{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:17:04Z","timestamp":1787894224136,"version":"build-2784847793"},"reference-count":55,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"David H. Koch Center for Applied Research in Genitourinary Cancers"},{"name":"Cancer Center Prostate Cancer SPORE","award":["NIH\/NCI P50 CA140388"],"award-info":[{"award-number":["NIH\/NCI P50 CA140388"]}]},{"name":"Cancer Center Prostate Cancer SPORE","award":["NIH\/NCI U01 CA224044"],"award-info":[{"award-number":["NIH\/NCI U01 CA224044"]}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01npwtv09","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Neuroendocrine prostate cancer (NEPC) is characterized by androgen receptor (AR) independence and poor response to conventional therapies, highlighting the need to unveil the molecular mechanisms behind NEPC. We previously showed that heme oxygenase 1 (HO-1, encoded by HMOX1) translocates to the nucleus exerting unexplored non-canonical functions. The present study delineates the nuclear interactome of HO-1, revealing a potential mechanism that impairs NEPC establishment. Through a proteomics approach integrated with bioinformatics analyses, we identified eleven novel nuclear interactors of HO-1. Unsupervised clustering analyses of RNA-seq data from prostate cancer (PCa) patient-derived xenografts (MDA PCa PDXs) and clinical cohorts demonstrated high expression of three HO-1 interactors (ILF3, SAFB, BCLAF1, and DDX17) in NEPC samples, with concomitant HMOX1 under-expression. Spatial transcriptomics in a mixed-histology tumor confirmed enrichment of the interactors in the NEPC foci. To better understand the link between HO-1 and NEPC, we established and characterized an in vitro model of NE transdifferentiation in PCa cell lines using forskolin to induce phenotypic reprogramming. HO-1 upregulation in transdifferentiated cells significantly attenuated the expression of NE markers and triggered a morphological shift, restoring epithelial phenotypes. This work identifies for the first time HO-1 nuclear interactome association with NEPC, where the HMOX1-ILF3-SAFB-BCLAF1-DDX17 print emerges as a useful marker for disease stratification.<\/jats:p>","DOI":"10.3390\/ijms27177635","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:15Z","timestamp":1787731875000},"page":"7635","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HO-1 Nuclear Interactome Implications in Neuroendocrine Transdifferentiation in Prostate Cancer"],"prefix":"10.3390","volume":"27","author":[{"given":"Rocio","family":"Seniuk","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-8036","authenticated-orcid":false,"given":"Pablo","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Tecnolog\u00eda (INTEC), Universidad Argentina de la Empresa (UADE), Buenos Aires C1073AAO, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-3506","authenticated-orcid":false,"given":"Agustina","family":"Sabater","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"},{"name":"Instituto de Tecnolog\u00eda (INTEC), Universidad Argentina de la Empresa (UADE), Buenos Aires C1073AAO, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-5775","authenticated-orcid":false,"given":"Gaston","family":"Pascual","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-2162","authenticated-orcid":false,"given":"Juan","family":"Bizzotto","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Tecnolog\u00eda (INTEC), Universidad Argentina de la Empresa (UADE), Buenos Aires C1073AAO, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lechuga","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Delfino","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"},{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4843-6441","authenticated-orcid":false,"given":"Peter D. 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Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1158\/2159-8290.CD-12-0460","article-title":"Molecular Classification of Prostate Cancer Progression: Foundation for Marker-Driven Treatment of Prostate Cancer","volume":"3","author":"Logothetis","year":"2013","journal-title":"Cancer Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1200\/JCO.2017.77.6880","article-title":"Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-Institutional Prospective Study","volume":"36","author":"Aggarwal","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.4045","article-title":"Divergent Clonal Evolution of Castration-Resistant Neuroendocrine Prostate Cancer","volume":"22","author":"Beltran","year":"2016","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/s43018-024-00838-6","article-title":"The Neuroendocrine Transition in Prostate Cancer Is Dynamic and Dependent on ASCL1","volume":"5","author":"Romero","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/0008-5472.CAN-24-1388","article-title":"Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1","volume":"84","author":"Rodarte","year":"2024","journal-title":"Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"eaav0891","DOI":"10.1126\/scitranslmed.aav0891","article-title":"Delta-like Protein 3 Expression and Therapeutic Targeting in Neuroendocrine Prostate Cancer","volume":"11","author":"Puca","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Luu Hoang, K.N., Anstee, J.E., and Arnold, J.N. (2021). The Diverse Roles of Heme Oxygenase-1 in Tumor Progression. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.658315"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chiang, S.K., Chen, S.E., and Chang, L.C. (2019). A Dual Role of Heme Oxygenase-1 in Cancer Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010039"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10456-011-9230-4","article-title":"Heme Oxygenase 1 (HO-1) Challenges the Angiogenic Switch in Prostate Cancer","volume":"14","author":"Ferrando","year":"2011","journal-title":"Angiogenesis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1158\/1541-7786.MCR-08-0325","article-title":"Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells","volume":"7","author":"Gueron","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1593\/neo.121358","article-title":"Unveiling the Association of STAT3 and HO-1 in Prostate Cancer: Role beyond Heme Degradation","volume":"14","author":"Elguero","year":"2012","journal-title":"Neoplasia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1038\/sj.bjc.6604081","article-title":"Nuclear Translocation of Haeme Oxygenase-1 Is Associated to Prostate Cancer","volume":"97","author":"Sacca","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lage-Vickers, S., Sanchis, P., Bizzotto, J., Toro, A., Sabater, A., Lavignolle, R., Anselmino, N., Labanca, E., Paez, A., and Navone, N. (2022). Exploiting Interdata Relationships in Prostate Cancer Proteomes: Clinical Significance of HO-1 Interactors. Antioxidants, 11.","DOI":"10.3390\/antiox11020290"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Scaffa, A., Tollefson, G.A., Yao, H., Rizal, S., Wallace, J., Oulhen, N., Carr, J.F., Hegarty, K., Uzun, A., and Dennery, P.A. (2022). Identification of Heme Oxygenase-1 as a Putative DNA-Binding Protein. Antioxidants, 11.","DOI":"10.3390\/antiox11112135"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm1586","article-title":"Heme Oxygenase-1 and Carbon Monoxide Suppress the Pathogenesis of Experimental Cerebral Malaria","volume":"13","author":"Pamplona","year":"2007","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Salloom, R.J., Ahmad, I.M., Sahtout, D.Z., Baine, M.J., and Abdalla, M.Y. (2024). Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and Implication in Cancer Therapy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179195"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3892\/ol.2021.13176","article-title":"Function of BCLAF1 in Human Disease","volume":"23","author":"Yu","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1042\/BCJ20160649","article-title":"The Increasing Diversity of Functions Attributed to the SAFB Family of RNA-\/DNA-Binding Proteins","volume":"473","author":"Norman","year":"2016","journal-title":"Biochem. J."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sun, T., Li, X., Zhang, Y., Zou, B., and Zhang, Y. (2024). ILF2: A Multifaceted Regulator in Malignant Tumors and Its Prospects as a Biomarker and Therapeutic Target. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1513979"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41422-025-01084-w","article-title":"Structural Insights into Spliceosome Fidelity: DHX35\u2013GPATCH1-Mediated Rejection of Aberrant Splicing Substrates","volume":"35","author":"Li","year":"2025","journal-title":"Cell Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Xu, K., Sun, S., Yan, M., Cui, J., Yang, Y., Li, W., Huang, X., Dou, L., Chen, B., and Tang, W. (2022). DDX5 and DDX17\u2014Multifaceted Proteins in the Regulation of Tumorigenesis and Tumor Progression. Front. Oncol., 12, Correction in Front Oncol. 2023, 13, 1204712. https:\/\/doi.org\/10.3389\/fonc.2023.1204712.","DOI":"10.3389\/fonc.2023.1204712"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e3632","DOI":"10.1002\/jgm.3632","article-title":"BRIX1 Promotes Ribosome Synthesis and Enhances Glycolysis by Selected Translation of GLUT1 in Colorectal Cancer","volume":"26","author":"Jiang","year":"2024","journal-title":"J. Gene Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Markiewicz, A., Sigorski, D., Markiewicz, M., Owczarczyk-Saczonek, A., and Placek, W. (2021). Caspase-14\u2014From Biomolecular Basics to Clinical Approach. A Review of Available Data. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115575"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s43032-021-00595-2","article-title":"Coiled-Coil Domain-Containing (CCDC) Proteins: Functional Roles in General and Male Reproductive Physiology","volume":"28","author":"Priyanka","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.4161\/cc.8.24.10242","article-title":"Peroxiredoxin 1 and Its Role in Cell Signaling","volume":"8","author":"Neumann","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4009354","DOI":"10.1155\/2022\/4009354","article-title":"Comprehensive Analysis and Validation of Solute Carrier Family 25 (SLC25) and Its Correlation with Immune Infiltration in Pan-Cancer","volume":"2022","author":"Liu","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1158\/1078-0432.CCR-23-2438","article-title":"Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-Derived Xenograft (MDA PCa PDX) Series","volume":"30","author":"Anselmino","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"ref_30","unstructured":"(2026, May 12). Spatial Transcriptomics of De Novo NEPC and ARPC\u2014STOMICS DataBase. Available online: https:\/\/db.cngb.org\/stomics\/datasets\/STDS0000227\/summary."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"D1053","DOI":"10.1093\/nar\/gkad933","article-title":"STOmicsDB: A Comprehensive Database for Spatial Transcriptomics Data Sharing, Analysis and Visualization","volume":"52","author":"Xu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Watanabe, R., Miura, N., Kurata, M., Kitazawa, R., Kikugawa, T., and Saika, T. (2023). Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108955"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagrm.2018.07.014","article-title":"MRGBP Promotes AR-Mediated Transactivation of KLK3 and TMPRSS2 via Acetylation of Histone H2A.Z in Prostate Cancer Cells","volume":"1861","author":"Ito","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) -Gene Regul. Mech."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00018-010-0497-1","article-title":"CAMP Initiates Early Phase Neuron-like Morphology Changes and Late Phase Neural Differentiation in Mesenchymal Stem Cells","volume":"68","author":"Zhang","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.62347\/GRQJ8158","article-title":"RB1 and P53 Are Diagnostic Markers for Treatment-Related Neuroendocrine Prostate Cancer: A Clinical and Pathological Analysis of 23 Cases","volume":"13","author":"Zhang","year":"2025","journal-title":"Am. J. Clin. Exp. Urol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e2570","DOI":"10.1038\/cddis.2016.420","article-title":"Heme Oxygenase-1 in the Forefront of a Multi-Molecular Network That Governs Cell\u2013Cell Contacts and Filopodia-Induced Zippering in Prostate Cancer","volume":"7","author":"Paez","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2015.09.004","article-title":"HO-1\/CO System in Tumor Growth, Angiogenesis and Metabolism\u2014Targeting HO-1 as an Anti-Tumor Therapy","volume":"74","author":"Loboda","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Nitti, M., Piras, S., Marinari, U.M., Moretta, L., Pronzato, M.A., and Furfaro, A.L. (2017). HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation. Antioxidants, 6.","DOI":"10.3390\/antiox6020029"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20621","DOI":"10.1074\/jbc.M607954200","article-title":"Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress","volume":"282","author":"Lin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.3390\/cimb45050273","article-title":"Pharmacological Significance of Heme Oxygenase 1 in Prostate Cancer","volume":"45","author":"Gayle","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2010.06.048","article-title":"Pro-Healing Potential of Hemin: An Inducer of Heme Oxygenase-1","volume":"645","author":"Ahanger","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1038\/s41467-018-06177-2","article-title":"Androgen Deprivation Promotes Neuroendocrine Differentiation and Angiogenesis Through CREB-EZH2-TSP1 Pathway in Prostate Cancers","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Anselmino, N., Bizzotto, J., Sanchis, P., Lage-Vickers, S., Ortiz, E., Valacco, P., Paez, A., Labanca, E., Meiss, R., and Navone, N. (2020). HO-1 Interactors Involved in the Colonization of the Bone Niche: Role of ANXA2 in Prostate Cancer Progression. Biomolecules, 10.","DOI":"10.3390\/biom10030467"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal Analysis Approaches in Ingenuity Pathway Analysis","volume":"30","author":"Green","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_45","first-page":"100141","article-title":"ClusterProfiler 4.0: A Universal Enrichment Tool for Interpreting Omics Data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"ref_46","unstructured":"(2026, May 12). Bioconductor\u2014Enrichplot. Available online: https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/enrichplot.html."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The CBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the CBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","article-title":"Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in CBioPortal","volume":"83","author":"Kundra","year":"2023","journal-title":"Cancer Res."},{"key":"ref_50","unstructured":"Kolde, R. (R Package Pheatmap, 2025). R Package Pheatmap, version 1.0.13; Pretty Heatmaps."},{"key":"ref_51","unstructured":"Kassambara, A., and Mundt, F. (R Package Factoextra, 2026). R Package Factoextra, version 2.0.0; Extract and Visualize the Results of Multivariate Data Analyses."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2016). ggplot2, Springer.","DOI":"10.1007\/978-3-319-24277-4"},{"key":"ref_54","unstructured":"Kassambara, A. (2026, May 12). R Package, Available online: https:\/\/rpkgs.datanovia.com\/ggpubr\/."},{"key":"ref_55","unstructured":"Neuwirth, E. (R Package RColorBrewer, 2022). R Package RColorBrewer, version 1.1-3; ColorBrewer Palettes."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7635\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:19:54Z","timestamp":1787890794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":55,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177635"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177635","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}