{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:24:17Z","timestamp":1787736257983,"version":"build-2784847793"},"reference-count":97,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Childhood obesity is an important global health issue closely related to metabolic syndrome and metabolic dysfunction-associated fatty liver disease (MASLD), currently the most common chronic liver disease in children. Oxidative stress and insulin resistance are the driving forces in hepatocyte injury and disease progression. There is growing interest in new biomarkers for detecting and monitoring metabolic and hepatic changes. We aimed to synthesize current evidence regarding biomarkers of oxidative stress and MASLD, and the potential modulatory role of selenium in pediatric populations. A literature search of PubMed, Scopus, Web of Science, and the Cochrane Library identified studies in children and adolescents (0\u201318 years) published between January 2000 and December 2025. Associative diagnostic biomarkers included indicators of oxidative damage, antioxidant-defense markers, and integrated oxidative stress indices, which appear promising but lack pediatric reference ranges, while prognostic biomarkers capture the inflammatory consequences of redox imbalance but with limited liver specificity. Metabolomics profiling and multiomics approaches remain experimental. Selenium, an essential trace element with antioxidant properties, plays a role in maintaining redox balance through selenoproteins, but pediatric evidence is limited and at times contradictory. Few biomarkers are clinically ready. Further longitudinal studies in pediatric populations are needed to better clarify the role of selenium, as well as to support the development of age-appropriate diagnostic strategies utilizing multiomics for MASLD, empowering clinicians to implement timely interventions in childhood obesity.<\/jats:p>","DOI":"10.3390\/ijms27177575","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:49:34Z","timestamp":1787582974000},"page":"7575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redox\u2013Metabolic Crosstalk in Pediatric MASLD: Biomarkers, Mechanisms, and the Emerging Role of Selenium"],"prefix":"10.3390","volume":"27","author":[{"given":"Sanja","family":"Panic Zaric","sequence":"first","affiliation":[{"name":"Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-5579","authenticated-orcid":false,"given":"Teofana-Otilia","family":"Bizerea-Moga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, First Pediatric Clinic, Center for Research on Growth and Developmental Disorders in Children, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Emergency Clinical Hospital for Children\u00a0\u2018Louis \u021aurcanu\u2019, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-4105","authenticated-orcid":false,"given":"Rade","family":"Vukovic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"},{"name":"School of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5268-3180","authenticated-orcid":false,"given":"Maja","family":"Janicijevic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Care Institute of Serbia \u201cDr Vukan Cupic\u201d, 11070 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9797","authenticated-orcid":false,"given":"Raluca","family":"Isac","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children\u00a0\u2018Louis \u021aurcanu\u2019, Iosif Nemoianu 2, 300011 Timi\u0219oara, Romania"},{"name":"Department of Pediatrics\u2014Third Pediatric Clinic, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-1856","authenticated-orcid":false,"given":"Tudor Voicu","family":"Moga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2014Gastroenterology Clinic, Advanced Regional Research Center in Gas-Troenterology and Hepatology, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Gastroenterology and Hepatology Clinic, \u2018Pius Br\u00eenzeu\u2019 County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-7228","authenticated-orcid":false,"given":"Alina","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2014Gastroenterology Clinic, Advanced Regional Research Center in Gas-Troenterology and Hepatology, \u2018Victor Babe\u0219\u2019 University of Medicine and Pharmacy Timi\u0219oara, Eftimie Murgu Sq no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Gastroenterology and Hepatology Clinic, \u2018Pius Br\u00eenzeu\u2019 County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1210\/clinem\/dgz010","article-title":"The effect of overweight and obesity on liver biochemical markers in children and adolescents","volume":"105","author":"Johansen","year":"2020","journal-title":"J. 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