{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:24:20Z","timestamp":1787736260057,"version":"build-2784847793"},"reference-count":67,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Oral squamous cell carcinoma (OSCC) prognosis remains limited by TNM staging alone. We conducted a systematic review and meta-analysis to evaluate preoperative neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR) ratios as prognostic markers. We searched PubMed\/MEDLINE, Scopus, Base, Google Scholar and ScienceDirect from inception to 30 May 2026. Eligible studies reported preoperative ratios and survival outcomes, namely, overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS), in surgically treated OSCC. Risk of bias was assessed with the QUIPS tool. Random-effects meta-analyses of multivariate hazard ratios (HRs) were primary; univariate data, heterogeneity, prediction intervals, sensitivity and subgroup analyses were also performed. Thirty-nine studies (12,153 patients; mostly East Asian retrospective cohorts) were included. Elevated NLR predicted worse overall survival (HR 1.51, 95% CI 1.32\u20131.73) and disease-specific survival (HR 2.00, 1.58\u20132.54). NLR also showed a significant association with DFS (HR = 1.47, 95% CI: 1.21\u20131.78), though the prediction interval crossed unity. PLR and LMR showed weaker, less consistent associations. Evidence was limited by predominant retrospective design, geographic concentration and variable cut-offs. Preoperative NLR is a reproducible, inexpensive prognostic biomarker that may complement TNM staging; standardized thresholds require prospective validation. The review was registered in PROSPERO; no specific funding was received.<\/jats:p>","DOI":"10.3390\/ijms27177638","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:05:46Z","timestamp":1787735146000},"page":"7638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Inflammatory Blood Indices as Prognostic Markers in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-9639","authenticated-orcid":false,"given":"Alexandros","family":"Louizakis","sequence":"first","affiliation":[{"name":"Laboratory of Oral and Maxillofacial Surgery, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-0396","authenticated-orcid":false,"given":"Dimitris","family":"Tatsis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-6766","authenticated-orcid":false,"given":"Asterios","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-5407","authenticated-orcid":false,"given":"Ioannis","family":"Astreidis","sequence":"additional","affiliation":[{"name":"Laboratory of Oral and Maxillofacial Surgery, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4858-6705","authenticated-orcid":false,"given":"Effimia","family":"Stergiadou","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Domvri","sequence":"additional","affiliation":[{"name":"Department of Pathology, George Papanikolaou General Hospital of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-5370","authenticated-orcid":false,"given":"Konstantinos","family":"Paraskevopoulos","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon","family":"Metallidis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Vahtsevanos","sequence":"additional","affiliation":[{"name":"Laboratory of Oral and Maxillofacial Surgery, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-1772","authenticated-orcid":false,"given":"Angeliki","family":"Cheva","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ding, M., Song, Y., Jing, J., Tian, M., Ding, L., Li, Q., Zhou, C., Dong, H., Ni, Y., and Mou, Y. (2021). The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients with Oral Squamous Cell Carcinoma. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.719513"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hasegawa, T., Iga, T., Takeda, D., Amano, R., Saito, I., Kakei, Y., Kusumoto, J., Kimoto, A., Sakakibara, A., and Akashi, M. (2020). Neutrophil-Lymphocyte Ratio Associated with Poor Prognosis in Oral Cancer: A Retrospective Study. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07063-1"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tsai, Y.T., Fang, K.H., Hsu, C.M., Lai, C.H., Chang, S.W., Huang, E.I., Tsai, M.S., Chang, G.H., and Luan, C.W. (2022). Prognostic Role of High-Sensitivity Modified Glasgow Prognostic Score for Patients with Operated Oral Cavity Cancer: A Retrospective Study. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.825967"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Xu, J., Wu, F., Jiang, Y., Han, C., Xing, X., Zhu, H., Chen, Y., and Li, Q. (2026). Prognostic Value of NLR versus PLR and LMR in Patients with Oral Squamous Cell Carcinoma: A Meta-Analysis. BMC Oral Health, 26.","DOI":"10.1186\/s12903-026-08098-9"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ruiz-Ranz, M., Lequerica-Fern\u00e1ndez, P., Rodr\u00edguez-Santamarta, T., Su\u00e1rez-S\u00e1nchez, F.J., L\u00f3pez-Pintor, R.M., Garc\u00eda-Pedrero, J.M., and de Vicente, J.C. (2022). Prognostic Implications of Preoperative Systemic Inflammatory Markers in Oral Squamous Cell Carcinoma, and Correlations with the Local Immune Tumor Microenvironment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.941351"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.amsu.2020.10.029","article-title":"Epidemiology and Pathology of Oral Squamous Cell Carcinoma in a Multi-Ethnic Population: Retrospective Study of 154 Cases over 7 Years in Qatar","volume":"60","author":"Elaiwy","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00432-025-06394-5","article-title":"Hematological Parameters as Predictors of Oral Cancer Prognosis: A Systematic Review and Meta-Analysis","volume":"152","author":"Alshahrani","year":"2026","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_8","first-page":"21","article-title":"Role of Monocyte Count and Neutrophil-to-Lymphocyte Ratio in Survival of Oral Cancer Patients","volume":"21","author":"Bobdey","year":"2017","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/lary.24105","article-title":"Refining the Role of Preoperative C-Reactive Protein by Neutrophil\/Lymphocyte Ratio in Oral Cavity Squamous Cell Carcinoma","volume":"123","author":"Fang","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nakashima, H., Matsuoka, Y., Yoshida, R., Nagata, M., Hirosue, A., Kawahara, K., Sakata, J., Arita, H., Hiraki, A., and Nakayama, H. (2016). Pre-Treatment Neutrophil to Lymphocyte Ratio Predicts the Chemoradiotherapy Outcome and Survival in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2079-6"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hed.24589","article-title":"Changing Epidemiology of Oral Squamous Cell Carcinoma of the Tongue: A Global Study","volume":"39","author":"Ng","year":"2017","journal-title":"Head Neck"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12032-012-0334-5","article-title":"High Neutrophil-to-Lymphocyte Ratio Is an Independent Marker of Poor Disease-Specific Survival in Patients with Oral Cancer","volume":"30","author":"Perisanidis","year":"2013","journal-title":"Med. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zakaria, S.S., Ramanathan, A., Mat Ripen, Z., Ghani, W.M.N., Yang, Y.H., Vincent-Chong, V.K., and Ismail, S.M. (2022). Prognostic Abilities of Pre- and Post-Treatment Inflammatory Markers in Oral Squamous Cell Carcinoma: Stepwise Modelling. Medicina, 58.","DOI":"10.3390\/medicina58101426"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00405-021-06786-6","article-title":"A Novel Clinical Signature Predicts the Survival of Elderly Patients with Oral Squamous Cell Carcinoma","volume":"279","author":"Zhou","year":"2022","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"13081","DOI":"10.1038\/s41598-018-31498-z","article-title":"Nomogram Based on Albumin and Neutrophil-to-Lymphocyte Ratio for Predicting the Prognosis of Patients with Oral Cavity Squamous Cell Carcinoma","volume":"8","author":"Kao","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.1038\/s41598-020-68991-3","article-title":"Prognostic Value of Systemic Inflammatory Markers for Oral Cancer Patients Based on the 8th Edition of AJCC Staging System","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ijom.2021.01.009","article-title":"A Preoperative Prognostic Nutritional Index Is a Prognostic Indicator in Oral Squamous Cell Carcinoma Patients Undergoing Radical Surgery","volume":"50","author":"Watabe","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/odi.13629","article-title":"Prognostic Value of Preoperative Lymphocyte-to-Monocyte Ratio in Oral Cancer Patients and Establishment of a Dynamic Nomogram","volume":"27","author":"Chen","year":"2021","journal-title":"Oral Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/0194599817745284","article-title":"Correlation of Inflammatory Markers, Survival, and COX2 Expression in Oral Cancer and Implications for Prognosis","volume":"158","author":"Sano","year":"2018","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.joms.2020.01.001","article-title":"Assessment of Pretreatment Neutrophil\/Lymphocyte Ratio and Platelet\/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma","volume":"78","author":"Tazeen","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/00016489.2017.1404640","article-title":"A Prognostic Scoring System Using Inflammatory Response Biomarkers in Oral Cavity Squamous Cell Carcinoma Patients Who Underwent Surgery-Based Treatment","volume":"138","author":"Park","year":"2018","journal-title":"Acta Otolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/cncr.32591","article-title":"Pretreatment Peripheral Blood Leukocytes Are Independent Predictors of Survival in Oral Cavity Cancer","volume":"126","author":"Valero","year":"2020","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e009617","DOI":"10.1136\/jitc-2024-009617","article-title":"Cancer Cell-Specific PD-L1 Expression Is a Predictor of Poor Outcome in Patients with Locally Advanced Oral Cavity Squamous Cell Carcinoma","volume":"12","author":"Wang","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.21873\/anticanres.13126","article-title":"Prognostic Significance of Pretreatment Lymphocyte-to-Monocyte Ratio in Patients with Tongue Cancer","volume":"39","author":"Furukawa","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/odi.13774","article-title":"A Novel Prognostic Score Based on Systemic Inflammatory Biomarkers for Patients with Oral Squamous Cell Carcinoma","volume":"28","author":"Zhuang","year":"2022","journal-title":"Oral Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Nie, Z., Zhao, P., Shang, Y., and Sun, B. (2021). Nomograms to Predict the Prognosis in Locally Advanced Oral Squamous Cell Carcinoma after Curative Resection. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08106-x"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/cam4.3738","article-title":"Comparative Prognostic Value of Different Preoperative Complete Blood Count Cell Ratios in Patients with Oral Cavity Cancer Treated with Surgery and Postoperative Radiotherapy","volume":"10","author":"Wu","year":"2021","journal-title":"Cancer Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.joms.2019.03.007","article-title":"Are Comorbidities Associated with Overall Survival in Patients with Oral Squamous Cell Carcinoma?","volume":"77","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lu, Z., Yan, W., Liang, J., Yu, M., Liu, J., Hao, J., Wan, Q., Liu, J., Luo, C., and Chen, Y. (2020). Nomogram Based on Systemic Immune-Inflammation Index to Predict Survival of Tongue Cancer Patients Who Underwent Cervical Dissection. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00341"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huang, L., Wu, W., and Hu, G. (2024). Prognostic Value of Platelet-to-Lymphocyte Ratio in Patients with Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-05026-7"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.2147\/CMAR.S211847","article-title":"Significance of the Neutrophil-to-Lymphocyte Ratio in Young Patients with Oral Squamous Cell Carcinoma","volume":"11","author":"Zhang","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/jamaoto.2016.3802","article-title":"Prognostic Performance of a Newstaging Category to Improve Discrimination of Disease-Specific Survival in Nonmetastatic Oral Cancer","volume":"143","author":"Lee","year":"2017","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.pathol.2016.07.003","article-title":"Programmed Cell Death-Ligand 1 Expression in Oral Squamous Cell Carcinoma Is Associated with an Inflammatory Phenotype","volume":"48","author":"Satgunaseelan","year":"2016","journal-title":"Pathology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.omtn.2019.03.012","article-title":"MiR-31-5p Is a Potential Circulating Biomarker and Therapeutic Target for Oral Cancer","volume":"16","author":"Lu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s12663-021-01524-1","article-title":"Prognostic Value of Lymph Node Density Compared to Pre-Operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients with Tongue Squamous Cell Carcinoma","volume":"21","author":"Khazravi","year":"2022","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.2147\/OTT.S140800","article-title":"Prognosis of Neutrophil-to-Lymphocyte Ratio in Clinical Early-Stage Tongue (CT1\/T2N0) Cancer","volume":"10","author":"Wu","year":"2017","journal-title":"OncoTargets Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13643-025-02752-z","article-title":"Practical Methods for Incorporating Summary Time-to-Event Data into Meta-Analysis: Updated Guidance","volume":"14","author":"Tierney","year":"2025","journal-title":"Syst. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"k4597","DOI":"10.1136\/bmj.k4597","article-title":"A Guide to Systematic Review and Meta-Analysis of Prognostic Factor Studies","volume":"364","author":"Riley","year":"2019","journal-title":"BMJ"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-Analysis in Clinical Trials","volume":"7","author":"Dersimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/sim.1482","article-title":"Improved tests for a random effects meta-regression with a single covariate","volume":"22","author":"Knapp","year":"2003","journal-title":"Stat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Jackson, D., Turner, R., Rhodes, K., and Viechtbauer, W. (2014). Methods for Calculating Confidence and Credible Intervals for the Residual Between-Study Variance in Random Effects Meta-Regression Models. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-103"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying Heterogeneity in a Meta-Analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"ref_43","unstructured":"Borenstein, M., Hedges, L.V., Higgins, J.P.T., and Rothstein, H. (2011). Introduction to Meta-Analysis, John Wiley & Sons Ltd."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Papers Bias in Meta-Analysis Detected by a Simple, Graphical Test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and Fill: A Simple Funnel-Plot-Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/1467-985X.00123","article-title":"What Works?: Selectivity Models and Meta-Analysis","volume":"162","author":"Copas","year":"1999","journal-title":"J. R. Stat. Soc. Ser. A Stat. Soc."},{"key":"ref_47","unstructured":"R Core Team (2024). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_48","unstructured":"Posit Team (2025). RStudio: Integrated Development Environment for R, Posit Software, PBC."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to Perform a Meta-Analysis with R: A Practical Tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid. Based Ment. Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting Meta-Analyses in R with the Metafor Package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Softw."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hed.25495","article-title":"Three Prognostic Indexes as Predictors of Response to Adjuvant Chemoradiotherapy in Patients with Oral Squamous Cell Carcinoma after Radical Surgery: A Large-Scale Prospective Study","volume":"41","author":"Chen","year":"2019","journal-title":"Head Neck"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Cheng, A., Wei, K., Xu, Q., Wang, C., Li, B., Liu, H., Zhang, L., Zhou, H., Huang, Y., and Zhang, Y. (2025). The Comparison of the Prognostic Value of Different Inflammation-Related Indicators in Patients with Oral Squamous Cell Carcinoma. Front. Genet., 16.","DOI":"10.3389\/fgene.2025.1652603"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cho, U., Sung, Y.E., Kim, M.S., and Lee, Y.S. (2022). Prognostic Role of Systemic Inflammatory Markers in Patients Undergoing Surgical Resection for Oral Squamous Cell Carcinoma. Biomedicines, 10.","DOI":"10.3390\/biomedicines10061268"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12967-018-1742-x","article-title":"Preoperative Systemic Immune-Inflammation Index Predicts Prognosis of Patients with Oral Squamous Cell Carcinoma after Curative Resection","volume":"16","author":"Diao","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Huang, C.H., Chou, Y.F., Hsieh, T.C., and Chen, P.R. (2023). Association of Neutrophil-to-Lymphocyte Ratio and Bloodstream Infections with Survival after Curative-Intent Treatment in Elderly Patients with Oral Cavity Squamous Cell Carcinoma. Diagnostics, 13.","DOI":"10.3390\/diagnostics13030493"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lin, Y.W., Kang, W.P., Huang, B.L., Qiu, Z.H., Wei, L.F., Zhang, B., Ding, T.Y., Luo, Y., Liu, C.T., and Chu, L.Y. (2021). Nomogram Based on Clinical Characteristics and Serological Inflammation Markers to Predict Overall Survival of Oral Tongue Squamous Cell Carcinoma Patient after Surgery. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-02028-7"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E30855","DOI":"10.1097\/MD.0000000000030855","article-title":"Prognostic Value of Preoperative Systemic Inflammatory Response as a Prognostic Indicator in Patients with Early-Stage Oral Squamous Cell Carcinoma","volume":"101","author":"Mikami","year":"2022","journal-title":"Medicine"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.joms.2016.12.023","article-title":"Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer","volume":"75","author":"Ong","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5125\/jkaoms.2016.42.5.243","article-title":"C-Reactive Protein\/Albumin Ratio as Prognostic Score in Oral Squamous Cell Carcinoma","volume":"42","author":"Park","year":"2016","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Trevisani, L.F.M., Kulcsar, I.F., Kulcsar, M.A.V., Dedivitis, R.A., Kowalski, L.P., and Matos, L.L. (2023). Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma. Cancers, 15.","DOI":"10.3390\/cancers15215245"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"15330338211043048","DOI":"10.1177\/15330338211043048","article-title":"A Prognostic Model Based on Clinicopathological Features and Inflammation- and Nutrition-Related Indicators Predicts Overall Survival in Surgical Patients with Tongue Squamous Cell Carcinoma","volume":"20","author":"Wei","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bjoms.2021.10.017","article-title":"Systemic Inflammatory Response in Predicting Outcomes of Patients Undergoing Curative Resection for Oral Squamous Cell Carcinoma","volume":"60","author":"Zubair","year":"2022","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e12219","DOI":"10.1111\/jicd.12219","article-title":"Preoperative Platelet Lymphocyte Ratio Is Superior to Neutrophil Lymphocyte Ratio to Be Used as Predictive Marker for Lymph Node Metastasis in Oral Squamous Cell Carcinoma","volume":"8","author":"Acharya","year":"2017","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1061780","DOI":"10.1155\/2018\/1061780","article-title":"Mediators of Inflammation\u2014A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma","volume":"2018","author":"Tampa","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-Related Inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/lio2.790","article-title":"Prognostic Value of Pretreatment Lymphocyte-to-Monocyte Ratio in Patients with Advanced Oral Cavity Cancer","volume":"7","author":"Supanimitjaroenporn","year":"2022","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Szilasi, Z., J\u00f3sa, V., Zrubka, Z., Mezei, T., Vass, T., Merkel, K., Helfferich, F., and Baranyai, Z. (2020). Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Prognostic Markers of Survival in Patients with Head and Neck Tumours\u2014Results of a Retrospective Multicentric Study. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17051742"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7638\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:06:50Z","timestamp":1787735210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":67,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177638"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177638","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}