{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:17:04Z","timestamp":1787894224160,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/QUI\/UI0313\/2013"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2013"]}]},{"award":["UID\/QUI\/UI0313\/2013"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2013"]}],"id":[{"id":"https:\/\/ror.org\/00snfqn58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>The present study investigates the physicochemical behavior of the first-line anti-tuberculosis drugs isoniazid (INH) and ethambutol, in the form of dihydrochloride (E\u00b7(HCl)2), in aqueous solutions containing the synthetic macrocyclic resorcinarene, C-tetra(propyl)resorcin[4]tetrasulfonate (Na4PRA) at 298.15 K. Taylor dispersion experiments were conducted to determine the ternary diffusion coefficients of these systems, offering valuable insights into their transport properties. Non-zero cross-diffusion coefficients (D12 and D21) demonstrate significant coupled transport, collectively indicating interactions between these antibiotics and the resorcinarene host. This behavior is highly consistent with the formation of a host\u2013guest complex. These diffusion measurements were complemented by NMR spectroscopy, which confirmed the formation of host\u2013guest complexes between the respective drugs and this resorcinarene, Na4PRA.<\/jats:p>","DOI":"10.3390\/ijms27177657","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:32Z","timestamp":1787756672000},"page":"7657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Sodium C-Tetra(propyl)resorcin[4]tetrasulfonate (Na4PRA) on Antituberculosis Drugs as Seen by Diffusometry and NMR Spectroscopy"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-8696","authenticated-orcid":false,"given":"Edilma","family":"Sanabria","sequence":"first","affiliation":[{"name":"Grupo GICRIM, Programa de Investigaci\u00f3n Criminal, Universidad Manuela Beltr\u00e1n, Avenida Circunvalar No. 60\u201300, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-1963","authenticated-orcid":false,"given":"Ana C. 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V.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogota, Carrera 30 No. 45-03, Bogot\u00e1 111311, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","first-page":"169","article-title":"Tuberculosis: Update","volume":"35","year":"2024","journal-title":"Rev. Med. Clin."},{"key":"ref_2","unstructured":"World Health Organization (2025). World Health Statistics: Monitoring Health for the SDGs, Sustainable Development Goals, World Health Organization. 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