{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:17:39Z","timestamp":1787807859477,"version":"build-2784847793"},"reference-count":62,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 111-2320-B-039-020-MY3"],"award-info":[{"award-number":["MOST 111-2320-B-039-020-MY3"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["CMU114-MF-28"],"award-info":[{"award-number":["CMU114-MF-28"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The APOA1 rs670 (\u221275 G&gt;A) polymorphism has been implicated in lipid metabolism and susceptibility to metabolic syndrome (MetS). However, individual studies have reported inconsistent associations with circulating apolipoprotein A1 (Apo A1) and lipid parameters, and no meta-analysis has comprehensively evaluated these associations stratified by metabolic disorder status. We therefore quantified the associations between APOA1 rs670 and serum Apo A1 and lipid parameters, and determined whether these associations are modified by metabolic disorder status. PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov were searched from inception to March 2026. Eligible studies reported APOA1 rs670 genotype data with quantitative lipid measurements. Forty studies involving 22,175 participants met the inclusion criteria. Pooled effect sizes were estimated as standardized mean differences (SMDs) with 95% confidence intervals (CIs) using random-effects models. This review was registered in PROSPERO (CRD420261333145). A allele carriers had significantly higher serum Apo A1 (SMD, 0.20; p &lt; 0.001) and HDL-C levels (SMD, 0.14; p &lt; 0.001) than GG homozygotes. Subgroup analyses stratified by metabolic disorder status revealed that the associations with Apo A1 (SMD, 0.53 vs. 0.11) and HDL-C (SMD, 0.23 vs. 0.08) were substantially stronger among individuals with metabolic disorders than among metabolically healthy individuals. No significant associations were observed for LDL-C or triglyceride levels. The APOA1 rs670 polymorphism is associated with higher circulating Apo A1 and HDL-C levels, with stronger associations in individuals with metabolic disorders. These findings suggest that metabolic status modifies the phenotypic effects of rs670 on the Apo A1\u2013HDL pathway.<\/jats:p>","DOI":"10.3390\/ijms27177622","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:01:07Z","timestamp":1787670067000},"page":"7622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context-Dependent Associations of the APOA1 rs670 Polymorphism with Apolipoprotein A1 and HDL Cholesterol: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"27","author":[{"given":"Chien-Yi","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 711301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-4261","authenticated-orcid":false,"given":"Yi-Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 406040, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Fen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 406040, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 406040, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-4992","authenticated-orcid":false,"given":"Wen-Chieh","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, China Medical University, Taichung 406040, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2023.02.003","article-title":"The global burden of metabolic disease: Data from 2000 to 2019","volume":"35","author":"Chew","year":"2023","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11906-018-0812-z","article-title":"The Global Epidemic of the Metabolic Syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men","volume":"288","author":"Lakka","year":"2002","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome\u2014A new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm.2937","article-title":"The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?","volume":"18","author":"Rader","year":"2012","journal-title":"Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrcardio.2017.115","article-title":"HDL and atherosclerotic cardiovascular disease: Genetic insights into complex biology","volume":"15","author":"Rosenson","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/353265a0","article-title":"Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI","volume":"353","author":"Rubin","year":"1991","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/MOL.0b013e328306a043","article-title":"The value of HDL genetics","volume":"19","author":"Holleboom","year":"2008","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1161\/01.ATV.15.10.1740","article-title":"G\u2192A Substitution at Position \u221275 of the Apolipoprotein A-I Gene Promoter","volume":"15","author":"Minnich","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_10","unstructured":"National Center for Biotechnology Information (2026, August 18). rs670 RefSNP Report, Available online: https:\/\/www.ncbi.nlm.nih.gov\/snp\/rs670."},{"key":"ref_11","first-page":"233","article-title":"G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations","volume":"7","author":"Jeenah","year":"1990","journal-title":"Mol. Biol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1161\/01.ATV.12.9.1017","article-title":"Interaction between a polymorphism of the apo A-I promoter region and smoking determines plasma levels of HDL and apo A-I","volume":"12","author":"Sigurdsson","year":"1992","journal-title":"Arterioscler. Thromb."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/gepi.1370110305","article-title":"Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: The European Atherosclerosis Research Study","volume":"11","author":"Talmud","year":"1994","journal-title":"Genet. Epidemiol."},{"key":"ref_14","first-page":"94","article-title":"The Effect of Interactions of Single Nucleotide Polymorphisms of APOA1\/APOC3 with Food Group Intakes on the Risk of Metabolic Syndrome","volume":"9","author":"Mirmiran","year":"2017","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ajcn\/75.1.38","article-title":"Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: The Framingham Study","volume":"75","author":"Ordovas","year":"2002","journal-title":"AM. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.atherosclerosis.2010.10.029","article-title":"Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk","volume":"214","author":"Phillips","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.5114\/aoms.2017.65233","article-title":"Apolipoprotein A1 polymorphisms and risk of coronary artery disease: A meta-analysis","volume":"13","author":"Xu","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhao, X.-N., Sun, Q., Cao, Y.-Q., Ran, X., and Cao, Y. (2021). Association between apolipoprotein gene polymorphisms and hyperlipidemia: A meta-analysis. BMC Genom. Data, 22.","DOI":"10.1186\/s12863-021-00968-1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1155\/2005\/195078","article-title":"APOA1-75 G to A substitution associated with severe forms of CAD, lower levels of HDL and apoA-I among northern Indians","volume":"21","author":"Chhabra","year":"2005","journal-title":"Dis. Markers"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1515\/bjmg-2017-0002","article-title":"Association of the Apolipoprotein A-I Gene Polymorphisms with Cardiovascular Disease Risk Factors and Atherogenic Indices in Patients from Assam, Northeast India","volume":"20","author":"Bora","year":"2017","journal-title":"Balk. J. Med. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-008-9751-3","article-title":"Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease","volume":"313","author":"Rai","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"ref_22","first-page":"753","article-title":"Associations of the apolipoprotein A-I gene polymorphism and serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations","volume":"21","author":"Li","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.gene.2018.10.050","article-title":"Association of apolipoprotein A1 and A5 polymorphisms with stroke subtypes in Han Chinese people in Taiwan","volume":"684","author":"Hsu","year":"2019","journal-title":"Gene"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, X., Guo, H., Li, Y., Wang, H., He, J., Mu, L., Hu, Y., Ma, J., Yan, Y., and Li, S. (2018). Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196042"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"509420","DOI":"10.1155\/2012\/509420","article-title":"Associations of polymorphisms in the apolipoprotein APOA1-C3-A5 gene cluster with acute coronary syndrome","volume":"2012","author":"Ding","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_26","first-page":"207","article-title":"Analysis of a new polymorphism in the human apolipoprotein A-I gene: Association with serum lipoprotein levels and coronary heart disease","volume":"28","author":"Bai","year":"1996","journal-title":"J. Cardiol."},{"key":"ref_27","first-page":"332","article-title":"Apolipoprotein A I Gene MspI Polymorphism in Relation to Endogenous Hypertriglyceridemia in Chinese Population","volume":"9","author":"Zhu","year":"2001","journal-title":"Editor. Off. Chin. J. Arterioscler."},{"key":"ref_28","first-page":"369","article-title":"Effects of apolipoprotein A1 gene rs670 and rs5069 polymorphisms on the plasma lipid profiles in healthy adolescents with different body mass index","volume":"36","author":"Song","year":"2014","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cccn.2005.04.004","article-title":"Relationship between plasma HDL subclasses distribution and apoA-I gene polymorphisms","volume":"360","author":"Jia","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/03014460802604268","article-title":"Apolipoprotein AI and Apolipoprotein B gene polymorphisms and lipid profile in Tamilian population","volume":"36","author":"Padmaja","year":"2009","journal-title":"Ann. Hum. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4930033","DOI":"10.1155\/2022\/4930033","article-title":"Association between ApoA1 Gene, Plasma Lipid Profile, hsCRP Level, and Risk of Arterial Stiffness in Thai Elderly","volume":"2022","author":"Supajaree","year":"2022","journal-title":"Adv. Prev. Med."},{"key":"ref_32","first-page":"665","article-title":"Relationships among apolipoprotein A1 gene polymorphisms, lipid levels and coronary atherosclerosis disease","volume":"116","author":"Zou","year":"2003","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1309\/AJCPKPTXQ3QN1IFG","article-title":"Apolipoprotein A1 gene polymorphism (G-75A and C+83T) in patients with myocardial infarction: A pilot study in a north Indian population","volume":"134","author":"Dawar","year":"2010","journal-title":"AM. J. Clin. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mgene.2015.10.005","article-title":"Single nucleotide polymorphisms of APOA1 gene and their relationship with serum apolipoprotein A-I concentrations in the native population of Assam","volume":"7","author":"Bora","year":"2016","journal-title":"Meta Gene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cca.2007.12.014","article-title":"APOA1\/C3\/A5 haplotype and risk of hypertriglyceridemia in Taiwanese","volume":"390","author":"Chien","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12020-011-9526-6","article-title":"Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran Lipid and Glucose Study","volume":"41","author":"Daneshpour","year":"2012","journal-title":"Endocrine"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Al-Bustan, S.A., Al-Serri, A.E., Annice, B.G., Alnaqeeb, M.A., and Ebrahim, G.A. (2013). Re-sequencing of the APOAI promoter region and the genetic association of the \u221275G > A polymorphism with increased cholesterol and low density lipoprotein levels among a sample of the Kuwaiti population. BMC Med. Genet., 14.","DOI":"10.1186\/1471-2350-14-90"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.clnesp.2020.05.016","article-title":"Association of rs670 variant of APOA-1 gene with cardiometabolic markers after consuming sesame, canola and sesame-canola oils in adults with and without type 2 diabetes mellitus","volume":"38","author":"Aghaei","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0022-2275(20)37642-2","article-title":"Apolipoprotein A-I\/C-III\/A-IV gene cluster in familial combined hyperlipidemia: Effects on LDL-cholesterol and apolipoproteins B and C-III","volume":"37","author":"Bu","year":"1996","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000006849","article-title":"Apolipoprotein A1 gene polymorphisms and risk of early coronary disease","volume":"90","author":"Reguero","year":"1998","journal-title":"Cardiology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.clnu.2019.04.030","article-title":"Association of rs670 variant of APOA1 gene with lipid profile and insulin resistance after 9 months of a high protein\/low carbohydrate vs a standard hypocaloric diet","volume":"39","author":"Izaola","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_42","first-page":"1288","article-title":"Influence of rs670 variant of APOA1 gene on serum HDL response to an enriched-polyunsaturated vs. an enriched-monounsaturated fat hypocaloric diet","volume":"36","author":"Primo","year":"2019","journal-title":"Nutr. Hosp."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.clnu.2017.12.007","article-title":"Implication of the rs670 variant of APOA1 gene with lipid profile, serum adipokine levels and components of metabolic syndrome in adult obese subjects","volume":"38","author":"Izaola","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.diabres.2018.05.040","article-title":"Role of rs670 variant of APOA1 gene on lipid profile, insulin resistance and adipokine levels in obese subjects after weight loss with a dietary intervention","volume":"142","author":"Izaola","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jdiacomp.2018.10.015","article-title":"Role of rs670 variant of APOA1 gene on metabolic response after a high fat vs. a low fat hypocaloric diets in obese human subjects","volume":"33","author":"Izaola","year":"2019","journal-title":"J. Diabetes Complicat."},{"key":"ref_46","first-page":"8472","article-title":"The association of the rs670 variant of APOA1 gene with insulin resistance and lipid profile in morbid obese patients after a biliopancreatic diversion surgery","volume":"22","author":"Pacheco","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1590\/S0100-879X2005000400006","article-title":"APOA1\/C3\/A4 gene cluster variability and lipid levels in Brazilian children","volume":"38","author":"Alves","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10238-009-0051-3","article-title":"Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity","volume":"9","author":"Chen","year":"2009","journal-title":"Clin. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e24015","DOI":"10.1590\/s2175-97902024e24015","article-title":"Single nucleotide polymorphisms in apolipoprotein A-I (rs670) and B (rs693) associated with serum lipoproteins and endothelial activation in COVID-19 outpatients","volume":"60","author":"Costa","year":"2024","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1034\/j.1399-0004.2002.610302.x","article-title":"Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein, serum lipoprotein and glucose levels","volume":"61","author":"Larson","year":"2002","journal-title":"Clin. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/mds.26022","article-title":"Lower plasma apolipoprotein A1 levels are found in Parkinson\u2019s disease and associate with apolipoprotein A1 genotype","volume":"30","author":"Swanson","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.atherosclerosis.2007.11.017","article-title":"The apolipoprotein AII rs5082 variant is associated with reduced risk of coronary artery disease in an Australian male population","volume":"199","author":"Xiao","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-2272(1996)13:1<1::AID-GEPI1>3.0.CO;2-D","article-title":"New MspI polymorphism at +83 bp of the human apolipoprotein AI gene: Association with increased circulating high density lipoprotein cholesterol levels","volume":"13","author":"Wang","year":"1996","journal-title":"Genet. Epidemiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/ATVBAHA.109.201020","article-title":"Genetic variants influencing circulating lipid levels and risk of coronary artery disease","volume":"30","author":"Waterworth","year":"2010","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"\u015aciskalska, M., and Milnerowicz, H. (2022). Importance of Polymorphisms in the Gene of Paraoxonase-1 (SNP rs662) and Apolipoprotein A-I (SNP rs670 and rs5069) in Non-Smoking and Smoking Healthy Subjects and Patients with Acute Pancreatitis. Genes, 13.","DOI":"10.3390\/genes13111968"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/MCB.06175-11","article-title":"Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor \u03b1 in mouse liver reveals extensive sharing of binding sites","volume":"32","author":"Boergesen","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13072-019-0260-2","article-title":"Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks","volume":"12","author":"Starks","year":"2019","journal-title":"Epigenet. Chromatin"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.gde.2008.07.016","article-title":"Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors","volume":"18","author":"Hong","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","article-title":"Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study","volume":"380","author":"Voight","year":"2012","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7622\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:22:28Z","timestamp":1787804548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":62,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177622"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177622","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}