{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:20:40Z","timestamp":1788326440576,"version":"build-2803163510"},"reference-count":175,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Approximately one billion people worldwide are affected by acute or chronic skin wounds, placing a substantial burden on healthcare systems. This burden is further increased by population aging, as wound healing is impaired in older individuals due to age-related changes in tissue repair. Structural and functional skin alterations associated with aging and wound healing have been extensively described, including cellular senescence and inflammaging. However, less is known about zinc homeostasis in aged skin and its impact on skin regeneration in aging. Zinc deficiency, which is common in older adults, may impair wound healing and contribute to the development of chronic wounds. The present review focuses on the age-related alterations of zinc homeostasis in the skin and the role of zinc in skin regeneration and wound healing.<\/jats:p>","DOI":"10.3390\/ijms27177713","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:48:36Z","timestamp":1788256116000},"page":"7713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Zinc\u2013Senescence Axis in Skin Aging and Wound Healing: A Narrative Review"],"prefix":"10.3390","volume":"27","author":[{"given":"Kerim","family":"Mutig","sequence":"first","affiliation":[{"name":"Department of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan"},{"name":"Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology, 119048 Sirius, Russia"},{"name":"Department of Pharmacology, Institute of Pharmacy Named After A.P. Nelyubin, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0974","authenticated-orcid":false,"given":"Prim B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulat","family":"Azhibek","sequence":"additional","affiliation":[{"name":"Department of Biosciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-1040","authenticated-orcid":false,"given":"Svetlana","family":"Lebedeva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmacy Named After A.P. Nelyubin, Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mamun, A.A., Shao, C., Geng, P., Wang, S., and Xiao, J. (2024). Recent Advances in Molecular Mechanisms of Skin Wound Healing and Its Treatments. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1395479"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and Molecular Mechanisms of Skin Wound Healing","volume":"25","author":"Martin","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","first-page":"1","article-title":"Decoding Wound Healing: Cellular Insights and Technological Advances","volume":"3","author":"Galvin","year":"2026","journal-title":"npj Biomed. 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