{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:16:31Z","timestamp":1788254191680,"version":"build-2803163510"},"reference-count":101,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pulsing Magnetic Field Therapy Research Fund","award":["E-551-00-0004-01"],"award-info":[{"award-number":["E-551-00-0004-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Duchenne and Becker X-linked muscular dystrophies are no longer viewed as disorders arising solely from passive sarcolemmal fragility but as diseases that progress because of disruption of cellular mechanotransduction. Evidence is accumulating that the gating of TRPC1 and TRPC3 mechanosensitive channels is altered in the absence of dystrophin, resulting in a breakdown of sarcoplasmic calcium homeostasis and preferential loss of type II glycolytic muscle fibres, while type I oxidative fibres are spared. TRPC1-mediated Ca2+ influx is known to activate the calcineurin\u2013NFAT pathway, upregulating PGC-1\u03b1 transcriptional activity to promote mitochondriogenesis, antioxidant defences, and the oxidative muscle phenotype. Calcineurin signalling also activates a compensatory pathway in dystrophinless muscle by inducing the expression of utrophin, a dystrophin autosomal homologue, capable of substituting for dystrophin at the muscle surface. This perspective explores the possibility that non-mechanical biophysical stimuli can be used to restore calcineurin signalling by non-invasively activating TRPC1. Pulsed electromagnetic field (PEMF) exposure has been shown to stimulate TRPC1-mediated Ca2+ entry and calcineurin-dependent signalling in skeletal muscle and may serve as a gentle method to induce utrophin expression in X-linked muscular dystrophies. By activating calcineurin compensatory mechanisms in these disorders, PEMF-based paradigms warrant future investigation as mechanistically grounded adjuvants to conventional therapies.<\/jats:p>","DOI":"10.3390\/ijms27177700","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:31:13Z","timestamp":1788251473000},"page":"7700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Mitohormesis as a Potential Non-Invasive Restorative Therapy for X-Linked Muscular Dystrophies"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-2033","authenticated-orcid":false,"given":"Jan Nikolas","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, Singapore 117599, Singapore"},{"name":"BICEPS Lab (Biolonic Currents Electromagnetic Pulsing Systems), National University of Singapore, Singapore 117599, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-1083","authenticated-orcid":false,"given":"Alfredo","family":"Franco-Obreg\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Institute of Health Technology and Innovation (iHealthtech), National University of Singapore, Singapore 117599, Singapore"},{"name":"BICEPS Lab (Biolonic Currents Electromagnetic Pulsing Systems), National University of Singapore, Singapore 117599, Singapore"},{"name":"NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Competence Center for Applied Biotechnology and Molecular Medicine, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(02)07815-7","article-title":"The muscular dystrophies","volume":"359","author":"Emery","year":"2002","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0140-6736(12)61897-2","article-title":"Muscular dystrophies","volume":"381","author":"Mercuri","year":"2013","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41431-022-01138-2","article-title":"Incidence of Duchenne muscular dystrophy in the modern era; an Australian study","volume":"30","author":"Kariyawasam","year":"2022","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.slsci.2016.07.004","article-title":"Phenotypic contrasts of Duchenne Muscular Dystrophy in women: Two case reports","volume":"9","author":"Nozoe","year":"2016","journal-title":"Sleep Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00109-009-0550-4","article-title":"Therapeutic targeting of signaling pathways in muscular dystrophy","volume":"88","author":"Bhatnagar","year":"2010","journal-title":"J. Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/mus.880010204","article-title":"Becker-type muscular dystrophy","volume":"1","author":"Bradley","year":"1978","journal-title":"Muscle Nerve"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/01.RES.0000126574.61061.25","article-title":"The dystrophin glycoprotein complex: Signaling strength and integrity for the sarcolemma","volume":"94","author":"Lapidos","year":"2004","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s42003-022-03980-y","article-title":"The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction","volume":"5","author":"Wilson","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.150.5.1209","article-title":"The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin","volume":"150","author":"Rybakova","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1440-1681.2004.04027.x","article-title":"Stretch-activated channels in stretch-induced muscle damage: Role in muscular dystrophy","volume":"31","author":"Yeung","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1139\/Y09-058","article-title":"Calcium and the damage pathways in muscular dystrophy","volume":"88","author":"Allen","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Dubinin, M.V., and Belosludtsev, K.N. (2023). Ion Channels of the Sarcolemma and Intracellular Organelles in Duchenne Muscular Dystrophy: A Role in the Dysregulation of Ion Homeostasis and a Possible Target for Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032229"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00028.2001","article-title":"Function and genetics of dystrophin and dystrophin-related proteins in muscle","volume":"82","author":"Blake","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1096\/fj.03-0453com","article-title":"Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibers","volume":"18","author":"Kumar","year":"2004","journal-title":"FASEB J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00007.2015","article-title":"Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy","volume":"96","author":"Allen","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/344670a0","article-title":"Calcium entry through stretch-inactivated ion channels in mdx myotubes","volume":"344","author":"Franco","year":"1990","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1113\/jphysiol.1994.sp020440","article-title":"Mechanosensitive ion channels in skeletal muscle from normal and dystrophic mice","volume":"481","author":"Lansman","year":"1994","journal-title":"J. Physiol."},{"key":"ref_18","first-page":"11856","article-title":"Cellular pathogenesis of Duchenne muscular dystrophy: Progressive myofibre degeneration, chronic inflammation, reactive myofibrosis and satellite cell dysfunction","volume":"33","author":"Dowling","year":"2023","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1083\/jcb.200203091","article-title":"Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers","volume":"158","author":"Vandebrouck","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1096\/fj.06-6683com","article-title":"Regulation of capacitative calcium entries by alpha1-syntrophin: Association of TRPC1 with dystrophin complex and the PDZ domain of alpha1-syntrophin","volume":"21","author":"Vandebrouck","year":"2007","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12562","DOI":"10.1111\/cpr.12562","article-title":"Syntrophins entangled in cytoskeletal meshwork: Helping to hold it all together","volume":"52","author":"Bhat","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.2147\/NDT.S93873","article-title":"Current and emerging treatment strategies for Duchenne muscular dystrophy","volume":"12","author":"Mah","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.ymthe.2018.07.011","article-title":"Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy","volume":"26","author":"Duan","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ymthe.2017.02.019","article-title":"Progress toward Gene Therapy for Duchenne Muscular Dystrophy","volume":"25","author":"Chamberlain","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mareedu, S., Million, E.D., Duan, D., and Babu, G.J. (2021). Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.647010"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Franco-Obregon, A., and Tai, Y.K. (2024). Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches?. Cells, 13.","DOI":"10.3390\/cells13151273"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1113\/jphysiol.2004.075275","article-title":"Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse","volume":"562","author":"Yeung","year":"2005","journal-title":"J. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.nbd.2006.08.010","article-title":"Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: Beneficial effect of pentoxifylline","volume":"24","author":"Rolland","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajpath.2010.11.027","article-title":"Long-term blocking of calcium channels in mdx mice results in differential effects on heart and skeletal muscle","volume":"178","author":"Jorgensen","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"C1344","DOI":"10.1152\/ajpcell.00056.2011","article-title":"Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice","volume":"301","author":"Matsumura","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.nmd.2006.07.024","article-title":"Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice","volume":"16","author":"Whitehead","year":"2006","journal-title":"Neuromuscul. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0906591106","article-title":"Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism","volume":"106","author":"Millay","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Choi, J.H., Jeong, S.Y., Oh, M.R., Allen, P.D., and Lee, E.H. (2020). TRPCs: Influential Mediators in Skeletal Muscle. Cells, 9.","DOI":"10.3390\/cells9040850"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12967-021-03191-9","article-title":"TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD","volume":"19","author":"Creismeas","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mus.22060","article-title":"Expression and association of TRPC1 with TRPC3 during skeletal myogenesis","volume":"44","author":"Cheung","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1113\/JP285263","article-title":"Hypochlorous acid exposure impairs skeletal muscle function and Ca2+ signalling: Implications for Duchenne muscular dystrophy pathology","volume":"601","author":"Lea","year":"2023","journal-title":"J. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0005-2736(00)00195-4","article-title":"Comparative analysis of the isoform expression pattern of Ca2+-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers","volume":"1466","author":"Froemming","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e2200003","DOI":"10.1002\/pmic.202200003","article-title":"Proteomic profiling of impaired excitation-contraction coupling and abnormal calcium handling in muscular dystrophy","volume":"22","author":"Dowling","year":"2022","journal-title":"Proteomics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.tibs.2024.05.004","article-title":"Re-evaluating TRP channel mechanosensitivity","volume":"49","author":"Cox","year":"2024","journal-title":"Trends Biochem. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-010-0847-8","article-title":"Canonical TRP channels and mechanotransduction: From physiology to disease states","volume":"460","author":"Patel","year":"2010","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2741\/3230","article-title":"The integrative function of TRPC channels","volume":"14","author":"Kiselyov","year":"2009","journal-title":"Front. Biosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1113\/JP271705","article-title":"The involvement of transient receptor potential canonical type 1 in skeletal muscle regrowth after unloading-induced atrophy","volume":"594","author":"Xia","year":"2016","journal-title":"J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1242\/jcs.037218","article-title":"TRPC1 regulates skeletal myoblast migration and differentiation","volume":"121","author":"Louis","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"C149","DOI":"10.1152\/ajpcell.00241.2009","article-title":"Role of TRPC1 channel in skeletal muscle function","volume":"298","author":"Zanou","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Franco-Obregon, A., Tai, Y.K., Wu, K.Y., Iversen, J.N., and Wong, C.J.K. (2023). The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective. Bioengineering, 10.","DOI":"10.3390\/bioengineering10080956"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1074\/jbc.M600981200","article-title":"Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins","volume":"281","author":"Lee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1042\/BJ20071504","article-title":"TRPC3-interacting triadic proteins in skeletal muscle","volume":"411","author":"Woo","year":"2008","journal-title":"Biochem. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00424-018-2211-3","article-title":"TRPC channels in exercise-mimetic therapy","volume":"471","author":"Oda","year":"2019","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kato, Y., Wu, D., Ito, T., Atef, Y., Ayukawa, K., Mi, X., Nishiyama, K., Nishimura, A., and Nishida, M. (2025). Inhibition of TRPC3-Nox2 Complex Formation Ameliorates Skeletal Muscle Atrophy. Antioxidants, 15.","DOI":"10.3390\/antiox15010038"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kaplan, K.M., and Morgan, K.G. (2022). The importance of dystrophin and the dystrophin associated proteins in vascular smooth muscle. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.1059021"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bbrc.2014.02.127","article-title":"Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca2+ levels in skeletal muscle","volume":"446","author":"Woo","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1038\/ncomms9526","article-title":"Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle","volume":"6","author":"Kerr","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lopez, J.R., Uryash, A., Faury, G., Esteve, E., and Adams, J.A. (2020). Contribution of TRPC Channels to Intracellular Ca2+ Dyshomeostasis in Smooth Muscle from mdx Mice. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00126"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Bonato, A., Raparelli, G., and Caruso, M. (2024). Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for Duchenne muscular dystrophy. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1496870"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12853","DOI":"10.1096\/fj.201900057R","article-title":"Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: Evidence of a magnetic mitohormetic mechanism","volume":"33","author":"Yap","year":"2019","journal-title":"FASEB J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Franco-Obregon, A. (2023). Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium-Mitochondrial Axis Invoked by Magnetic Field Exposure. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101176"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.biochem.75.103004.142622","article-title":"Signaling pathways in skeletal muscle remodeling","volume":"75","author":"Olson","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.physiol.010908.163216","article-title":"Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies","volume":"71","author":"Wallace","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(88)90463-1","article-title":"Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy","volume":"52","author":"Webster","year":"1988","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1469-7793.2000.00379.x","article-title":"Mitochondrial function and antioxidative defence in human muscle: Effects of endurance training and oxidative stress","volume":"528","author":"Tonkonogi","year":"2000","journal-title":"J. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Heydemann, A. (2018). Skeletal Muscle Metabolism in Duchenne and Becker Muscular Dystrophy-Implications for Therapies. Nutrients, 10.","DOI":"10.3390\/nu10060796"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9387","DOI":"10.1073\/pnas.0308179101","article-title":"TRPC3 channels confer cellular memory of recent neuromuscular activity","volume":"101","author":"Rosenberg","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Noorani, M.M., Noel, R.C., and Marrelli, S.P. (2011). Upregulated TRPC3 and Downregulated TRPC1 Channel Expression during Hypertension is Associated with Increased Vascular Contractility in Rat. Front. Physiol., 2.","DOI":"10.3389\/fphys.2011.00042"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Iversen, J.N., Tai, Y.K., Wu, K.Y., Wong, C.J.K., Lim, H.Y., and Franco-Obregon, A. (2025). Magnetically Stimulated Myogenesis Recruits a CRY2-TRPC1 Photosensitive Signaling Axis. Cells, 14.","DOI":"10.3390\/cells14030231"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9343","DOI":"10.1038\/s41467-025-64435-6","article-title":"Structural mechanism of the agonist binding on human TRPC3 channel","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"eadw7185","DOI":"10.1126\/scisignal.adw7185","article-title":"Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow","volume":"18","author":"Earley","year":"2025","journal-title":"Sci. Signal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000342461","article-title":"Role of TRPC1 and TRPC3 channels in contraction and relaxation of mouse thoracic aorta","volume":"50","author":"Kochukov","year":"2013","journal-title":"J. Vasc. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/glia.23180","article-title":"TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis In Vivo","volume":"65","author":"Belkacemi","year":"2017","journal-title":"Glia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.jbchem.a003063","article-title":"Calcineurin as a multifunctional regulator","volume":"131","author":"Shibasaki","year":"2002","journal-title":"J. Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.1073\/pnas.0308035101","article-title":"NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching","volume":"101","author":"McCullagh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11143","DOI":"10.1096\/fj.201903005RR","article-title":"Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1alpha expression: Follow-up to an in vitro magnetic mitohormetic study","volume":"34","author":"Tai","year":"2020","journal-title":"FASEB J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.celrep.2014.08.035","article-title":"NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity","volume":"8","author":"Ehlers","year":"2014","journal-title":"Cell Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.153.2.329","article-title":"Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway","volume":"153","author":"Horsley","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1093\/emboj\/19.16.4323","article-title":"Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis","volume":"19","author":"Youn","year":"2000","journal-title":"EMBO J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1242\/jcs.198978","article-title":"Distinct roles of NFATc1 and NFATc4 in human primary myoblast differentiation and in the maintenance of reserve cells","volume":"130","author":"Perroud","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.bbamcr.2010.03.019","article-title":"Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes","volume":"1803","author":"Reddy","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e14517","DOI":"10.14814\/phy2.14517","article-title":"GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production","volume":"8","author":"Whitley","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1073\/pnas.1232352100","article-title":"An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle","volume":"100","author":"Handschin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/hmg\/ddh037","article-title":"Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice","volume":"13","author":"Chakkalakal","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1750-3639.1996.tb00781.x","article-title":"Utrophin: A structural and functional comparison to dystrophin","volume":"6","author":"Blake","year":"1996","journal-title":"Brain Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-009-8089-5","article-title":"The roles of the dystrophin-associated glycoprotein complex at the synapse","volume":"41","author":"Pilgram","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1750-3639.2009.00275.x","article-title":"Differential expression of utrophin-A and -B promoters in the central nervous system (CNS) of normal and dystrophic mdx mice","volume":"20","author":"Baby","year":"2010","journal-title":"Brain Pathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1073\/pnas.0932671100","article-title":"Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin\/NFAT signaling","volume":"100","author":"Chakkalakal","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1083\/jcb.200808027","article-title":"Sarcospan reduces dystrophic pathology: Stabilization of the utrophin-glycoprotein complex","volume":"183","author":"Peter","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.fmre.2022.07.004","article-title":"Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy","volume":"2","author":"Wu","year":"2022","journal-title":"Fundam. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1111\/febs.12295","article-title":"The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy","volume":"280","author":"Marshall","year":"2013","journal-title":"FEBS J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1113\/jphysiol.2014.274332","article-title":"Utrophin regulates modal gating of mechanosensitive ion channels in dystrophic skeletal muscle","volume":"592","author":"Tan","year":"2014","journal-title":"J. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/19336950.2015.1040211","article-title":"Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle","volume":"9","author":"Lansman","year":"2015","journal-title":"Channels"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e12391","DOI":"10.14814\/phy2.12391","article-title":"Disease course in mdx:utrophin+\/- mice: Comparison of three mouse models of Duchenne muscular dystrophy","volume":"3","author":"McDonald","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/nar\/gkm1107","article-title":"Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling","volume":"36","author":"Chakkalakal","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clinbiochem.2007.01.006","article-title":"Decreased calcineurin activity in circulation of Duchenne muscular dystrophy","volume":"40","author":"Sundaram","year":"2007","journal-title":"Clin. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e2000146","DOI":"10.1002\/adbi.202000146","article-title":"Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities","volume":"4","author":"Kurth","year":"2020","journal-title":"Adv. Biosyst."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1172\/JCI36277","article-title":"Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin\/NFAT activation","volume":"118","author":"Frey","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"C553","DOI":"10.1152\/ajpcell.00096.2006","article-title":"Calcium controls smooth muscle TRPC gene transcription via the CaMK\/calcineurin-dependent pathways","volume":"292","author":"Morales","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"C56","DOI":"10.1152\/ajpcell.00377.2002","article-title":"Ca2+ transients activate calcineurin\/NFATc1 and initiate fast-to-slow transformation in a primary skeletal muscle culture","volume":"285","author":"Kubis","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1152\/japplphysiol.00015.2005","article-title":"Role of Ca2+\/calmodulin-dependent kinases in skeletal muscle plasticity","volume":"99","author":"Chin","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1074\/jbc.M111.283218","article-title":"Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes","volume":"287","author":"Storch","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_99","first-page":"211","article-title":"Mitochondrial Dysfunction in Duchenne Muscular Dystrophy","volume":"2014","author":"Thomas","year":"2014","journal-title":"Open J. Endocr. Metab. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/ars.2019.7949","article-title":"Redox Signaling in Widespread Health Benefits of Exercise","volume":"33","author":"Louzada","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1038\/s41598-019-39532-4","article-title":"Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres","volume":"9","author":"Omairi","year":"2019","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7700\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:34:18Z","timestamp":1788251658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/27\/17\/7700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":101,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ijms27177700"],"URL":"https:\/\/doi.org\/10.3390\/ijms27177700","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}