bromo-4,5-dihydroxybenzaldehyde protects keratinocytes from particulate matter 2.5-induced damages. Antioxidants, 12.","DOI":"10.3390\/antiox12061307"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbrc.2017.04.160","article-title":"Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor","volume":"488","author":"Qiao","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","first-page":"18","article-title":"Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization","volume":"713","author":"Gualtieri","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/13510002.2022.2036507","article-title":"Lycium barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy","volume":"27","author":"Zhu","year":"2022","journal-title":"Redox Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4103\/0366-6999.212942","article-title":"PM2.5 exposure elicits oxidative stress responses and mitochondrial apoptosis pathway activation in HaCaT keratinocytes","volume":"130","author":"Hu","year":"2017","journal-title":"Chin. Med. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e23806","DOI":"10.1002\/jbt.23806","article-title":"The inhibitory effect of chlorogenic acid on oxidative stress and apoptosis induced by PM2.5 in HaCaT keratinocytes","volume":"38","author":"Herath","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4062\/biomolther.2024.053","article-title":"C-peptide ameliorates particulate matter 2.5-induced skin cell apoptosis by inhibiting NADPH oxidation","volume":"33","author":"Fernando","year":"2025","journal-title":"Biomol. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jdermsci.2015.01.011","article-title":"The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption","volume":"78","author":"Pan","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chemosphere.2017.08.076","article-title":"Cell death pathways of particulate matter toxicity","volume":"188","author":"Peixoto","year":"2017","journal-title":"Chemosphere"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.7150\/ijms.46421","article-title":"PM2.5-related cell death patterns","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"978","DOI":"10.21037\/atm-21-2146","article-title":"Autophagy attenuates particulate matter 2.5-induced damage in HaCaT cells","volume":"9","author":"Dai","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0305-4","article-title":"Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications","volume":"51","author":"Ryu","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1096\/fj.202001357R","article-title":"Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging","volume":"34","author":"Reynolds","year":"2020","journal-title":"FASEB J."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Martic, I., Jansen-Durr, P., and Cavinato, M. (2022). Effects of air pollution on cellular senescence and skin aging. Cells, 11.","DOI":"10.3390\/cells11142220"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Lee, Y.I., Choi, S., Roh, W.S., Lee, J.H., and Kim, T.G. (2021). Cellular senescence and inflammaging in the skin microenvironment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083849"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s12276-025-01480-7","article-title":"Hallmarks of cellular senescence: Biology, mechanisms, regulations","volume":"57","author":"Ajoolabady","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3892\/etm.2024.12563","article-title":"Protective effects of astaxanthin on particulate matter 2.5-induced senescence in HaCaT keratinocytes via maintenance of redox homeostasis","volume":"28","author":"Zhen","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"116738","DOI":"10.1016\/j.ecoenv.2024.116738","article-title":"Interleukin-24: A molecular mediator of particulate matter\u2019s impact on skin aging","volume":"282","author":"Seong","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1111\/jocd.16558","article-title":"Matrix metalloproteinases on skin photoaging","volume":"23","author":"Feng","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"153276","DOI":"10.1016\/j.phymed.2020.153276","article-title":"Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis","volume":"77","author":"Ko","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Kubo, H., Moriyama, M., Goto, S., Miyake, Y., Nakamura, M., Ozeki, Y., Nakamura, Y., and Moriyama, H. (2025). Sage extract and ascorbic acid derivative inhibit melanogenesis via downregulating keratinocyte-derived GM-CSF. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0325242"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"116850","DOI":"10.1016\/j.envpol.2021.116850","article-title":"Particulate matter promotes hyperpigmentation via AhR\/MAPK signaling activation and by increasing \u03b1-MSH paracrine levels in keratinocytes","volume":"278","author":"Shi","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"105063","DOI":"10.1016\/j.envint.2019.105063","article-title":"Potential role of PM2.5 in melanogenesis","volume":"132","author":"Peng","year":"2019","journal-title":"Environ. Int."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"100981","DOI":"10.1016\/j.arr.2019.100981","article-title":"Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders","volume":"57","author":"Bellei","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"496","DOI":"10.5021\/ad.2020.32.6.496","article-title":"Effects of particulate matter in a mouse model of oxazolone-induced atopic dermatitis","volume":"32","author":"Bae","year":"2020","journal-title":"Ann. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e145185","DOI":"10.1172\/jci.insight.145185","article-title":"Particulate matter causes skin barrier dysfunction","volume":"6","author":"Kim","year":"2021","journal-title":"JCI Insight"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Teng, W.L., Huang, P.H., Wang, H.C., Tseng, C.H., and Yen, F.L. (2021). Pterostilbene attenuates particulate matter-induced oxidative stress, inflammation and aging in keratinocytes. Antioxidants, 10.","DOI":"10.3390\/antiox10101552"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Yang, C.Y., Pan, C.C., Tseng, C.H., and Yen, F.L. (2022). Antioxidant, anti-inflammation and antiaging activities of Artocarpus altilis methanolic extract on urban particulate matter-induced HaCaT keratinocytes damage. Antioxidants, 11.","DOI":"10.3390\/antiox11112304"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.jid.2017.04.031","article-title":"Regulation of the glycerol transporter, aquaporin-3, by histone deacetylase-3 and p53 in keratinocytes","volume":"137","author":"Choudhary","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bcp.2018.07.032","article-title":"From TCDD-mediated toxicity to searches of physiologic AhR functions","volume":"155","author":"Bock","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Dawe, H.R., and Di Meglio, P. (2025). The aryl hydrocarbon receptor (AhR): Peacekeeper of the skin. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041618"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41577-019-0125-8","article-title":"The aryl hydrocarbon receptor: An environmental sensor integrating immune responses in health and disease","volume":"19","author":"Rothhammer","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Fernandez-Gallego, N., Sanchez-Madrid, F., and Cibrian, D. (2021). Role of AhR ligands in skin homeostasis and cutaneous inflammation. Cells, 10.","DOI":"10.3390\/cells10113176"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"115371","DOI":"10.1016\/j.bcp.2022.115371","article-title":"Functions of the aryl hydrocarbon receptor (AhR) beyond the canonical AhR\/ARNT signaling pathway","volume":"208","author":"Sondermann","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.tibs.2026.02.018","article-title":"Advances in understanding aryl hydrocarbon receptor structure, function, and modulation","volume":"51","author":"Shang","year":"2026","journal-title":"Trends Biochem. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/mol.107.040204","article-title":"Repression of aryl hydrocarbon receptor (AhR) signaling by AhR repressor: Role of DNA binding and competition for AhR nuclear translocator","volume":"73","author":"Evans","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jep.2016.05.002","article-title":"Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS\/MAPKs pathways","volume":"189","author":"Lee","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Zhen, A.X., Piao, M.J., Hyun, Y.J., Kang, K.A., Madushan Fernando, P.D.S., Cho, S.J., Ahn, M.J., and Hyun, J.W. (2019). Diphlorethohydroxycarmalol attenuates fine particulate matter-induced subcellular skin dysfunction. Mar. Drugs, 17.","DOI":"10.3390\/md17020095"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/tox.24183","article-title":"Anti-pollutant effect of oleic acid against urban particulate matter is mediated via regulation of AhR- and TRPV1-mediated signaling in vitro","volume":"39","author":"Choi","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1096\/fba.2021-00056","article-title":"Adaptive responses to air pollution in human dermal fibroblasts and their potential roles in aging","volume":"3","author":"Reynolds","year":"2021","journal-title":"FASEB Bioadv."},{"key":"ref_124","first-page":"3227","article-title":"PM2.5 induces apoptosis, oxidative stress injury and melanin metabolic disorder in human melanocytes","volume":"19","author":"Suo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2021.05.003","article-title":"Skin biological responses to urban pollution in an ex vivo model","volume":"348","author":"Patatian","year":"2021","journal-title":"Toxicol. Lett."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/cbin.12233","article-title":"Shikonin protects skin cells against oxidative stress and cellular dysfunction induced by fine particulate matter","volume":"48","author":"Shilnikova","year":"2024","journal-title":"Cell Biol. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/toxsci\/kfv230","article-title":"Skin damage mechanisms related to airborne particulate matter exposure","volume":"149","author":"Magnani","year":"2016","journal-title":"Toxicol. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1111\/jocd.16321","article-title":"Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study","volume":"23","author":"Ferrara","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100066","DOI":"10.1016\/j.mocell.2024.100066","article-title":"Protective effect of 3-bromo-4,5-dihydroxybenzaldehyde against PM2.5-induced cell cycle arrest and autophagy in keratinocytes","volume":"47","author":"Herath","year":"2024","journal-title":"Mol. Cells"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Piao, M.J., Kang, K.A., Zhen, A.X., Fernando, P., Ahn, M.J., Koh, Y.S., Kang, H.K., Yi, J.M., Choi, Y.H., and Hyun, J.W. (2019). Particulate matter 2.5 mediates cutaneous cellular injury by inducing mitochondria-associated endoplasmic reticulum stress: Protective effects of ginsenoside Rb1. Antioxidants, 8.","DOI":"10.3390\/antiox8090383"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Lee, G.H., Maeng, J., Kim, S.Y., Yun, H.Y., Jeong, G.S., and Jeong, H.G. (2025). Anti-inflammasome effect of impressic acid on diesel exhaust particulate matter-induced NLRP1 inflammasome via the Keap1\/p62\/Nrf2-signaling pathway in keratinocytes. Antioxidants, 14.","DOI":"10.3390\/antiox14050610"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.toxlet.2010.10.019","article-title":"Asian dust storm particles induce a broad toxicological transcriptional program in human epidermal keratinocytes","volume":"200","author":"Choi","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"134324","DOI":"10.1016\/j.ijbiomac.2024.134324","article-title":"Fucoidan refined from Saccharina japonica ameliorates ambient particulate matter-induced inflammation in keratinocytes, underlying fibroblasts, and 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice","volume":"277","author":"Kirindage","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Choi, J., Moon, M.Y., Han, G.Y., Chang, M.S., Yang, D., and Cha, J. (2021). Phellodendron amurense extract protects human keratinocytes from PM2.5-induced inflammation via PAR-2 signaling. Biomolecules, 11.","DOI":"10.3390\/biom11010023"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"121168","DOI":"10.1016\/j.jep.2026.121168","article-title":"Flavonoid-rich Phyla nodiflora fraction promotes Keap1 degradation and Nrf2\/HO-1 activation to attenuate particulate matter-induced oxidative stress in human keratinocytes","volume":"360","author":"Lin","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Park, S.Y., Byun, E.J., Lee, J.D., Kim, S., and Kim, H.S. (2018). Air pollution, autophagy, and skin aging: Impact of particulate matter (PM10) on human dermal fibroblasts. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092727"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0009-2797(02)00068-6","article-title":"Ah receptor and NF-\u03baB interactions: Mechanisms and physiological implications","volume":"141","author":"Tian","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1073\/pnas.1722124115","article-title":"Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis","volume":"115","author":"Fu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature05683","article-title":"Dioxin receptor is a ligand-dependent E3 ubiquitin ligase","volume":"446","author":"Ohtake","year":"2007","journal-title":"Nature"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.jid.2016.06.627","article-title":"Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity","volume":"136","author":"Haas","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41423-025-01264-z","article-title":"The AhR-OVOL1-ID1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation","volume":"22","author":"Chen","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e2931","DOI":"10.1038\/cddis.2017.322","article-title":"Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis","volume":"8","author":"Tsuji","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Hashimoto-Hachiya, A., Tsuji, G., Murai, M., Yan, X., and Furue, M. (2018). Upregulation of FLG, LOR, and IVL expression by Rhodiola crenulata root extract via aryl hydrocarbon receptor: Differential involvement of OVOL1. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061654"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jid.2023.07.027","article-title":"Benvitimod inhibits IL-4- and IL-13-induced tight junction impairment by activating AhR\/ARNT pathway and inhibiting STAT6 phosphorylation in human keratinocytes","volume":"144","author":"Wang","year":"2024","journal-title":"J. Investig. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e156501","DOI":"10.1172\/JCI156501","article-title":"Human \u03b2-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway","volume":"132","author":"Peng","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.freeradbiomed.2020.11.018","article-title":"Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells","volume":"163","author":"Tocmo","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1038\/jid.2015.285","article-title":"The Janus-Faced role of aryl hydrocarbon receptor signaling in the skin: Consequences for prevention and treatment of skin disorders","volume":"135","author":"Esser","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jdermsci.2018.02.014","article-title":"Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis","volume":"90","author":"Uchi","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0009-2797(97)00111-7","article-title":"Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole","volume":"110","author":"Wei","year":"1998","journal-title":"Chem. Biol. Interact."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Rannug, A. (2020). How the AhR became important in intestinal homeostasis\u2014A diurnal FICZ\/AhR\/CYP1A1 feedback controls both immunity and immunopathology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165681"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bcp.2016.06.005","article-title":"Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AhR activation time","volume":"115","author":"Farmahin","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"O\u2019Driscoll, C.A., Gallo, M.E., Hoffmann, E.J., Fechner, J.H., Schauer, J.J., Bradfield, C.A., and Mezrich, J.D. (2018). Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AhR) in vitro. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0209690"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"171492","DOI":"10.1016\/j.scitotenv.2024.171492","article-title":"Effects and mechanisms of polycyclic aromatic hydrocarbons in inflammatory skin diseases","volume":"925","author":"Jin","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the Nrf2 and Keap1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Jeong, J., Wahyudi, L.D., Keum, Y.S., Yang, H., and Kim, J.H. (2018). E-p-methoxycinnamoyl-\u03b1-L-rhamnopyranosyl ester, a phenylpropanoid isolated from Scrophularia buergeriana, increases nuclear factor erythroid-derived 2-related factor 2 stability by inhibiting ubiquitination in human keratinocytes. Molecules, 23.","DOI":"10.3390\/molecules23040768"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/med.21257","article-title":"Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents","volume":"32","author":"Magesh","year":"2012","journal-title":"Med. Res. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mc.20465","article-title":"Molecular mechanisms of Nrf2-mediated antioxidant response","volume":"48","author":"Li","year":"2009","journal-title":"Mol. Carcinog."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.apsb.2015.05.008","article-title":"Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents","volume":"5","author":"Abed","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.abb.2016.10.010","article-title":"Keap1 as the redox sensor of the antioxidant response","volume":"617","author":"Sihvola","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Kim, M.J., and Jeon, J.H. (2022). Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052846"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-pharmtox-052220-104025","article-title":"Targeting Nrf2 and its downstream processes: Opportunities and challenges","volume":"62","author":"Torrente","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3109\/10715762.2010.507670","article-title":"Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases","volume":"44","author":"Singh","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4724920","DOI":"10.1155\/2019\/4724920","article-title":"The Nrf2\/HO-1 axis as targets for flavanones: Neuroprotection by pinocembrin, naringenin, and eriodictyol","volume":"2019","author":"Habtemariam","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Ross, D., and Siegel, D. (2017). Functions of NQO1 in cellular protection and CoQ10 metabolism and its potential role as a redox sensitive molecular switch. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00595"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cotox.2017.10.005","article-title":"NQO1 in protection against oxidative stress","volume":"7","author":"Ross","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"dmm052126","DOI":"10.1242\/dmm.052126","article-title":"Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation","volume":"18","author":"Koch","year":"2025","journal-title":"Dis. Model. Mech."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"116761","DOI":"10.1016\/j.bcp.2025.116761","article-title":"The AhR-Nrf2-JDP2 gene battery: Ligand-induced AhR transcriptional activation","volume":"233","author":"Wuputra","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/exd.14541","article-title":"Aryl hydrocarbon receptor\/nuclear factor E2-related factor 2 (AhR\/Nrf2) signalling: A novel therapeutic target for atopic dermatitis","volume":"31","author":"Hwang","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/toxsci\/kfp115","article-title":"Introducing the \u201cTCDD-inducible AhR-Nrf2 gene battery\u201d","volume":"111","author":"Yeager","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"101530","DOI":"10.1016\/j.redox.2020.101530","article-title":"The aryl hydrocarbon receptor as a target of environmental stressors- Implications for pollution mediated stress and inflammatory responses","volume":"34","author":"Vogel","year":"2020","journal-title":"Redox Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"111534","DOI":"10.1016\/j.biopha.2021.111534","article-title":"Natural compounds protect the skin from airborne particulate matter by attenuating oxidative stress","volume":"138","author":"Diao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e19316","DOI":"10.7717\/peerj.19316","article-title":"Natural products as promising therapeutics for fine particulate matter-induced skin damage: A review of pre-clinical studies on skin inflammation and barrier dysfunction","volume":"13","author":"Jeayeng","year":"2025","journal-title":"PeerJ"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/tx700302s","article-title":"Covalent modification at cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3","volume":"21","author":"Rachakonda","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"ref_174","first-page":"5198138","article-title":"Keap1 cystenine 151 as a potential target for artemisitene-induced Nrf2 activation","volume":"2019","author":"Liu","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1128\/MCB.24.24.10941-10953.2004","article-title":"Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1096\/fj.201500109R","article-title":"Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury","volume":"30","author":"Chen","year":"2016","journal-title":"FASEB J."},{"key":"ref_177","first-page":"RP97632","article-title":"Capsaicin acts as a novel Nrf2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the Keap1-Nrf2 interaction","volume":"13","author":"Liu","year":"2025","journal-title":"eLife"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e0658","DOI":"10.1097\/HC9.0000000000000658","article-title":"A novel Keap1 inhibitor, tiliroside, activates Nrf2 to protect against acetaminophen-induced oxidative stress and acute liver injury","volume":"9","author":"Cai","year":"2025","journal-title":"Hepatol. Commun."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/ptr.8099","article-title":"Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization","volume":"38","author":"Ning","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Kwack, M.H., Bang, J.S., and Lee, W.J. (2022). Preventative effects of antioxidants against PM10 on serum IgE concentration, mast cell counts, inflammatory cytokines, and keratinocyte differentiation markers in DNCB-induced atopic dermatitis mouse model. Antioxidants, 11.","DOI":"10.3390\/antiox11071334"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fct.2013.12.015","article-title":"Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2\/ARE activation: Akt and AMPK\u03b1 as upstream targets","volume":"65","author":"Kundu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.chembiol.2010.03.013","article-title":"A small-molecule inducer of the antioxidant response element","volume":"17","author":"Hur","year":"2010","journal-title":"Chem. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"112813","DOI":"10.1016\/j.fct.2022.112813","article-title":"Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation","volume":"160","author":"Lu","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/j.1476-5381.2011.01232.x","article-title":"CCAAT\/enhancer-binding protein \u03b2 activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor","volume":"164","author":"Han","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/bi801637q","article-title":"(\u2212)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor","volume":"48","author":"Yin","year":"2009","journal-title":"Biochemistry"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"24445","DOI":"10.1021\/acsomega.0c02896","article-title":"Xanthohumol effect on 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated Japanese quails in terms of serum lipids, liver enzymes, estradiol, and thyroid hormones","volume":"5","author":"Leskow","year":"2020","journal-title":"ACS Omega"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41467-023-38478-6","article-title":"Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice","volume":"14","author":"Ondrova","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"105593","DOI":"10.1016\/j.jff.2023.105593","article-title":"Particulate matter-induced skin inflammation is suppressed by polyphenol-enriched dietary supplement via inhibition of the AhR\/ARNT signaling pathway","volume":"106","author":"Sim","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"153418","DOI":"10.1016\/j.phymed.2020.153418","article-title":"Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis","volume":"81","author":"Lee","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Lin, C.H., Chou, C.C., Lee, Y.H., and Hung, C.C. (2022). Curcumin facilitates aryl hydrocarbon receptor activation to ameliorate inflammatory astrogliosis. Molecules, 27.","DOI":"10.3390\/molecules27082507"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.jid.2024.04.022","article-title":"Biological effects of CYP11A1-derived vitamin D and lumisterol metabolites in the skin","volume":"144","author":"Slominski","year":"2024","journal-title":"J. Investig. Dermatol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"117711","DOI":"10.1016\/j.bcp.2026.117711","article-title":"Metabolic activation of lumisterol to biologically active metabolites and their mechanism of action","volume":"246","author":"Slominski","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Slominski, A.T., Kim, T.K., Slominski, R.M., Song, Y., Qayyum, S., Placha, W., Janjetovic, Z., Kleszczynski, K., Atigadda, V., and Song, Y. (2023). Melatonin and its metabolites can serve as agonists on the aryl hydrocarbon receptor and peroxisome proliferator-activated receptor gamma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015496"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"113820","DOI":"10.1016\/j.bcp.2020.113820","article-title":"Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification","volume":"173","author":"Shin","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e27527","DOI":"10.1016\/j.heliyon.2024.e27527","article-title":"Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-\u03baB and Nrf2 pathways","volume":"10","author":"Salem","year":"2024","journal-title":"Heliyon"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"101206","DOI":"10.1016\/j.redox.2019.101206","article-title":"Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms","volume":"24","author":"Chaiprasongsuk","year":"2019","journal-title":"Redox Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41598-017-01305-2","article-title":"Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of Nrf2-mediated pathways","volume":"7","author":"Janjetovic","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"111842","DOI":"10.1016\/j.ejmech.2019.111842","article-title":"Targeting aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs)","volume":"185","author":"Dolciami","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Safe, S., Jin, U.H., Park, H., Chapkin, R.S., and Jayaraman, A. (2020). Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators (SAhRMs). Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186654"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphs.2025.06.005","article-title":"Phenylalanine amide derivatives promote FLG expression via AhR activation in normal human epidermal keratinocytes","volume":"159","author":"Sumitomo","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.freeradbiomed.2019.08.012","article-title":"Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2\/AhR","volume":"143","author":"Pavon","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/tx100389r","article-title":"Modification of Keap1 cysteine residues by sulforaphane","volume":"24","author":"Hu","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Brennan, M.S., Matos, M.F., Li, B., Hronowski, X., Gao, B., Juhasz, P., Rhodes, K.J., and Scannevin, R.H. (2015). Dimethyl fumarate and monoethyl fumarate exhibit differential effects on Keap1, Nrf2 activation, and glutathione depletion in vitro. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120254"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.freeradbiomed.2012.06.023","article-title":"Validation of the multiple sensor mechanism of the Keap1-Nrf2 system","volume":"53","author":"Takaya","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"103482","DOI":"10.1016\/j.redox.2024.103482","article-title":"Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis","volume":"79","author":"Han","year":"2025","journal-title":"Redox Biol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1124\/dmd.104.002253","article-title":"tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand","volume":"33","author":"Gharavi","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1073\/pnas.1121572109","article-title":"Keap1 degradation by autophagy for the maintenance of redox homeostasis","volume":"109","author":"Taguchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00403-018-1825-9","article-title":"Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: A review of clinical data","volume":"310","author":"Landeck","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/jpet.114.218818","article-title":"The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes","volume":"352","author":"Helwa","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jdermsci.2016.10.003","article-title":"Inhibition of aryl hydrocarbon receptor signaling and induction of Nrf2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes","volume":"85","author":"Uchi","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jdermsci.2023.01.008","article-title":"Cannabidiol mediates epidermal terminal differentiation and redox homeostasis through aryl hydrocarbon receptor (AhR)-dependent signaling","volume":"109","author":"Jang","year":"2023","journal-title":"J. Dermatol. Sci."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"112705","DOI":"10.1016\/j.celrep.2023.112705","article-title":"Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways","volume":"42","author":"Ganapathy","year":"2023","journal-title":"Cell Rep."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/acs.chemrestox.1c00364","article-title":"Alternaria alternata mycotoxins activate the aryl hydrocarbon receptor and Nrf2-ARE pathway to alter the structure and immune response of colon epithelial cells","volume":"35","author":"Groestlinger","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2023.12.013","article-title":"Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: A clinical review","volume":"154","author":"Silverberg","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jid.2017.05.004","article-title":"Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans","volume":"137","author":"Smith","year":"2017","journal-title":"J. Investig. Dermatol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7573\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:15:00Z","timestamp":1787717700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":215,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177573"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177573","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]}}}